Tatiana Segura
Professor of Biomedical Engineering
Professor Tatiana Segura received her BS degree in Bioengineering from the University of California Berkeley and her doctorate in Chemical Engineering from Northwestern University. Her graduate work in designing and understanding non-viral gene delivery from hydrogel scaffolds was supervised by Prof. Lonnie Shea. She pursued post-doctoral training at the Swiss Federal Institute of Technology, Lausanne under the guidance of Prof. Jeffrey Hubbell, where her focus was self-assembled polymer systems for gene and drug delivery. Professor Segura's Laboratory studies the use of materials for minimally invasive in situ tissue repair. On this topic, she has published 113 peered reviewed publications to date. She has been recognized with the Outstanding Young Investigator Award from the American Society of Gene and Cell Therapy, the American Heart Association National Scientist Development Grant, and the CAREER award from National Science Foundation. She was Elected to the College of Fellows at the American Institute for Medical and Biological Engineers (AIMBE) in 2017. She spent the first 11 years of her career at UCLA department of Chemical and Biomolecular Engineering and has recently relocated to Duke University, where she holds appointments in Biomedical Engineering, Neurology and Dermatology.
Current Research Interests
The design of biomaterials to promote endogenous repair and reducing inflammation through the design of the geometry of the material, and delivering genes, proteins and drugs.
Current Appointments & Affiliations
- Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2018
- Professor in Neurology, Neurology, Clinical Science Departments 2019
- Affiliate of the Regeneration Next Initiative, Regeneration Next Initiative, Institutes and Centers 2017
Contact Information
- Background
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Education, Training, & Certifications
- Ph.D., Northwestern University 2004
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Duke Appointment History
- Visiting Professor in the Department of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2017 - 2018
- Recognition
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In the News
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FEB 10, 2021 -
NOV 11, 2020 Pratt School of Engineering -
NOV 5, 2019 Pratt School of Engineering -
MAY 21, 2018 Pratt School of Engineering -
AUG 22, 2017 Pratt School of Engineering
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Awards & Honors
- Research
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Selected Grants
- Pharmacological Sciences Training Grant awarded by National Institutes of Health 2020 - 2025
- Engineering Adaptive Immune Responses from Hydrogel Scaffolds to Promote Tissue Regeneration awarded by National Institutes of Health 2020 - 2025
- Biomaterials to promote synapse formation after stroke awarded by National Institutes of Health 2020 - 2024
- VEGF ligand presentation and therapeutic angiogenesis awarded by National Institutes of Health 2012 - 2024
- Non-Canonical Pathways for Electrogene Transfer awarded by National Institutes of Health 2018 - 2022
- University Training Program in Biomolecular and Tissue Engineering awarded by National Institutes of Health 1994 - 2022
- Cell and Gene Replacement Strategies for Arginase Deficiency awarded by University of California - Los Angeles 2018 - 2022
- Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
- Engineering Injectable Microporous Hydrogels for Brain Repair awarded by National Institutes of Health 2018 - 2020
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External Relationships
- Tempo therapeutics
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Griffin, Donald R., Maani M. Archang, Chen-Hsiang Kuan, Westbrook M. Weaver, Jason S. Weinstein, An Chieh Feng, Amber Ruccia, et al. “Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing.” Nature Materials 20, no. 4 (April 2021): 560–69. https://doi.org/10.1038/s41563-020-00844-w.Full Text
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Anderson, A. R., and T. Segura. “Injectable Biomaterials for Treatment of Glioblastoma.” Advanced Materials Interfaces 7, no. 20 (October 1, 2020). https://doi.org/10.1002/admi.202001055.Full Text
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Wilson, Katrina L., S Thomas Carmichael, and Tatiana Segura. “Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke.” Journal of Visualized Experiments : Jove, no. 164 (October 2020). https://doi.org/10.3791/61450.Full Text
