Scholars@Duke
Aatif Mairaj Husain

Aatif Mairaj Husain

Professor of Neurology
Neurology, Epilepsy and Sleep
aatif.husain@duke.edu
Duke Box 2720, Duke University Medical Center, Durham, NC 27710
2424 Erwin Road, Suite 1001, Office 10021, Durham, NC 27705

Selected Publications

A Novel Technique for Intraoperative Mapping of the Somatosensory Cortex.

Journal Article World Neurosurg · August 2024 OBJECTIVE: Intraoperative mapping of the nervous system is used to identify "eloquent" cortical areas. In this technical report, we describe a novel way of mapping the somatosensory cortex so that injury to those critical pathways can be avoided. METHODS: ... Full text Link to item Cite

Resolving a "W-Shaped" P100 Waveform: Is It Normal or Abnormal?

Journal Article J Clin Neurophysiol · July 9, 2024 Pattern-reversal visual evoked potentials are used to assess the visual pathways. The main waveform of interest is the P100, which is best recorded with electrodes over the mid-occipital region. Most often, the P100 waveform has negative-positive-negative ... Full text Link to item Cite

Development of an International Standard Set of Outcomes and Measurement Methods for Routine Practice for Adults with Epilepsy: The International Consortium for Health Outcomes Measurement Consensus Recommendations.

Journal Article Epilepsia · July 2024 At present, there is no internationally accepted set of core outcomes or measurement methods for epilepsy clinical practice. Therefore, the International Consortium for Health Outcomes Measurement (ICHOM) convened an international working group of experts ... Full text Link to item Cite

Development of an International Standard Set of Outcomes and Measurement Methods for Routine Practice for Infants, Children, and Adolescents with Epilepsy: The International Consortium for Health Outcomes Measurement Consensus Recommendations.

Journal Article Epilepsia · July 2024 At present, there is no internationally accepted set of core outcomes or measurement methods for epilepsy clinical practice. The International Consortium for Health Outcomes Measurement (ICHOM) convened an international working group of experts in epilepsy ... Full text Link to item Cite

Facilitation of motor evoked potentials after tetanic peripheral nerve stimulation.

Journal Article Clin Neurophysiol · June 2024 OBJECTIVE: Tetanic stimulation of a peripheral nerve prior to transcranial electrical stimulation (TES) may enhance motor evoked potential (MEP) amplitudes. The purpose of this study was to investigate the post-tetanic MEP (p-MEP) technique in improving ME ... Full text Link to item Cite

Intravenous Ganaxolone: Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability in Healthy Adults.

Journal Article Clin Pharmacol Drug Dev · March 2024 Ganaxolone, a neuroactive steroid anticonvulsant that modulates both synaptic and extrasynaptic γ-aminobutyric acid type A (GABAA ) receptors, is in development for treatment of status epilepticus (SE) and rare epileptic disorders, and has been approved in ... Full text Link to item Cite

Dosing and transition characteristics in people with narcolepsy transitioning from sodium oxybate to low-sodium oxybate: Data from the real-world TENOR study.

Journal Article Sleep medicine · January 2024 ObjectiveThe Transition Experience of persons with Narcolepsy taking Oxybate in the Real-world (TENOR) study assessed the real-world experience of people with narcolepsy switching from sodium oxybate (SXB) to low-sodium oxybate (LXB; 92 % less sod ... Full text Cite

Effectiveness and tolerability in people with narcolepsy transitioning from sodium oxybate to low-sodium oxybate: Data from the real-world TENOR study.

Journal Article Sleep Med · September 2023 OBJECTIVES: The Transition Experience of persons with Narcolepsy taking Oxybate in the Real-world (TENOR) study was conducted to provide real-world insight into the experience of people with narcolepsy switching from sodium oxybate (SXB) to low-sodium oxyb ... Full text Link to item Cite

Automated Interpretation of Clinical Electroencephalograms Using Artificial Intelligence.

Journal Article JAMA Neurol · August 1, 2023 IMPORTANCE: Electroencephalograms (EEGs) are a fundamental evaluation in neurology but require special expertise unavailable in many regions of the world. Artificial intelligence (AI) has a potential for addressing these unmet needs. Previous AI models add ... Full text Link to item Cite

Guidelines for Qualifications of Neurodiagnostic Personnel: A Joint Position Statement of the American Clinical Neurophysiology Society, the American Association of Neuromuscular & Electrodiagnostic Medicine, the American Society of Neurophysiological Monitoring, and ASET-The Neurodiagnostic Society.

Journal Article J Clin Neurophysiol · May 1, 2023 The Guidelines for Qualifications of Neurodiagnostic Personnel (QNP) document has been created through the collaboration of the American Clinical Neurophysiology Society (ACNS), the American Society of Neurophysiological Monitoring (ASNM), the American Ass ... Full text Link to item Cite

Guidelines for Qualifications of Neurodiagnostic Personnel: A Joint Position Statement of the American Clinical Neurophysiology Society, the American Association of Neuromuscular & Electrodiagnostic Medicine, the American Society of Neurophysiological Monitoring, and ASET - The Neurodiagnostic Society.

Journal Article Neurodiagn J · March 2023 The Guidelines for Qualifications of Neurodiagnostic Personnel (QNP) document has been created through the collaboration of the American Clinical Neurophysiology Society (ACNS), the American Society of Neurophysiological Monitoring (ASNM), the American Ass ... Full text Link to item Cite

Evaluation of a tailored epilepsy training program for healthcare providers in Uganda.

Journal Article Epilepsy Behav · January 2023 OBJECTIVE: This study evaluated an epilepsy training program for healthcare workers that was designed to improve their knowledge of epilepsy, its treatment, and its psychosocial effects. METHODS: This single group, before and after survey was conducted in ... Full text Link to item Cite

Symptom Severity and Treatment Satisfaction in Patients with Idiopathic Hypersomnia: The Real World Idiopathic Hypersomnia Outcomes Study (ARISE).

