Scholars@Duke
Samira Musah

Samira Musah

Assistant Professor in the Department of Biomedical Engineering
Biomedical Engineering
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Selected Publications

Kidney Disease Modeling with Organoids and Organs-on-Chips.

Journal Article Annual review of biomedical engineering · July 2024 Kidney disease is a global health crisis affecting more than 850 million people worldwide. In the United States, annual Medicare expenditures for kidney disease and organ failure exceed $81 billion. Efforts to develop targeted therapeutics are limited by a ... Full text Cite

Advancing drug discovery for glomerulopathies using stem-cell-derived kidney models.

Journal Article Trends in pharmacological sciences · April 2023 Chronic kidney disease (CKD) is an epidemic that affects millions worldwide. The glomerulus, a specialized unit of the nephron, is highly susceptible to injury. Human induced pluripotent stem cells (iPSCs) have emerged as an attractive resource for modelin ... Full text Cite

Isogenic Kidney Glomerulus Chip Engineered from Human Induced Pluripotent Stem Cells.

Journal Article Journal of visualized experiments : JoVE · November 2022 Chronic kidney disease (CKD) affects 15% of the U.S. adult population, but the establishment of targeted therapies has been limited by the lack of functional models that can accurately predict human biological responses and nephrotoxicity. Advancements in ... Full text Cite

Uncovering SARS-CoV-2 kidney tropism.

Journal Article Nature reviews. Molecular cell biology · August 2021 Full text Cite

Introductions to the Community: Early-Career Researchers in the Time of COVID-19.

Journal Article Cell stem cell · August 2020 COVID-19 has unfortunately halted lab work, conferences, and in-person networking, which is especially detrimental to researchers just starting their labs. Through social media and our reviewer networks, we met some early-career stem cell investigators imp ... Full text Open Access Cite

Guided Differentiation of Mature Kidney Podocytes from Human Induced Pluripotent Stem Cells Under Chemically Defined Conditions.

Journal Article Journal of visualized experiments : JoVE · July 2020 Kidney disease affects more than 10% of the global population and costs billions of dollars in federal expenditures. The most severe forms of kidney disease and eventual end-stage renal failure are often caused by the damage to the glomerular podocytes, wh ... Full text Open Access Cite

Directed differentiation of human induced pluripotent stem cells into mature kidney podocytes and establishment of a Glomerulus Chip.

Journal Article Nature protocols · July 2018 Protocols have been established to direct the differentiation of human induced pluripotent stem (iPS) cells into nephron progenitor cells and organoids containing many types of kidney cells, but it has been difficult to direct the differentiation of iPS ce ... Full text Cite

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip.

Journal Article Nature biomedical engineering · January 2017 An in vitro model of the human kidney glomerulus - the major site of blood filtration - could facilitate drug discovery and illuminate kidney-disease mechanisms. Microfluidic organ-on-a-chip technology has been used to model the human proximal tubul ... Full text Cite

Engineered in vitro disease models.

Chapter · January 2015 The ultimate goal of most biomedical research is to gain greater insight into mechanisms of human disease or to develop new and improved therapies or diagnostics. Although great advances have been made in terms of developing disease models in animals, such ... Full text Cite

Substratum-induced differentiation of human pluripotent stem cells reveals the coactivator YAP is a potent regulator of neuronal specification.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · September 2014 Physical stimuli can act in either a synergistic or antagonistic manner to regulate cell fate decisions, but it is less clear whether insoluble signals alone can direct human pluripotent stem (hPS) cell differentiation into specialized cell types. We previ ... Full text Cite

Glycosaminoglycan-binding hydrogels enable mechanical control of human pluripotent stem cell self-renewal.

Journal Article ACS nano · November 2012 Reaping the promise of human embryonic stem (hES) cells hinges on effective defined culture conditions. Efforts to identify chemically defined environments for hES cell propagation would benefit from understanding the relevant functional properties of the ... Full text Cite

Synthetic polymer scaffold supports human embryonic stem cell adhesion and proliferation in defined conditions

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · August 19, 2012 Link to item Cite

High-throughput discovery of synthetic surfaces that support proliferation of pluripotent cells.

Journal Article Journal of the American Chemical Society · February 2010 Synthetic materials that promote the growth or differentiation of cells have advanced the fields of tissue engineering and regenerative medicine. Most functional biomaterials are based on a handful of peptide sequences derived from protein ligands for cell ... Full text Cite

Comparative studies of quercetin interactions with monophosphate nucleotides using UV-Vis spectroscopy and electrochemical techniques

Journal Article Electroanalysis · January 1, 2007 The nature and extent of the interactions of phytoestrogens such as quercetin (Q) with monophosphate nucleotides have implications in cell cycle arrest, DNA damage, and inhibition of intracellular enzymes involved with cell proliferation. We have studied t ... Full text Cite