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McMillan, Alexander H., Emma K. Thomée, Alessandra Dellaquila, Hussam Nassman, Tatiana Segura, and Sasha Cai Lesher-Pérez. “Rapid Fabrication of Membrane-Integrated Thermoplastic Elastomer Microfluidic Devices.” Micromachines 11, no. 8 (July 28, 2020). https://doi.org/10.3390/mi11080731.Full Text
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Darling, Nicole J., Weixian Xi, Elias Sideris, Alexa R. Anderson, Cassie Pong, S Thomas Carmichael, and Tatiana Segura. “Click by Click Microporous Annealed Particle (MAP) Scaffolds.” Advanced Healthcare Materials 9, no. 10 (May 2020): e1901391. https://doi.org/10.1002/adhm.201901391.Full Text
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Daly, A. C., L. Riley, T. Segura, and J. A. Burdick. “Hydrogel microparticles for biomedical applications.” Nature Reviews Materials 5, no. 1 (January 1, 2020): 20–43. https://doi.org/10.1038/s41578-019-0148-6.Full Text
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Riley, Lindsay, Lucas Schirmer, and Tatiana Segura. “Granular hydrogels: emergent properties of jammed hydrogel microparticles and their applications in tissue repair and regeneration.” Current Opinion in Biotechnology 60 (December 2019): 1–8. https://doi.org/10.1016/j.copbio.2018.11.001.Full Text
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Truong, Norman F., Evan Kurt, Nairi Tahmizyan, Sasha Cai Lesher-Pérez, Mabel Chen, Nicole J. Darling, Weixian Xi, and Tatiana Segura. “Microporous annealed particle hydrogel stiffness, void space size, and adhesion properties impact cell proliferation, cell spreading, and gene transfer.” Acta Biomaterialia 94 (August 2019): 160–72. https://doi.org/10.1016/j.actbio.2019.02.054.Full Text
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Truong, Norman F., Sasha Cai Lesher-Pérez, Evan Kurt, and Tatiana Segura. “Pathways Governing Polyethylenimine Polyplex Transfection in Microporous Annealed Particle Scaffolds.” Bioconjugate Chemistry 30, no. 2 (February 2019): 476–86. https://doi.org/10.1021/acs.bioconjchem.8b00696.Full Text
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Pannier, Angela K., Tyler Kozisek, and Tatiana Segura. “Surface- and Hydrogel-Mediated Delivery of Nucleic Acid Nanoparticles.” Methods in Molecular Biology (Clifton, N.J.) 1943 (January 2019): 177–97. https://doi.org/10.1007/978-1-4939-9092-4_12.Full Text
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Darling, Nicole J., Elias Sideris, Naomi Hamada, S Thomas Carmichael, and Tatiana Segura. “Injectable and Spatially Patterned Microporous Annealed Particle (MAP) Hydrogels for Tissue Repair Applications.” Advanced Science (Weinheim, Baden Wurttemberg, Germany) 5, no. 11 (November 2018): 1801046. https://doi.org/10.1002/advs.201801046.Full Text
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Villate-Beitia, Ilia, Norman F. Truong, Idoia Gallego, Jon Zárate, Gustavo Puras, José Luis Pedraz, and Tatiana Segura. “Hyaluronic acid hydrogel scaffolds loaded with cationic niosomes for efficient non-viral gene delivery.” Rsc Advances 8, no. 56 (September 12, 2018): 31934–42. https://doi.org/10.1039/c8ra05125a.Full Text
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Youngblood, Richard L., Norman F. Truong, Tatiana Segura, and Lonnie D. Shea. “It's All in the Delivery: Designing Hydrogels for Cell and Non-viral Gene Therapies.” Molecular Therapy : The Journal of the American Society of Gene Therapy 26, no. 9 (September 2018): 2087–2106. https://doi.org/10.1016/j.ymthe.2018.07.022.Full Text
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Nih, Lina R., Shiva Gojgini, S Thomas Carmichael, and Tatiana Segura. “Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke.” Nature Materials 17, no. 7 (July 2018): 642–51. https://doi.org/10.1038/s41563-018-0083-8.Full Text
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Zhu, Suwei, Shuoran Li, Helena Escuin-Ordinas, Robert Dimatteo, Weixian Xi, Antoni Ribas, and Tatiana Segura. “Accelerated wound healing by injectable star poly(ethylene glycol)-b-poly(propylene sulfide) scaffolds loaded with poorly water-soluble drugs.” Journal of Controlled Release : Official Journal of the Controlled Release Society 282 (July 2018): 156–65. https://doi.org/10.1016/j.jconrel.2018.05.006.Full Text