Journal Article Nat Sci Sleep · 2023 OBJECTIVE: Idiopathic hypersomnia is a debilitating sleep disorder characterized by excessive daytime sleepiness, sleep inertia, and prolonged sleep duration. The patient burden of idiopathic hypersomnia is poorly understood. The Real World Idiopathic Hype ... Full text Link to item Cite

Impairment in Functioning and Quality of Life in Patients with Idiopathic Hypersomnia: The Real World Idiopathic Hypersomnia Outcomes Study (ARISE).

Journal Article Nat Sci Sleep · 2023 PURPOSE: Idiopathic hypersomnia is a debilitating neurologic sleep disorder characterized by excessive daytime sleepiness, sleep inertia, and prolonged sleep. Its impact on patients' quality of life and daily functioning has not been fully elucidated. The ... Full text Link to item Cite

Intraoperative Electromyography in Awake Minimally Invasive Transforaminal Lumbar Interbody Fusion: A Case Study on Nerve Activation Under the Effects of Local Anesthesia.

Journal Article J Clin Neurophysiol · November 1, 2022 With the versatility of lumbar spine surgery continually expanding, intraoperative electromyography (EMG) has become a common adjunct used to reduce risk of nerve injury and postoperative neurologic deficit. EMG monitoring has been deemed particularly usef ... Full text Link to item Cite

Intravenous ganaxolone for the treatment of refractory status epilepticus: Results from an open-label, dose-finding, phase 2 trial.

Journal Article Epilepsia · September 2022 OBJECTIVE: Patients with refractory status epilepticus (RSE) have failed treatment with benzodiazepines and ≥1 second-line intravenous (IV) antiseizure medication (ASM). Guidelines recommend IV anesthesia when second-line ASMs have failed, but potential ha ... Full text Link to item Cite

Association Between Standardized Mortality Ratio and Utilization of Care in US Veterans With Drug-Resistant Epilepsy Compared With All US Veterans and the US General Population.

Journal Article JAMA Neurol · September 1, 2022 IMPORTANCE: Drug-resistant epilepsy (DRE) is thought to be associated with increased mortality, but larger population-based studies are lacking. Additionally, the benefit of effective management in DRE lacks evidence. OBJECTIVE: To examine the association ... Full text Link to item Cite

Neurological Prognostication After Hypoglycemic Coma: Role of Clinical and EEG Findings.

Journal Article Neurocrit Care · August 2022 BACKGROUND: Hypoglycemic coma (HC) is an uncommon but severe clinical condition associated with poor neurological outcome. There is a dearth of robust neurological prognostic factors after HC. On the other hand, there is an increasing body of literature on ... Full text Link to item Cite

Motor Evoked Potentials Double Train Stimulation: Optimal Number of Pulses per Train.

Journal Article J Clin Neurophysiol · July 1, 2022 PURPOSE: In neurophysiologic intraoperative monitoring, double train transcranial electrical stimulation (dt-TES) for motor evoked potentials (MEP) consists of an initial, facilitating train of stimuli followed by a second, testing, train. The optimal numb ... Full text Link to item Cite

Thermal Protection Strategies and Neuromonitoring during Ablation.

Journal Article Semin Intervent Radiol · April 2022 Advanced interventional pain management approaches seek to lesion neural targets to achieve desirable analgesia; however, equally important is preservation of motor and sensory function for regional bystander nerves. The topic of neuroprotection is also re ... Full text Link to item Cite

"Quadripolar" Transcranial Electrical Stimulation for Motor Evoked Potentials.

Journal Article J Clin Neurophysiol · January 1, 2022 PURPOSE: To determine if transcranial electrical stimulation (TES)-induced motor evoked potentials (MEPs) are of higher amplitude when using two electrodes as anodes and two as cathodes, known as "quadripolar stimulation." METHODS: Patients who underwent T ... Full text Link to item Cite

Farewell: My Eight Wonderful Years.

Journal Article J Clin Neurophysiol · January 1, 2022 Full text Link to item Cite

Dorsal root entry zone procedure and other surgeries for pain.

Chapter · 2022 Pain is a very common symptom that often serves a protective function. It is typically treated medically. When pain becomes chronic and intractable, it no longer serves a protective function and often requires more aggressive forms of treatment. Many types ... Full text Link to item Cite

Overview of intraoperative neuromonitoring.

Chapter · 2022 Intraoperative neuromonitoring (IONM) is used widely to reduce neurologic adverse postoperative outcomes. A variety of techniques are used. Initial techniques were used as far back as the 1930s, and the variety of methods expanded greatly since the 1980s. ... Full text Link to item Cite

Safety and Efficacy of Natalizumab as Adjunctive Therapy for People With Drug-Resistant Epilepsy: A Phase 2 Study.

Journal Article Neurology · November 2, 2021 BACKGROUND AND OBJECTIVES: To explore efficacy/safety of natalizumab, a humanized monoclonal anti-α4-integrin antibody, as adjunctive therapy in adults with drug-resistant focal epilepsy. METHODS: Participants with ≥6 seizures during the 6-week baseline pe ... Full text Link to item Cite

Differentiation of Epileptic and Psychogenic Nonepileptic Seizures Using Single-Channel Surface Electromyography.

Journal Article J Clin Neurophysiol · September 1, 2021 PURPOSE: Epileptic seizures (ES) and psychogenic nonepileptic seizures (PNES) are difficult to differentiate when based on a patient's self-reported symptoms. This study proposes review of objective data captured by a surface electromyography (sEMG) wearab ... Full text Link to item Cite

Importance of access to epilepsy monitoring units during the COVID-19 pandemic: consensus statement of the International League Against Epilepsy and the International Federation of Clinical Neurophysiology∗

Journal Article Epileptic Disorders · August 1, 2021 Restructuring of healthcare services during the COVID-19 pandemic has led to lockdown of epilepsy monitoring units (EMUs) in many hospitals. The ad-hoc taskforce of the International League Against Epilepsy (ILAE) and the International Federation of Clinic ... Full text Cite

Importance of access to epilepsy monitoring units during the COVID-19 pandemic: consensus statement of the International League Against Epilepsy and the International Federation of Clinical Neurophysiology.

