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James Andrew Alspaugh II

James B. Duke Distinguished Professor of Medicine
Medicine, Infectious Diseases
Duke Box 102359, Durham, NC 27710
DUMC Box 102359, 163 Hanes House, Trent Drive, Durham, NC 27710

Research Interests


Dr. Andrew Alspaugh is a physician-scientist with a research focus on the molecular pathogenesis of human fungal infections. He has a strong commitment to clinical and research training in microbiology/infectious diseases, as well as to the professional development of graduate students, post-doctoral trainees, and junior faculty. A practicing Adult Infectious Diseases physician, he is also actively involved in the training of Infectious Diseases clinical fellows, especially aspiring physician-scientists. Within the Duke School of Medicine, he was the director of the first-year Medical Microbiology course for eight years. He is also a co-director of the Tri-Institutional Molecular Mycology and Pathogenesis Training Program, a long-standing program to prepare post-doctoral scholars to become leaders in fungal research. For five years, he served as the course director for the Marine Biological Laboratories “Molecular Mycology” course, an international research training course in medical mycology.

 

His laboratory research program focuses on the molecular pathogenesis of human fungal infections. These infections occur in our most vulnerable patient populations, especially those with severe defects in immunity. In basic and translational studies, he has defined specific ways in which fungal sense and respond to various stress signals to survive within the infected host.

 

Website:

 

https://medicine.duke.edu/profile/james-andrew-alspaugh

 

 

Selected Grants


Cell and Molecular Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 2026 - 2031

Genetics and Genomics Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2026 - 2031

Copper homeostasis in fungal pathogenesis (R01)

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2026 - 2031

Transdisciplinary Research in Infectious Diseases to Engage Third-year medical students (TRIDENT) R25

Inst. Training Prgm or CMESignificant Contributor · Awarded by National Institute of Allergy and Infectious Diseases · 2025 - 2030

Interdisciplinary Research Training Program in AIDS

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2010 - 2030

2/3 CTSA K12 Program at Duke University

ResearchMentor · Awarded by National Center for Advancing Translational Sciences · 2025 - 2030

Novel Host-Response Biomarker Diagnostics for Invasive Aspergillosis

ResearchCo-Mentor · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2029

Genomic determinants of antibiotic treatment failure in S. aureus bacteremia

ResearchCo-Mentor · Awarded by National Institutes of Health · 2024 - 2029

Tri-Institutional Molecular Mycology and Pathogenesis Training Program

Inst. Training Prgm or CMECo-Principal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2029

Stimulating Access to Research in Residency (StARR) - NIAID

Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of Allergy and Infectious Diseases · 2018 - 2029

Coordinated responses to host-derived stresses in C. neoformans

ResearchPrincipal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2023 - 2028

Alspaugh Novo Nordisk

ResearchPrincipal Investigator · Awarded by University of Copenhagen · 2022 - 2026

Cell and Molecular Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 2021 - 2026

Duke Physician Scientist Development program

ResearchCo-Principal Investigator · Awarded by Burroughs Wellcome Fund · 2018 - 2025

Arrestin proteins mediate microbial cellular adaptation and fungal virulence - R21

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2025

Transplant Infectious Diseases Interdisciplinary Research Training Grant (TIDIRTG)

Inst. Training Prgm or CMEAdvisor · Awarded by National Institutes of Health · 2018 - 2024

Metal Homeostasis in Yeast (R01)

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2024

Postdoctoral Training in Genomic Medicine Research

Inst. Training Prgm or CMECo-Mentor · Awarded by National Institutes of Health · 2017 - 2023

Role of osteopontin in innate immunity during infections and inflammation

ResearchCollaborator · Awarded by National Institutes of Health · 2011 - 2023

Coordinated Regulation of Virulence Genes in C. neoformans

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2022

Defining pH-Sensing in Fungal Virulence (F31)

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2022

Mining the Coprophilous Mycobiome for new Cryptococcus Antiinfectives and Antifungal Synergists

ResearchPrincipal Investigator · Awarded by University of Iowa · 2017 - 2020

Genetics Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1979 - 2020

Organization and Function of Cellular Structure

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2020

Temperature-dependent transposon mobilization in Cryptococcus neoformans

ResearchConsultant · Awarded by National Institutes of Health · 2017 - 2020

Physician-Scientist Institutional Award: Increasing Opportunities for the M.D. Interested in a Research Career

ResearchCo-Principal Investigator · Awarded by Burroughs Wellcome Fund · 2017 - 2018

Ras Signaling in C. neoformans virulence and development

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2008 - 2014

C. neoformans cAMP signaling and pathogenesis

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2006 - 2009

Ras signaling in C. neoformans virulence and development

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2003

Signal transduction and virulence in C Neoformans

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1998 - 2002

Signal Transduction And Virulence In C Neoformans

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1998 - 2002

External Relationships


  • Burroughs Wellcome Fund - Foundation
  • McGraw Hill publishing
  • Nova Nordisk Foundation

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.