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Qingwen Chen

Selected Publications

Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes.

Journal Article Advanced science (Weinheim, Baden-Wurttemberg, Germany) · August 2025 Epigenetic clocks in blood have shown promise as tools to quantify biological age, displaying robust associations with morbidity and all-cause mortality. Whilst the effect of cell-type heterogeneity on epigenetic clock estimates has been explored, such stu ... Full text Cite

Serum microRNA expression quantitative trait loci in children with asthma colocalize with asthma-related GWAS results.

Journal Article NPJ genomic medicine · July 2025 Asthma poses a significant public health burden. Despite identifying more than a hundred genetic risk loci in genome-wide association studies (GWAS), the underlying functional mechanisms remain poorly understood. Studying omics, especially microRNAs (miRNA ... Full text Cite

Association between buprenorphine dose and outcomes among pregnant persons with opioid use disorder.

Journal Article American journal of obstetrics and gynecology · July 2025 BackgroundOpioid use disorder contributes to maternal morbidity and mortality in the United States. Little is known about how the patterns of buprenorphine dose and duration throughout pregnancy may affect neonatal and postpartum outcomes.Obje ... Full text Cite

A roadmap to precision medicine through post-genomic electronic medical records.

Journal Article Nature communications · February 2025 The promise of integrating Electronic Medical Records (EMR) and genetic data for precision medicine has largely fallen short due to its omission of environmental context over time. Post-genomic data can bridge this gap by capturing the real-time dynamic re ... Full text Cite

Quantifying the stochastic component of epigenetic aging.

Journal Article Nature aging · June 2024 DNA methylation clocks can accurately estimate chronological age and, to some extent, also biological age, yet the process by which age-associated DNA methylation (DNAm) changes are acquired appears to be quasi-stochastic, raising a fundamental question: h ... Full text Cite

Metabolite signatures associated with microRNA miR-143-3p serve as drivers of poor lung function trajectories in childhood asthma.

Journal Article EBioMedicine · April 2024 BackgroundLung function trajectories (LFTs) have been shown to be an important measure of long-term health in asthma. While there is a growing body of metabolomic studies on asthma status and other phenotypes, there are no prospective studies of t ... Full text Cite

Contraceptive Use Among Traditional Medicare And Medicare Advantage Enrollees.

Journal Article Health affairs (Project Hope) · January 2024 Medicare is the primary source of health insurance coverage for reproductive-age people with Social Security Disability Insurance. However, Medicare does not require contraceptive coverage for pregnancy prevention, and little is known about contraceptive u ... Full text Cite

The value of prospective metabolomic susceptibility endotypes: broad applicability for infectious diseases.

Journal Article EBioMedicine · October 2023 BackgroundAs new infectious diseases (ID) emerge and others continue to mutate, there remains an imminent threat, especially for vulnerable individuals. Yet no generalizable framework exists to identify the at-risk group prior to infection. Metabo ... Full text Cite

Sex-related differences in the prevalence of substance use disorders, treatment, and overdose among parents with young children.

Journal Article Addictive behaviors reports · June 2023 IntroductionRisk factors and treatment rates for substance use disorders (SUDs) differ by sex. Females often have greater childcare and household responsibilities than males, which may inhibit SUD treatment. We examined how SUD, medication for opi ... Full text Cite

Duration of medication for opioid use disorder during pregnancy and postpartum by race/ethnicity: Results from 6 state Medicaid programs.

Journal Article Drug and alcohol dependence · June 2023 BackgroundMedication for opioid use disorder (MOUD) is evidence-based treatment during pregnancy and postpartum. Prior studies show racial/ethnic differences in receipt of MOUD during pregnancy. Fewer studies have examined racial/ethnic difference ... Full text Cite

Explaining Racial-ethnic Disparities in the Receipt of Medication for Opioid Use Disorder during Pregnancy.

Journal Article Journal of addiction medicine · November 2022 ObjectiveFactors contributing to racial and ethnic disparities in medication for opioid use disorder (MOUD) receipt during pregnancy are largely unknown. We quantified the contribution of individual, healthcare access and quality, and community fa ... Full text Cite

Disparities in geographic access to medical oncologists.

Journal Article Health services research · October 2022 ObjectiveThe objective of this study is to identify disparities in geographic access to medical oncologists at the time of diagnosis.Data sources/study setting2014-2016 Pennsylvania Cancer Registry (PCR), 2019 CMS Base Provider Enrollment ... Full text Cite

Outcomes associated with the use of medications for opioid use disorder during pregnancy.

Journal Article Addiction (Abingdon, England) · December 2021 AimTo test the effect of the duration of medication for opioid use disorder (MOUD) use during pregnancy on maternal, perinatal and neonatal outcomes.DesignRetrospective cohort analysis of claims, encounter and pharmacy data.Setting Full text Cite

Substance use disorders and risk of severe maternal morbidity in the United States.

Journal Article Drug and alcohol dependence · November 2020 BackgroundThe contribution of substance use disorders to the burden of severe maternal morbidity in the United States is poorly understood. The objective was to estimate the independent association between substance use disorders during pregnancy ... Full text Cite