Ammon Milton Fager

Journal Article J Thromb Haemost · June 2024 BACKGROUND: Until recently, the treatment of hemophilia A relied on factor (F)VIII replacement. However, up to one-third of patients with severe hemophilia A develop neutralizing alloantibodies that render replacement therapies ineffective. The development ... Full text Link to item Cite

Stopping the bleed when platelets don’t stick

Journal Article Nature Cardiovascular Research · February 1, 2024 Defects in platelet adhesion at sites of injury can lead to excessive bleeding. A study by Gandhi et al. investigates a new bispecific antibody as a possible therapy to prevent bleeding in patients with inherited defects in platelet adhesion. ... Full text Cite

Inhalation of an RNA aptamer that selectively binds extracellular histones protects from acute lung injury.

Journal Article Mol Ther Nucleic Acids · March 14, 2023 Acute lung injury (ALI) is a syndrome of acute inflammation, barrier disruption, and hypoxemic respiratory failure associated with high morbidity and mortality. Diverse conditions lead to ALI, including inhalation of toxic substances, aspiration of gastric ... Full text Open Access Link to item Cite

Biology of Coagulation and Coagulopathy in Neurologic Surgery.

Journal Article Neurosurg Clin N Am · October 2018 Hemostasis is a cell-based process that is regulated in a tissue-specific manner by the differential expression of procoagulant and anticoagulant factors on endothelial cells from different sites throughout the vasculature. The central nervous system, in p ... Full text Link to item Cite

Human platelets express endothelial protein C receptor, which can be utilized to enhance localization of factor VIIa activity.

Journal Article J Thromb Haemost · September 2018 UNLABELLED: Essentials Factor VIIa binds activated platelets to promote hemostasis in hemophilia patients with inhibitors. The interactions and sites responsible for platelet-FVIIa binding are not fully understood. Endothelial cell protein C receptor (EPCR ... Full text Link to item Cite

Perioperative Management of the Gynecologic Patient on Long-term Anticoagulation.

Journal Article Clin Obstet Gynecol · June 2018 The perioperative management of patients taking antithrombotic or antiplatelet medications is based on an assessment of the individual patient's risk for thrombosis or bleeding, the specific medication involved, and the nature of the planned procedure. Thi ... Full text Link to item Cite

Properties of procoagulant platelets: defining and characterizing the subpopulation binding a functional prothrombinase.

Journal Article Arterioscler Thromb Vasc Biol · December 2010 OBJECTIVE: The goal of this study was to define and characterize the subpopulation of platelets capable of regulating the functional interactions of factors Va (FVa) and Xa (FXa) on the thrombin-activated platelet surface. METHODS AND RESULTS: Flow cytomet ... Full text Link to item Cite

The COPI complex functions in nuclear envelope breakdown and is recruited by the nucleoporin Nup153.

Journal Article Dev Cell · September 2003 Nuclear envelope breakdown is a critical step in the cell cycle of higher eukaryotes. Although integral membrane proteins associated with the nuclear membrane have been observed to disperse into the endoplasmic reticulum at mitosis, the mechanisms involved ... Full text Link to item Cite

Domain-specific antibodies reveal multiple-site topology of Nup153 within the nuclear pore complex.

Journal Article J Struct Biol · 2002 Nup153, one of the best characterized nuclear pore complex proteins (nucleoporins), plays a critical role in the import of proteins into the nucleus as well as in the export of RNAs and proteins from the nucleus. Initially an epitope of Nup153 was found to ... Full text Link to item Cite