Andrzej Stanislaw Kosinski

Journal Article Circ Cardiovasc Interv · January 2, 2026 BACKGROUND: Cardiac conduction disturbances remain the most frequent complication of transcatheter aortic valve replacement (TAVR), but the clinical implications of new left bundle branch block (LBBB) after TAVR remain controversial. Here, we aim to assess ... Full text Link to item Cite

The application of transfer learning to T1ρ MRI tibiofemoral cartilage segmentation.

Journal Article J Biomech · January 2026 Proteoglycans are critical to the ability of cartilage to withstand loading, and their concentration can be probed in vivo through measurement of T1ρ MRI relaxation times. Machine learning models have demonstrated the potential to replace manual segmentati ... Full text Link to item Cite

Prediction of Heart Failure Hospitalization or Death After TAVR.

Journal Article Circ Cardiovasc Interv · December 31, 2025 BACKGROUND: Heart failure (HF) remains a significant burden following transcatheter aortic valve replacement, adversely impacting survival and quality of life. Identification of patients who may benefit from closer monitoring or adjunctive medical therapy ... Full text Link to item Cite

Will a Conservative Case Selection Strategy Improve Hospital-Level TAVR Performance Metrics?

Journal Article Circ Cardiovasc Interv · December 4, 2025 BACKGROUND: Current national performance metrics rank transcatheter aortic valve replacement (TAVR) centers based on risk-adjusted outcomes. This could make operators/centers less inclined to offer TAVR in high-risk cases. METHODS: We used simulation model ... Full text Link to item Cite

A deep learning-based approach for measuring patellar cartilage deformations from knee MR images.

Journal Article J Biomech · November 2025 While knee osteoarthritis (OA) is a leading cause of disability in the United States, OA within the patellofemoral joint is understudied compared to the tibiofemoral joint. Mechanical alterations to cartilage may be among the first changes indicative of ea ... Full text Link to item Cite

Chronic Conditions and Patient-Centered Outcomes After Transcatheter Aortic Valve Intervention.

Journal Article JACC Adv · November 2025 BACKGROUND: Transcatheter aortic valve intervention (TAVI) has revolutionized the care of older adults with aortic stenosis. OBJECTIVES: The objectives of the study were to examine associations between chronic conditions and outcomes after TAVI and to desc ... Full text Link to item Cite

Influence of Failure to Rescue on Mortality After Transcatheter Aortic Valve Replacement.

Journal Article Ann Thorac Surg Short Rep · September 2025 BACKGROUND: Mortality after transcatheter aortic valve replacement (TAVR) varies among centers. "Failure to rescue" (FTR) patients from post-TAVR complications may represent an unexplored opportunity for TAVR process improvement. METHODS: The Society of Th ... Full text Link to item Cite

Resting Supine for 45 Minutes Yields Consistent Baseline Lumbar Intervertebral Disc Height in Asymptomatic Participants.

Journal Article Ann Biomed Eng · August 2025 PURPOSE: Intervertebral disc (IVD) height fluctuates diurnally as the spine is exposed to periods of high and low loading. Therefore, accounting for loading history prior to measuring in vivo IVD height is important when investigating IVD mechanics. Howeve ... Full text Link to item Cite

Clinical outcomes of direct oral anticoagulant versus warfarin after transcatheter aortic valve replacement: From the STS/ACC TVT registry.

Journal Article Am Heart J · July 2025 BACKGROUND: Transcatheter aortic valve replacement (TAVR) recipients frequently have an indication for long-term oral anticoagulation, including atrial fibrillation or systemic thromboembolic disease. It remains unclear if there are differences in safety a ... Full text Link to item Cite

Lobectomy vs Sublobar Resection in The Society of Thoracic Surgeons Database: Importance of Patient Factors and Lymph Node Evaluation.

Journal Article Ann Thorac Surg · May 2025 BACKGROUND: Prospective randomized trials have demonstrated noninferior survival between sublobar resection and lobectomy in healthy patients with non-small cell lung cancer with tumors ≤2 cm. However, some patient attributes are not well represented in ra ... Full text Link to item Cite

Outcomes of Transcatheter Aortic Valve Replacement in Low-Risk Patients in the United States: A Report From the STS/ACC TVT Registry.