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Dimatteo, Robert, Nicole J. Darling, and Tatiana Segura. “In situ forming injectable hydrogels for drug delivery and wound repair.” Advanced Drug Delivery Reviews 127 (March 19, 2018): 167–84. https://doi.org/10.1016/j.addr.2018.03.007.Full Text
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Truong, Norman F., and Tatiana Segura. “Sustained Transgene Expression via Hydrogel-Mediated Gene Transfer Results from Multiple Transfection Events.” Acs Biomaterials Science & Engineering 4, no. 3 (March 2018): 981–87. https://doi.org/10.1021/acsbiomaterials.7b00957.Full Text
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Ding, Yichen, Arash Abiri, Parinaz Abiri, Shuoran Li, Chih-Chiang Chang, Kyung In Baek, Jeffrey J. Hsu, et al. “Integrating light-sheet imaging with virtual reality to recapitulate developmental cardiac mechanics.” Jci Insight 2, no. 22 (November 16, 2017). https://doi.org/10.1172/jci.insight.97180.Full Text
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Li, S., L. R. Nih, H. Bachman, P. Fei, Y. Li, E. Nam, R. Dimatteo, S. T. Carmichael, T. H. Barker, and T. Segura. “Hydrogels with precisely controlled integrin activation dictate vascular patterning and permeability.” Nature Materials 16, no. 9 (September 1, 2017): 953–61. https://doi.org/10.1038/nmat4954.Full Text
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Nih, Lina R., Elias Sideris, S Thomas Carmichael, and Tatiana Segura. “Injection of Microporous Annealing Particle (MAP) Hydrogels in the Stroke Cavity Reduces Gliosis and Inflammation and Promotes NPC Migration to the Lesion.” Advanced Materials (Deerfield Beach, Fla.) 29, no. 32 (August 2017). https://doi.org/10.1002/adma.201606471.Full Text
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Ray, A., S. Li, T. Segura, and A. Ozcan. “High-Throughput Quantification of Nanoparticle Degradation Using Computational Microscopy and Its Application to Drug Delivery Nanocapsules.” Acs Photonics 4, no. 5 (May 17, 2017): 1216–24. https://doi.org/10.1021/acsphotonics.7b00122.Full Text
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Zhu, X., S. Gojgini, T. H. Chen, P. Fei, S. Dong, C. M. Ho, and T. Segura. “Directing three-dimensional multicellular morphogenesis by self-organization of vascular mesenchymal cells in hyaluronic acid hydrogels.” Journal of Biological Engineering 11, no. 1 (April 3, 2017). https://doi.org/10.1186/s13036-017-0055-6.Full Text
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Nih, L. R., P. Moshayedi, I. L. Llorente, A. R. Berg, J. Cinkornpumin, W. E. Lowry, T. Segura, and S. T. Carmichael. “Engineered HA hydrogel for stem cell transplantation in the brain: Biocompatibility data using a design of experiment approach.” Data in Brief 10 (February 1, 2017): 202–9. https://doi.org/10.1016/j.dib.2016.11.069.Full Text
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Sideris, E., D. R. Griffin, Y. Ding, S. Li, W. M. Weaver, D. Di Carlo, T. Hsiai, and T. Segura. “Particle Hydrogels Based on Hyaluronic Acid Building Blocks.” Acs Biomaterials Science and Engineering 2, no. 11 (November 14, 2016): 2034–41. https://doi.org/10.1021/acsbiomaterials.6b00444.Full Text
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Li, Jie, Linlin Zhang, Yang Liu, Jing Wen, Di Wu, Duo Xu, Tatiana Segura, Jing Jin, Yunfeng Lu, and Hui Wang. “An intracellular protein delivery platform based on glutathione-responsive protein nanocapsules.” Chemical Communications (Cambridge, England) 52, no. 93 (November 2016): 13608–11. https://doi.org/10.1039/c6cc05099a.Full Text
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Moshayedi, Pouria, Lina R. Nih, Irene L. Llorente, Andrew R. Berg, Jessica Cinkornpumin, William E. Lowry, Tatiana Segura, and S Thomas Carmichael. “Systematic optimization of an engineered hydrogel allows for selective control of human neural stem cell survival and differentiation after transplantation in the stroke brain.” Biomaterials 105 (October 2016): 145–55. https://doi.org/10.1016/j.biomaterials.2016.07.028.Full Text
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Zhu, Xiaolu, Shiva Gojgini, Ting-Hsuan Chen, Fang Teng, Peng Fei, Siyan Dong, Tatiana Segura, and Chih-Ming Ho. “Three dimensional tubular structure self-assembled by vascular mesenchymal cells at stiffness interfaces of hydrogels.” Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 83 (October 2016): 1203–11. https://doi.org/10.1016/j.biopha.2016.08.018.Full Text
