Scholars@Duke
Amy Martha Pastva

Amy Martha Pastva

Professor in Orthopaedic Surgery
Orthopaedic Surgery, Physical Therapy
amy.pastva@dm.duke.edu
DUMC 104002, Durham, NC 27710
311 Trent Drive, Durham, NC 27710

Selected Publications

Comparison of Physical Frailty Assessments in Heart Failure With Preserved Ejection Fraction.

Journal Article JACC Adv · December 2024 BACKGROUND: Frailty is a known determinant of poor clinical outcomes in heart failure with preserved ejection fraction (HFpEF). However, prevalence estimates and effect sizes vary in part due to multiple tools available to measure frailty. OBJECTIVES: This ... Full text Link to item Cite

Disparities in Access to, Use of, and Quality of Rehabilitation After Stroke in the United States: A Scoping Review.

Journal Article Arch Phys Med Rehabil · November 2, 2024 OBJECTIVES: To summarize current reports in the literature on disparities in rehabilitation after stroke; identify gaps in our understanding of rehabilitation disparities; and make recommendations for future research. DATA SOURCES: A health sciences librar ... Full text Link to item Cite

Early In-Bed Cycle Ergometry With Critically Ill, Mechanically Ventilated Patients: Statistical Analysis Plan for CYCLE (Critical Care Cycling to Improve Lower Extremity Strength), an International, Multicenter, Randomized Clinical Trial.

Journal Article JMIR Res Protoc · October 28, 2024 BACKGROUND: Survivors of critical illness are at risk of developing physical dysfunction following intensive care unit (ICU) discharge. ICU-based rehabilitation interventions, such as early in-bed cycle ergometry, may improve patients' short-term physical ... Full text Link to item Cite

Social Determinants of Health and the Use of Community-Based Rehabilitation Following Stroke: Methodologic Considerations.

Journal Article Arch Rehabil Res Clin Transl · September 2024 Social determinants are nonmedical factors frequently used to study disparities in health outcomes but have not been widely explored in regard to rehabilitation service utilization. In our National Institutes of Child Health and Human Development-funded st ... Full text Link to item Cite

Digital Health Innovations to Promote Physical Activities in Patients with Cancer.

Journal Article Stud Health Technol Inform · July 24, 2024 This study evaluates the Exercise Planning and Tracking (EPT) tool, a digital health solution, designed to enhance physical activity (PA) in patients with cancer. Utilizing a tailored PA database, the tool aids in tracking and planning exercises and monito ... Full text Link to item Cite

Early physical rehabilitation dosage in the intensive care unit associates with hospital outcomes after critical COVID-19.

Journal Article Crit Care · July 18, 2024 OBJECTIVE: To examine the relationship between physical rehabilitation parameters including an approach to quantifying dosage with hospital outcomes for patients with critical COVID-19. DESIGN: Retrospective practice analysis from March 5, 2020, to April 1 ... Full text Link to item Cite

Using Multiphase Optimization Strategy and Human-Centered Design to Create an Integrated Model of Palliative Care Skills in Home-Based Physical Therapy for Advanced Heart Failure.

Journal Article J Palliat Med · April 2024 Background: Many older adults with advanced heart failure receive home health rehabilitation after hospitalization. Yet, integration of palliative care skills into rehabilitation is limited. Objective: Describe using the Multiphase Optimization Strategy (M ... Full text Link to item Cite

Referral to Community-Based Rehabilitation Following Acute Stroke: Findings From the COMPASS Pragmatic Trial.

Journal Article Circ Cardiovasc Qual Outcomes · January 2024 BACKGROUND: Few studies on care transitions following acute stroke have evaluated whether referral to community-based rehabilitation occurred as part of discharge planning. Our objectives were to describe the extent to which patients discharged home were r ... Full text Link to item Cite

Relationship of Age And Mobility Levels During Physical Rehabilitation With Clinical Outcomes in Critical Illness.