Journal Article Circulation · April 22, 2025 BACKGROUND: Real-world low-risk transcatheter aortic valve replacement (TAVR) outcomes in the United States have not been assessed comprehensively versus pivotal trials, which is a key component of measuring the quality of clinical technology adoption. MET ... Full text Link to item Cite

Out-of-Hospital 30-Day Mortality After Mitral TEER: Insights From the STS/ACC TVT Registry.

Journal Article JACC Cardiovasc Interv · April 14, 2025 BACKGROUND: Transcatheter edge-to-edge repair of mitral valve (mTEER) is increasingly being adopted, with improved outcomes. However, it remains crucial to evaluate short-term out-of-hospital mortality to elucidate areas for further improvement. OBJECTIVES ... Full text Link to item Cite

Genomic classifiers and prognosis of localized prostate cancer: a systematic review.

Journal Article Prostate Cancer Prostatic Dis · March 2025 BACKGROUND: Refinement of the risk classification for localized prostate cancer is warranted to aid in clinical decision making. A systematic analysis was undertaken to evaluate the prognostic ability of three genomic classifiers, Decipher, GPS, and Prolar ... Full text Link to item Cite

Temporal Changes in Procedural Success and Clinical Outcomes of MTEER by Mechanism of MR: Analysis of the STS/TVT Registry.

Journal Article Circ Cardiovasc Interv · March 2025 BACKGROUND: With the expansion of indications for mitral transcatheter edge-to-edge repair into nondegenerative etiologies, it is unknown whether changes in technical success and clinical outcomes have occurred. METHODS: The Society of Thoracic Surgeons/Am ... Full text Link to item Cite

Longitudinal Follow-up of Medicare Patients After Esophageal Cancer Resection in the STS Database.

Journal Article Ann Thorac Surg · February 2025 BACKGROUND: Understanding characteristics associated with survival after esophagectomy for cancer is critical to preoperative risk stratification. This study sought to define predictors for long-term survival after esophagectomy for cancer in Medicare pati ... Full text Link to item Cite

Impact of Genomic Classifiers on Risk Stratification and Treatment Intensity in Patients With Localized Prostate Cancer : A Systematic Review.

Journal Article Ann Intern Med · February 2025 BACKGROUND: Tissue-based genomic classifiers (GCs) have been developed to improve prostate cancer (PCa) risk assessment and treatment recommendations. PURPOSE: To summarize the impact of the Decipher, Oncotype DX Genomic Prostate Score (GPS), and Prolaris ... Full text Link to item Cite

Transition from acute to chronic low back pain in a community-based cohort.

Journal Article J Pain · January 2025 The transition from acute to chronic low back pain (LBP) in community settings is not well understood. The purpose of this study was to assess the feasibility of recruitment and estimate the transition and continuation of chronic LBP. We also explored char ... Full text Link to item Cite

Trends in Transcatheter Aortic Valve Replacement Outcomes: Insights From the STS/ACC TVT Registry.

Journal Article JAMA Cardiol · December 1, 2024 IMPORTANCE: Although transcatheter aortic valve replacement (TAVR) outcomes in the US have improved substantially since 2011, it is unknown whether these trends have continued since 2019. OBJECTIVE: To examine changes in risk-adjusted TAVR outcomes from 20 ... Full text Link to item Cite

Does Tibial Plateau Slope and Depth Influence ACL Strain In Vivo?

Journal Article Orthop J Sports Med · December 2024 BACKGROUND: The anterior cruciate ligament (ACL) is loaded under tension when the tibia translates anteriorly relative to the femur. The shape of the articular surfaces of the tibiofemoral joint may influence the amount of anterior tibial translation under ... Full text Link to item Cite

Mitral Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation With Preserved Left Ventricular Function.

Journal Article JACC Cardiovasc Interv · November 11, 2024 BACKGROUND: Outcomes of mitral transcatheter edge-to-edge repair (MTEER) in patients with secondary mitral regurgitation (sMR) and preserved left ventricular ejection fraction (LVEF) are uncertain. OBJECTIVES: This study sought to describe outcomes of MTEE ... Full text Link to item Cite

A comparison of three methods for establishing an ACL reference length in vivo.

