Journal ArticleMatrix biology plus · December 2024
Diabetic nephropathy results from chronic (or uncontrolled) hyperglycemia and is the leading cause of kidney failure. The kidney's glomerular podocytes are highly susceptible to diabetic injury and subsequent non-reversible degeneration. We generated a hum ...
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Journal ArticleBiomedicines · November 2024
Hypertensive nephropathy (HN) is a leading cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD), contributing to significant morbidity, mortality, and rising healthcare costs. In this review article, we explore the role of epigenetic me ...
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Journal ArticleBioengineering (Basel, Switzerland) · October 2024
Stem cell fate decisions, including proliferation, differentiation, morphological changes, and viability, are impacted by microenvironmental cues such as physical and biochemical signals. However, the specific impact of matrix elasticity on kidney cell dev ...
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Journal ArticleInternational journal of molecular sciences · August 2024
In the human body, the vascular system plays an indispensable role in maintaining homeostasis by supplying oxygen and nutrients to cells and organs and facilitating the removal of metabolic waste and toxins. Blood vessels-the key constituents of the vascul ...
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Journal ArticleAnnual review of biomedical engineering · July 2024
Kidney disease is a global health crisis affecting more than 850 million people worldwide. In the United States, annual Medicare expenditures for kidney disease and organ failure exceed $81 billion. Efforts to develop targeted therapeutics are limited by a ...
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Journal ArticleScience advances · June 2024
Organ-on-chip (OOC) systems are revolutionizing tissue engineering by providing dynamic models of tissue structure, organ-level function, and disease phenotypes using human cells. However, nonbiological components of OOC devices often limit the recapitulat ...
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Journal ArticleTrends in pharmacological sciences · April 2023
Chronic kidney disease (CKD) is an epidemic that affects millions worldwide. The glomerulus, a specialized unit of the nephron, is highly susceptible to injury. Human induced pluripotent stem cells (iPSCs) have emerged as an attractive resource for modelin ...
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Journal ArticleACS chemical biology · December 2022
The most severe forms of kidney diseases are often associated with irreversible damage to the glomerular podocytes, the highly specialized epithelial cells that encase glomerular capillaries and regulate the removal of toxins and waste from the blood. Seve ...
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Journal ArticleAnnals of the New York Academy of Sciences · December 2022
Complex three-dimensional in vitro organ-like models, or organoids, offer a unique biological tool with distinct advantages over two-dimensional cell culture systems, which can be too simplistic, and animal models, which can be too complex and may fail to ...
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Journal ArticleJournal of visualized experiments : JoVE · November 2022
Chronic kidney disease (CKD) affects 15% of the U.S. adult population, but the establishment of targeted therapies has been limited by the lack of functional models that can accurately predict human biological responses and nephrotoxicity. Advancements in ...
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Journal ArticleBioengineering (Basel, Switzerland) · April 2022
Podocytes derived from human induced pluripotent stem (hiPS) cells are enabling studies of kidney development and disease. However, many of these studies are carried out in traditional tissue culture plates that do not accurately recapitulate the molecular ...
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Journal ArticleDevelopment (Cambridge, England) · February 2022
The proper development and patterning of organs rely on concerted signaling events emanating from intracellular and extracellular molecular and biophysical cues. The ability to model and understand how these microenvironmental factors contribute to cell fa ...
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Journal ArticleFront Cell Dev Biol · 2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the Coronavirus disease 2019 (COVID-19), which has resulted in over 5.9 million deaths worldwide. While cells in the respiratory system are the initial target of SARS-CoV-2, there is mount ...
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Journal ArticleCurrent transplantation reports · January 2022
Purpose of reviewKidney disease affects more than 13% of the world population, and current treatment options are limited to dialysis and organ transplantation. The generation of kidney organoids from human-induced pluripotent stem (hiPS) cells cou ...
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Journal ArticlebioRxiv · November 17, 2021
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the Coronavirus disease 2019 (COVID-19), which was declared a pandemic by the World Health Organization (WHO) in March 2020. The disease has caused more than 5.1 million deaths ...
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Journal ArticleMicromachines · August 2021
Progress in understanding kidney disease mechanisms and the development of targeted therapeutics have been limited by the lack of functional in vitro models that can closely recapitulate human physiological responses. Organ Chip (or organ-on-a-chip) microf ...
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Journal ArticleCell stem cell · May 2021
A recurring theme throughout our year-long "Introductions to the community: Early-career researchers in the time of COVID-19" Voices series was resiliency and adaptation to new and uncertain circumstances. Here, Cell Stem Cell talks with three new investig ...
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Chapter · January 1, 2021
Podocytes play an important role in maintaining the function of the glomerulus, and their loss or dysfunction contribute to the initiation and progression of kidney disease. The tissue interface consisting of podocytes and fenestrated endothelial cells con ...
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Chapter · January 1, 2021
Human pluripotent stem cells hold tremendous promise for understanding tissue development and disease mechanisms, and for in vitro modeling of organ function. However, the use of stem cells to model and understand human kidney development had remained elus ...
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Journal ArticleCell stem cell · August 2020
COVID-19 has unfortunately halted lab work, conferences, and in-person networking, which is especially detrimental to researchers just starting their labs. Through social media and our reviewer networks, we met some early-career stem cell investigators imp ...
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Journal ArticleJournal of visualized experiments : JoVE · July 2020
Kidney disease affects more than 10% of the global population and costs billions of dollars in federal expenditures. The most severe forms of kidney disease and eventual end-stage renal failure are often caused by the damage to the glomerular podocytes, wh ...
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Journal ArticleNature protocols · July 2018
Protocols have been established to direct the differentiation of human induced pluripotent stem (iPS) cells into nephron progenitor cells and organoids containing many types of kidney cells, but it has been difficult to direct the differentiation of iPS ce ...
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Journal ArticleNature biomedical engineering · January 2017
An in vitro model of the human kidney glomerulus - the major site of blood filtration - could facilitate drug discovery and illuminate kidney-disease mechanisms. Microfluidic organ-on-a-chip technology has been used to model the human proximal tubul ...
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Chapter · January 2015
The ultimate goal of most biomedical research is to gain greater insight into mechanisms of human disease or to develop new and improved therapies or diagnostics. Although great advances have been made in terms of developing disease models in animals, such ...
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Journal ArticleProceedings of the National Academy of Sciences of the United States of America · September 2014
Physical stimuli can act in either a synergistic or antagonistic manner to regulate cell fate decisions, but it is less clear whether insoluble signals alone can direct human pluripotent stem (hPS) cell differentiation into specialized cell types. We previ ...
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Journal ArticleACS nano · November 2012
Reaping the promise of human embryonic stem (hES) cells hinges on effective defined culture conditions. Efforts to identify chemically defined environments for hES cell propagation would benefit from understanding the relevant functional properties of the ...
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Journal ArticleJournal of the American Chemical Society · February 2010
Synthetic materials that promote the growth or differentiation of cells have advanced the fields of tissue engineering and regenerative medicine. Most functional biomaterials are based on a handful of peptide sequences derived from protein ligands for cell ...
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Journal ArticleElectroanalysis · January 1, 2007
The nature and extent of the interactions of phytoestrogens such as quercetin (Q) with monophosphate nucleotides have implications in cell cycle arrest, DNA damage, and inhibition of intracellular enzymes involved with cell proliferation. We have studied t ...
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