Journal Article Arch Rehabil Res Clin Transl · December 2023 OBJECTIVE: To determine whether age, mobility level, and change in mobility level across the first 3 physical rehabilitation sessions associate with clinical outcomes of patients who are critically ill. DESIGN: Retrospective, observational cohort study. SE ... Full text Link to item Cite

Relationship of Race With Functional and Clinical Outcomes With the REHAB-HF Multidomain Physical Rehabilitation Intervention for Older Patients With Acute Heart Failure.

Journal Article J Am Heart Assoc · November 7, 2023 Background The REHAB-HF (Rehabilitation Therapy in Older Acute Heart Failure Patients) randomized trial demonstrated that a 3-month transitional, tailored, progressive, multidomain physical rehabilitation intervention improves physical function, frailty, d ... Full text Link to item Cite

An interprofessional initiative to improve the “drop to shock” interval on a college campus

Journal Article Teaching and Learning in Nursing · October 1, 2023 This project engaged healthcare students in an interprofessional (IP) activity to design a program to increase awareness of automated external defibrillators device locations on campus. A Plan-Do-Study-Act approach was used. We highlight how an IP activity ... Full text Cite

Critical Care Cycling to Improve Lower Extremity Strength (CYCLE): protocol for an international, multicentre randomised clinical trial of early in-bed cycling for mechanically ventilated patients.

Journal Article BMJ Open · June 23, 2023 INTRODUCTION: In-bed leg cycling with critically ill patients is a promising intervention aimed at minimising immobility, thus improving physical function following intensive care unit (ICU) discharge. We previously completed a pilot randomised controlled ... Full text Link to item Cite

Abstract P471: Predictors of Referral to Community-Based Rehabilitation Following Stroke

Conference Circulation · February 28, 2023 Background: While several studies have examined care transitions following stroke, few have assessed use of rehabilitation. We explored factors predictive of referral to community-based rehabilitation ... Full text Cite

Physical activity and relationship to physical function, quality of life, and cognitive function in older patients with acute decompensated heart failure.

Journal Article Am Heart J · February 2023 BACKGROUND: Volitional physical activity level is predictive of a variety of health outcomes, but has not been examined in patients recently hospitalized for acute decompensated HF (ADHF). METHODS: Ten to 14 days after index hospitalization for ADHF, 93 pa ... Full text Link to item Cite

Frailty and Effects of a Multidomain Physical Rehabilitation Intervention Among Older Patients Hospitalized for Acute Heart Failure: A Secondary Analysis of a Randomized Clinical Trial.

Journal Article JAMA Cardiol · February 1, 2023 IMPORTANCE: Frailty is common among older patients with acute decompensated heart failure (ADHF) and is associated with worse quality of life (QOL) and a higher risk of clinical events. Frailty can also limit recovery and response to interventions. In the ... Full text Link to item Cite

Methodological and Clinimetric Evaluation of Inspiratory Respiratory Muscle Ultrasound in the Critical Care Setting: A Systematic Review and Meta-Analysis.

Journal Article Crit Care Med · February 1, 2023 OBJECTIVE: Significant variations exist in the use of respiratory muscle ultrasound in intensive care with no society-level consensus on the optimal methodology. This systematic review aims to evaluate, synthesize, and compare the clinimetric properties of ... Full text Link to item Cite

A pilot study to assess the feasibility of a remotely monitored high-intensity interval training program prior to allogeneic hematopoietic stem cell transplantation.

Journal Article PLoS One · 2023 INTRODUCTION: Although allogeneic hematopoietic stem cell transplantation (HCT) can be a curative therapy for hematologic disorders, it is associated with treatment-related complications and losses in cardiorespiratory fitness and physical function. High-i ... Full text Link to item Cite

Severity of functional impairments by race and sex in older patients hospitalized with acute decompensated heart failure.

Journal Article J Am Geriatr Soc · December 2022 BACKGROUND: Older patients hospitalized with acute decompensated heart failure (ADHF) have marked functional impairments, which may contribute to their delayed and incomplete recovery and persistently poor outcomes. However, whether impairment severity dif ... Full text Link to item Cite

Obesity Status and Physical Rehabilitation in Older Patients Hospitalized With Acute HF: Insights From REHAB-HF.