Journal Article J Biomech · November 2024 As anterior cruciate ligament (ACL) injuries are highly prevalent among active individuals, it is vital to better understand the loading conditions which lead to injury. One method for doing so is through measurement of dynamic, in vivo ACL strain. To meas ... Full text Link to item Cite

Trends, Predictors, and Outcomes of Bleeding Complications After Mitral Transcatheter Edge-to-Edge Repair: TVT Registry Insights.

Journal Article JACC Cardiovasc Interv · October 28, 2024 BACKGROUND: Bleeding events after arterial transcatheter procedures are associated with increased morbidity and mortality. The frequency and clinical implications of bleeding after mitral transcatheter edge-to-edge repair (M-TEER) have not been well-studie ... Full text Link to item Cite

The Society of Thoracic Surgeons Database Analysis: Comparing Sublobar Techniques in Stage IA Lung Cancer.

Journal Article Ann Thorac Surg · September 2024 BACKGROUND: This study compares sublobar resections-wedge resection and segmentectomy-in clinical stage IA lung cancers. It tests the hypothesis that overall survival after wedge resection is similar to segmentectomy. METHODS: Adults undergoing wedge resec ... Full text Link to item Cite

Impact of Cerebral Embolic Protection Devices on Disabling Stroke After TAVR: Updated Results From the STS/ACC TVT Registry.

Journal Article Circ Cardiovasc Interv · September 2024 BACKGROUND: Cerebral embolic protection devices (EPDs) were developed to mitigate the risk of stroke during transcatheter aortic valve replacement (TAVR), but their benefit remains unproven. In the PROTECTED-TAVR trial (Stroke Protection With Sentinel Duri ... Full text Link to item Cite

Association of Baseline Tricuspid Regurgitation With Health Status and Clinical Outcomes After TAVR and Mitral TEER.

Journal Article JACC Cardiovasc Interv · August 26, 2024 BACKGROUND: Tricuspid regurgitation (TR) is associated with worse clinical outcomes after transcatheter aortic valve replacement (TAVR) and mitral transcatheter edge-to-edge repair (M-TEER), but little is known about its association with health status outc ... Full text Link to item Cite

Impact of Elevated Gradients After Transcatheter Aortic Valve Implantation for Degenerated Surgical Aortic Valve Bioprostheses.

Journal Article Circ Cardiovasc Interv · July 2024 BACKGROUND: Elevated aortic valve gradients are common after transcatheter aortic valve implantation for degenerated surgical aortic valve replacement bioprostheses, but their clinical impact is uncertain. METHODS: A total of 12 122 patients who underwent ... Full text Link to item Cite

Procedure Volume and Outcomes With WATCHMAN Left Atrial Appendage Occlusion.

Journal Article Circ Cardiovasc Interv · June 2024 BACKGROUND: Procedure volumes are associated with outcomes for many cardiovascular procedures, leading to guidelines on minimum volume thresholds for certain procedures; however, the volume-outcome relationship with left atrial appendage occlusion is poorl ... Full text Link to item Cite

Seventeen-Year National Pain Prevalence Trends Among U.S. Military Veterans.

Journal Article J Pain · May 2024 U.S. military veterans experience higher pain prevalence than nonveterans. However, it is unclear how the disparities in pain prevalence have changed over time because previous trend studies are limited to veterans using the Veterans Health Administration. ... Full text Link to item Cite

Comparison of Transcatheter Edge-to-Edge Mitral Valve Repair for Primary Mitral Regurgitation Outcomes to Hospital Volumes of Surgical Mitral Valve Repair.

Journal Article Circ Cardiovasc Interv · April 2024 BACKGROUND: Transcatheter edge-to-edge mitral valve (MV) repair (TEER) is an effective treatment for patients with primary mitral regurgitation at prohibitive risk for surgical MV repair (MVr). High-volume MVr centers and high-volume TEER centers have bett ... Full text Link to item Cite

National Variation in Hospital MTEER Outcomes and Correlation With TAVR Outcomes: STS/ACC TVT Registry Analysis.

Journal Article JACC Cardiovasc Interv · February 26, 2024 BACKGROUND: A single, multitiered valve center designation has been proposed to publicly identify centers with expertise for all valve therapies. The correlation between transcatheter aortic valve replacement (TAVR) and mitral transcatheter edge-to-edge re ... Full text Link to item Cite

National Variability in Pacemaker Implantation Rate Following TAVR: Insights From the STS/ACC TVT Registry.