Journal Article Epileptic Disord · August 1, 2021 Restructuring of healthcare services during the COVID-19 pandemic has led to lockdown of epilepsy monitoring units (EMUs) in many hospitals. The ad-hoc taskforce of the International League Against Epilepsy (ILAE) and the International Federation of Clinic ... Full text Link to item Cite

Standardization of neurophysiology signal data into the DICOM® standard.

Journal Article Clin Neurophysiol · April 2021 A standard format for neurophysiology data is urgently needed to improve clinical care and promote research data exchange. Previous neurophysiology format standardization projects have provided valuable insights into how to accomplish the project. In medic ... Full text Link to item Cite

Conversational analysis of consciousness during seizures.

Journal Article Epilepsy Behav · November 2020 OBJECTIVE: The objectives of the study were to 1) investigate how patients with epilepsy describe the subjective, conscious experience of having a seizure and 2) determine whether certain themes and descriptions correspond to specific types of epilepsy. ME ... Full text Link to item Cite

Incidence and duration of common, early-onset adverse events occurring during 2 randomized, placebo-controlled, phase 3 studies of sodium oxybate in participants with narcolepsy.

Journal Article J Clin Sleep Med · September 15, 2020 STUDY OBJECTIVES: To determine the time course and duration of common, early-onset treatment-emergent adverse events (TEAEs) associated with sodium oxybate (SXB) use in adults with narcolepsy. METHODS: These were post hoc analyses of two 8-week, randomized ... Full text Link to item Cite

Drug Trials in Status Epilepticus: Current Evidence and Future Concepts.

Journal Article J Clin Neurophysiol · September 2020 Status epilepticus (SE) is a neurologic emergency with high morbidity and mortality. After many advances in the field, several unanswered questions remain for optimal treatment after the early stage of SE. This narrative review describes some of the import ... Full text Link to item Cite

The Impact of COVID-19 on Epilepsy Care: A Survey of the American Epilepsy Society Membership.

Journal Article Epilepsy Curr · September 2020 The COVID-19 pandemic has impacted the delivery of care to people with epilepsy (PWE) in multiple ways including limitations on in-person contact and restrictions on neurophysiological procedures. To better study the effect of the pandemic on PWE, members ... Full text Link to item Cite

Barriers and facilitators to implementation of epilepsy self-management programs: a systematic review using qualitative evidence synthesis methods.

Journal Article Syst Rev · April 25, 2020 BACKGROUND: Epilepsy affects nearly 50 million people worldwide. Self-management is critical for individuals with epilepsy in order to maintain optimal physical, cognitive, and emotional health. Implementing and adopting a self-management program requires ... Full text Open Access Link to item Cite

Self-management of Epilepsy: A Systematic Review.

Journal Article Ann Intern Med · July 16, 2019 BACKGROUND: Although self-management is recommended for persons with epilepsy, its optimal strategies and effects are uncertain. PURPOSE: To evaluate the components and efficacy of self-management interventions in the treatment of epilepsy in community-dwe ... Full text Open Access Link to item Cite

Did This Patient Have Cardiac Syncope?: The Rational Clinical Examination Systematic Review.

Journal Article JAMA · June 25, 2019 IMPORTANCE: Syncope can result from a reduction in cardiac output from serious cardiac conditions, such as arrhythmias or structural heart disease (cardiac syncope), or other causes, such as vasovagal syncope or orthostatic hypotension. OBJECTIVE: To perfo ... Full text Link to item Cite

Loss of Vestibular Ocular Reflex in Nonconvulsive Status Epilepticus.

Journal Article Neurocrit Care · June 2019 BACKGROUND: Electroencephalogram (EEG) findings of generalized periodic discharges (GPDs) with triphasic morphology were introduced as a metabolic phenomenon, but more recently have been associated with epileptic phenomenon. Resolution of EEG findings alon ... Full text Link to item Cite

Continuous EEG Monitoring-The Neurologist's Crystal Ball.

Journal Article Epilepsy Curr · January 2019 UNLABELLED: Time to Epileptiform Activity and EEG Background Recovery Are Independent Predictors After Cardiac Arrest Westhall E, Rose I, Rundgren M, Bro-Jeppesen J, Kjaergaard J, Hassager C, Lindehammar H, Horn J, Ullen S, Nielsen N, Friberg H, Cronberg T ... Full text Link to item Cite

Randomized trial of lacosamide versus fosphenytoin for nonconvulsive seizures.

Journal Article Ann Neurol · June 2018 OBJECTIVE: The optimal treatment of nonconvulsive seizures in critically ill patients is uncertain. We evaluated the comparative effectiveness of the antiseizure drugs lacosamide (LCM) and fosphenytoin (fPHT) in this population. METHODS: The TRENdS (Treatm ... Full text Link to item Cite

Generalized Periodic Discharges: A Topical Review.

Journal Article J Clin Neurophysiol · May 2018 Generalized periodic discharges (GPDs) are generalized discharges that recur with a relatively uniform morphology and duration. They have a quantifiable interdischarge interval. Over the past decade, our understanding of these waveforms has improved consid ... Full text Link to item Cite

Transnasal Transsphenoidal Elevation of Optic Chiasm in Secondary Empty Sella Syndrome Following Prolactinoma Treatment.

Journal Article World Neurosurg · April 2018 BACKGROUND: Prolactinomas are typically treated nonsurgically with a dopamine agonist. Once the tumor shrinks, adjacent eloquent structures, such as the optic apparatus, can become skeletonized and herniate into the dilated parasellar space. CASE DESCRIPTI ... Full text Link to item Cite

Magnesium Sulfate-Induced Motor Evoked Potential Changes.

Journal Article Neurodiagn J · 2018 Motor evoked potentials (MEPs) are commonly used during neurophysiologic intraoperative monitoring. Anesthetic, homeostatic, surgical, and technical factors can cause a change in MEPs. The authors describe a case in which a bolus of magnesium sulfate resul ... Full text Link to item Cite

Lower Extremity Somatosensory Evoked Potential P37 Waveform Optimization.