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Darling, Nicole J., Yiu-Sun Hung, Shruti Sharma, and Tatiana Segura. “Controlling the kinetics of thiol-maleimide Michael-type addition gelation kinetics for the generation of homogenous poly(ethylene glycol) hydrogels.” Biomaterials 101 (September 2016): 199–206. https://doi.org/10.1016/j.biomaterials.2016.05.053.Full Text
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Escuin-Ordinas, Helena, Shuoran Li, Michael W. Xie, Lu Sun, Willy Hugo, Rong Rong Huang, Jing Jiao, et al. “Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors.” Nature Communications 7 (August 2016): 12348. https://doi.org/10.1038/ncomms12348.Full Text
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Nih, Lina Ratiba, Stanley Thomas Carmichael, and Tatiana Segura. “Hydrogels for brain repair after stroke: an emerging treatment option.” Current Opinion in Biotechnology 40 (August 2016): 155–63. https://doi.org/10.1016/j.copbio.2016.04.021.Full Text
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Stavrakis, Alexandra I., Suwei Zhu, Vishal Hegde, Amanda H. Loftin, Alyssa G. Ashbaugh, Jared A. Niska, Lloyd S. Miller, Tatiana Segura, and Nicholas M. Bernthal. “In Vivo Efficacy of a "Smart" Antimicrobial Implant Coating.” The Journal of Bone and Joint Surgery. American Volume 98, no. 14 (July 2016): 1183–89. https://doi.org/10.2106/jbjs.15.01273.Full Text
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Zhu, Suwei, and Tatiana Segura. “Cell-Demanded VEGF Release via Nanocapsules Elicits Different Receptor Activation Dynamics and Enhanced Angiogenesis.” Annals of Biomedical Engineering 44, no. 6 (June 2016): 1983–92. https://doi.org/10.1007/s10439-016-1581-y.Full Text
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Lesher-Perez, Sasha Cai, Tatiana Segura, and Christopher Moraes. “Getting there is half the battle: recent advances in delivering therapeutics.” Integrative Biology : Quantitative Biosciences From Nano to Macro 8, no. 1 (January 2016): 8–11. https://doi.org/10.1039/c5ib90052b.Full Text
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Siegman, Shayne, Norman F. Truong, and Tatiana Segura. “Encapsulation of PEGylated low-molecular-weight PEI polyplexes in hyaluronic acid hydrogels reduces aggregation.” Acta Biomaterialia 28 (December 2015): 45–54. https://doi.org/10.1016/j.actbio.2015.09.020.Full Text
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Boehnke, Natalie, Cynthia Cam, Erhan Bat, Tatiana Segura, and Heather D. Maynard. “Imine Hydrogels with Tunable Degradability for Tissue Engineering.” Biomacromolecules 16, no. 7 (July 2015): 2101–8. https://doi.org/10.1021/acs.biomac.5b00519.Full Text
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Griffin, Donald R., Westbrook M. Weaver, Philip O. Scumpia, Dino Di Carlo, and Tatiana Segura. “Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks.” Nature Materials 14, no. 7 (July 2015): 737–44. https://doi.org/10.1038/nmat4294.Full Text
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Zhu, Suwei, Lina Nih, S Thomas Carmichael, Yunfeng Lu, and Tatiana Segura. “Enzyme-Responsive Delivery of Multiple Proteins with Spatiotemporal Control.” Advanced Materials (Deerfield Beach, Fla.) 27, no. 24 (June 2015): 3620–25. https://doi.org/10.1002/adma.201500417.Full Text
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Tokatlian, Talar, Cynthia Cam, and Tatiana Segura. “Porous hyaluronic acid hydrogels for localized nonviral DNA delivery in a diabetic wound healing model.” Advanced Healthcare Materials 4, no. 7 (May 2015): 1084–91. https://doi.org/10.1002/adhm.201400783.Full Text
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Lam, Jonathan, S Thomas Carmichael, William E. Lowry, and Tatiana Segura. “Hydrogel design of experiments methodology to optimize hydrogel for iPSC-NPC culture.” Advanced Healthcare Materials 4, no. 4 (March 2015): 534–39. https://doi.org/10.1002/adhm.201400410.Full Text
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Cam, C., S. Zhu, N. F. Truong, P. O. Scumpia, and T. Segura. “Systematic evaluation of natural scaffolds in cutaneous wound healing.” Journal of Materials Chemistry B 3, no. 40 (January 1, 2015): 7986–92. https://doi.org/10.1039/c5tb00807g.Full Text
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Du, Juanjuan, Jing Jin, Yang Liu, Jie Li, Talar Tokatlian, Zuhong Lu, Tatiana Segura, Xu-bo Yuan, Xianjin Yang, and Yunfeng Lu. “Correction to Gold-Nanocrystal-Enhanced Bioluminescent Nanocapsules.” Acs Nano 9 (2015): 2213–2213.