Journal Article JACC Cardiovasc Interv · February 12, 2024 BACKGROUND: Although permanent pacemaker (PPM) implantation is a common complication of transcatheter aortic valve replacement (TAVR), hospital variation and change in PPM implantation rates are ill defined. OBJECTIVES: The aim of this study was to determi ... Full text Link to item Cite

Transcatheter Edge-to-Edge Repair in COAPT-Ineligible Patients With Functional Mitral Regurgitation.

Journal Article J Am Coll Cardiol · January 30, 2024 BACKGROUND: Mitral valve transcatheter edge-to-edge repair (MTEER) was approved in the United States for treatment of functional mitral regurgitation (FMR) based on results from the COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Th ... Full text Link to item Cite

Interventions to Improve Long-Term Adherence to Physical Rehabilitation: A Systematic Review.

Journal Article J Geriatr Phys Ther · January 12, 2024 OBJECTIVE: To evaluate the impact of physical rehabilitation interventions, supplemented with one or more adherence-enhancing components, on outcomes among adults with hip or knee osteoarthritis or chronic lower back pain. DESIGN: Primary literature search ... Full text Link to item Cite

Impact of Diabetes on Pathologic Response to Multimodality Therapy for Esophageal Cancer.

Journal Article Ann Thorac Surg · January 2024 BACKGROUND: The incidence of esophageal cancer has increased faster than that of most cancers. Evidence from other malignant neoplasms suggests that diabetic patients have a worse response to multimodality therapy. We hypothesized that diabetic patients wi ... Full text Link to item Cite

Characterizing Acute Low Back Pain in a Community-Based Cohort: Results from a Feasibility Cohort Study.

Journal Article J Pain Res · 2024 INTRODUCTION: Acute low back pain (LBP) is a common experience; however, the associated pain severity, pain frequency, and characteristics of individuals with acute LBP in community settings have yet to be well understood. In this manuscript, two acute-LBP ... Full text Link to item Cite

Association Between Polyvascular Disease and Transcatheter Aortic Valve Replacement Outcomes: Insights From the STS/ACC TVT Registry.

Journal Article Circ Cardiovasc Interv · December 2023 BACKGROUND: Atherosclerotic cardiovascular disease is highly prevalent in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement (TAVR). Polyvascular disease (PVD), defined as involvement of ≥2 vascular beds (VBs), that is, ... Full text Link to item Cite

Heart failure medical therapy prior to mitral transcatheter edge-to-edge repair: the STS/ACC Transcatheter Valve Therapy Registry.

Journal Article Eur Heart J · November 21, 2023 BACKGROUND AND AIMS: Guideline-directed medical therapy (GDMT) is recommended before mitral valve transcatheter edge-to-edge repair (MTEER) in patients with heart failure (HF) and severe functional mitral regurgitation (FMR). Whether MTEER is being perform ... Full text Link to item Cite

Outcomes of Transcatheter Aortic Valve Replacement in Asymptomatic or Minimally Symptomatic Aortic Stenosis.

Journal Article JACC Cardiovasc Interv · November 13, 2023 BACKGROUND: Little is known about the outcomes of transcatheter aortic valve replacement (TAVR) in minimally symptomatic patients. OBJECTIVES: The authors aimed to evaluate the outcomes of patients with minimally symptomatic severe aortic stenosis treated ... Full text Link to item Cite

The effects of a 6-month weight loss intervention on physical function and serum biomarkers in older adults with and without osteoarthritis.

Journal Article Osteoarthr Cartil Open · September 2023 OBJECTIVE: To examine the effects of a 6-month weight loss intervention on physical function, inflammatory biomarkers, and metabolic biomarkers in both those with and without osteoarthritis (OA). DESIGN: 59 individuals ≥60 years old with obesity and a func ... Full text Link to item Cite

Mediators of Improvement in TAVR Outcomes Over Time: Insights From the STS-ACC TVT Registry.

