Scholars@Duke
William Clark Meyers

William Clark Meyers

Medical Professor in the Department of Surgery
Surgery
wmeyers@vincerainstitute.com
Box 3704 Med Ctr, Durham, NC 27710
Dept of Surgery, Durham, NC 27710

Selected Publications

Core Muscle Injuries: Preoperative Imaging and Postoperative Considerations.

Journal Article Semin Musculoskelet Radiol · February 2025 Core muscle injuries constitute a significant source of pain and functional impairment among elite athletes. Understanding the anatomy and biomechanics centered at the pubic bone joint is necessary to interpret imaging findings. Dedicated athletic pubalgia ... Full text Link to item Cite

Heterotopic Ossification and Platelet-Rich Plasma in Core Muscle Injuries: A Single-Institution Experience Over 6 Years.

Journal Article Am J Sports Med · January 2024 BACKGROUND: A 2015 study of platelet-rich plasma (PRP) for groin injuries in National Football League (NFL) players alerted the authors to the possibility that PRP is associated with heterotopic ossification (HO). The current study of athletes seen between ... Full text Link to item Cite

Core Muscle Injuries in Baseball Players

Journal Article Clinics in Sports Medicine · January 1, 2024 Full text Cite

Postoperative MR Imaging of the Pubic Symphysis and Athletic Pubalgia.

Journal Article Magn Reson Imaging Clin N Am · November 2022 MR imaging evaluation can be valuable in patients with prior surgery for athletic pubalgia presenting with new, recurrent, or persistent groin pain. The clinical and interventional history as well as comparison with preoperative imaging is essential for im ... Full text Link to item Cite

Ultrasound-guided Procedures Allow Delay of Definitive Treatment for Core Muscle Injuries.

Journal Article Med Sci Sports Exerc · February 1, 2022 INTRODUCTION: Core muscle injuries (CMI) are common in every sport. To minimize lost playing time, providers apply various nonsurgical treatments, including platelet-rich plasma, corticosteroids, ultrasound (US)-guided percutaneous tenotomy, and prolothera ... Full text Link to item Cite

Core Muscle Injury: Open your Eyes - It’s the Core

Chapter · January 1, 2022 This chapter is an introduction to the core. Defined as the entire body from the chest to mid-thigh, it can be generally broken up into four broad categories: the hip joints, the skeletal muscles, the spine, and everything else. Understanding the anatomy i ... Full text Cite

Diagnosis and Management of Core Muscle Injuries

Journal Article Operative Techniques in Orthopaedics · December 1, 2019 Lower abdominal and groin injuries are among the most common causes of pain and lost playing time in sports. Treating these injuries requires understanding the anatomy of the core and how the various components interact. Every muscle of the core is subject ... Full text Cite

Imaging of the Pelvis and Lower Extremity: Demystifying Uncommon Sources of Pelvic Pain.

Journal Article Radiol Clin North Am · November 2018 Pelvic pain can result from gastrointestinal, gynecologic, urologic, neurologic, and musculoskeletal sources. This article focuses on the musculoskeletal lesions that contribute to acute and chronic pain throughout the musculoskeletal core. Armed with an u ... Full text Link to item Cite

Core Muscle Injuries in Athletes.

Journal Article Curr Sports Med Rep · February 2018 Lower abdominal and groin injuries are among the most common causes of pain and lost playing time in sports. Perhaps the most important obstacle in understanding these injuries is the lack of consensus on nomenclature. There have been numerous advances in ... Full text Link to item Cite

Editorial Commentary: Core Muscle Injuries or Athletic Pubalgia-Finally the Real Sausage, Not Just the Same Ole Baloney.

Journal Article Arthroscopy · May 2017 In their paper "Prevalence of Surgical Repair for Athletic Pubalgia and Impact on Performance in Football Athletes Participating in the National Football League Combine," Knapik et al. cut through the baloney in the literature on "sports hernia" and apply ... Full text Link to item Cite

WHipple-ABACUS, a simple, validated risk score for 30-day mortality after pancreaticoduodenectomy developed using the ACS-NSQIP database.

Conference Surgery · November 2016 BACKGROUND: Pancreaticoduodenectomy needs simple, validated risk models to better identify 30-day mortality. The goal of this study is to develop a simple risk score to predict 30-day mortality after pancreaticoduodenectomy. METHODS: We reviewed cases of p ... Full text Link to item Cite

Ultrasound-guided Interventions for Core and Hip Injuries in Athletes.

Journal Article Radiol Clin North Am · September 2016 Trauma and the mechanical strain of high-energy activity predispose athletes to pelvic injuries. Magnetic resonance imaging remains the primary modality for diagnosing these conditions, but ultrasonography-guided interventions are important in the manageme ... Full text Link to item Cite

Doha agreement meeting on terminology and definitions in groin pain in athletes.

Journal Article Br J Sports Med · June 2015 BACKGROUND: Heterogeneous taxonomy of groin injuries in athletes adds confusion to this complicated area. AIM: The 'Doha agreement meeting on terminology and definitions in groin pain in athletes' was convened to attempt to resolve this problem. Our aim wa ... Full text Link to item Cite

Core muscle injuries

Chapter · July 1, 2014 Over the past half century, people have used a number of terms to describe the musculoskeletal injuries that affect the abdomen, pelvis and thighs of athletes. The terms reflect the various specialty disciplines of those who use them and obscure cohesive i ... Full text Cite

Core muscle injury (a better name than "athletic pubalgia" or "sports hernia")

Journal Article Current Orthopaedic Practice · January 1, 2014 The following represents a review of the literature over the past several years on muscular injuries within the body's core. The first focus was on what we should call these injuries. The article then goes into more depth about diagnosis, imaging, and indi ... Full text Cite

Current understanding of core muscle injuries (Athletic Pubalgia, Sports Hernia)

Chapter · November 1, 2013 Introduction: Groin injuries commonly encountered by physicians and surgeons who treat athletes of all ages and at all levels of competition may be quality-of-life changing or even career ending. The purpose of this chapter is to serve as a cornerstone fou ... Full text Cite

Magnetic resonance imaging of athletic pubalgia and the sports hernia: current understanding and practice.

Journal Article Magn Reson Imaging Clin N Am · February 2013 Magnetic resonance imaging (MRI) has become the standard imaging modality for activity-related groin pain. Lesions, including rectus abdominis/adductor aponeurosis injury and osteitis pubis, can be accurately identified and delineated in patients with clin ... Full text Link to item Cite

Review of MRI technique and imaging findings in athletic pubalgia and the "sports hernia".

Journal Article Eur J Radiol · December 2012 The clinical syndrome of athletic pubalgia has prematurely ended many promising athletic careers, has made many active, fitness conscious adults more sedentary, and has served as a diagnostic and therapeutic conundrum for innumerable trainers and physician ... Full text Link to item Cite

High incidence of athletic pubalgia symptoms in professional athletes with symptomatic femoroacetabular impingement.

Journal Article Arthroscopy · October 2012 PURPOSE: The purpose of this study was to identify the incidence of symptoms consistent with athletic pubalgia (AP) in athletes requiring surgical treatment for femoroacetabular impingement (FAI) and the frequency of surgical treatment of both AP and FAI i ... Full text Link to item Cite

Thoracoabdominal and pelvic injuries

Chapter · September 26, 2012 Cite

Understanding "Sports Hernia" (Athletic Pubalgia): The Anatomic and Pathophysiologic Basis for Abdominal and Groin Pain in Athletes

Journal Article Operative Techniques in Sports Medicine · March 1, 2012 Recent publicity and some scientific reports suggest increasing success in treating an entity called "sports hernia," more accurately named athletic pubalgia. The primary purpose of this article is to portray what we believe to be the key concepts for unde ... Full text Cite

Current analysis of women athletes with pelvic pain.

Journal Article Med Sci Sports Exerc · August 2011 BACKGROUND AND METHODS: Accurate diagnosis and effective management of pelvic pain in women have become more challenging now that the number of women athletes and the number of diagnostic possibilities are increasing. We conducted a prospective study of wo ... Full text Link to item Cite

Athletic Pubalgia

Chapter · January 1, 2011 Full text Cite

The spectrum of MR imaging in athletic pubalgia.

Journal Article Radiol Clin North Am · November 2010 Many athletes struggle with groin pain for years without ever receiving a clear diagnosis or being offered an effective treatment plan. Confusion among treatment providers can also frequently lead to suboptimal surgeries for presumed hernias or nerve entra ... Full text Link to item Cite

Gender differences in cholesterol nucleation in native bile: estrogen is a potential contributory factor.

Journal Article J Membr Biol · December 2009 The incidence of gallstone disease is two to three times higher in women than in men, and female sex hormones, particularly estrogens, have been implicated as contributory factors. Cholesterol nucleation is the initial step in gallstone pathogenesis and pr ... Full text Link to item Cite

Using a structured, computer-administered questionnaire for evaluating health-related QOL with chronic lower extremity wounds.