Journal Article JACC Heart Fail · December 2022 BACKGROUND: In the REHAB-HF (Rehabilitation Therapy in Older Acute Heart Failure Patients) trial, a novel, early, transitional, multidomain rehabilitation intervention improved physical function, frailty, quality of life (QOL), and depression in older pati ... Full text Link to item Cite

Quality of Life Trajectory and Its Mediators in Older Patients With Acute Decompensated Heart Failure Receiving a Multi-Domain Rehabilitation Intervention: Results From the Rehabilitation Therapy in Older Acute Heart Failure Patients Trial.

Journal Article Circ Heart Fail · December 2022 BACKGROUND: As patients with heart failure experience worsening of their condition, including acute decompensated heart failure, quality of life deteriorates. However, the trajectory of quality of life changes and their determinants in the context of the R ... Full text Link to item Cite

Research interrupted: applying the CONSERVE 2021 Statement to a randomized trial of rehabilitation during critical illness affected by the COVID-19 pandemic.

Journal Article Trials · September 2, 2022 RATIONALE: The COVID-19 pandemic disrupted non-COVID critical care trials globally as intensive care units (ICUs) prioritized patient care and COVID-specific research. The international randomized controlled trial CYCLE (Critical Care Cycling to Improve Lo ... Full text Link to item Cite

Geriatric Assessment Reveals Actionable Impairments in Hematopoietic Stem Cell Transplantation Candidates Age 18 to 80 Years.

Journal Article Transplant Cell Ther · August 2022 Allogeneic hematopoietic stem cell transplantation (HCT) is a potentially curative treatment for both malignant and nonmalignant hematologic diseases; however, reported rates of treatment-related mortality approach 30%. Outcomes are worse in patients who b ... Full text Link to item Cite

Intervention Adherence in REHAB-HF: Predictors and Relationship With Physical Function, Quality of Life, and Clinical Events.

Journal Article J Am Heart Assoc · June 7, 2022 Background The REHAB-HF (Rehabilitation Therapy in Older Acute Heart Failure Patients) trial showed that a novel, early, transitional, tailored, progressive, multidomain physical rehabilitation intervention improved physical function and quality of life in ... Full text Link to item Cite

Skilled Nursing and Inpatient Rehabilitation Facility Use by Medicare Fee-for-Service Beneficiaries Discharged Home After a Stroke: Findings From the COMPASS Trial.

Journal Article Arch Phys Med Rehabil · May 2022 OBJECTIVES: To examine the effect of a comprehensive transitional care model on the use of skilled nursing facility (SNF) and inpatient rehabilitation facility (IRF) care in the 12 months after acute care discharge home following stroke; and to identify pr ... Full text Link to item Cite

Mobility Levels With Physical Rehabilitation Delivered During and After Extracorporeal Membrane Oxygenation: A Marker of Illness Severity or an Indication of Recovery?

Journal Article Phys Ther · March 1, 2022 OBJECTIVE: The aims of this study were to determine whether physical rehabilitation intervention for individuals who required extracorporeal membrane oxygenation (ECMO) is associated with clinical outcomes and to assess whether the patient mobility respons ... Full text Link to item Cite

Economic Outcomes of Rehabilitation Therapy in Older Patients With Acute Heart Failure in the REHAB-HF Trial: A Secondary Analysis of a Randomized Clinical Trial.

Journal Article JAMA Cardiol · February 1, 2022 IMPORTANCE: In the Rehabilitation Therapy in Older Acute Heart Failure Patients (REHAB-HF) trial, a novel 12-week rehabilitation intervention demonstrated significant improvements in validated measures of physical function, quality of life, and depression, ... Full text Link to item Cite

Physical Rehabilitation in Older Patients Hospitalized with Acute Heart Failure and Diabetes: Insights from REHAB-HF.

Journal Article Am J Med · January 2022 BACKGROUND: Prior studies showed an attenuated response to exercise training among patients with heart failure and type 2 diabetes mellitus. We explored the interaction between diabetes status and a novel, transitional, tailored, progressive rehabilitation ... Full text Link to item Cite

Rehabilitation Intervention in Older Patients With Acute Heart Failure With Preserved Versus Reduced Ejection Fraction.