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Lam, J., W. E. Lowry, S. T. Carmichael, and T. Segura. “Delivery of iPS-NPCs to the stroke cavity within a hyaluronic acid matrix promotes the differentiation of transplanted cells.” Advanced Functional Materials 24, no. 44 (November 26, 2014): 7053–62. https://doi.org/10.1002/adfm.201401483.Full Text
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Du, Juanjuan, Jing Jin, Yang Liu, Jie Li, Talar Tokatlian, Zuhong Lu, Tatiana Segura, Xu-Bo Yuan, Xianjin Yang, and Yunfeng Lu. “Gold-nanocrystal-enhanced bioluminescent nanocapsules.” Acs Nano 8, no. 10 (October 13, 2014): 9964–69. https://doi.org/10.1021/nn504371h.Full Text
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Nowak-Sliwinska, Patrycja, Tatiana Segura, and M Luisa Iruela-Arispe. “The chicken chorioallantoic membrane model in biology, medicine and bioengineering.” Angiogenesis 17, no. 4 (October 2014): 779–804. https://doi.org/10.1007/s10456-014-9440-7.Full Text
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Lam, Jonathan, Norman F. Truong, and Tatiana Segura. “Design of cell-matrix interactions in hyaluronic acid hydrogel scaffolds.” Acta Biomaterialia 10, no. 4 (April 2014): 1571–80. https://doi.org/10.1016/j.actbio.2013.07.025.Full Text
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Griffin, Donald R., Jacob Borrajo, Allyson Soon, Giovanny F. Acosta-Vélez, Victor Oshita, Nicole Darling, Julia Mack, Thomas Barker, M Luisa Iruela-Arispe, and Tatiana Segura. “Hybrid photopatterned enzymatic reaction (HyPER) for in situ cell manipulation.” Chembiochem : A European Journal of Chemical Biology 15, no. 2 (January 7, 2014): 233–42. https://doi.org/10.1002/cbic.201300687.Full Text
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Cam, Cynthia, and Tatiana Segura. “Chemical sintering generates uniform porous hyaluronic acid hydrogels.” Acta Biomaterialia 10, no. 1 (January 2014): 205–13. https://doi.org/10.1016/j.actbio.2013.10.002.Full Text
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Lam, Jonathan, Bill Lowry, S Thomas Carmichael, and Tatiana Segura. “Optimizing hydrogels in vitro for transplantation of iPS-NPCs in vivo after stroke,” 2014.
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Tokatlian, Talar, Cynthia Cam, and Tatiana Segura. “Non-viral DNA delivery from porous hyaluronic acid hydrogels in mice.” Biomaterials 35, no. 2 (January 2014): 825–35. https://doi.org/10.1016/j.biomaterials.2013.10.014.Full Text
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Zhu, S., and T. Segura. “Hydrogel-based nanocomposites of therapeutic proteins for tissue repair.” Current Opinion in Chemical Engineering 4 (January 1, 2014): 128–36. https://doi.org/10.1016/j.coche.2013.12.009.Full Text
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Cam, C., and T. Segura. “Matrix-based gene delivery for tissue repair.” Current Opinion in Biotechnology 24, no. 5 (October 1, 2013): 855–63. https://doi.org/10.1016/j.copbio.2013.04.007.Full Text
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Dhaliwal, Anandika, Victor Oshita, and Tatiana Segura. “Transfection in the third dimension.” Integrative Biology : Quantitative Biosciences From Nano to Macro 5, no. 10 (October 2013): 1206–16. https://doi.org/10.1039/c3ib40086g.Full Text
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Lam, Jonathan, and Tatiana Segura. “The modulation of MSC integrin expression by RGD presentation.” Biomaterials 34, no. 16 (May 2013): 3938–47. https://doi.org/10.1016/j.biomaterials.2013.01.091.Full Text
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Pannier, Angela K., and Tatiana Segura. “Surface- and hydrogel-mediated delivery of nucleic acid nanoparticles.” Methods in Molecular Biology (Clifton, N.J.) 948 (January 2013): 149–69. https://doi.org/10.1007/978-1-62703-140-0_11.Full Text
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Tokatlian, Talar, Cynthia Cam, Shayne N. Siegman, Yuguo Lei, and Tatiana Segura. “Design and characterization of microporous hyaluronic acid hydrogels for in vitro gene transfer to mMSCs.” Acta Biomaterialia 8, no. 11 (November 2012): 3921–31. https://doi.org/10.1016/j.actbio.2012.07.014.Full Text