Journal Article Ostomy Wound Manage · September 15, 2009 Patients with chronic wounds of the lower extremity (CWLEs) often experience functional disability and emotional distress; incorporating health-related quality of life (HRQoL) measurements in clinical practice may improve understanding of chronic wound pat ... Link to item Cite

Comparison of four different immunosuppression protocols without long-term steroid therapy in kidney recipients monitored by surveillance biopsy: five-year outcomes.

Journal Article Transpl Immunol · November 2008 Induction and maintenance immunosuppression protocols with or without long-term steroid therapy in kidney transplant recipients are variable and are transplant center-specific. The aim of this prospective randomized pilot study was to compare 5-year outcom ... Full text Link to item Cite

Experience with "sports hernia" spanning two decades.

Journal Article Ann Surg · October 2008 OBJECTIVE AND BACKGROUND: Athletic pubalgia (AP) is a leading cause of athlete loss from competitive sports. Commonly misnamed "sports hernia," AP is a set of pelvic injuries involving the abdominal and pelvic musculature outside the ball-and-socket hip jo ... Full text Link to item Cite

Rescue of a living donor with liver transplantation.

Journal Article Am J Transplant · July 2008 Postoperative liver failure is a rare complication after living donor liver resection. This is a case report of a 22-year-old healthy donor who was rescued with liver transplantation 11 days after right hemihepatectomy. Nine months later the patient is ali ... Full text Link to item Cite

Athletic pubalgia and the "sports hernia": MR imaging findings.

Journal Article Radiology · June 2008 PURPOSE: To retrospectively determine the sensitivity and specificity of magnetic resonance (MR) imaging findings in patients with clinical athletic pubalgia, with either surgical or physical examination findings as the reference standard. MATERIALS AND ME ... Full text Link to item Cite

Long-term outcome of early steroid withdrawal after kidney transplantation in African American recipients monitored by surveillance biopsy.

Journal Article Am J Transplant · March 2008 Generally chronic steroid therapy is standard care for African American (AA) kidney recipients because of their higher incidence of rejections and lower long-term graft survival. This prospective study evaluated the long-term safety and efficacy of early s ... Full text Link to item Cite

Spectrum of MRI findings in clinical athletic pubalgia.

Journal Article Semin Musculoskelet Radiol · March 2008 Athletic pubalgia is a frequently encountered syndrome for clinicians who treat active patients participating in a wide variety of athletic endeavors worldwide. Pathologies associated with this clinical scenario span anatomically from the pubic symphysis t ... Full text Link to item Cite

Anatomy, pathology, and MRI findings in the sports hernia.

Journal Article Semin Musculoskelet Radiol · March 2008 "Sports hernia" is a frequently used term on athletic injury reports and in the sportscasting media, but its true definition remains elusive in the medical literature. Magnetic resonance imaging (MRI) is a useful tool in the evaluation of clinical athletic ... Full text Link to item Cite

Chronic wounds of the lower extremity: a preliminary performance measurement set.

Journal Article Plast Reconstr Surg · January 2008 BACKGROUND: Chronic wounds of the lower extremity, a well-known condition with a high prevalence, high cost, variable practice pattern, and poor clinical outcome, are often managed by a nonintegrated health care system. The authors formed a multispecialty ... Full text Link to item Cite

Athletic pubalgia and "sports hernia": optimal MR imaging technique and findings.

Journal Article Radiographics · 2008 Groin injuries are common in athletes who participate in sports that require twisting at the waist, sudden and sharp changes in direction, and side-to-side ambulation. Such injuries frequently lead to debilitating pain and lost playing time, and they may b ... Full text Link to item Cite

Understanding "Sports Hernia" (Athletic Pubalgia): The Anatomic and Pathophysiologic Basis for Abdominal and Groin Pain in Athletes

Journal Article Operative Techniques in Sports Medicine · October 1, 2007 Recent publicity and some scientific reports suggest increasing success in treating an entity called "sports hernia," more accurately named athletic pubalgia. The primary purpose of this article is to portray what we believe to be the key concepts for unde ... Full text Cite

Death of a living liver donor from illicit drugs.

Journal Article Liver Transpl · August 2007 In children with acute hepatic failure, it has been suggested to offer living donor transplantation to all parents when a deceased donor organ can not be provided. Ethically, living related donation is coercive by its very nature, especially in emergencies ... Full text Link to item Cite

Commentary

Book · December 1, 2006 Full text Cite

Abdomen and Pelvis

Chapter · January 1, 2006 Full text Cite

Extraarticular sources of hip pain

Chapter · December 1, 2005 The task of diagnosing and managing extraarticular causes for hip and groin pain represents one of the greatest challenges in sports medicine. The differential diagnosis for hip and groin pain is broad and includes intraarticular hip disorders, acute and c ... Full text Cite

Protein kinase C-alpha regulation of gallbladder Na+ transport becomes progressively more dysfunctional during gallstone formation.

Journal Article J Lab Clin Med · October 2005 Gallbladder Na+ absorption and biliary Ca2+ are both increased during gallstone formation and may promote cholesterol nucleation. Na+/H+ exchange (NHE) is a major pathway for gallbladder Na+ transport. Ca2+-dependent second messengers, including protein ki ... Full text Link to item Cite

Gallbladder Na+/H+ exchange activity is up-regulated prior to cholesterol crystal formation.

Journal Article Eur J Clin Invest · August 2005 BACKGROUND: Gallbladder Na+ and H2O absorption are increased prior to gallstone formation and may promote cholesterol nucleation. Na+/H+ exchange (NHE) isoforms NHE2 and NHE3 are involved in gallbladder Na+ transport in prairie dogs. We examined whether in ... Full text Link to item Cite

Anatomic basis for evaluation of abdominal and groin pain in athletes

Journal Article Operative Techniques in Sports Medicine · January 1, 2005 Full text Cite

Safety and efficacy of living donor liver preservation with HTK solution.

Conference Transplant Proc · 2005 BACKGROUND: In living donor liver transplantation (LDLTx) organ procurement is usually well controlled, and allows to assess liver preservation and graft function under standardized conditions. Because publications on histidine-tryptophan-ketoglutarate (HT ... Full text Link to item Cite

Laparoscopic esophagomyotomy for achalasia: does anterior hemifundoplication affect clinical outcome?

Conference Ann Surg · June 2004 OBJECTIVE: To determine whether the addition of anterior hemifundoplication to laparoscopic esophagomyotomy for achalasia yields better clinical outcomes than laparoscopic esophagomyotomy alone. SUMMARY BACKGROUND DATA: Although hemifundoplication may prev ... Full text Link to item Cite

Prospective, randomized, multicenter, controlled trial of a bioartificial liver in treating acute liver failure.

Journal Article Ann Surg · May 2004 OBJECTIVE: The HepatAssist liver support system is an extracorporeal porcine hepatocyte-based bioartificial liver (BAL). The safety and efficacy of the BAL were evaluated in a prospective, randomized, controlled, multicenter trial in patients with severe a ... Full text Link to item Cite

Robotic surgery: a current perspective.

Journal Article Ann Surg · January 2004 OBJECTIVE: To review the history, development, and current applications of robotics in surgery. BACKGROUND: Surgical robotics is a new technology that holds significant promise. Robotic surgery is often heralded as the new revolution, and it is one of the ... Full text Link to item Cite

Sorting through methods of dividing the liver

Journal Article European Surgery - Acta Chirurgica Austriaca · January 1, 2004 Background: No doubt, liver surgery has become safer over the past two decades. Many people jump to the conclusion that this increase in safety is due primarily to new methods of dissecting through the liver. Methods: We did a literature search over the pe ... Full text Cite

Hepatic surgery

Chapter · January 1, 2004 INTRODUCTION The laparoscopic approach may be changing the field of hepatic surgery. Many traditional hepatobiliary procedures are now potentially feasible via the laparoscope. However, the data are not “in” yet. Liver surgery via the laparoscope is inhere ... Cite

Effect of hepatic artery flow on bile secretory function after cold ischemia.

Journal Article Am J Transplant · February 2003 These studies evaluated the influence of hepatic arterial flow on biliary secretion after cold ischemia. Preparation of livers for transplantation or hepatic support impairs biliary secretion. The earliest indication of cold preservation injury during repe ... Full text Link to item Cite

Postoperative hypoxemia from clinically suspected pulmonary embolism complicated by patent foramen ovale.

Journal Article JSLS · 2003 Postoperative hypoxemia can be a challenging diagnostic and management dilemma for the clinician. We present here a case of postoperative hypoxemia following laparoscopic gastric bypass surgery secondary to presumed pulmonary embolism complicated with a pa ... Link to item Cite

Surgical management of chronic lower abdominal and groin pain in high-performance athletes.