Journal Article JACC Heart Fail · October 2021 OBJECTIVES: This study assessed for treatment interactions by ejection fraction (EF) subgroup (≥45% [heart failure with preserved ejection fraction (HFpEF); vs <45% [heart failure with reduced ejection fraction (HFrEF)]). BACKGROUND: The REHAB-HF trial sho ... Full text Open Access Link to item Cite

Is Discordance Between Recommended and Actual Postacute Discharge Setting a Risk Factor for Readmission in Patients With Congestive Heart Failure?

Journal Article J Am Heart Assoc · August 3, 2021 Background Readmissions in patients with congestive heart failure are common and often preventable. Limited data suggest that patients discharged to a less intensive postacute care setting than recommended are likely to readmit. We examined whether postacu ... Full text Link to item Cite

Physical Rehabilitation for Older Patients Hospitalized for Heart Failure.

Journal Article N Engl J Med · July 15, 2021 BACKGROUND: Older patients who are hospitalized for acute decompensated heart failure have high rates of physical frailty, poor quality of life, delayed recovery, and frequent rehospitalizations. Interventions to address physical frailty in this population ... Full text Link to item Cite

Functional electrical stimulation in-bed cycle ergometry in mechanically ventilated patients: a multicentre randomised controlled trial.

Journal Article Thorax · July 2021 PURPOSE: To investigate the effect of functional electrical stimulation-assisted cycle ergometry (FES-cycling) on muscle strength, cognitive impairment and related outcomes. METHODS: Mechanically ventilated patients aged ≥18 years with sepsis or systemic i ... Full text Link to item Cite

Towards "mobility is medicine": Socioecological factors and hospital mobility in older adults.

Journal Article J Am Geriatr Soc · July 2021 BACKGROUND: Understanding the factors that influence hospital mobility, especially in the context of a heightened focus on falls prevention, is needed to improve care. OBJECTIVE: This qualitative study uses a socioecological framework to explore factors th ... Full text Link to item Cite

Relationship of physical function with quality of life in older patients with acute heart failure.

Journal Article J Am Geriatr Soc · July 2021 BACKGROUND: Older patients with acute decompensated heart failure (ADHF) have severely impaired physical function (PF) and quality of life (QOL). However, relationships between impairments in PF and QOL are unknown but are relevant to clinical practice and ... Full text Open Access Link to item Cite

Cognition, Physical Function, and Quality of Life in Older Patients With Acute Decompensated Heart Failure.

Journal Article J Card Fail · March 2021 BACKGROUND: Older adults with acute decompensated heart failure have persistently poor clinical outcomes. Cognitive impairment (CI) may be a contributing factor. However, the prevalence of CI and the relationship of cognition with other patient-centered fa ... Full text Link to item Cite

Movement Matters, and So Does Context: Lessons Learned From Multisite Implementation of the Movement Matters Activity Program for Stroke in the Comprehensive Postacute Stroke Services Study.

Journal Article Arch Phys Med Rehabil · March 2021 The purpose of this Special Communication is to discuss the rationale and design of the Movement Matters Activity Program for Stroke (MMAP) and explore implementation successes and challenges in home health and outpatient therapy practices across the strok ... Full text Link to item Cite

Three-Fourths of ICU Physical Therapists Report Use of Assistive Equipment and Technology in Practice: Results of an International Survey

Journal Article Journal of Acute Care Physical Therapy · January 2021 Introduction:Patients surviving critical illness develop persistent functional mobility impairments that significantly impact their quality of life. Early rehabilitation interventions in ... Full text Cite

Acute skeletal muscle wasting and dysfunction predict physical disability at hospital discharge in patients with critical illness.

Journal Article Crit Care · November 4, 2020 BACKGROUND: Patients surviving critical illness develop muscle weakness and impairments in physical function; however, the relationship between early skeletal muscle alterations and physical function at hospital discharge remains unclear. The primary purpo ... Full text Link to item Cite

Role of anabolic testosterone agents and structured exercise to promote recovery in ICU survivors.

