Scholars@Duke
Alissa R Carver

Alissa R Carver

Clinical Faculty in the Department of Obstetrics and Gynecology
Obstetrics and Gynecology

Selected Publications

Storage of Placental Blood - A Feasibility Study for Development of a Fetal Blood Bank.

Journal Article J Pediatr Surg · September 2025 OBJECTIVE: Neonates transfused with adult donor blood (rich in HbA) have a precipitous drop in fetal hemoglobin (HbF) levels. This study evaluates the feasibility of collection and storage of placental cord blood. METHODS: Prospective study patients with u ... Full text Link to item Cite

Delivery outcomes in the subsequent pregnancy following the conservative management of placenta accreta spectrum disorder: a systematic review and meta-analysis.

Journal Article Am J Obstet Gynecol · May 2024 OBJECTIVE: Cesarean hysterectomy is generally presumed to decrease maternal morbidity and mortality secondary to placenta accreta spectrum disorder. Recently, uterine-sparing techniques have been introduced in conservative management of placenta accreta sp ... Full text Link to item Cite

External Validation of Postpartum Hemorrhage Prediction Models Using Electronic Health Record Data.

Journal Article Am J Perinatol · April 2024 OBJECTIVE: A recent study leveraging machine learning methods found that postpartum hemorrhage (PPH) can be predicted accurately at the time of labor admission in the U.S. Consortium for Safe Labor (CSL) dataset, with a C-statistic as high as 0.93. These C ... Full text Link to item Cite

Placenta accreta spectrum care infrastructure: an evidence-based review of needed resources supporting placenta accreta spectrum care.

Journal Article Am J Obstet Gynecol MFM · January 2024 The incidence of placenta accreta spectrum, the deeply adherent placenta with associated increased risk of maternal morbidity and mortality, has seen a significant rise in recent years. Therefore, there has been a rise in clinical and research focus on thi ... Full text Link to item Cite

When blood is not an option: Optimal bloodless management of severe anemia in pregnancy.

Journal Article J Obstet Gynaecol Res · November 2022 Standard treatment for severe anemia in pregnancy is allogeneic blood transfusion, but this is not acceptable to all patients. Options for alternative anemia treatment are available. In this case report, a 32-year-old G2P1 woman who was a Jehovah's Witness ... Full text Link to item Cite

Fetal hemoglobin levels in premature newborns. Should we reconsider transfusion of adult donor blood?

Journal Article J Pediatr Surg · November 2021 PURPOSE: The aim of this study was to assess the percent decrease in fetal hemoglobin (HbF) after transfusion of adult-derived donor packed red blood cell (pRBC) units in extremely low gestational age newborns (ELGANs). METHODS: Control percent fetal hemog ... Full text Link to item Cite

Conjoined twins: an obstetrician's guide to prenatal care and delivery management.

Journal Article J Perinatol · October 2021 OBJECTIVE: Obstetricians infrequently encounter conjoined twins. Much of the clinical care literature focuses on postnatal management from a neonatology and pediatric surgery perspective; guidance on obstetrical management is limited. We outline steps for ... Full text Link to item Cite

Evaluation of Implementation and Unit Impact of a Hypertensive Disorder of Pregnancy Guideline: A Model-Based Approach

Journal Article Journal of Doctoral Nursing Practice · January 1, 2021 Background: Hypertensive disorders of pregnancy are a leading cause of maternal mortality and morbidity. To address this, a large Midwestern hospital initiated a practice guideline. Practice guidelines should improve outcomes, but implementation of these r ... Full text Cite

User Perceptions of an Electronic Maternal Alerting System.

Journal Article A A Pract · September 2020 This survey study evaluates the user experience of an electronic maternal early warning system that generates automated pages. Survey domains included the system's effect on patient care, alarm fatigue, and continued use of the system. The response rate wa ... Full text Link to item Cite

Use of a Novel Electronic Maternal Surveillance System and the Maternal Early Warning Criteria to Detect Severe Postpartum Hemorrhage.

Journal Article Anesth Analg · September 2020 BACKGROUND: A leading cause of preventable maternal death is related to delayed response to clinical warning signs. Electronic surveillance systems may improve detection of maternal morbidity with automated notifications. This retrospective observational s ... Full text Link to item Cite

The effect of maternal pravastatin therapy on adverse sensorimotor outcomes of the offspring in a murine model of preeclampsia.

Journal Article Int J Dev Neurosci · April 2014 Animal and human studies show that in-utero exposure to preeclampsia alters fetal programming and results in long-term adverse cardiovascular outcomes in the offspring. Human epidemiologic data also suggest that offspring born to preeclamptic mothers are a ... Full text Link to item Cite

Maternal pravastatin prevents altered fetal brain development in a preeclamptic CD-1 mouse model.

Journal Article PLoS One · 2014 OBJECTIVE: Using an animal model, we have previously shown that preeclampsia results in long-term adverse neuromotor outcomes in the offspring, and this phenotype was prevented by antenatal treatment with pravastatin. This study aims to localize the altere ... Full text Link to item Cite

Vaginal birth after cesarean and trial of labor after cesarean: what should we be recommending relative to maternal risk:benefit?

Journal Article Womens Health (Lond) · July 2012 Trial of labor after cesarean (TOLAC) delivery is currently a hot obstetrical topic owing to the acute rise in the rate of cesarean deliveries, both primary and repeat. When the physician and patient are considering TOLAC, several factors should be conside ... Full text Link to item Cite

Monochorionic diamniotic twin pregnancy: timing and duration of sonographic surveillance for detection of twin-twin transfusion syndrome.

Journal Article J Ultrasound Med · March 2011 OBJECTIVE: Twin-twin transfusion syndrome complicates up to 15% of monochorionic diamniotic gestations. Current recommendations for sonographic surveillance in monochorionic diamniotic pregnancies for detection of twin-twin transfusion syndrome vary. Our o ... Full text Link to item Cite

The perceived impact of duty hour restrictions on the residency environment: a survey of residency program directors.

Conference Am J Obstet Gynecol · June 2006 OBJECTIVE: The purpose of this study was to characterize residency program director baseline perceptions regarding the effect of resident duty hour limitations on key components of the graduate medical education environment. STUDY DESIGN: This was a survey ... Full text Link to item Cite

The scope of duty hour-associated residency structure modifications.

Conference Am J Obstet Gynecol · January 2006 OBJECTIVE: The purpose of this study was to characterize the duty hours-associated modifications made to the educational and patient care structure of obstetrics and gynecology residency programs, and the relationship of these modifications to residency pr ... Full text Link to item Cite

Misoprostol for labor induction in women with term premature rupture of membranes: a meta-analysis.

Conference Obstet Gynecol · September 2005 OBJECTIVE: To systematically review published data evaluating the comparative use of misoprostol with placebo/expectant management or oxytocin for labor induction in women with term (> or = 36 weeks of gestation) premature rupture of membranes. DATA SOURCE ... Full text Link to item Cite