Overview
Dr. Maldonado specializes in pediatric retinal diseases, pediatric and adult ophthalmic genetics, and inherited retinal diseases. He completed a fellowship in pediatric retinal imaging at Duke Ophthalmology. He also completed ophthalmic genetics and electrophysiology and medical retina fellowships at the National Institutes of Health (NIH-NEI).
Prior to joining Duke, he was the Director and Founder of the Ophthalmic Genetics and Electrophysiology Service at the University of Kentucky Medical Center.
Dr. Maldonado provides pediatric medical retina services in addition to pediatric and adult inherited retinal disease care.
Prior to joining Duke, he was the Director and Founder of the Ophthalmic Genetics and Electrophysiology Service at the University of Kentucky Medical Center.
Dr. Maldonado provides pediatric medical retina services in addition to pediatric and adult inherited retinal disease care.
Current Appointments & Affiliations
Associate Professor of Ophthalmology
·
2024 - Present
Ophthalmology, Vitreoretinal Diseases & Surgery,
Ophthalmology
Recent Publications
A novel missense TUBB4B variant outside of the canonical hotspot is associated with cone-rod dystrophy and sensorineural hearing loss.
Journal Article Ophthalmic Genet · October 7, 2025 INTRODUCTION: Pathogenic variants in TUBB4B, which encodes the β-tubulin 4B isotype of microtubule subunits, have been associated with Leber congenital amaurosis with early-onset deafness (LCAEOD), an autosomal dominant condition characterized by early and ... Full text Link to item CiteNatural History of Autosomal Recessive IMPG2-Associated Retinal Dystrophy.
Journal Article Am J Ophthalmol · October 2025 PURPOSE: To describe the natural history of autosomal recessive IMPG2-associated retinal dystrophy. DESIGN: Multicenter international retrospective case series. METHODS: Review of clinical notes, retinal imaging including fundus autofluorescence (FAF) and ... Full text Link to item CiteInherited retinal diseases in Kentucky: diagnostic yield, gene variants, and novel mutations in a U.S. population.
Journal Article BMC Med Genomics · August 28, 2025 BACKGROUND: Inherited retinal diseases (IRDs) are a group of heterogeneous conditions leading to visual impairment and blindness with over 280 associated genes identified so far. This study aims to provide an initial characterization of the clinical and ge ... Full text Link to item CiteRecent Grants
A Phase 1/2, First-in-Human, Open-label, Assessor-Masked, Randomized, Controlled, Dose Escalation/Expansion Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of a Subretinal Injection of SB-007 in Subjects with Stargardt Disease (ST
Clinical TrialPrincipal Investigator · Awarded by SpliceBio, SL · 2025 - 2030A Randomized, Double-Masked, Controlled, Parallel-Group, Multicenter, Phase 2/3 Clinical Trial Investigating the Efficacy and Safety of ADX-2191 in Adults with Retinitis Pigmentosa
Clinical TrialPrincipal Investigator · Awarded by Aldeyra Therapeutics · 2024 - 2029A Phase 2/3, Randomized, Controlled, Masked, Multi-center Study to Evaluate the Efficacy, Safety and Tolerability of Two Doses of AGTC-501, a Recombinant Adeno-associated Virus Vector Expressing RPGR (rAAV2tYF-GRK1-RPGR), Compared to an Untreated
Clinical TrialPrincipal Investigator · Awarded by Beacon Therapeutics, Inc. · 2024 - 2029View All Grants
Education, Training & Certifications
Pontificia Universidad Catolica, Facultad de Medicina (Ecuador) ·
2002
M.D.