Journal Article Curr Opin Crit Care · October 2020 PURPOSE OF REVIEW: ICU survivors frequently suffer significant, prolonged physical disability. 'ICU Survivorship', or addressing quality-of-life impairments post-ICU care, is a defining challenge, and existing standards of care fail to successfully address ... Full text Link to item Cite

Novel approaches to metabolic assessment and structured exercise to promote recovery in ICU survivors.

Journal Article Curr Opin Crit Care · August 2020 PURPOSE OF REVIEW: Survivorship or addressing impaired quality of life (QoL) in ICU survivors has been named 'the defining challenge of critical care' for this century to address this challenge; in addition to optimal nutrition, we must learn to employ tar ... Full text Open Access Link to item Cite

Randomized Pragmatic Trial of Stroke Transitional Care: The COMPASS Study.

Journal Article Circ Cardiovasc Qual Outcomes · June 2020 Background The objectives of this study were to develop and test in real-world clinical practice the effectiveness of a comprehensive postacute stroke transitional care (TC) management program. Methods and Results The COMPASS study (Comprehensive Post-Acut ... Full text Link to item Cite

Implementation of a billable transitional care model for stroke patients: the COMPASS study.

Journal Article BMC Health Serv Res · December 19, 2019 BACKGROUND: The COMprehensive Post-Acute Stroke Services (COMPASS) pragmatic trial compared the effectiveness of comprehensive transitional care (COMPASS-TC) versus usual care among stroke and transient ischemic attack (TIA) patients discharged home from N ... Full text Link to item Cite

Frailty Among Older Decompensated Heart Failure Patients: Prevalence, Association With Patient-Centered Outcomes, and Efficient Detection Methods.

Journal Article JACC Heart Fail · December 2019 OBJECTIVES: This study sought to assess the prevalence of frailty, its associations with physical function, quality of life (QoL), cognition, and depression and to investigate more efficient methods of detection in older patients hospitalized with acute de ... Full text Link to item Cite

Geriatric Assessment Identifies Impairments in Younger Candidates for Allogeneic Hematopoietic Stem Cell Transplantation

Conference Blood · November 13, 2019 Introduction: Geriatric assessment (GA) is a multidimensional evaluation of patient health and function that may detect impairments not identified as part of routine care, predict treatment-related morbidity and mortality, and inform treatment plan ... Full text Cite

Cardiac Rehabilitation in Older Adults with Heart Failure: Fitting a Square Peg in a Round Hole.

Journal Article Clin Geriatr Med · November 2019 Cardiac rehabilitation (CR) is a structured exercise and lifestyle program that improves mortality and quality of life in patients with heart failure (HF) with reduced ejection fraction. However, significant gaps remain in optimizing CR for older adults wi ... Full text Link to item Cite

A 1-Month Physical Therapy-Based Outpatient Program for Adults Awaiting Lung Transplantation: A Retrospective Analysis of Exercise Capacity, Symptoms, and Quality of Life.

Journal Article Cardiopulm Phys Ther J · April 2019 PURPOSE: Rehabilitation can improve health outcomes in candidates for lung transplantation. The purpose of this study was to retrospectively evaluate the effect of a one-month physical therapy (PT)-based outpatient program on exercise capacity, symptoms, q ... Full text Link to item Cite

Point of Care Quantitative Assessment of Muscle Health in Older Individuals: An Investigation of Quantitative Muscle Ultrasound and Electrical Impedance Myography Techniques.

Journal Article Geriatrics (Basel) · December 16, 2018 Background: Muscle health is recognized for its critical role in the functionality and well-being of older adults. Readily accessible, reliable, and inexpensive methods of measuring muscle health are needed to advance research and clinical care. Methods: I ... Full text Link to item Cite

Physical Function, Frailty, Cognition, Depression, and Quality of Life in Hospitalized Adults ≥60 Years With Acute Decompensated Heart Failure With Preserved Versus Reduced Ejection Fraction.

Conference Circ Heart Fail · November 2018 BACKGROUND: Older hospitalized acute decompensated heart failure (HF) patients have persistently poor outcomes and delayed recovery regardless of ejection fraction (EF). We hypothesized that impairments in physical function, frailty, cognition, mood, and q ... Full text Link to item Cite

COMPASS-CP: An Electronic Application to Capture Patient-Reported Outcomes to Develop Actionable Stroke and Transient Ischemic Attack Care Plans.

