Genetically-engineered polypeptide carrier for thermal targeting of therapeutics
Publication
, Journal Article
Meyer, DE; Kong, G; Dewhirst, M; Chilkoti, A
Published in: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
December 1, 1999
We report the synthesis of a environmentally-responsive polypeptide carrier for thermally-targeted delivery of radionuclide therapeutics. We hypothesized that systemically-injected radionuclide-polypeptide conjugates are likely to be cleared from circulation under physiological conditions, while externally-induced local hyperthermia at tumor sites will result in radionuclide accumulation because of carrier aggregation. We report preliminary in vivo results which support this hypothesis.
Duke Scholars
Published In
Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
ISSN
0589-1019
Publication Date
December 1, 1999
Volume
2
Start / End Page
1289
Citation
APA
Chicago
ICMJE
MLA
NLM
Meyer, D. E., Kong, G., Dewhirst, M., & Chilkoti, A. (1999). Genetically-engineered polypeptide carrier for thermal targeting of therapeutics. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 2, 1289.
Meyer, D. E., G. Kong, M. Dewhirst, and A. Chilkoti. “Genetically-engineered polypeptide carrier for thermal targeting of therapeutics.” Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings 2 (December 1, 1999): 1289.
Meyer DE, Kong G, Dewhirst M, Chilkoti A. Genetically-engineered polypeptide carrier for thermal targeting of therapeutics. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 1999 Dec 1;2:1289.
Meyer, D. E., et al. “Genetically-engineered polypeptide carrier for thermal targeting of therapeutics.” Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, vol. 2, Dec. 1999, p. 1289.
Meyer DE, Kong G, Dewhirst M, Chilkoti A. Genetically-engineered polypeptide carrier for thermal targeting of therapeutics. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 1999 Dec 1;2:1289.
Published In
Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
ISSN
0589-1019
Publication Date
December 1, 1999
Volume
2
Start / End Page
1289