Alice Bryn Salter

Journal Article Nat Med · April 2010 Hematopoietic stem cell (HSC) self-renewal is regulated by both intrinsic and extrinsic signals. Although some of the pathways that regulate HSC self-renewal have been uncovered, it remains largely unknown whether these pathways can be triggered by deliver ... Full text Link to item Cite

Inhibition of aldehyde dehydrogenase expands hematopoietic stem cells with radioprotective capacity.

Journal Article Stem Cells · March 31, 2010 Hematopoietic stem cells (HSCs) are enriched for aldehyde dehydrogenase (ALDH) activity and ALDH is a selectable marker for human HSCs. However, the function of ALDH in HSC biology is not well understood. We sought to determine the function of ALDH in regu ... Full text Link to item Cite

Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo.

Journal Article Blood · February 26, 2009 Hematopoietic stem cells (HSCs) reside in association with bone marrow (BM) sinusoidal vessels in vivo, but the function of BM endothelial cells (ECs) in regulating hematopoiesis is unclear. We hypothesized that hematopoietic regeneration following injury ... Full text Link to item Cite

Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture.

Journal Article Mol Endocrinol · February 2009 The retinoid X receptor (RXR) contributes to the regulation of diverse biological pathways via its role as a heterodimeric partner of several nuclear receptors. However, RXR has no established role in the regulation of hematopoietic stem cell (HSC) fate. I ... Full text Link to item Cite

Gene expression signatures of radiation response are specific, durable and accurate in mice and humans.

Journal Article PLoS One · April 2, 2008 BACKGROUND: Previous work has demonstrated the potential for peripheral blood (PB) gene expression profiling for the detection of disease or environmental exposures. METHODS AND FINDINGS: We have sought to determine the impact of several variables on the P ... Full text Open Access Link to item Cite

Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice.

Journal Article Blood · March 15, 2007 Flk-1(+) endothelial progenitors contribute critically to the definitive onset of hematopoiesis during embryogenesis. Recent studies have suggested that adult sources of endothelial cells also possess hematopoietic activity. In this study, we sought to det ... Full text Link to item Cite