Journal Article Circ Cardiovasc Qual Outcomes · August 2018 Background Patient-reported outcomes (PROs) are clinical tools that measure patients' goals of care and assess patient-reported physical, mental, and social well-being. Despite their value in advancing patient-centered care, routine use of PROs in stroke m ... Full text Link to item Cite

A Person-Centered Approach to Poststroke Care: The COMprehensive Post-Acute Stroke Services Model.

Journal Article J Am Geriatr Soc · May 2018 Many individuals who have had a stroke leave the hospital without postacute care services in place. Despite high risks of complications and readmission, there is no standard in the United States for postacute stroke care after discharge home. We describe t ... Full text Link to item Cite

Effects of Structured Exercise Interventions for Older Adults Hospitalized With Acute Medical Illness: A Systematic Review.

Journal Article J Aging Phys Act · April 1, 2018 This review examined effects of structured exercise (aerobic walking, with or without complementary modes of exercise) on cardiorespiratory measures, mobility, functional status, healthcare utilization, and quality of life in older adults (≥60 years) hospi ... Full text Link to item Cite

Strategies for supporting intervention fidelity in the rehabilitation therapy in older acute heart failure patients (REHAB-HF) trial.

Journal Article Contemp Clin Trials · January 2018 INTRODUCTION: Acute decompensated heart failure (ADHF) is the leading cause of hospitalization in older adults. Rehabilitation Therapy in Older Acute Heart Failure Patients (REHAB-HF) trial is a multi-site clinical trial to determine if physical rehabilita ... Full text Link to item Cite

The Comprehensive Post-Acute Stroke Services (COMPASS) study: design and methods for a cluster-randomized pragmatic trial.

Journal Article BMC Neurol · July 17, 2017 BACKGROUND: Patients discharged home after stroke face significant challenges managing residual neurological deficits, secondary prevention, and pre-existing chronic conditions. Post-discharge care is often fragmented leading to increased healthcare costs, ... Full text Link to item Cite

Rehabilitation Therapy in Older Acute Heart Failure Patients (REHAB-HF) trial: Design and rationale.

Journal Article Am Heart J · March 2017 BACKGROUND: Acute decompensated heart failure (ADHF) is a leading cause of hospitalization in older persons in the United States. Reduced physical function and frailty are major determinants of adverse outcomes in older patients with hospitalized ADHF. How ... Full text Link to item Cite

Promoting Older Adult Physical Activity Throughout Care Transitions Using an Interprofessional Approach.

Journal Article J Nurse Pract · January 2017 The nurse practitioner plays a key role in monitoring and improving physical activity and function of older adults. Physical activity is an essential component of care management for all older adults, even those who are frail with multimorbidities. All phy ... Full text Link to item Cite

Depression and functional capacity independently predict mortality following lung transplantation

Conference American Journal of Respiratory and Critical Care Medicine · 2017 Cite

Observation of physical activity patterns in patients intubated at least 48 hours in intensive care

Journal Article American Journal of Respiratory and Critical Care Medicine · 2017 Cite

Comparison of Frequency of Frailty and Severely Impaired Physical Function in Patients ≥60 Years Hospitalized With Acute Decompensated Heart Failure Versus Chronic Stable Heart Failure With Reduced and Preserved Left Ventricular Ejection Fraction.

Journal Article Am J Cardiol · June 15, 2016 Older patients with acute decompensated heart failure (ADHF) have persistently poor outcomes including frequent rehospitalization despite guidelines-based therapy. We hypothesized that such patients have multiple, severe impairments in physical function, c ... Full text Link to item Cite

High Rates of Post-Transplant Depressive Symptoms Identified Using the CES-D

Conference The Journal of Heart and Lung Transplantation · April 2016 Full text Cite

Surfactant Protein-A Promotes Resolution Of Allergic Airways

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2016 Link to item Cite

Impact Of Age And Icu Mobility Scores On Healthcare Outcomes

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2016 Link to item Cite

Functional electrical stimulation cycling pre- and post-bilateral orthotopic lung transplantation: A case report

Conference Cardiopulmonary Physical Therapy Journal · 2016 Research Platform Presentation ... Cite

Functional electrical stimulation cycling pre- and postbilateral orthotopic lung transplantation: A case report.