Journal Article Curr Sports Med Rep · October 2002 Formerly, most of the causes and treatments of chronic lower abdominal and groin pain in high-performance athletes eluded sports medicine specialists. Now we are much better at identifying and managing the different syndromes. Most of the advances are base ... Full text Link to item Cite

Regulation of NFkappaB in hepatic ischemic preconditioning.

Journal Article J Am Coll Surg · September 2002 BACKGROUND: The second messengers tyrosine kinase (TK) and protein kinase C (PKC) have been implicated in mediating the cellular signaling cascade during hepatic ischemic preconditioning (IPC). We evaluated the role of TK and PKC on the modulation of the t ... Full text Link to item Cite

Porcine hepatic phospholipid efflux during reperfusion after cold ischemia.

Journal Article J Surg Res · March 2002 BACKGROUND: Cold preservation produces hepatic injury that is difficult to assess during early reperfusion. The value of reperfusion plasma choline phospholipid in predicting subsequent organ function is documented in these studies. MATERIALS AND METHODS: ... Full text Link to item Cite

Donor hepatic function: a factor in postreperfusion syndrome.

Journal Article J Gastrointest Surg · 2002 Reperfusion of support livers after cold preservation produces hemodynamic instability (i.e., postreperfusion syndrome) in the recipient during both orthotopic liver transplantation and extracorporeal liver perfusion. We evaluated the effect of the normal ... Full text Link to item Cite

Protective effects of ischemic preconditioning on the cold-preserved liver are tyrosine kinase dependent.

Journal Article Transplantation · August 15, 2001 BACKGROUND: Little data exist regarding the use of ischemic preconditioning before sustained hepatic cold storage. We hypothesized that ischemic preconditioning protects hepatic grafts via a tyrosine kinase-dependent pathway. METHODS: Six porcine livers un ... Full text Link to item Cite

Elevated intrahepatic pressures and decreased hepatic tissue blood flow prevent gas embolus during limited laparoscopic liver resections.

Journal Article Surg Endosc · July 2001 BACKGROUND: As new techniques are emerging for laparoscopic liver resections, concerns have been raised about the development of gas embolus related to the CO(2) pneumoperitoneum. We hypothesized that elevated intrahepatic vascular pressures and decreased ... Full text Link to item Cite

Protein kinase C inhibition abrogates hepatic ischemic preconditioning responses.

Journal Article J Surg Res · May 15, 2001 INTRODUCTION: A transient period of warm ischemia prior to a longer ischemic episode (ischemic preconditioning) protects the hepatic graft from cold ischemia. The mechanism for this protection is unknown, as is the role of protein kinase C in ischemic prec ... Full text Link to item Cite

Immediate and long-term outcomes after lateral pancreaticojejunostomy for chronic pancreatitis.

Journal Article Am Surg · May 2001 Lateral pancreaticojejunostomy (LPJ) is the recommended surgical treatment of intractable pain from chronic pancreatitis (CP) with obstruction and ductal dilatation. This study evaluated the etiology, morbidity, mortality, hospital costs, and quality of li ... Link to item Cite

MR findings in athletes with pubalgia.

Journal Article Skeletal Radiol · May 2001 OBJECTIVE: To describe the MR findings in athletes with pubalgia. DESIGN AND PATIENTS: Pelvic MR images of 32 athletes (30 men, 2 women) with pubalgia were studied. T1-weighted and T2-weighted (SE and FSE) and STIR images in the axial and coronal planes we ... Full text Link to item Cite

Hemodynamic and metabolic variables predict porcine ex vivo liver function.

Journal Article J Surg Res · March 2001 Early recognition of hepatic function during initial graft reperfusion is important in beginning hepatic support perfusions as well as in liver transplantation. We hypothesized that both hemodynamic and metabolic perfusion variables obtained immediately af ... Full text Link to item Cite

V-PYRRO/NO: an hepato-selective nitric oxide donor improves porcine liver hemodynamics and function after ischemia reperfusion.

Journal Article Transplantation · January 27, 2001 BACKGROUND: The role of nitric oxide (NO) in ischemia reperfusion (I/R) injury is controversial as both beneficial and harmful effects have been reported. We explored the potential role of a pharmacological agent recently shown to generate NO metabolically ... Full text Link to item Cite

Bosentan, an endothelin antagonist, augments hepatic graft function by reducing graft circulatory impairment following ischemia/reperfusion injury.

Journal Article J Gastrointest Surg · 2001 Endothelin is a potent hepatic vasoconstrictor. We evaluated the role of an endothelin antagonist in hepatic ischemia/reperfusion injury. Bosentan, a novel endothelin receptor antagonist, was infused directly into the portal vein prior to cold ischemia and ... Full text Link to item Cite

Alterations in intrahepatic hemodynamics of the harvested porcine liver.

Journal Article J Gastrointest Surg · 2001 Hemodynamic properties of a donor liver, during initial reperfusion, are associated with the degree of graft preservation injury and have been proposed to correlate with subsequent markers of liver function. In the present study, hepatic hemodynamics, that ... Full text Link to item Cite

Viral infection abrogates CD8(+) T-cell deletion induced by costimulation blockade.

Journal Article J Surg Res · September 2000 BACKGROUND: Treatment with a single donor-specific transfusion (DST) plus a brief course of anti-CD154 monoclonal antibody (mAb) prolongs skin allograft survival in mice. It is known that prolongation of allograft survival by this method depends in part on ... Full text Link to item Cite

NFkappaB expression during cold ischemia correlates with postreperfusion graft function.

Journal Article J Surg Res · September 2000 In liver transplantation, activation of NFkappaB occurs upon reperfusion, yet few data exist regarding NFkappaB activation during cold ischemia. We hypothesized that activation of NFkappaB may initially occur during cold ischemia, prior to reperfusion, and ... Full text Link to item Cite

Hand-assisted laparoscopic surgery (HALS) with the HandPort system: initial experience with 68 patients.

Journal Article Ann Surg · May 2000 OBJECTIVE: To evaluate the feasibility and potential benefits of hand-assisted laparoscopic surgery with the HandPort System, a new device. SUMMARY BACKGROUND DATA: In hand-assisted laparoscopic surgery, the surgeon inserts a hand into the abdomen while pn ... Full text Link to item Cite

Liver metastases from breast cancer: long-term survival after curative resection.

Journal Article Surgery · April 2000 BACKGROUND: Liver metastases from breast cancer are associated with a poor prognosis (median survival < 6 months). A subgroup of these patients with no dissemination in other organs may benefit from surgery. Available data in the literature suggest that on ... Full text Link to item Cite

Bile acids in xenogeneic ex-vivo liver perfusion: function of xenoperfused livers and compatibility with human bile salts and porcine livers.

Journal Article Transplantation · January 27, 2000 BACKGROUND: In recent years, hepatic support systems using xenogeneic cells have been developed to support patients in fulminant hepatic failure. The extent to which xenogeneic hepatocytes metabolize and excrete human organic anions is unclear. In these st ... Full text Link to item Cite

Management of severe lower abdominal or inguinal pain in high-performance athletes. PAIN (Performing Athletes with Abdominal or Inguinal Neuromuscular Pain Study Group).

Journal Article Am J Sports Med · 2000 The purpose of this study was to gain insight into the pathophysiologic processes of severe lower-abdominal or inguinal pain in high-performance athletes. We evaluated 276 patients; 175 underwent pelvic floor repairs. Of the 157 athletes who had not underg ... Full text Link to item Cite

Biliary secretion of extracorporeal porcine livers with single and dual vessel perfusion.

Journal Article Transplantation · August 15, 1999 BACKGROUND: Hepatic support systems that provide detoxification without biliary secretion (i.e., isolated hepatocyte systems) are sufficient to improve encephalopathy and bridge patients to transplantation. However, biliary secretion may be critical when h ... Full text Link to item Cite

Handoscopic surgery: a prospective multicenter trial of a minimally invasive technique for complex abdominal surgery. Southern Surgeons' Club Study Group.

Journal Article Arch Surg · May 1999 HYPOTHESIS: We hypothesized that hand-assisted laparoscopic surgery (a new technique that involves a surgeon's hand passing through a pneumoperitoneum-protecting sleeve device and assisting in laparoscopic surgery) is feasable and outcomes are comparable t ... Link to item Cite

Injury to aberrant bile ducts during cholecystectomy: a common cause of diagnostic error and treatment delay.

Journal Article AJR Am J Roentgenol · April 1999 OBJECTIVE: The purpose of this study was to determine the prevalence of injured aberrant bile ducts in a population with complications after cholecystectomy and to determine whether such injury resulted in significant delay in the diagnosis and treatment o ... Full text Link to item Cite

Laparoscopic gastrectomy in the porcine model: our initial experience with a new hand-assist device.

