Selected Grants
McCain/Bayh Glioblastoma Consortium
Clinical TrialPrincipal Investigator · Awarded by Department of Defense · 2025 - 2029Innate Antiviral Signals for Cancer Immunotherapy
ResearchCollaborator · Awarded by National Institute of Neurological Disorders and Stroke · 2018 - 2028Resolving Spatiotemporal Dynamics of Recombinant Poliovirus Immunotherapy
ResearchCollaborator · Awarded by National Cancer Institute · 2023 - 2028The Role of SMARCAL1 Depletion on Increased Immunogenicity in ALT+ Gliomas
FellowshipCo-Sponsor · Awarded by National Institutes of Health · 2025 - 2028Modulation of STING to enhance the efficacy of treatments for diffuse midline glioma
ResearchMentor · Awarded by Alex's Lemonade Stand · 2024 - 2028Phase 2 trial of a novel peptide vaccine targeting CMV antigen for newly diagnosed pediatric high grade glioma and diffuse intrinsic pontine glioma and recurrent medulloblastoma
ResearchInvestigator · Awarded by Food and Drug Administration · 2021 - 2027ATRXmutations,innate immune activation and therapeutic vunerabilityin malignant gliomas
ResearchPrincipal Investigator · Awarded by National Cancer Institute · 2022 - 2027Enhancing the efficacy of Radiation Therapy for brainstem glioma by targeting ATM
ResearchMentor · Awarded by National Cancer Institute · 2022 - 2027Targeting DNA replication stress to activate innate inflammation in diffuse midline gliomas with H3K27M mutations
ResearchSignificant Contributor · Awarded by Chadtough Defeat DIPG Foundation · 2024 - 2027Connect 1906 Phase 2 trial of a novel peptide vaccine (PEP-CMV) targeting CMV antigen for newly diagnosed pediatric high-grade glioma and diffuse intrinsic pontine glioma and recurrent medulloblastoma
Clinical TrialPrincipal Investigator · Awarded by Research Institute at Nationwide Children's Hospital · 2024 - 20266-thio-2'-deoxyguanosine: A Novel Immunogenic Telomerase-Mediated Therapy in Glioblastoma - A Duke and UTSW Collaboration
ResearchPrincipal Investigator · Awarded by National Cancer Institute · 2021 - 2026PNOC 019: A Randomized, Double-Blinded, Pilot Trial of Neoadjuvant Checkpoint Inhibition followed by Combination Adjuvant Checkpoint Inhibition in Children and Young Adults with Recurrent or Progressive High Grade Glioma (HGG)
Clinical TrialPrincipal Investigator · Awarded by The Regents of the University of California · 2021 - 2026Nervous system control and regulation of the immune system following neurological insults
ResearchEvaluator · Awarded by National Institute of Neurological Disorders and Stroke · 2023 - 2026Genomic and Spatial Expression Analysis of Oligodendroglioma to Identify Novel Therapeutic and Prognostic Targets
ResearchMentor · Awarded by Doris Duke Charitable Foundation, Inc. · 2022 - 2026PRECLINICAL THERAPEUTIC SCREENING FOR NEW THERAPIES FOR GLIOBLASTOMA MULTIFORME
ResearchPrincipal Investigator · Awarded by Jewish Communal Fund · 2022 - 2026PRECLINICAL THERAPEUTIC SCREENING FOR NEW THERAPIES FOR GLIOBLASTOMA MULTIFORME
ResearchCo Investigator · Awarded by Jewish Communal Fund · 2007 - 2026CONNECT 1903: Larotrectinib for Children with high-grade glioma with NTRK Fusion
Clinical TrialPrincipal Investigator · Awarded by Research Institute at Nationwide Children's Hospital · 2021 - 2026Duke Center for Advancement of Child Health (CAtCH).