Conference American Journal of Respiratory and Critical Care Medicine · 2015 Cite

S-Nitrosylation Of Sp-D In A Mouse Model Of Pulmonary Lymphangioleiomyomatosis (lam)

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2013 Link to item Cite

Novel role for surfactant protein A in gastrointestinal graft-versus-host disease.

Journal Article J Immunol · May 15, 2012 Featured Publication Graft-versus-host disease (GVHD) is a severe and frequent complication of allogeneic bone marrow transplantation (BMT) that involves the gastrointestinal (GI) tract and lungs. The pathobiology of GVHD is complex and involves immune cell recognition of host ... Full text Link to item Cite

Surfactant protein A modulates induction of regulatory T cells via TGF-β.

Journal Article J Immunol · May 1, 2012 Featured Publication TCR signaling plays a critical role in regulatory T cell (Treg) development. However, the mechanism for tissue-specific induction of Tregs in the periphery remains unclear. We observed that surfactant protein A (SP-A)-deficient mice have impaired expressio ... Full text Link to item Cite

Surfactant protein A integrates activation signal strength to differentially modulate T cell proliferation.

Journal Article J Immunol · February 1, 2012 Featured Publication Pulmonary surfactant lipoproteins lower the surface tension at the alveolar-airway interface of the lung and participate in host defense. Previous studies reported that surfactant protein A (SP-A) inhibits lymphocyte proliferation. We hypothesized that SP- ... Full text Link to item Cite

Increased Nitric Oxide Production Prevents Airway Hyperresponsiveness in Caveolin-1 Deficient Mice Following Endotoxin Exposure.

Journal Article J Allergy Ther · January 25, 2012 BACKGROUND: Caveolin-1, the hallmark protein of caveolae, is highly expressed within the lung in the epithelium, endothelium, and in immune cells. In addition to its classical roles in cholesterol metabolism and endocytosis, caveolin-1 has also been shown ... Full text Link to item Cite

S-Nitrosylated surfactant protein D (SP-D) exacerbates LPS-induced lung inflammation

Conference American Journal of Respiratory and Critical Care Medicine · 2012 Cite

Lung effector memory and activated CD4+ T cells display enhanced proliferation in surfactant protein A-deficient mice during allergen-mediated inflammation.

Journal Article J Immunol · March 1, 2011 Featured Publication Although many studies have shown that pulmonary surfactant protein (SP)-A functions in innate immunity, fewer studies have addressed its role in adaptive immunity and allergic hypersensitivity. We hypothesized that SP-A modulates the phenotype and prevalen ... Full text Link to item Cite

Nitric oxide mediates relative airway hyporesponsiveness to lipopolysaccharide in surfactant protein A-deficient mice.

Journal Article Am J Respir Cell Mol Biol · February 2011 Featured Publication Surfactant protein A (SP-A) mediates innate immune cell responses to LPS, a cell wall component of gram-negative bacteria that is found ubiquitously in the environment and is associated with adverse health effects. Inhaled LPS induces lung inflammation and ... Full text Link to item Cite

Exercise training and LPS-induced changes in SP-A and SP-D expression

Conference American Journal of Respiratory and Critical Care Medicine · 2011 Cite

Review: Collectins link innate and adaptive immunity in allergic airway disease.

Journal Article Innate Immun · June 2010 Featured Publication Although the lipoprotein complex of pulmonary surfactant has long been recognized as essential for reducing lung surface tension, its role in lung immune host defense has only relatively recently been elucidated. Surfactant-associated proteins A (SP-A) and ... Full text Link to item Cite

Lipopolysaccharide- induced lung injury is associated with post-translational modifications of Surfactant Protein D

Conference American Journal of Respiratory and Critical Care Medicine · 2010 Cite

Loss of caveolin-1 expression leads to decreased calcium flux in freshly isolated airway smooth muscle cells

Conference American Journal of Respiratory and Critical Care Medicine · 2010 Cite

SP-A modulates CD4+ T cell phenotype and function during allergen-mediated inflammation

Conference American Journal of Respiratory and Critical Care Medicine · 2009 Cite

AHR Is Attenuated in Caveolin-1 Deficient Mice

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2009 Link to item Cite

SP-A Modulates CD4+T Cell Phenotype and Function during Allergen-Mediated Inflammation.