Journal Article Neurodiagn J · 2018 Somatosensory evoked potentials (SEPs) using tibial nerve stimulation are used during neurophysiologic intraoperative monitoring (NIOM). These SEPs produce a P37 waveform that is recorded from scalp electrodes. In this study, we attempted to determine the ... Full text Link to item Cite

Ellen Grass Memorial Lecture: Clinical Neurophysiology in the Treatment of Disease.

Journal Article Neurodiagn J · 2018 Clinical neurophysiology has a long-standing history and value in the diagnosis of neurologic diseases. Because of their unique ability to assess physiology and function of the nervous system, electroencephalography (EEG), evoked potentials, electromyograp ... Full text Link to item Cite

Brexanolone as adjunctive therapy in super-refractory status epilepticus.

Journal Article Ann Neurol · September 2017 OBJECTIVE: Super-refractory status epilepticus (SRSE) is a life-threatening form of status epilepticus that continues or recurs despite 24 hours or more of anesthetic treatment. We conducted a multicenter, phase 1/2 study in SRSE patients to evaluate the s ... Full text Link to item Cite

Management of critical care seizures

Chapter · January 1, 2017 Seizures are encountered frequently in critically ill patients, especially in patients with acute brain injury of various forms. Continuous EEG monitoring is absolutely essential for the diagnosis and management due to the fact that the majority of seizure ... Full text Cite

Neurophysiological Intraoperative Monitoring During Aortic Arch Surgery.

Journal Article Semin Cardiothorac Vasc Anesth · December 2016 Circulatory management during replacement of the aortic arch is complex and involves a period of circulatory arrest to provide a bloodless field during arch vessel anastomosis. To guard against ischemic brain injury, tissue metabolic demand is reduced by s ... Full text Link to item Cite

Implementation of an established algorithm and modifications for the identification of epilepsy patients in the veterans health administration.

Journal Article Epilepsy Res · November 2016 Identification of epilepsy patients from administrative data in large managed healthcare organizations is a challenging task. The objectives of this report are to describe the implementation of an established algorithm and different modifications for the e ... Full text Link to item Cite

Electroencephalography During Hemiarch Replacement With Moderate Hypothermic Circulatory Arrest.

Journal Article Ann Thorac Surg · February 2016 BACKGROUND: This study aimed to characterize intraoperative electroencephalography (EEG) during moderate hypothermic circulatory arrest (MHCA) with selective antegrade cerebral perfusion (SACP), which has not been described previously. METHODS: This was a ... Full text Link to item Cite

Bone Health

Chapter · 2016 Link to item Cite

Normal EEG

Chapter · 2016 Link to item Cite

Lacosamide in status epilepticus: Update on the TRENdS study.

Journal Article Epilepsy Behav · August 2015 Many patients with critical illness have been noted to have nonconvulsive seizures (NCSs) and nonconvulsive status epilepticus (NCSE). How aggressively these seizures should be treated is unclear. Many investigators feel that the morbidity of NCSs and NCSE ... Full text Link to item Cite

Diagnostic Accuracy of Electrographic Seizure Detection by Neurophysiologists and Non-Neurophysiologists in the Adult ICU Using a Panel of Quantitative EEG Trends.

Journal Article J Clin Neurophysiol · August 2015 PURPOSE: To evaluate the sensitivity and specificity of a panel of quantitative EEG (qEEG) trends for seizure detection in adult intensive care unit (ICU) patients when reviewed by neurophysiologists and non-neurophysiologists. METHODS: One hour qEEG panel ... Full text Open Access Link to item Cite

Baseline EEG pattern on continuous ICU EEG monitoring and incidence of seizures.

Journal Article J Clin Neurophysiol · April 2015 PURPOSE: To identify the probability of detecting nonconvulsive seizures based on the initial pattern seen in the first 30 minutes of continuous EEG (cEEG) monitoring. METHODS: Continuous EEG monitoring reports from 243 adult patients were reviewed, assess ... Full text Open Access Link to item Cite

Consensus statement on continuous EEG in critically ill adults and children, part II: personnel, technical specifications, and clinical practice.

Journal Article J Clin Neurophysiol · April 2015 INTRODUCTION: Critical Care Continuous EEG (CCEEG) is a common procedure to monitor brain function in patients with altered mental status in intensive care units. There is significant variability in patient populations undergoing CCEEG and in technical spe ... Full text Link to item Cite

Consensus statement on continuous EEG in critically ill adults and children, part I: indications.

Journal Article J Clin Neurophysiol · April 2015 INTRODUCTION: Critical Care Continuous EEG (CCEEG) is a common procedure to monitor brain function in patients with altered mental status in intensive care units. There is significant variability in patient populations undergoing CCEEG and in technical spe ... Full text Link to item Cite

Nonconvulsive seizure control in the intensive care unit.

Journal Article Curr Treat Options Neurol · March 2015 Nonconvulsive seizures (NCS) occur in as many as 20 % of comatose critically ill patients. These seizures need to be treated; however, the urgency with which this must be done and the medications that should be used are unclear. Often, data from treatment ... Full text Link to item Cite

Characteristics of Veterans diagnosed with seizures within Veterans Health Administration.

Journal Article J Rehabil Res Dev · 2015 The purpose of this report is to describe the demographics of Veterans diagnosed with seizures and taking antiepileptic drugs (AEDs) within the Veterans Health Administration (VHA) during fiscal year (FY) 2011 (October 1, 2010, to September 30, 2011), part ... Full text Link to item Cite

Tethered Cord Surgery

Chapter · 2015 Cite

Welcome to the new Journal of Clinical Neurophysiology.

Journal Article J Clin Neurophysiol · April 2014 Full text Link to item Cite

Predictors of electrocerebral inactivity with deep hypothermia.

Journal Article J Thorac Cardiovasc Surg · March 2014 OBJECTIVE: Cooling to electrocerebral inactivity (ECI) by electroencephalography (EEG) remains the gold standard to maximize cerebral and systemic organ protection during deep hypothermic circulatory arrest (DHCA). We sought to determine predictors of ECI ... Full text Link to item Cite

Treatment of Recurrent Electrographic Nonconvulsive Seizures (TRENdS) study.

