Journal ArticleOptica · April 1, 2023
This paper experimentally examines different configurations of a multi-camera array microscope (MCAM) imaging technology. The MCAM is based upon a densely packed array of “micro-cameras” to jointly image across a large field-of-view (FOV) at high resolutio ...
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Journal ArticleElife · December 14, 2022
The dynamics of living organisms are organized across many spatial scales. However, current cost-effective imaging systems can measure only a subset of these scales at once. We have created a scalable multi-camera array microscope (MCAM) that enables compr ...
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Dataset · February 10, 2022
The dynamics of living organisms are organized across many spatial scales, yet existing, cost-effective imaging systems can measure only a subset of these scales at once. Here, we have created a scalable multi-camera array microscope (MCAM) that enables co ...
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Journal ArticleCurr Opin Neurobiol · December 2020
Detailed quantification of neural dynamics across the entire brain will be the key to genuinely understanding perception and behavior. With the recent developments in microscopy and biosensor engineering, the zebrafish has made a grand entrance in neurosci ...
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ConferenceOptics InfoBase Conference Papers · January 1, 2019
We present a micro-camera array microscope that images at cellular-level detail across hundreds of square centimeters. We demonstrate how this microscope can image the behavior and fluorescent neural activity of freely swimming zebrafish ...
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Journal ArticleCell · November 3, 2016
Detailed descriptions of brain-scale sensorimotor circuits underlying vertebrate behavior remain elusive. Recent advances in zebrafish neuroscience offer new opportunities to dissect such circuits via whole-brain imaging, behavioral analysis, functional pe ...
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Journal ArticleElife · March 22, 2016
In the absence of salient sensory cues to guide behavior, animals must still execute sequences of motor actions in order to forage and explore. How such successive motor actions are coordinated to form global locomotion trajectories is unknown. We mapped t ...
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Journal ArticleNeuron · February 3, 2016
Escape behaviors deliver organisms away from imminent catastrophe. Here, we characterize behavioral responses of freely swimming larval zebrafish to looming visual stimuli simulating predators. We report that the visual system alone can recruit lateralized ...
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Journal ArticleNat Methods · November 2015
In order to localize the neural circuits involved in generating behaviors, it is necessary to assign activity onto anatomical maps of the nervous system. Using brain registration across hundreds of larval zebrafish, we have built an expandable open-source ...
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Journal ArticleNat Neurosci · April 2010
Existing techniques for monitoring neural activity in awake, freely behaving vertebrates are invasive and difficult to target to genetically identified neurons. We used bioluminescence to non-invasively monitor the activity of genetically specified neurons ...
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