Journal Article Surg Laparosc Endosc · January 1999 Many advanced laparoscopic cases remain technically difficult and are less widely accepted. To a great extent, advanced laparoscopic surgery is handicapped by the loss of a surgeon's tactile sense. The concept of introducing the surgeon's hand as an aid to ... Link to item Cite

We've come a long way, baby!

Journal Article J Am Coll Surg · November 1998 Full text Link to item Cite

Hepatocellular carcinoma.

Journal Article Br J Surg · October 1998 BACKGROUND: Hepatocellular carcinoma is one of the world's most common malignancies. The aims of the present paper are to review data on (1) epidemiology and screening programmes for the early detection of the tumour and (2) advances in the diagnostic imag ... Full text Link to item Cite

Laparoscopic surgery and the systemic immune response.

Journal Article Ann Surg · March 1998 OBJECTIVE: The authors review studies relating to the immune responses evoked by laparoscopic surgery. SUMMARY BACKGROUND DATA: Laparoscopic surgery has gained rapid acceptance based on clinical grounds. Patients benefit from faster recovery, decreased pai ... Full text Link to item Cite

Induction of C-MET mRNA in pancreatic cell lines in serum free condition by inflammatory cytokines

Journal Article FASEB Journal · December 1, 1997 It is well established that the c- met oncogene encodes a protein receptor of i90KDa (hepatocyte growth factor receptor) which transmits multifunctional signals such as regulation of cell proliferation, motility and morphogenesis. Moghul e_t aj (1 ) descri ... Cite

The approach to the patient with single and multiple liver metastases, pulmonary metastases, and intra-abdominal metastases from colorectal carcinoma.

Journal Article Hematol Oncol Clin North Am · August 1997 Recurrent colorectal carcinoma constitutes a major health care problem, with 90,000 patients diagnosed annually with metastatic disease. Recent advances have offered treatment to selected patients with liver, lung, and intra-abdominal metastases. Resection ... Full text Link to item Cite

Zebra pattern: a diagnostically challenging hepatic parenchymal enhancement pattern at CT arterial portography.

Journal Article Radiology · April 1997 PURPOSE: To investigate the effect of arterial injection site and splenic volume on the hepatic zebra pattern seen at computed tomographic (CT) arterial portography. MATERIALS AND METHODS: Images from CT arterial portographic examinations, performed via ei ... Full text Link to item Cite

Collision tumour of the ampulla of Vater: carcinoid and adenocarcinoma.

Journal Article HPB Surg · 1997 Obstructive jaundice is most commonly due to luminal stones or lesions of the head of the pancreas and more rarely ampullary and primary common bile duct lesions. Obstruction due to lesions of the ampulla of Vater may be due to adenocarcinoma which has a s ... Full text Link to item Cite

Abdominal wall sinus: a late complication of gallstone spillage during laparoscopic cholecystectomy.

Journal Article HPB Surg · 1997 Long term complications of laparoscopic cholecystectomy are uncommon. However, as experience with this procedure accumulates, sporadic reports of non-biliary complication have been published. We report a case of abdominal wall sinus formation secondary to ... Full text Link to item Cite

The management of tumors of the ampulla of Vater by local resection.

Journal Article Ann Surg · November 1996 OBJECTIVE: The authors report on indications and results of local excision of tumors of the ampulla of Vater. SUMMARY BACKGROUND DATA: Local excision of ampullary tumors has been performed for nearly a century but remains controversial. The use of this pro ... Full text Link to item Cite

Quality of life after treatment for pancreatitis.

Journal Article Ann Surg · June 1996 OBJECTIVE: The authors evaluated the morbidity, mortality, and quality of life after pancreatic debridement for necrosis and compared these values to those for quality of life after elective medical and surgical management for chronic pancreatitis. SUMMARY ... Full text Link to item Cite

Regeneration of a transplanted liver after right hepatic lobectomy.

Journal Article Liver Transpl Surg · May 1996 Liver regeneration has been described after heterotopic liver transplantation, small-for-size orthotopic liver transplantation and reduced-size liver transplantation. In this report, we document the regenerative response of a whole liver transplant to majo ... Full text Link to item Cite

Adenosine nucleotides in bile.

Journal Article Am J Physiol · February 1996 Activation of purinergic receptors by ATP stimulates Cl- efflux in biliary epithelial cells. To determine whether purinergic agonists are present under physiological conditions, we have assayed mammalian bile for nucleotides and assessed whether hepatoma a ... Full text Link to item Cite

What's new in gastrointestinal and hepatobiliary surgery.

Journal Article J Am Coll Surg · February 1996 Link to item Cite

Low insertion of hepatic segmental duct VII-VIII is an important cause of major biliary injury or misdiagnosis.

Journal Article Am J Surg · January 1996 BACKGROUND: The importance of variant anatomy is only mentioned generally in most articles in this era of laparoscopic cholecystectomy. We report a series of 14 patients in whom a seemingly low insertion of hepatic segmental duct VII-VIII was clinically im ... Full text Link to item Cite

Mechanisms of gastric and esophageal perforations during laparoscopic Nissen fundoplication.

Journal Article Ann Surg · January 1996 OBJECTIVE: The purpose of this study was to determine possible mechanisms of 17 gastric and esophageal perforations that occurred during laparoscopic Nissen fundoplication. METHODS: Specific details of each perforation relating to mechanism of injury, surg ... Full text Link to item Cite

Biliary drainage operations for stones in the era of laparoscopic surgery

Journal Article Problems in General Surgery · December 1, 1995 Cite

Transforming growth factor-beta receptors and mannose 6-phosphate/insulin-like growth factor-II receptor expression in human hepatocellular carcinoma.

Journal Article Ann Surg · August 1995 OBJECTIVE: The authors examined the expression of transforming growth factor-beta receptor (TGF-beta r) types I and II and the mannose 6-phosphate/insulin-like growth factor-II receptor (M6-P/IGF-IIr) in human hepatocellular carcinoma (HCC). SUMMARY BACKGR ... Full text Link to item Cite

Invited Commentary

Journal Article Archives of Surgery · January 1, 1995 Full text Cite

Management of biliary complications after heart transplantation.

Journal Article J Heart Lung Transplant · 1995 BACKGROUND: Immunosuppression increases the risk of biliary complications in heart transplant recipients. METHODS: Patients undergoing heart transplantation since 1986 who were at risk for cholelithiasis (n = 60) were retrospectively studied. RESULTS: Chol ... Link to item Cite

The use of pancreatic ductoscopy in the operative management of benign and malignant pancreatic disorders.

Journal Article Surg Endosc · January 1995 Direct visualization of the pancreatic duct was helpful in decision making during complex pancreaticobiliary operations. Two-, 3-, or 5-mm scopes were introduced into the pancreatic ducts of 32 patients with pancreatic disorders. Scopes were passed into th ... Full text Link to item Cite

Down-regulation of transforming growth factor beta receptor type I, II, and III during liver regeneration.

Journal Article Am J Surg · January 1995 BACKGROUND: After partial hepatectomy (PH), it has been shown that hepatocytes are resistant to the mitoinhibitory effects of transforming growth factor beta (TGF-beta). Three types of TGF-beta receptors have been characterized in mammals. MATERIALS AND ME ... Full text Link to item Cite

Mechanisms of injury in porcine livers perfused with blood of patients with fulminant hepatic failure.

Journal Article Transplantation · December 15, 1994 Hyperacute rejection of renal and cardiac xenografts is initiated by the reaction of recipient natural antibodies and complement with endothelial cell antigens of the donor organ. The liver is thought to be less susceptible to this form of rejection; howev ... Link to item Cite

Interventional radiology in the management of bile duct injuries.

Journal Article Surg Clin North Am · August 1994 The advent of laparoscopic cholecystectomy has brought an increased number of bile duct injuries to the attention of surgeons and interventional radiologists. The spectrum of injury ranges from cystic duct stump leakage to partial obstruction to complete o ... Link to item Cite

Expression of alpha 1-adrenergic receptor subtype mRNA in rat tissues and human SK-N-MC neuronal cells: implications for alpha 1-adrenergic receptor subtype classification.

Journal Article Mol Pharmacol · August 1994 At least three subtypes of alpha 1-adrenergic receptors (alpha 1ARs) have been identified using molecular techniques (alpha 1a/d, alpha 1b, and alpha 1c), whereas two subtypes of alpha 1ARs have been identified pharmacologically (alpha 1A and alpha 1B); ho ... Link to item Cite

Hepatic adenoma: MR characteristics and correlation with pathologic findings.

Journal Article AJR Am J Roentgenol · July 1994 OBJECTIVE: The purpose of this study was to describe the MR appearance of hepatic adenomas and correlate the MR imaging features with pathologic findings. MATERIALS AND METHODS: MR examinations were performed in 14 patients with 66 hepatic adenomas. The di ... Full text Link to item Cite

Common bile duct evaluation in the era of laparoscopic cholecystectomy. 1050 cases later.