Journal Article Epilepsia · September 2013 Nonconvulsive seizures (NCS) and nonconvulsive status epilepticus (NCSE) are electrographic seizures (ESz) that are not associated with overt clinical seizure activity. NCS are distinct ESz, whereas NCSE has ongoing, continuous electrographic seizure activ ... Full text Link to item Cite

Use of pregabalin for nonconvulsive seizures and nonconvulsive status epilepticus.

Journal Article Seizure · March 2013 PURPOSE: To determine the efficacy of pregabalin (PGB) in treatment of frequent nonconvulsive seizures (NCS) and nonconvulsive status epilepticus (NCSE) in critically ill patients. METHODS: In this retrospective study, 21 patients were identified as having ... Full text Open Access Link to item Cite

Classification of parasomnias

Chapter · January 1, 2013 Parasomnias are undesirable events or experiences occurring in sleep or during transitions to and from sleep. This category of disorders includes a varied set of disorders that can be classified based upon the sleep stage in which they predominantly occur. ... Full text Cite

Exome sequencing followed by large-scale genotyping fails to identify single rare variants of large effect in idiopathic generalized epilepsy.

Journal Article Am J Hum Genet · August 10, 2012 Idiopathic generalized epilepsy (IGE) is a complex disease with high heritability, but little is known about its genetic architecture. Rare copy-number variants have been found to explain nearly 3% of individuals with IGE; however, it remains unclear wheth ... Full text Link to item Cite

Dorsal column mapping for intramedullary spinal cord tumor resection decreases dorsal column dysfunction.

Journal Article J Spinal Disord Tech · June 2012 STUDY DESIGN: Retrospective cohort study and technical report. OBJECTIVE: To demonstrate, through our institutional series of intramedullary spinal tumor resection, the potential avoidance of dorsal column dysfunction after using dorsal column mapping. SUM ... Full text Link to item Cite

Long-term safety and efficacy in patients with uncontrolled partial-onset seizures treated with adjunctive lacosamide: results from a Phase III open-label extension trial.

Journal Article Epilepsia · March 2012 PURPOSE: To evaluate the long-term (up to 5 years exposure) safety and efficacy of lacosamide as adjunctive therapy in patients with uncontrolled partial-onset seizures taking one to three concomitant antiepileptic drugs (AEDs) in open-label extension tria ... Full text Link to item Cite

Neurophysiologic intraoperative monitoring of the glossopharyngeal and vagus nerves.

Journal Article J Clin Neurophysiol · December 2011 Neurophysiologic intraoperative monitoring (NIOM) of the glossopharyngeal and vagus nerves (CN IX and X) is often used during surgeries involving the lower brain stem. Although both of these nerves contain sensory, autonomic, and motor fibers, it is the mo ... Full text Link to item Cite

Cranial nerve monitoring.

Journal Article J Clin Neurophysiol · December 2011 Full text Link to item Cite

Nocturnal epilepsy in adults.

Journal Article J Clin Neurophysiol · April 2011 Epileptic seizures are often strongly influenced by the sleep-wake cycle. In many patients, seizures occur predominantly or exclusively during sleep. These cases can often represent a diagnostic dilemma. A high degree of suspicion combined with knowledge o ... Full text Link to item Cite

Sleep-wake functioning along the cancer continuum: focus group results from the Patient-Reported Outcomes Measurement Information System (PROMIS(®)).

Journal Article Psychooncology · October 2010 OBJECTIVE: Cancer and its treatments disturb sleep-wake functioning; however, there is little information available on the characteristics and consequences of sleep problems associated with cancer. As part of an effort to improve measurement of sleep-wake ... Full text Link to item Cite

Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.

Journal Article Brain · July 2010 Partial epilepsies have a substantial heritability. However, the actual genetic causes are largely unknown. In contrast to many other common diseases for which genetic association-studies have successfully revealed common variants associated with disease r ... Full text Link to item Cite

Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes.

Journal Article Am J Hum Genet · May 14, 2010 Deletions at 16p13.11 are associated with schizophrenia, mental retardation, and most recently idiopathic generalized epilepsy. To evaluate the role of 16p13.11 deletions, as well as other structural variation, in epilepsy disorders, we used genome-wide sc ... Full text Link to item Cite

Understanding therapeutic equivalence in epilepsy.

Journal Article CNS Spectr · February 2010 The issues surrounding generic drug substitution in patients with epilepsy are complex. The substitution of one formulation of an antiepileptic drug (AED) for another is controversial. Well-reasoned and defensible cases can be made both for and against suc ... Full text Link to item Cite

Utility of levetiracetam in patients with subarachnoid hemorrhage.

Journal Article Seizure · December 2009 PURPOSE: To determine the utility and tolerability of levetiracetam (LEV) compared to phenytoin (PHT) in preventing clinical seizures in patients with subarachnoid hemorrhage (SAH). METHODS: Utility and tolerability of PHT and LEV in patients with SAH were ... Full text Link to item Cite

Prognostic value of neurophysiologic intraoperative monitoring in tethered cord syndrome surgery.

Journal Article J Clin Neurophysiol · August 2009 Neurophysiologic intraoperative monitoring is used in surgery for tethered cord syndrome. Our objective was to determine if neurophysiologic intraoperative monitoring is helpful in identifying which patients will have worsening symptoms after surgery. The ... Full text Link to item Cite

Weight loss in narcolepsy patients treated with sodium oxybate.

Journal Article Sleep Med · June 2009 INTRODUCTION: Narcolepsy is often associated with increased body weight. Sodium oxybate has efficacy in many narcolepsy symptoms. The purpose of this study was to evaluate the effects of sodium oxybate on weight in patients with narcolepsy. METHODS: Charts ... Full text Link to item Cite

Neurophysiologic intraoperative monitoring in children.

Journal Article J Clin Neurophysiol · April 2009 Full text Link to item Cite

Neurophysiologic intraoperative monitoring during surgery for tethered cord syndrome.

Journal Article J Clin Neurophysiol · April 2009 Tethered cord syndrome (TCS) occurs when the distal spinal cord is adherent to inelastic tissue. This results in sensorimotor deficits in the lower extremities, bowel and bladder dysfunction, and musculoskeletal deformities. Tethered cord syndrome is often ... Full text Link to item Cite

Visual evoked potentials with CRT and LCD monitors: when newer is not better.

