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James Andrew Alspaugh II

Professor of Medicine
Medicine, Infectious Diseases
Duke Box 102359, Durham, NC 27710
DUMC Box 102359, 303 Sands Building, Research Drive, Durham, NC 27710

Selected Grants


Novel Host-Response Biomarker Diagnostics for Invasive Aspergillosis

ResearchCo-Mentor · Awarded by National Institutes of Health · 2024 - 2029

Genomic determinants of antibiotic treatment failure in S. aureus bacteremia

ResearchCo-Mentor · Awarded by National Institutes of Health · 2024 - 2029

Tri-Institutional Molecular Mycology and Pathogenesis Training Program

Inst. Training Prgm or CMECo-Principal Investigator · Awarded by National Institutes of Health · 2024 - 2029

Stimulating Access to Research in Residency (StARR) - NIAID

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2018 - 2029

Coordinated responses to host-derived stresses in C. neoformans

ResearchPrincipal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2023 - 2028

Cell and Molecular Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026

Alspaugh Novo Nordisk

ResearchPrincipal Investigator · Awarded by University of Copenhagen · 2022 - 2026

Duke Physician Scientist Development program

ResearchCo-Principal Investigator · Awarded by Burroughs Wellcome Fund · 2018 - 2025

Interdisciplinary Research Training Program in AIDS

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2010 - 2025

Genetic and Genomics Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2020 - 2025

Arrestin proteins mediate microbial cellular adaptation and fungal virulence - R21

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2025

Transplant Infectious Diseases Interdisciplinary Research Training Grant (TIDIRTG)

Inst. Training Prgm or CMEAdvisor · Awarded by National Institutes of Health · 2018 - 2024

Metal Homeostasis in Yeast (R01)

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2024

Postdoctoral Training in Genomic Medicine Research

Inst. Training Prgm or CMECo-Mentor · Awarded by National Institutes of Health · 2017 - 2023

Role of osteopontin in innate immunity during infections and inflammation

ResearchCollaborator · Awarded by National Institutes of Health · 2011 - 2023

Coordinated Regulation of Virulence Genes in C. neoformans

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2022

Defining pH-Sensing in Fungal Virulence (F31)

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2022

Mining the Coprophilous Mycobiome for new Cryptococcus Antiinfectives and Antifungal Synergists

ResearchPrincipal Investigator · Awarded by University of Iowa · 2017 - 2020

Genetics Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1979 - 2020

Organization and Function of Cellular Structure

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2020

Temperature-dependent transposon mobilization in Cryptococcus neoformans

ResearchConsultant · Awarded by National Institutes of Health · 2017 - 2020

Physician-Scientist Institutional Award: Increasing Opportunities for the M.D. Interested in a Research Career

ResearchCo-Principal Investigator · Awarded by Burroughs Wellcome Fund · 2017 - 2018

Ras Signaling in C. neoformans virulence and development

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2008 - 2014

C. neoformans cAMP signaling and pathogenesis

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2006 - 2009

Ras signaling in C. neoformans virulence and development

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2003

Signal transduction and virulence in C Neoformans

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1998 - 2002

Signal Transduction And Virulence In C Neoformans

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1998 - 2002

External Relationships


  • Infectious Diseases Society of America
  • McGraw Hill publishing
  • Nova Nordisk Foundation

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.