Journal Article Ann Surg · June 1994 OBJECTIVE: The authors documented the evolution of common bile duct (CBD) evaluation after the development of laparoscopic cholecystectomy (LC) and CBD exploration. Emphasis was placed on stratification of CBD stone risk so that subgroups could be selected ... Link to item Cite

One thousand liver transplants. The lessons learned.

Journal Article Ann Surg · May 1994 OBJECTIVE: To evaluate the first 1000 liver transplants performed at UCLA Medical Center to determine factors responsible for improved results. SUMMARY BACKGROUND DATA: Liver transplant has evolved impressively since the first case was performed in 1963. T ... Full text Link to item Cite

An earlier report of cholelithoptysis.

Journal Article Gastroenterology · May 1994 Full text Link to item Cite

Transforming growth factor-beta 1 and mannose 6-phosphate/insulin-like growth factor-II receptor expression during intrahepatic bile duct hyperplasia and biliary fibrosis in the rat.

Journal Article Hepatology · February 1994 These studies investigate the role of transforming growth factor-beta 1, a potent inhibitor of epithelial cell proliferation and stimulator of extracellular matrix biosynthesis, during intrahepatic bile duct hyperplasia and biliary fibrosis. These pathogen ... Link to item Cite

The effect of propofol on the canine sphincter of Oddi.

Journal Article HPB Surg · 1994 To assess the effect of propofol on the canine sphincter of Oddi(SO), sphincter of Oddi manometry (SOM) was performed in fasting dogs which had undergone cholecystectomy and placement of modified Thomas duodenal cannulae. Using two water-perfused, single-l ... Full text Link to item Cite

Detection of focal hepatic masses: STIR MR vs. CT during arterial portography.

Journal Article J Comput Assist Tomogr · 1994 OBJECTIVE: Our goal was to compare short tau inversion recovery MRI (STIR) to CT during arterial portography (CTAP) in the detection of hepatic lesions. MATERIALS AND METHODS: Over a 24 month period, 40 patients evaluated for possible hepatic resection und ... Full text Link to item Cite

Non-operative management of a common bile duct injury sustained during cholecystectomy in a morbidly obese patient. (Non-operative repair of CBD injury).

Journal Article HPB Surg · 1994 A 29 year old morbidly obese patient suffered injury to his common bile duct during cholecystectomy. Subsequent access to the biliary tree was obtained by using a long heavy gauge needle after first opacifying the system with contrast injection through a n ... Full text Link to item Cite

Laparoscopic Nissen fundoplication: operative results and short-term follow-up.

Journal Article Am J Surg · January 1994 The operative results, outcome, and short-term follow-up after laparoscopic exploration for Nissen fundoplication were evaluated in 35 patients with symptomatic gastroesophageal reflux and reflux-induced pulmonary disease. There were 19 female and 16 male ... Full text Link to item Cite

Cholelithoptysis and cholelithorrhea: rare complications of laparoscopic cholecystectomy.

Journal Article Gastroenterology · December 1993 Laparoscopic cholecystectomy is now considered a safe procedure for the management of cholelithiasis. During the procedure, stone spillage can occur and is usually not considered a serious complication. Clearance of stones can be laborious and is often avo ... Full text Link to item Cite

Nodular regenerative hyperplasia in partial hepatectomy specimens.

Journal Article Am J Surg Pathol · November 1993 To investigate possible associations of nodular regenerative hyperplasia (NRH) with antitumor chemotherapy, we reviewed 72 partial hepatic resections (55 with metastatic tumor, 12 hepatocellular carcinomas, and five benign neoplasms). Thirty autopsy livers ... Full text Link to item Cite

Clinical features and mechanisms of major laparoscopic biliary injury.

Journal Article Semin Ultrasound CT MR · October 1993 Laparoscopic cholecystectomy has quickly become the gold standard for the treatment of symptomatic cholelithiasis. With the introduction of this new technique has come a learning curve, with a higher than expected initial rate of complications. The most si ... Full text Link to item Cite

Exogenous neuropeptide Y blocks myoelectric activity in the upper gastrointestinal tract of starved dogs. Brain neuropeptide Y converts a fasting pattern of myoelectric activity to a fed pattern.

Journal Article Scand J Gastroenterol · June 1993 The effect of intracerebroventricular (ICV) neuropeptide Y (NPY) on the migrating motor complex (MMC) was examined in five starved dogs. Myoelectric activity was recorded using gastric, duodenal, and jejunal electrodes. Intragastric pressure was monitored ... Full text Link to item Cite

Management of major biliary complications after laparoscopic cholecystectomy.

Journal Article Ann Surg · May 1993 OBJECTIVE: A total of 50 major bile duct injuries after laparoscopic cholecystectomy were managed by the Duke University Hepatobiliary Service from 1990-1992. The management of these complex cases is reviewed. SUMMARY BACKGROUND DATA: Laparoscopic cholecys ... Full text Link to item Cite

Complications of laparoscopic cholecystectomy.

Journal Article Am J Surg · April 1993 Laparoscopic cholecystectomy is a safe and effective treatment of cholelithiasis in experienced hands. Mortality is rare. The Southern Surgeons Club data and several other recent large series indicate that major complications occur in less than 3% of patie ... Full text Link to item Cite

Invited commentary

Journal Article World Journal of Surgery · March 1, 1993 Full text Cite

Technique of intraluminal biliary ultrasonography during laparoscopic cholecystectomy.

Journal Article Am J Surg · February 1993 Intraluminal ultrasonography of the common duct was performed in nine patients undergoing laparoscopic cholecystectomy, using a system comprising a 20-MHz crystal in a 95-cm, blunt-tipped 6F sheath, mechanically rotated at 1,800 rpm. The probe was introduc ... Full text Link to item Cite

The effect of octreotide on hepatic regeneration in rats.

Journal Article Surgery · January 1993 The effect of the long-acting somatostatin analog octreotide on liver regeneration was studied in rats in vitro and in vivo. The effect of continuous subcutaneous octreotide infusion on regenerative liver weight and relative DNA synthesis was examined in r ... Link to item Cite

Secretin receptors in a new preparation of plasma membranes from intrahepatic biliary epithelium.

Journal Article J Surg Res · January 1993 Secretin is thought to cause choleresis by acting on a receptor expressed by bile duct epithelial cells. In this study, the receptor was characterized using a new preparation of intrahepatic bile duct plasma membranes. Hyperplastic biliary trees were obtai ... Full text Link to item Cite

Focal fatty infiltration: a cause of nontumorous defects in the left hepatic lobe during CT arterial portography.

Journal Article J Comput Assist Tomogr · 1993 OBJECTIVE: The purpose of this work was to determine the frequency and significance of characteristic nontumorous low attenuation defects found in the left hepatic lobe during CT arterial portography (CTAP). MATERIALS AND METHODS: Eighty CTAPs performed ov ... Link to item Cite

Continuing evolution in the approach to severe liver trauma.

Journal Article Ann Surg · November 1992 Surgical and radiologic techniques from computed tomography (CT) scanning and embolization to temporary gauze packing and mesh hepatorrhaphy have been developed to make the management of severe liver injuries more effective. Surgical approaches for severe ... Full text Link to item Cite

Intracerebroventricular neuropeptide Y stimulates bile secretion via a vagal mechanism.

Journal Article Gut · November 1992 UNLABELLED: The effect of intracerebroventricular injection of neuropeptide Y on biliary secretion was studied in conscious dogs, prepared with gastric and duodenal fistulas and cerebroventricular guides. Bile secretion was increased in a dose-dependent fa ... Full text Link to item Cite

CT arterial portography: causes of technical failure and variable liver enhancement.

Journal Article AJR Am J Roentgenol · October 1992 OBJECTIVE: We studied the causes of technical failure and enhancement variability encountered during CT arterial portography. MATERIALS AND METHODS: CT arterial portograms and digital arteriograms were obtained via the superior mesenteric artery before par ... Full text Link to item Cite

Bile acid transport in the anhepatic rat.

Journal Article Gastroenterology · September 1992 Hepatocyte dysfunction eventually results in the loss of canalicular bile formation. Without canalicular flow, intestinal bile acid may originate from plasma by reverse transport. Anhepatic rats with preserved intestinal function permit evaluation of such ... Full text Link to item Cite

Malignant biliary obstruction: efficacy of thin-section dynamic CT in determining resectability.

Journal Article AJR Am J Roentgenol · September 1992 OBJECTIVE: Several authorities advocate the use of preoperative angiography to determine the resectability of pancreatic and periampullary tumors, claiming that CT alone is not sufficiently accurate for this purpose. Our objective was to assess the value o ... Full text Link to item Cite

The effects of liver denervation on the regulation of hepatic biliary secretion.