Inst. Training Prgm or CMEMentor · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2021 - 2026CONNECT 1702: A Phase 1b STudy of PTC596 in Children with Newly Diagnosed Diffuse Intrinsic Pointine Glioma and High-Grade Glioma
Clinical TrialPrincipal Investigator · Awarded by Research Institute at Nationwide Children's Hospital · 2021 - 2025Duke SPORE in Brain Cancer
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2014 - 2025NEWLY DIAGNOSED CHILDREN (LESS THAN 10 YEARS OLD) WITH MEDULLOBLASTOMA AND OTHER CENTRAL NERVOUS SYSTEMPRIMITIVE NEURO-ECTODERMAL TUMORS:CLINICAL AND MOLECULAR RISK-TAILORED INTENSIVE AND COMPRESSED INDUCTION CHEMOTHERAPY FOLLOWED BY CONSOLIDATION WI
Clinical TrialPrincipal Investigator · Awarded by Research Institute at Nationwide Children's Hospital · 2019 - 2025NINDS Research Education Programs for Residents and Fellows in Neurosurgery
Inst. Training Prgm or CMEMentor · Awarded by National Institute of Neurological Disorders and Stroke · 2009 - 2025A programmable, cell type-specific, RNA-based tool to treat diffuse intrinsic pontine glioma (DIPG)
ResearchCollaborator · Awarded by B*Cured · 2023 - 2024Existing Sample Review for nFerence Collaboration
ResearchPrincipal Investigator · Awarded by nference, Inc. · 2022 - 2024SJMB12: A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma
Clinical TrialPrincipal Investigator · Awarded by St. Jude Children's Research Hospital · 2014 - 2024Experimental Therapy for Brain Tumors
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2018 - 2024Identifying brainstem glioma subtypes that can be radiosensitized by ATM inhibition
ResearchCo-Mentor · Awarded by Pediatric Brain Tumor Foundation · 2019 - 2023ATRX Mutations in Determining Immunity Against Glioma
ResearchPrincipal Investigator · Awarded by Brain Tumor Research Charity · 2021 - 2023PNOC022 A Combination Therapy Trial using an Adaptive Platform Design for Children and Young Adults with Diffuse Midline Gliomas (DMGs) including Diffuse Intrinsic Pontine Gliomas (DIPGs) at Initial D
Clinical TrialPrincipal Investigator · Awarded by The Regents of the University of California · 2022 - 2023Enhancing the efficacy of radiation therapy for brainstem gliomas
ResearchMentor · Awarded by St. Baldrick's Foundation · 2020 - 2022A Phase II study of Panobinostat in Paediatric, Adolescent and Young Adult Patients with Solid Tumours (ATRT)
Clinical TrialPrincipal Investigator · Awarded by Australian and New Zealand Children's Haematology/Oncology Group · 2021 - 2022Is Low Tumor Mutational Burden Predictive of Response to Oncolytic Polio Virus Therapy in Recurrent Glioblastoma?
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2022Collaborative Network for Neuroooncology Clinical Trials (CONNECT)
ResearchPrincipal Investigator · Awarded by Cincinnati Children's Hospital Medical Center · 2020 - 2022LGG-14C03: A Phase III study comparing two carboplatin containing regimens for children and young adults with previously untreated low grade glioma
Clinical TrialPrincipal Investigator · Awarded by Ann & Robert H Lurie Children's Hospital of Chicago · 2018 - 2021Poliovirus-Instigated APC Responses Against BRaf(V600E) for Pediatric Brain Tumor Immunotherapy
ResearchPrincipal Investigator · Awarded by V Foundation for Cancer Research · 2018 - 2021Recombinant Attenuated Poliovirus Immunization Vectors Targeting H3.3(K27M) in DIPG
ResearchPrincipal Investigator · Awarded by Michael Mosier Defeat DIPG Foundation · 2018 - 2019External Relationships
- Immunogenesis
- Kestral Inc
- MAIA Inc
- The Jackson Laboratory
This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.