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Grover, Gregory N., Jonathan Lam, Thi H. Nguyen, Tatiana Segura, and Heather D. Maynard. “Biocompatible hydrogels by oxime Click chemistry.” Biomacromolecules 13, no. 10 (October 2012): 3013–17. https://doi.org/10.1021/bm301346e.Full Text
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Dhaliwal, A., J. Lam, M. Maldonado, C. Lin, and T. Segura. “Extracellular matrix modulates non-viral gene transfer to mouse mesenchymal stem cells.” Soft Matter 8, no. 5 (February 7, 2012): 1451–59. https://doi.org/10.1039/c1sm06591b.Full Text
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Dhaliwal, Anandika, Maricela Maldonado, Clayton Lin, and Tatiana Segura. “Cellular cytoskeleton dynamics modulates non-viral gene delivery through RhoGTPases.” Plos One 7, no. 4 (January 2012): e35046. https://doi.org/10.1371/journal.pone.0035046.Full Text
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Zhang, Jianjun, Talar Tokatlian, Jin Zhong, Quinn K. T. Ng, Michaela Patterson, William E. Lowry, S Thomas Carmichael, and Tatiana Segura. “Physically associated synthetic hydrogels with long-term covalent stabilization for cell culture and stem cell transplantation.” Advanced Materials (Deerfield Beach, Fla.) 23, no. 43 (November 2011): 5098–5103. https://doi.org/10.1002/adma.201103349.Full Text
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Anderson, Sean M., Shayne N. Siegman, and Tatiana Segura. “The effect of vascular endothelial growth factor (VEGF) presentation within fibrin matrices on endothelial cell branching.” Biomaterials 32, no. 30 (October 2011): 7432–43. https://doi.org/10.1016/j.biomaterials.2011.06.027.Full Text
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Gojgini, Shiva, Talar Tokatlian, and Tatiana Segura. “Utilizing cell-matrix interactions to modulate gene transfer to stem cells inside hyaluronic acid hydrogels.” Molecular Pharmaceutics 8, no. 5 (October 2011): 1582–91. https://doi.org/10.1021/mp200171d.Full Text
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Wen, Jing, Sean M. Anderson, Juanjuan Du, Ming Yan, Jun Wang, Meiqing Shen, Yunfeng Lu, and Tatiana Segura. “Controlled protein delivery based on enzyme-responsive nanocapsules.” Advanced Materials (Deerfield Beach, Fla.) 23, no. 39 (October 2011): 4549–53. https://doi.org/10.1002/adma.201101771.Full Text
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Anderson, Sean M., Bhupinder Shergill, Zachary T. Barry, Eleana Manousiouthakis, Tom T. Chen, Elliot Botvinick, Manu O. Platt, M Luisa Iruela-Arispe, and Tatiana Segura. “VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF.” Integrative Biology : Quantitative Biosciences From Nano to Macro 3, no. 9 (September 2011): 887–96. https://doi.org/10.1039/c1ib00037c.Full Text
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Lei, Yuguo, Maha Rahim, Quinn Ng, and Tatiana Segura. “Hyaluronic acid and fibrin hydrogels with concentrated DNA/PEI polyplexes for local gene delivery.” Journal of Controlled Release : Official Journal of the Controlled Release Society 153, no. 3 (August 2011): 255–61. https://doi.org/10.1016/j.jconrel.2011.01.028.Full Text
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Collier, Joel H., and Tatiana Segura. “Evolving the use of peptides as components of biomaterials.” Biomaterials 32, no. 18 (June 2011): 4198–4204. https://doi.org/10.1016/j.biomaterials.2011.02.030.Full Text
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Ng, Quinn K. T., Helen Su, Amanda Lee Armijo, Johannes Czernin, Caius G. Radu, and Tatiana Segura. “Clustered Arg-Gly-Asp peptides enhances tumor targeting of nonviral vectors.” Chemmedchem 6, no. 4 (April 2011): 623–27. https://doi.org/10.1002/cmdc.201000541.Full Text
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Zhang, Jianjun, Yuguo Lei, Anandika Dhaliwal, Quinn Kt Ng, Juanjuan Du, Ming Yan, Yunfeng Lu, and Tatiana Segura. “Protein-polymer nanoparticles for nonviral gene delivery.” Biomacromolecules 12, no. 4 (April 2011): 1006–14. https://doi.org/10.1021/bm101354a.Full Text