Journal Article Transplantation · July 1992 Effects of liver denervation on bile formation were studied in eight dogs prepared with chronic biliary fistulas. The animals were studied in the basal state, after feeding, and during infusion of glucagon 50 ng/kg/min, secretin 2 U/kg/hr, or somatostatin ... Full text Link to item Cite

Mechanisms of major biliary injury during laparoscopic cholecystectomy.

Journal Article Ann Surg · March 1992 Laparoscopic cholecystectomy has become the procedure of choice for surgical removal of the gallbladder. The most significant complication of this new technique is injury to the bile duct. Twelve cases of bile duct injury during laparoscopic cholecystectom ... Full text Link to item Cite

Localization and characterization of secretin binding sites expressed by rat bile duct epithelium.

Journal Article Gastroenterology · March 1992 The goal of the present studies was to identify and characterize the site of secretin action in the liver. Sections of normal and bile duct-ligated rat livers were used for in vitro 125I-secretin receptor autoradiography. Saturable binding was observed in ... Full text Link to item Cite

The technique of laparoscopic cholecystectomy in children.

Journal Article Ann Surg · February 1992 Twelve children underwent elective laparoscopic cholecystectomy for symptomatic cholelithiasis during a 10-month period in one institution. The operative technique that has been described for adults was modified because of the smaller dimensions of pediatr ... Full text Link to item Cite

Reply

Journal Article Gastroenterology · January 1, 1992 Full text Cite

Laparoscopic cholecystectomy in young patients with sickle hemoglobinopathies.

Journal Article J Pediatr · January 1992 Nine young patients with sickle hemoglobinopathies successfully underwent laparoscopic cholecystectomy; no complications resulted from the procedure. The mean postoperative hospital stay was 1.6 days. This technique appears to be a safe and efficacious pro ... Full text Link to item Cite

An endoscopic retrograde cholangiopancreatography (ERCP)-based algorithm for the management of pancreatic pseudocysts.

Journal Article Am J Surg · January 1992 In the treatment of pancreatic pseudocysts, percutaneous and endoscopic drainage have, in certain cases, become alternatives to surgery. However, each treatment modality carries risks of complications and recurrences that may be minimized by the appropriat ... Full text Link to item Cite

An analysis of laparoscopic cholecystectomy.

Journal Article N Engl J Med · September 26, 1991 Full text Link to item Cite

Indications for and the technique of local resection of tumors of the papilla of Vater.

Journal Article Arch Surg · May 1991 Local resection of tumors of the papilla of Vater was performed in six cases (three benign adenomas and three adenocarcinomas). Pathology was suggested in all cases by endoscopic biopsy and confirmed by operative excision. A method of excision of the tumor ... Full text Link to item Cite

A prospective analysis of 1518 laparoscopic cholecystectomies.

Other N Engl J Med · April 18, 1991 BACKGROUND AND METHODS: The Southern Surgeons Club conducted a prospective study of 1518 patients who underwent laparoscopic cholecystectomy for treatment of gallbladder disease in order to evaluate the safety of this procedure. RESULTS: Seven hundred fift ... Full text Link to item Cite

Biliary response to glucagon in humans.

Journal Article Ann Surg · April 1991 Glucagon has been demonstrated to have profound effect on biliary secretion in several species. Glucagon's biliary effects were studied in humans following biliary tract surgery. Nine patients underwent common bile duct exploration and insertion of a ballo ... Full text Link to item Cite

Effective surgical adjuvant therapy for high-risk rectal carcinoma.

Journal Article N Engl J Med · March 14, 1991 BACKGROUND: Radiation therapy as an adjunct to surgery for rectal cancer has been shown to reduce local recurrence but has not improved survival. In a previous study, combined radiation and chemotherapy improved survival significantly as compared with surg ... Full text Link to item Cite

Endoscopic sphincterotomy complications and their management: an attempt at consensus.

Journal Article Gastrointest Endosc · 1991 Despite its relative safety (in comparison with surgery), and undoubted role in many clinical circumstances, biliary sphincterotomy is the most dangerous procedure routinely performed by endoscopists. Complications occur in about 10% of patients; 2 to 3% h ... Full text Link to item Cite

Invited Commentary

Journal Article HPB Surgery · January 1, 1991 Full text Cite

Effective surgical adjuvant therapy for high-risk rectal carcinoma: Comments

Journal Article Gastroenterologie Clinique et Biologique · January 1, 1991 Cite

Abdominal musculature abnormalities as a cause of groin pain in athletes. Inguinal hernias and pubalgia.

Journal Article Am J Sports Med · 1991 There has been increasing interest within the European sports medicine community regarding the etiology and treatment of groin pain in the athlete. Groin pain is most commonly caused by musculotendinous strains of the adductors and other muscles crossing t ... Full text Link to item Cite

Hepatic abscess. Changes in etiology, diagnosis, and management.

Conference Ann Surg · December 1990 Most recent reviews of pyogenic hepatic abscess emphasize percutaneous versus open surgical management and devote little time to studying the etiology or the clinical condition of the patient. In this study a detailed review was performed with a computeriz ... Full text Link to item Cite

Primary leiomyoma of the liver.

Journal Article Am J Gastroenterol · December 1990 A 30-yr-old woman with right upper quadrant abdominal pain was found to have a hepatic leiomyoma. This is the youngest patient in whom this rare tumor has been found. The diagnostic approach toward gastrointestinal leiomyomata is emphasized, including the ... Link to item Cite

Evaluation of selective liver denervation methods.

Journal Article Am J Physiol · November 1990 This study compares four methods of hepatic denervation and defines the rate and physiological significance of reinnervation. Five groups of rats were prepared: 10 underwent orthotopic liver transplantation. In nine rats a 90% aqueous phenol solution was a ... Full text Link to item Cite

A model for biliary and vascular access in the unanesthetized, unrestrained rat.

Journal Article Physiol Behav · October 1990 Conventional methods for vascular access and bile collection in the rat, such as the isolated perfused liver, study under anesthesia, and animal restraint, do not allow study of a physiologically intact rat. A simple technique for vascular access and monit ... Full text Link to item Cite

Biliary response to glucagon and insulin following hepatic transplantation in humans.

Journal Article J Surg Res · August 1990 Glucagon and insulin are postulated to be physiologic regulators of hepatic biliary secretion. Effects of these hormones were studied following orthotopic transplantation. Five adult hepatic graft recipients had triple lumen t-tubes placed at the time of s ... Full text Link to item Cite

Hepatic hemangiomas vs metastases: MR differentiation at 1.5 T.

Journal Article AJR Am J Roentgenol · July 1990 We retrospectively studied the value of MR imaging at 1.5 T in distinguishing hepatic hemangiomas (n = 15) from metastases (n = 15) by using (1) lesion/liver signal-intensity ratios, (2) contrast/noise ratios, and (3) T2 relaxation time on long TR/TE spin- ... Full text Link to item Cite

Subtotal colectomy for familial polyposis. A clinical series and review of the literature.

Journal Article Arch Surg · May 1990 Familial polyposis is an inherited syndrome in which untreated persons have virtually a 100% incidence of developing colon cancer. Much controversy exists over whether subtotal colectomy with ileoproctostomy is the appropriate procedure in these patients o ... Full text Link to item Cite

Clinical significance of ultrasonographically detected coincidental gallstones.

Journal Article Dig Dis Sci · April 1990 The clinical profiles of 139 patients with gallstones found coincidentally during ultrasonography were reviewed and the patients followed prospectively for five years. Indications for ultrasonography included follow-up of abdominal malignancy (33%), evalua ... Full text Link to item Cite

Free jejunal interposition graft for reconstruction of the esophagus.

Journal Article Head Neck · 1990 Forty-seven patients underwent pharyngoesophageal reconstruction using a free jejunal interposition graft (FJIG) at Duke University Medical Center from 1978 through 1987. There were 30 men and 17 women with ages ranging from 38 to 87 years old (mean age, 6 ... Full text Link to item Cite

Surgical management of pancreatic lymphoma.

Journal Article Arch Surg · November 1989 The clinical and pathologic records of 12 patients with pancreatic lymphoma were reviewed retrospectively to determine distinguishing clinical features. Radiologically, all patients had large abdominal masses in the region of the pancreas. Preoperative per ... Full text Link to item Cite

Effects of monosulfate esters of taurochenodeoxycholate on bile flow and biliary lipids in hamsters.

Journal Article J Lipid Res · May 1989 The effect of the 3 alpha- and 7 alpha-monosulfate esters of taurochenodeoxycholate on bile flow and biliary lipids was compared to the effect of unsulfated taurochenodeoxycholate. Test bile salts were infused directly into the portal circulation through a ... Link to item Cite

Abdominal leiomyosarcoma: aggressive management.