Journal Article Neurology · January 13, 2009 BACKGROUND: The stimulus for pattern reversal visual evoked potentials (PRVEP) has traditionally been delivered by a cathode ray tube (CRT) monitor. Liquid crystal display (LCD) monitors have become more affordable and are being used instead of CRT monitor ... Full text Link to item Cite

Levetiracetam in children with refractory status epilepticus.

Journal Article Epilepsy Behav · January 2009 The objective of this study was to investigate the utility of levetiracetam (LEV) in children with refractory status epilepticus (RSE). Records of children with RSE who received LEV as adjunctive therapy were reviewed. Over a 7-year period, 11 children had ... Full text Link to item Cite

Guideline twelve: guidelines for long-term monitoring for epilepsy.

Journal Article Am J Electroneurodiagnostic Technol · December 2008 Link to item Cite

Dorsal root entry zone procedures and other surgeries for pain

Journal Article Handbook of Clinical Neurophysiology · December 1, 2008 Full text Cite

Surgery for tethered cord syndrome and other cauda equina lesions

Journal Article Handbook of Clinical Neurophysiology · December 1, 2008 Full text Cite

Core elements of epilepsy diagnosis and management: expert consensus from the Leadership in Epilepsy, Advocacy, and Development (LEAD) faculty.

Journal Article Curr Med Res Opin · December 2008 BACKGROUND: Although epilepsy is relatively common, only a limited number of specialized epilepsy centers exist in the United States. Therefore, epilepsy diagnosis and management frequently occur in the community setting. This can complicate patient manage ... Full text Link to item Cite

Pediatric narcolepsy.

Journal Article Brain Dev · November 2008 Narcolepsy is a disabling disease with a prevalence of 0.05%. It is characterized by excessive daytime sleepiness, cataplexy, sleep paralysis, hypnogogic hallucinations, automatic behavior, and disrupted nocturnal sleep. The presentation can be very variab ... Full text Link to item Cite

"Real world" thoracic endografting: results with the Gore TAG device 2 years after U.S. FDA approval.

Journal Article Ann Thorac Surg · November 2008 BACKGROUND: The Gore TAG thoracic endoprosthesis (W. L. Gore and Associates, Flagstaff, AZ) was approved by the U.S. Food and Drug Administration (FDA) for the treatment of thoracic aortic aneurysms on March 23, 2005, and remains the only FDA approved thor ... Full text Link to item Cite

Ictal EEG remains the prominent predictor of seizure-free outcome after temporal lobectomy in epileptic patients with normal brain MRI.

Journal Article Seizure · October 2008 PURPOSE: While an abnormal pre-operative high-resolution brain MRI portends a favorable outcome in patients undergoing resective epilepsy surgery for medically intractable localization-related epilepsy (LRE), a normal MRI is less favorable. Ascertaining de ... Full text Link to item Cite

Neurophysiological intraoperative monitoring of the glossopharyngeal nerve: technical case report.

Journal Article Neurosurgery · October 2008 OBJECTIVE: Neurophysiological intraoperative monitoring of the glossopharyngeal nerve has been performed only with needle electrodes inserted into the pharyngeal muscles or soft palate. We describe a noninvasive method of monitoring this cranial nerve. MET ... Full text Link to item Cite

Neurophysiological intraoperative monitoring of the glossopharyngeal nerve: Technical case report

Journal Article Neurosurgery · October 1, 2008 OBJECTIVE: Neurophysiological intraoperative monitoring of the glossopharyngeal nerve has been performed only with needle electrodes inserted into the pharyngeal muscles or soft palate. We describe a noninvasive method of monitoring this cranial nerve. MET ... Cite

Use of levetiracetam in subarachnoid hemorrhage

Conference EPILEPSIA · October 1, 2007 Link to item Cite

Neurophysiologic intraoperative monitoring during endovascular stent graft repair of the descending thoracic aorta.

Journal Article J Clin Neurophysiol · August 2007 Conventional surgery on the descending thoracic aorta for aneurysm or dissection repair typically involves open thoracotomy and cross-clamping of the aorta. These procedures are associated with the potential for significant neurologic morbidity due to spin ... Full text Link to item Cite

Neurophysiologic intraoperative monitoring during aortic surgery

Journal Article Journal of Clinical Neurophysiology · August 1, 2007 Full text Cite

Assessment of hairline EEG as a screening tool for nonconvulsive status epilepticus.

Journal Article Epilepsia · May 2007 PURPOSE: Because of the high incidence of nonconvulsive status epilepticus (NCSE), the attraction of a "quick and easy" screening electroencephalogram (EEG) is obvious. Previous studies have shown utility of hairline EEG in diagnosing epilepsy. However, th ... Full text Link to item Cite

Neurophysiologic assessment of mucopolysaccharidosis III.

Journal Article Clin Neurophysiol · September 2006 OBJECTIVE: To describe finding of various neurophysiologic tests in patients with mucopolysaccharidosis III (MPS III) early in the disease course. METHODS: Patients were evaluated with flash visual evoked potentials (VEP), brainstem auditory evoked potenti ... Full text Link to item Cite

Guest editorial

Journal Article Journal of Clinical Neurophysiology · August 1, 2006 Full text Cite

Guest editorial.

Journal Article J Clin Neurophysiol · June 2006 Full text Link to item Cite

Normal adult EEG and patterns of uncertain significance.

Journal Article J Clin Neurophysiol · June 2006 A thorough understanding of a normal EEG is critical in defining those patterns that are abnormal. Because EEG is unique in the ability to support a clinical diagnosis of epilepsy, epileptiform patterns merit careful consideration. Certain benign patterns ... Full text Link to item Cite

Electroencephalographic assessment of coma.

Journal Article J Clin Neurophysiol · June 2006 Altered mental status ranging from confusion to deep unresponsiveness can be described as coma. Electroencephalography is an important tool in assessing comatose patients. Some EEG patterns are seen with lighter stages of coma and have a good prognosis, wh ... Full text Link to item Cite

Neurophysiologic studies in Krabbe disease.