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Lei, Yuguo, Shiva Gojgini, Jonathan Lam, and Tatiana Segura. “The spreading, migration and proliferation of mouse mesenchymal stem cells cultured inside hyaluronic acid hydrogels.” Biomaterials 32, no. 1 (January 2011): 39–47. https://doi.org/10.1016/j.biomaterials.2010.08.103.Full Text
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Zhang, J., J. Du, M. Yan, A. Dhaliwal, J. Wen, F. Liu, T. Segura, and Y. Lu. “Synthesis of protein nano-conjugates for cancer therapy.” Nano Research 4, no. 5 (January 1, 2011): 425–33. https://doi.org/10.1007/s12274-011-0098-9.Full Text
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Lei, Yuguo, Suxian Huang, Pooria Sharif-Kashani, Yong Chen, Pirouz Kavehpour, and Tatiana Segura. “Incorporation of active DNA/cationic polymer polyplexes into hydrogel scaffolds.” Biomaterials 31, no. 34 (December 2010): 9106–16. https://doi.org/10.1016/j.biomaterials.2010.08.016.Full Text
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Tokatlian, Talar, Chadwick T. Shrum, Warren M. Kadoya, and Tatiana Segura. “Protease degradable tethers for controlled and cell-mediated release of nanoparticles in 2- and 3-dimensions.” Biomaterials 31, no. 31 (November 2010): 8072–80. https://doi.org/10.1016/j.biomaterials.2010.07.030.Full Text
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Dhaliwal, Anandika, Maricela Maldonado, Zenas Han, and Tatiana Segura. “Differential uptake of DNA-poly(ethylenimine) polyplexes in cells cultured on collagen and fibronectin surfaces.” Acta Biomaterialia 6, no. 9 (September 2010): 3436–47. https://doi.org/10.1016/j.actbio.2010.03.038.Full Text
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Du, Juanjuan, Changming Yu, Daocheng Pan, Jianmin Li, Wei Chen, Ming Yan, Tatiana Segura, and Yunfeng Lu. “Quantum-dot-decorated robust transductable bioluminescent nanocapsules.” Journal of the American Chemical Society 132, no. 37 (September 2010): 12780–81. https://doi.org/10.1021/ja104299t.Full Text
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Lei, Yuguo, Quinn K. T. Ng, and Tatiana Segura. “Two and three-dimensional gene transfer from enzymatically degradable hydrogel scaffolds.” Microscopy Research and Technique 73, no. 9 (September 2010): 910–17. https://doi.org/10.1002/jemt.20840.Full Text
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Tokatlian, Talar, and Tatiana Segura. “siRNA applications in nanomedicine.” Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology 2, no. 3 (May 2010): 305–15. https://doi.org/10.1002/wnan.81.Full Text
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Chen, Tom T., Alfonso Luque, Sunyoung Lee, Sean M. Anderson, Tatiana Segura, and M Luisa Iruela-Arispe. “Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells.” The Journal of Cell Biology 188, no. 4 (February 2010): 595–609. https://doi.org/10.1083/jcb.200906044.Full Text
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Yan, Ming, Juanjuan Du, Zhen Gu, Min Liang, Yufang Hu, Wenjun Zhang, Saul Priceman, et al. “A novel intracellular protein delivery platform based on single-protein nanocapsules.” Nature Nanotechnology 5, no. 1 (January 2010): 48–53. https://doi.org/10.1038/nnano.2009.341.Full Text
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Anderson, Sean M., Tom T. Chen, M Luisa Iruela-Arispe, and Tatiana Segura. “The phosphorylation of vascular endothelial growth factor receptor-2 (VEGFR-2) by engineered surfaces with electrostatically or covalently immobilized VEGF.” Biomaterials 30, no. 27 (September 2009): 4618–28. https://doi.org/10.1016/j.biomaterials.2009.05.030.Full Text
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Ng, Quinn K. T., Marie K. Sutton, Pan Soonsawad, Li Xing, Holland Cheng, and Tatiana Segura. “Engineering clustered ligand binding into nonviral vectors: alphavbeta3 targeting as an example.” Molecular Therapy : The Journal of the American Society of Gene Therapy 17, no. 5 (May 2009): 828–36. https://doi.org/10.1038/mt.2009.11.Full Text
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Lei, Yuguo, and Tatiana Segura. “DNA delivery from matrix metalloproteinase degradable poly(ethylene glycol) hydrogels to mouse cloned mesenchymal stem cells.” Biomaterials 30, no. 2 (January 2009): 254–65. https://doi.org/10.1016/j.biomaterials.2008.09.027.Full Text