Journal Article South Med J · March 1989 We retrospectively reviewed 34 cases of intra-abdominal leiomyosarcoma treated between 1967 and 1986. Thirty-three patients had operation, and the primary tumor was removed in all but one. Fifteen patients had peritoneal implants at initial surgical explor ... Full text Link to item Cite

Deaths from gallstones. Incidence and associated clinical factors.

Journal Article Ann Surg · February 1989 The purpose of this study was to determine the incidence of death as the initial manifestation of cholelithiasis. Records of patients who died or underwent cholecystectomy for gallstone-related disease at Duke University Medical Center between 1976 and 198 ... Full text Link to item Cite

Limitations of angiography for mesenteric ischemia caused by midgut carcinoid tumors.

Journal Article Cardiovasc Intervent Radiol · 1989 Mesenteric ischemia associated with carcinoid tumors often presents with nonspecific abdominal pain and is usually due to mesenteric branch artery occlusion caused by elastic vascular sclerosis. Mesenteric ischemia was defined by the operative findings of ... Full text Link to item Cite

Gastric adenocarcinoma: CT versus surgical staging.

Journal Article Radiology · May 1988 Seventy-five patients with gastric carcinoma underwent preoperative staging with computed tomography (CT). In 14 patients, CT failed to demonstrate lymphadenopathy despite the presence of malignant lymph nodes at surgery. In 13 patients, CT demonstrated en ... Full text Link to item Cite

Toothbrush swallowing.

Journal Article Arch Surg · March 1988 We encountered four cases of toothbrush swallowing and reviewed the literature on this subject. A total of 31 toothbrushes within the gastrointestinal tract have been reported. None have passed spontaneously. Several have caused significant complications r ... Full text Link to item Cite

Internal radiation for bile duct cancer.

Journal Article World J Surg · February 1988 Full text Link to item Cite

Regulation of biliary protein secretion in dogs.

Journal Article Proc Soc Exp Biol Med · February 1988 The biliary secretion of protein in response to bile acids and other agents known to increase bile flow was examined in a chronic bile fistula dog model. Infusion of 25, 50, or 75 mumole/kg/hr sodium taurocholate after 3 hr of bile fistulization increased ... Full text Link to item Cite

DU-PAN-2 levels in serum and pancreatic ductal fluids of patients with benign and malignant pancreatic disease.

Journal Article Pancreas · 1988 Previous studies have shown that the DU-PAN-2 antigen is elevated in approximately 70% of serum samples obtained from pancreatic adenocarcinoma patients, and within the normal range (less than 400 U/ml) in 99% of normal subjects. In this study, the DU-PAN- ... Full text Link to item Cite

Hepatic adenoma: MR appearance mimicking focal nodular hyperplasia.

Journal Article J Comput Assist Tomogr · 1988 A hepatic adenoma (HA) nearly isointense to normal liver on short and long repetition and echo time spin echo pulse sequences is presented. Contrary to previous expectations, the case shows that a single hepatic mass with these signal characteristics on ma ... Link to item Cite

Effect of glucagon on hepatic biliary secretion in humans

Journal Article Surgical Forum · January 1, 1988 Cite

Comparison of human and rat hepatocyte metabolism and mutagenic activation of 2-acetylaminofluorene.

Journal Article Cancer Res · November 15, 1987 A method has been developed to assess the metabolism and mutagenic activation of carcinogens using human and rodent hepatocytes in vitro. A slicing technique which was especially useful for nonperfusable biopsy and resected surgical human liver tissue was ... Link to item Cite

Influence of apolipoprotein E on soluble and heparin-immobilized hepatic lipase.

Journal Article Am J Physiol · June 1987 The effect of human apolipoprotein E (apoE), either alone or in combination with apoC, on the lipolysis of a radiolabeled triglyceride emulsion was studied with hepatic lipase in solution and immobilized on heparin-Sepharose. The soluble hepatic lipase was ... Full text Link to item Cite

Bile flow--an index of ischemic injury.

Journal Article J Surg Res · May 1987 Bile formation is an active secretory process involving bile salt-dependent and -"independent" mechanisms. This study was performed to determine the effect of selected periods of warm ischemia on biliary secretion. Rats were studied using an in situ liver ... Full text Link to item Cite

A new clamp for hepatic resection.

Journal Article Surg Gynecol Obstet · April 1987 Link to item Cite

Adenocarcinoma of the stomach. Changing patterns over the last 4 decades.

Journal Article Ann Surg · January 1987 A retrospective study was performed on 255 consecutive patients admitted to a single hospital from 1953-1983 with a follow-up of 100%. The number of proximal esophagogastric junction and fundus tumors increased significantly over the last 4 decades from 21 ... Full text Link to item Cite

Pylorus-preserving pancreatoduodenectomy. A clinical and physiologic appraisal.

Journal Article Ann Surg · December 1986 Since 1978, 252 patients from different centers in the world have undergone pylorus-preserving pancreatoduodenectomy. Fifty-five per cent of the patients had malignant tumors in the region of the head of the pancreas. The overall operative mortality rate w ... Full text Link to item Cite

Fatal pulmonary bile embolism following acute acalculous cholecystitis.

Journal Article Arch Surg · October 1986 A 52-year-old man died during reoperation for bleeding after the development of acute postoperative acalculous cholecystitis. While the liver was being manipulated during surgery, the pulmonary artery diastolic pressure increased suddenly, cardiac output a ... Full text Link to item Cite

Effect of cyclosporine on bile secretion in rats.

Journal Article Am J Surg · January 1986 Short-term effects of cyclosporine were studied in the isolated perfused rat liver model. Bile flow was inhibited by cyclosporine in 2 mg/kg and 20 mg/kg doses but not by a 0.2 mg/kg dose. Cholestasis was accompanied by a decrease in bile acid secretion, i ... Full text Link to item Cite

Effects of bombesin on fasting bile formation.

Journal Article Ann Surg · January 1986 Adult dogs were previously prepared by cholecystectomy, ligation of the lesser pancreatic duct, and insertion of cannulae into the duodenum and stomach. After a 2-week period of postoperative recovery and an overnight fast, bile ducts were cannulated, gast ... Full text Link to item Cite

Bile salt regulation of a canalicular enzyme: Effect of ileal bypass

Journal Article Surgical Forum · January 1, 1986 Cite

Effects of serotonin on canine bile formation.

Journal Article Surgery · November 1985 Long-term studies were performed on dogs previously prepared by cholecystectomy, ligation of the lesser pancreatic duct, and insertion of a duodenal cannula. After an overnight fast, bile duct cannulation and stabilization of bile flow with intravenous (IV ... Link to item Cite

Liver transplantation.

Journal Article Invest Radiol · November 1985 Full text Link to item Cite

Pharyngoesophageal reconstruction using free jejunal interposition grafts.

Journal Article Arch Otolaryngol · November 1985 Forty patients underwent pharyngoesophageal reconstruction with a free jejunal interposition graft (FJIG). Three categories of disease were treated: (1) primary upper aerodigestive tract carcinomas, (2) recurrent carcinomas, and (3) benign pharyngoesophage ... Full text Link to item Cite

Carcinoma of the pancreas. Therapeutic efficacy as defined by a serodiagnostic test utilizing a monoclonal antibody.

Journal Article Ann Surg · October 1985 DU-PAN-2 is a high molecular weight glycoprotein defined by a murine monoclonal antibody elicited to a pancreatic ductal adenocarcinoma cell line. This monoclonal antibody recognizes an oncofetal antigen present on the surface of pancreatic tumor cells. Th ... Full text Link to item Cite

Inhibition of bile flow by intravenous arginine hydrochloride.

Journal Article Surgery · September 1985 One proposed mechanism for the cholestasis associated with total parenteral nutrition is infusion of amino acids. Arginine, 19 mumol/kg/min, was infused for a short time in healthy dogs with a biliary fistula to test the effect of endogenous hormone releas ... Link to item Cite

Revascularized jejunal graft replacing the cervical esophagus: radiographic evaluation.

Journal Article AJR Am J Roentgenol · September 1985 Free jejunal autotransplantation is a successful surgical procedure for reconstruction of the cervical esophagus in treatment of carcinoma of the pharyngoesophagus. Radiographic assessment is essential in the postoperative evaluation of these patients. Twe ... Full text Link to item Cite

Successful management of late-onset primary lymphatic hypoplasia.

Journal Article Surgery · June 1985 Primary lymphedema of the extremities, abdomen, or chest is an unusual and difficult clinical problem with few guidelines for management. A case is reported of lymphedema acquired at the age of 61 years, with associated massive chylous ascites and chylotho ... Link to item Cite

Clinical studies of an oncofetal antigen (DU-PAN-2) detected by a monoclonal antibody to pancreatic adenocarcinoma

Journal Article Proceedings of the American Association for Cancer Research · January 1, 1985 Cite

Somatostatinoma of the endocrine pancreas: CT findings.