Journal Article Suppl Clin Neurophysiol · 2006 Full text Link to item Cite

Brainstem auditory evoked potential monitoring: when is change in wave V significant?

Journal Article Neurology · November 22, 2005 BACKGROUND: The probability of hearing loss during cerebellopontine angle (CPA) surgery can be reduced by using brainstem auditory evoked potential (BAEP) intraoperative monitoring (IOM). A wave V latency prolongation of 1.0 milliseconds or amplitude decre ... Full text Link to item Cite

A double-blind, placebo-controlled study demonstrates sodium oxybate is effective for the treatment of excessive daytime sleepiness in narcolepsy.

Journal Article J Clin Sleep Med · October 15, 2005 STUDY OBJECTIVE: Assess the efficacy of sodium oxybate for the treatment of narcolepsy with an emphasis on excessive daytime sleepiness. DESIGN: Eight-week, multicenter, double-blind, placebo-controlled trial. SETTING: Forty-two sleep clinics in the United ... Link to item Cite

Further evidence supporting the use of sodium oxybate for the treatment of cataplexy: a double-blind, placebo-controlled study in 228 patients.

Journal Article Sleep Med · September 2005 BACKGROUND AND PURPOSE: To measure the effect of the nocturnal administration of sodium oxybate on cataplexy in patients with narcolepsy. PATIENTS AND METHODS: This trial was conducted with 228 adult narcolepsy/cataplexy patients in 42 sleep clinics. Patie ... Full text Link to item Cite

Review of neonatal EEG.

Journal Article Am J Electroneurodiagnostic Technol · March 2005 Neonatal electroencephalography (EEG) presents some of the most difficult challenges in EEG interpretation. It differs significantly in many ways from EEG of older children and adults. Technologically, acquisition of a neonatal EEG is significantly more di ... Link to item Cite

Krabbe disease: neurophysiologic studies and MRI correlations.

Journal Article Neurology · August 24, 2004 BACKGROUND: Krabbe disease (KD) is a rare hereditary leukodystrophy affecting children mostly in the first 6 months of life; later onset has been reported as well. OBJECTIVE: To review abnormalities in neurophysiologic studies in children with KD and deter ... Full text Link to item Cite

Brain-stem auditory and visual evoked potentials in children with Krabbe disease.

Journal Article Clin Neurophysiol · July 2004 OBJECTIVE: There are few reports in the literature detailing brain-stem auditory and visual evoked potentials (BAEP and VEP) in children with Krabbe disease (KD). The purpose of this study was to provide a descriptive analysis of the BAEP and VEP findings ... Full text Link to item Cite

Diet therapy for narcolepsy.

Journal Article Neurology · June 22, 2004 The effects of a low-carbohydrate, ketogenic diet (LCKD) on sleepiness and other narcolepsy symptoms were studied. Nine patients with narcolepsy were asked to adhere to the Atkins' diet plan, and their symptoms were assessed using the Narcolepsy Symptom St ... Full text Link to item Cite

CPAP compliance in sleep apnea patients with and without laboratory CPAP titration.

Journal Article Sleep Breath · March 2004 Advances in auto-adjusting positive airway pressure technology for obstructive sleep apnea now permit this treatment to be initiated outside of the sleep laboratory environment, bypassing the need for laboratory-based titration studies. Thus far, little re ... Full text Link to item Cite

Should women with obstructive sleep apnea syndrome be screened for hypothyroidism?

Journal Article Sleep Breath · December 2003 This study was conducted to determine if there is a significant increase in prevalence of hypothyroidism in women with OSAS such that screening might be warranted. Women undergoing polysomnography (PSG) at Duke University between January 1, 2000 and August ... Full text Link to item Cite

Non-convulsive status epilepticus.

Journal Article J Neurol Neurosurg Psychiatry · November 2003 Full text Link to item Cite

Delayed visual maturation associated with auditory neuropathy/dyssynchrony.

Journal Article J Child Neurol · May 2003 Delayed visual maturation is a term used to describe infants who initially seem blind but subsequently have a marked improvement. The mechanism of visual loss and the subsequent improvement remains unknown. Auditory neuropathy/dyssynchrony is a condition o ... Full text Link to item Cite

Changes in depressive symptoms after continuous positive airway pressure treatment for obstructive sleep apnea.

Journal Article Sleep Breath · March 2003 It is generally believed that obstructive sleep apnea (OSA) causes depression in some patients, yet it is unknown whether this depression is an actual clinical phenomenon or purely a result of overlapping somatic/physical symptoms shared by both disorders. ... Full text Link to item Cite

Non-convulsive status epilepticus: usefulness of clinical features in selecting patients for urgent EEG.

Journal Article J Neurol Neurosurg Psychiatry · February 2003 BACKGROUND: Non-convulsive status epilepticus (NCSE) is status epilepticus without obvious tonic-clonic activity. Patients with NCSE have altered mental state. An EEG is needed to confirm the diagnosis, but obtaining an EEG on every patient with altered me ... Full text Link to item Cite

Evaluation and comparison of Tranquility and AutoSet T autotitrating CPAP machines.

Journal Article J Clin Neurophysiol · 2003 The objective of this study was to determine the effectiveness of two autotitrating continuous positive airway pressure (auto-CPAP), the Tranquility (Respironics, Inc., Murrysville, PA, U.S.A.) and the AutoSet T (ResMed Corp., Poway, CA, U.S.A). Patients w ... Full text Link to item Cite

Epilepsy associated with lupus anticoagulant.

Journal Article Seizure · April 2002 INTRODUCTION: Lupus anticoagulant (LA) is commonly present in patients with systemic lupus erythematosus (SLE) who present with an ischemic cerebral stroke. Reports have noted the presence of LA in patients with epilepsy who do not have SLE. These patients ... Full text Link to item Cite

Neurophysiological monitoring for the nucleus caudalis dorsal root entry zone operation.