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Adelöw, Catharina, Tatiana Segura, Jeffrey A. Hubbell, and Peter Frey. “The effect of enzymatically degradable poly(ethylene glycol) hydrogels on smooth muscle cell phenotype.” Biomaterials 29, no. 3 (January 2008): 314–26. https://doi.org/10.1016/j.biomaterials.2007.09.036.Full Text
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Segura, Tatiana, Hugo Schmokel, and Jeffrey A. Hubbell. “RNA interference targeting hypoxia inducible factor 1alpha reduces post-operative adhesions in rats.” The Journal of Surgical Research 141, no. 2 (August 2007): 162–70. https://doi.org/10.1016/j.jss.2006.07.045.Full Text
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Segura, Tatiana, and Jeffrey A. Hubbell. “Synthesis and in vitro characterization of an ABC triblock copolymer for siRNA delivery.” Bioconjugate Chemistry 18, no. 3 (May 2007): 736–45. https://doi.org/10.1021/bc060284y.Full Text
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Segura, Tatiana. “Materials for cell-triggered and efficient gene transfer.” Nanomedicine: Nanotechnology, Biology and Medicine 3 (2007): 344–344.
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Segura, T. “Formulations and Delivery Limitations of Nucleic-Acid-Based Therapies,” August 24, 2006, 1013–59. https://doi.org/10.1002/9780470117118.ch07c.Full Text
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Bengali, Zain, Angela K. Pannier, Tatiana Segura, Brian C. Anderson, Jae-Hyung Jang, Thomas A. Mustoe, and Lonnie D. Shea. “Gene delivery through cell culture substrate adsorbed DNA complexes.” Biotechnology and Bioengineering 90, no. 3 (May 2005): 290–302. https://doi.org/10.1002/bit.20393.Full Text
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Segura, Tatiana, Peter H. Chung, and Lonnie D. Shea. “DNA delivery from hyaluronic acid-collagen hydrogels via a substrate-mediated approach.” Biomaterials 26, no. 13 (May 2005): 1575–84. https://doi.org/10.1016/j.biomaterials.2004.05.007.Full Text
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Segura, Tatiana, Brian C. Anderson, Peter H. Chung, Rebecca E. Webber, Kenneth R. Shull, and Lonnie D. Shea. “Crosslinked hyaluronic acid hydrogels: a strategy to functionalize and pattern.” Biomaterials 26, no. 4 (February 2005): 359–71. https://doi.org/10.1016/j.biomaterials.2004.02.067.Full Text
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Segura, Tatiana, Matthew J. Volk, and Lonnie D. Shea. “Substrate-mediated DNA delivery: role of the cationic polymer structure and extent of modification.” Journal of Controlled Release : Official Journal of the Controlled Release Society 93, no. 1 (November 2003): 69–84. https://doi.org/10.1016/j.jconrel.2003.08.003.Full Text
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Segura, Tatiana, and Lonnie D. Shea. “Surface-tethered DNA complexes for enhanced gene delivery.” Bioconjugate Chemistry 13, no. 3 (May 2002): 621–29. https://doi.org/10.1021/bc015575f.Full Text
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Segura, T., and L. D. Shea. “Materials for non-viral gene delivery.” Annual Review of Materials Science 31 (January 1, 2001): 25–46. https://doi.org/10.1146/annurev.matsci.31.1.25.Full Text
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Theses and Dissertations
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Segura, Tatiana. “Engineering substrate-mediated gene delivery: A novel DNA delivery strategy,” 2004.
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- Teaching & Mentoring
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Recent Courses
- BME 394: Projects in Biomedical Engineering (GE) 2021
- BME 790: Advanced Topics for Graduate Students in Biomedical Engineering 2021
- BME 790L: Advanced Topics with the Lab for Graduate Students in Biomedical Engineering 2020
- BME 791: Graduate Independent Study 2020
- BME 792: Continuation of Graduate Independent Study 2020
- EGR 393: Research Projects in Engineering 2020
- BME 790: Advanced Topics for Graduate Students in Biomedical Engineering 2019
- BME 791: Graduate Independent Study 2019
- EGR 393: Research Projects in Engineering 2019
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