Journal Article J Comput Assist Tomogr · October 1984 Somatostatinoma is the rarest of the pancreatic islet cell tumors with only eight previously reported cases. We report a recent case in a 62-year-old man including CT findings and 1 year follow-up. ... Full text Link to item Cite

The hepatic extraction of gastric inhibitory polypeptide and insulin.

Journal Article Endocrinology · September 1984 The hepatic extractions of gastric inhibitory polypeptide (GIP) and insulin were determined using in vitro and in vivo methods to assess the role of the liver in GIP metabolism and the possible effect of GIP on the hepatic extraction of insulin. During in ... Full text Link to item Cite

Detection of a pancreatic cancer-associated antigen (DU-PAN-2 antigen) in serum and ascites of patients with adenocarcinoma.

Journal Article Proc Natl Acad Sci U S A · August 1984 A competition radioimmunoassay was developed, utilizing a murine monoclonal antibody to human pancreatic adenocarcinoma cells. Immunoblotting of a standard antigen preparation from either serum or ascites fluid after electrophoresis in 1% agarose showed th ... Full text Link to item Cite

Hepatic resection for metastatic cancer.

Journal Article Ann Surg · February 1984 One-year survival is infrequent in patients with metastatic cancer to the liver. This report includes 21 patients who underwent hepatic resection between 1974 and 1981. Operative procedures included one trisegmentectomy, 12 right hepatic lobectomies, two l ... Full text Link to item Cite

Effects of dibutyryl cyclic AMP and theophylline on biliary cholesterol secretion.

Journal Article J Surg Res · January 1984 Glucagon increases hepatocellular cAMP and decreases biliary cholesterol output. In these experiments, we examined the relation between cAMP and biliary cholesterol secretion. Bile flow and composition were measured in conscious dogs previously prepared by ... Full text Link to item Cite

Effects of bombesin on bile secretion

Journal Article Surgical Forum · January 1, 1984 Cite

Insulin or glucagon choleresis in the isolated perfused guinea pig liver.

Journal Article Proc Soc Exp Biol Med · May 1983 Insulin and glucagon choleresis was studied in an in situ, isolated perfused guinea pig liver system. Glucagon caused a small, significant increase in bile salt independent flow (1.83 +/- 0.19 to 2.02 +/- 0.23 microliter g-1 min-1), and dose-related increm ... Full text Link to item Cite

Somatostatin-induced cholestasis can be independent of portal blood flow.

Journal Article Surgery · May 1983 Short-term experiments were performed on adult mongrel dogs (15 to 25 kg) anesthetized with sodium pentobarbital. The operative procedure included cholecystectomy, side-to-side mesocaval shunt with ligation of the portal vein, and cannulation of the common ... Link to item Cite

Marginal ulcer. A difficult surgical problem.

Journal Article Ann Surg · May 1982 One hundred sixty-six patients with documented recurrent or marginal ulcers following previous ulcer operations were seen at Duke Medical Center and the Durham VA Hospital from 1950 through 1980. Patients with the diagnosis of gastrinoma were excluded from ... Full text Link to item Cite

Gallbladder density and iodine concentration in humans during oral cholecystography. A comparison of iopanoic acid and iopronic acid.

Journal Article Invest Radiol · 1982 A comparison of two oral cholecystopaques, iopanoic acid (Telepaque) and iopronic acid (Oravue), was performed using normal volunteers. Using a double-blind crossover design, comparisons were made between the degree of gallbladder opacification and the amo ... Full text Link to item Cite

Chronic primary intestinal pseudo-obstruction.

Journal Article Surgery · February 1981 Chronic primary intestinal pseudo-obstruction (CPIP) has received attention despite of its unclear etiology and infrequent occurrence. Recently a patient with this disorder had evidence of a primary visceral neuropathy. Reviewing the literature, we found 3 ... Link to item Cite

Effect of total laryngectomy on esophageal motility.

Journal Article Ann Otol Rhinol Laryngol · 1981 Total laryngectomy for cancer can result in dysphagia and altered esophageal motility. Manometric changes in the upper esophageal sphincter (UES), and in proximal and distal esophageal function have been reported. However, most studies have failed to take ... Full text Link to item Cite

Effect of apolipoproteins on the induction of hepatic steatosis in rats.

Journal Article Gastroenterology · January 1981 The incorporation of apolipoprotein E isolated from human very low density lipoproteins on a triglyceride emulsion produced a substantial increment in hepatic triglyceride after 1 h of in vitro perfusion through the isolated liver of a fasted rat. Both gro ... Link to item Cite

Evisceration prevented suppression of bile secretion by somatostatin

Journal Article Surgical Forum · January 1, 1981 Cite

Selective biliary secretion of basal and glucagon-inhibited neutral sterol after triparanol administration.

Journal Article Surgery · July 1980 Biliary cholesterol secretion was studied in dogs with chronic bile fistulas, using glucagon, an inhibitor of biliary cholesterol secretion, and triparanol, an inhibitor of cholesterol synthesis. Glucagon inhibited neutral sterol secretion before and after ... Link to item Cite

Surgical resection for benign and malignant liver disease.

Journal Article Ann Surg · May 1980 The indications for major hepatic resections in 32 patients and the results are presented. Twelve right lobectomies, eight partial left lobectomies, five left lobectomies, four extended right lobectomies and three partial right lobectomies were performed w ... Full text Link to item Cite

Effect of apoproteins on hepatic uptake of triglyceride emulsions in the rat.

Journal Article J Clin Invest · March 1980 The addition of apoprotein E isolated from human very low density lipoproteins to both rat lymph chylomicrons and a triglyceride emulsion significantly increased the hepatic uptake of these particles in a nonrecycling isolated rat liver perfusion system. T ... Full text Link to item Cite

Postoperative function of "free" jejunal transplants for replacement of the cervical esophagus.

Journal Article Ann Surg · 1980 The postoperative function of "free" jejunal autotransplants for replacement of the pharyngoesophagus after palliative resection was evaluated in nine patients using clinical assessment, cinefluoroscopy, manometry, and electrical studies. After an initial ... Full text Link to item Cite

Glucagon or insulin suppressed biliary lipid excretion in dog and man.

Journal Article Ann Surg · December 1979 The possibility that gastrointestinal hormones influence biliary lipid secretion was studied further in chronic bile fistula dogs and subsequently in a patient with a balloon-occludable t-tube. After stabilization of bile flow in the dog by infusing 500 mg ... Full text Link to item Cite

Alimentary tract complications after renal transplantation.

Journal Article Ann Surg · October 1979 A computer analysis of post renal transplantation gastrointestinal problems was performed to identify important associated clinical factors. Thirty-seven per cent of all transplant recipients developed one or more significant problems. Hemorrhage, nondiver ... Full text Link to item Cite

Hyperacidity and hypergastrinemia following extensive intestinal resection.

Journal Article World J Surg · September 20, 1979 Increased gastric acid secretion occurs after extensive intestinal resection in man, dog, rat, and monkey. Hypergastrinemia has been observed in patients with short gut syndrome and appears to accompany the hyperacidity after intestinal resection in dog, r ... Full text Link to item Cite

Inhibition of basal and meal-stimulated choleresis by somatostatin.

Journal Article Surgery · August 1979 The effect of somatostatin, an inhibitor of release of a number of gastrointestinal and other hormones, on choleresis was investigated in chronic, bile fistula dogs with taurocholate-stabilized bile flow. Somatostatin inhibited both fasting and meal-stimul ... Link to item Cite

Diagnosis and surgical treatment of colonic endometriosis.

Journal Article Arch Surg · February 1979 Endometriosis is sufficiently common that it should always be considered in the differential diagnosis of colon lesions of women of childbearing age. Seven selected cases illustrate problems in diagnosis and management of endometriosis of the colon. Charac ... Full text Link to item Cite

Diagnosis and surgical treatment of colonic endometriosis

Journal Article Obstetrical and Gynecological Survey · January 1, 1979 Full text Cite

Regulation of hepatic biliary secretion.

Journal Article Annu Rev Physiol · 1979 Full text Link to item Cite

Effect of glucagon and insulin upon biliary lipid secretion.

Journal Article Am J Surg · January 1979 The choleretic hormones, glucagon and insulin, were studied to determine whether they influence biliary lipid secretion in the dog. Glucagon was found to decrease biliary cholesterol and phospholipid secretion. These findings provide further support for a ... Full text Link to item Cite

Effect of glucagon and insulin on biliary lipid secretion

Journal Article Scandinavian Journal of Gastroenterology · January 1, 1978 Because previous studies have suggested that glucagon and insulin stimulate canalicular choleresis, it seemed important to investigate their lipid secretory effects. Dogs were prepared with cholecystectomy, ligation of the lesser pancreatic duct, and inser ... Cite