Journal Article Neurosurgery · April 2002 OBJECTIVE: The purpose of this report is to describe a neurophysiological monitoring technique that can decrease the incidence of complications while maintaining the effectiveness of the nucleus caudalis dorsal root entry zone (DREZ) operation. METHODS: Ne ... Full text Link to item Cite

Reflex seizures and non-ketotic hyperglycemia: an unresolved issue.

Journal Article Seizure · January 2002 Reflex seizures are a rare form of epilepsy, the pathogenesis of which is unclear. They have been reported in the setting of non-ketotic hyperglycemia (NKH) and are considered to be neuroendocrine in origin. We report a diabetic patient with movement-induc ... Full text Link to item Cite

Lateralized seizure termination: relationship to outcome following anterior temporal lobectomy.

Journal Article Epilepsy Res · November 2001 Determination of side of seizure onset is critical for a successful outcome following epilepsy surgery. Little is known about the significance of lateralized seizure termination. Sustained seizure activity contralateral to side of seizure onset, following ... Full text Link to item Cite

Intractable epilepsy following radiosurgery for arteriovenous malformation.

Journal Article J Neurosurg · November 2001 Radiosurgery is often used to treat arteriovenous malformations (AVMs) located in deep brain locations. Most of these procedures are successful not only in obliterating the AVM but also in decreasing the frequency and severity of associated seizures. Altho ... Full text Link to item Cite

Slow wave sleep rebound and REM rebound following the first night of treatment with CPAP for sleep apnea: correlation with subjective improvement in sleep quality.

Journal Article Sleep Med · May 2001 Objective: The purpose of this study was to correlate changes in PSG parameters between the diagnostic polysomnogram (dPSG) and the first night of treatment with continuous positive airway pressure (CPAP) (cpapPSG) to subjective improvement in sleep qualit ... Full text Link to item Cite

Rem sleep behavior disorder: potential relationship to post-traumatic stress disorder.

Journal Article J Clin Neurophysiol · March 2001 Rapid eye movement sleep behavior disorder (RBD) is a parasomnia in which there is enactment, often violent, of dream mentation. Although this syndrome is sometimes associated with neurologic disorders, psychiatric comorbidity is not typical. The authors p ... Full text Link to item Cite

Comparison of MRI and MRA findings in children with a variety of neurologic conditions.

Journal Article Pediatr Neurol · October 2000 The role of MRA in the evaluation of children is evolving. We compared MRA and MRI in children with a variety of neurologic conditions to determine when MRA provides positive, cost-beneficial information. A total of 114 patients were retrospectively studie ... Full text Link to item Cite

West syndrome in tuberous sclerosis complex.

Journal Article Pediatr Neurol · September 2000 West syndrome occurs commonly in children with tuberous sclerosis complex and is associated with a grave prognosis for cognitive and seizure outcomes. We sought to determine the epilepsy outcome of children with tuberous sclerosis complex and West syndrome ... Full text Link to item Cite

Characteristics of valproic acid resistant juvenile myoclonic epilepsy.

Journal Article Seizure · September 2000 Juvenile myoclonic epilepsy (JME) is often exquisitely responsive to treatment with valproic acid (VPA). However, a subset of patients does not respond to this medication and often has intractable seizures. We wanted to identify differences between these t ... Full text Link to item Cite

Improved sexual function in three men taking lamotrigine for epilepsy.

Journal Article South Med J · March 2000 Little information exists about the effects of newer antiepileptic drugs (AEDs) on sexual function in men with epilepsy. We report a series of three male veterans whose sexual disorders improved with lamotrigine. All three had partial seizures. One patient ... Link to item Cite

Tuberous sclerosis complex and epilepsy: prognostic significance of electroencephalography and magnetic resonance imaging.

Journal Article J Child Neurol · February 2000 Tuberous sclerosis complex is a disease that affects many organs, including the central nervous system. Nervous system involvement in the form of hamartomas often results in seizures. In this study we wanted to determine the outcome of epilepsy in tuberous ... Full text Link to item Cite

Lamotrigine-induced blepharospasm.

Journal Article Pharmacotherapy · July 1999 Movement disorders such as tremor and ataxia occur commonly during therapy with antiepileptic drugs (AEDs). Dystonias, however, are rare. Blepharospasm, although reported with neuroleptic agents, has never been reported with AEDs. Our patient developed ble ... Full text Link to item Cite

Generalized periodic epileptiform discharges: etiologies, relationship to status epilepticus, and prognosis.

Journal Article J Clin Neurophysiol · January 1999 Generalized periodic epileptiform discharges (GPEDs) are generalized, synchronous electrographic discharges. This study investigates etiologies, relationship to status epilepticus (SE), and the prognosis for patients with GPEDs. All EEGs with GPEDs perform ... Full text Link to item Cite

Post-stroke proprioceptive reflex epilepsy

Conference EPILEPSIA · January 1, 1999 Link to item Cite

Cost analysis of analog versus digital elctroencephalography

Journal Article Neurodiagnostic Journal · September 1, 1998 Though analog electroencephalography (AEEG) has been used by EEG laboratories for many years, many laboratories have switched recently to the newer digital EEG (DEEG) technology. We analyzed the cost-effectiveness and long-term financial implications of DE ... Cite

Sexual dysfunction in male veterans with epilepsy

Journal Article Journal of Epilepsy · May 1, 1998 Much has been written about sexual dysfunction in men with epilepsy. We wanted to determine the frequency and nature of sexual disorders in our highly selected population of male veterans. Charts of the 184 men with epilepsy followed in the Neurodiagnostic ... Full text Cite

Neurological picture. Mimetic smile.

Journal Article J Neurol Neurosurg Psychiatry · August 1997 Full text Link to item Cite

Mimetic smile

Journal Article Journal of Neurology Neurosurgery and Psychiatry · January 1, 1997 Cite

Transesophageal echocardiography in diagnosing cardioembolic stroke.

Journal Article Clin Cardiol · December 1995 Stroke is a disease with high morbidity and mortality that afflicts older people. The most common type of stroke is ischemic, and 15-20% of these strokes are cardioembolic. Because clinical features are not very specific for the type of stroke, diagnostic ... Full text Link to item Cite