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2009 Link to item Cite

Interaction of lung collectin SP-A with NO regulates airway hyperresponsiveness in a mouse model of allergic asthma

Conference American Journal of Respiratory and Critical Care Medicine · 2008 Research Platform Presentation ... Cite

Immunomodulatory roles of surfactant proteins A and D: implications in lung disease.

Journal Article Proc Am Thorac Soc · July 2007 Featured Publication Surfactant, a lipoprotein complex, was originally described for its essential role in reducing surface tension at the air-liquid interface of the lung; however, it is now recognized as being a critical component in lung immune host defense. Surfactant prot ... Full text Link to item Cite

The paradoxical role of SP-A in allergeninduced lung disease

Conference American Journal of Respiratory and Critical Care Medicine · 2007 Cite

RU486 blocks the anti-inflammatory effects of exercise in a murine model of allergen-induced pulmonary inflammation.

Journal Article Brain Behav Immun · September 2005 Featured Publication In an ovalbumin (OVA)-driven murine model of allergic pulmonary inflammation, we have shown previously that moderate-intensity aerobic exercise training attenuates inflammatory responses, disease progression, and NF-kappaB activation within the sensitized ... Full text Link to item Cite

RU486 reversed the exercised-induced anti-inflammatory effects in asthma

Conference American Journal of Respiratory and Critical Care Medicine · April 2004 Cite

Aerobic exercise attenuates airway inflammatory responses in a mouse model of atopic asthma.

Journal Article J Immunol · April 1, 2004 Featured Publication Recent reports indicate that aerobic exercise improves the overall physical fitness and health of asthmatic patients. The specific exercise-induced improvements in the pathology of asthma and the mechanisms by which these improvements occur, however, are i ... Full text Link to item Cite

EXERCISE YOUR ASTHMA.

Conference Cardiopulmonary Physical Therapy Journal · December 2003 Research Platform Presentation ... Full text Cite

Aerobic exercise: Unrealized therapeutic potential in the treatment of atopic asthma

Conference American Journal of Respiratory and Critical Care Medicine · 2003 Cite

EFFECTS OF AEROBIC EXERCISE ON IMMUNE RESPONSES WITHIN THE ASTHMATIC LUNG.

Conference Cardiopulmonary Physical Therapy Journal · March 2002 Full text Cite

Physical function assessment in older adults

Conference Educational Workshop ... Cite

“Challenging and closing the gaps in care.”

Conference Invited speaker, opening speaker for the Cardiovascular Research Platform Presentations ... Cite

Team-Based Learning

Conference Invited Speaker ... Cite

Shifting paradigms in delivery of care

Conference Invited Speaker, Opening Speaker for the Cardiovascular Research Platform Presentations ... Cite

Prevention to intervention for patients with pulmonary disease

Conference Invited Speaker, Opening Speaker for the Pulmonary Research Platform Presentations ... Cite

Early mobilization of critically ill patients

Conference Educational Workshop ... Cite

ICU-Acquired Muscle Weakness

Conference 9/14/14 - Center for Aging 9/25/14 - Critical Care Grand Rounds 4/8/15 - Anesthesia Grand Rounds ... Cite

Team-Based Learning in DPT Curricula

Conference Invited speaker ... Cite

Early mobilization in the ICU

Conference Invited Discussant ... Cite

Surfactant Proteins: Saying No to SNO

Conference Invited Speaker ... Cite

In search of novel asthma treatments

Conference Invited speaker ... Cite

The search for novel asthma treatments

Conference Invited speaker ... Cite

Impact of Age, Illness Severity, and ICU Mobility Status on Patient Outcomes

Journal Article Annals of the American Thoracic Society Cite