Journal Article Circ Cardiovasc Interv · July 2023 BACKGROUND: Over the past decade, there has been substantial improvement in outcomes after transcatheter aortic valve replacement. Many patient and procedural factors have also changed over that time, making it challenging to untangle the drivers of those ... Full text Link to item Cite

Using Randomized Controlled Trials to Estimate the Effect of Community Interventions for Childhood Asthma.

Journal Article Prev Chronic Dis · June 1, 2023 INTRODUCTION: The Centers for Disease Control and Prevention's Controlling Childhood Asthma and Reducing Emergencies initiative aims to prevent 500,000 emergency department (ED) visits and hospitalizations within 5 years among children with asthma through ... Full text Link to item Cite

Complications of Intravenous Tenecteplase Versus Alteplase for the Treatment of Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.

Journal Article Stroke · May 2023 BACKGROUND: Prior systematic reviews have compared the efficacy of intravenous tenecteplase and alteplase in acute ischemic stroke, assigning their relative complications as a secondary objective. The objective of the present study is to determine whether ... Full text Link to item Cite

Facilitating Shared Decision Making Among Black Patients at Risk for Sudden Cardiac Arrest : A Randomized Clinical Trial.

Journal Article Ann Intern Med · May 2023 BACKGROUND: Racial disparities in implantable cardioverter-defibrillator (ICD) implantation are multifactorial and are partly explained by higher refusal rates. OBJECTIVE: To assess the effectiveness of a video decision support tool for Black patients elig ... Full text Link to item Cite

Modeling the Association of Volume vs Composite Outcome Thresholds With Outcomes and Access to Transcatheter Aortic Valve Implantation in the US.

Journal Article JAMA Cardiol · May 1, 2023 IMPORTANCE: Professional societies and the Centers for Medicare & Medicaid Services suggest volume thresholds to ensure quality in transcatheter aortic valve implantation (TAVI). OBJECTIVE: To model the association of volume thresholds vs spoke-and-hub imp ... Full text Link to item Cite

Robotic Esophagectomy Trends and Early Surgical Outcomes: The US Experience.

Conference Ann Thorac Surg · March 2023 BACKGROUND: Recent esophagectomy trends were evaluated to describe the shift in surgical approach and outcomes using The Society of Thoracic Surgeons General Thoracic Surgery Database. METHODS: All patients who underwent an esophagectomy with gastric condu ... Full text Link to item Cite

The Impact of Hearing Loss and Its Treatment on Health-Related Quality of Life Utility: a Systematic Review with Meta-analysis.

Journal Article J Gen Intern Med · February 2023 BACKGROUND: Hearing loss significantly impacts health-related quality of life (QoL), yet the effects of current treatments on QoL utility remain uncertain. Our objective was to describe the impact of untreated and treated hearing loss on QoL utility to inf ... Full text Link to item Cite

In vivo intervertebral disc mechanical deformation following a treadmill walking "stress test" is inversely related to T1rho relaxation time.

Journal Article Osteoarthritis Cartilage · January 2023 OBJECTIVE: To assess the in vivo relationship between the mechanical response of intervertebral discs (IVDs) to dynamic activity and IVD biochemical composition assessed via T1rho relaxation imaging. DESIGN: Eighteen asymptomatic participants with no histo ... Full text Link to item Cite

Impact of Chest Wall Resection on Mortality After Lung Resection for Non-Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · December 2022 BACKGROUND: Lung cancer invading the chest wall is treated with concomitant en bloc lung and chest wall resection (CWR). It is unclear how CWR affects postoperative outcomes of lung resection. We hypothesized that CWR would be associated with increased ris ... Full text Link to item Cite

Risk of Each of the Five Lung Lobectomies: A Society of Thoracic Surgeons Database Analysis.

Journal Article Ann Thorac Surg · November 2022 BACKGROUND: The perioperative risk of pulmonary lobectomy as a solitary procedure has been extensively studied, yet the differences in outcomes between lobes, which have unique anatomy and a different amount of lung parenchyma, are entirely unknown. The pu ... Full text Link to item Cite

Telehealth for the Longitudinal Management of Chronic Conditions: Systematic Review.

Journal Article J Med Internet Res · August 26, 2022 BACKGROUND: Extensive literature support telehealth as a supplement or adjunct to in-person care for the management of chronic conditions such as congestive heart failure (CHF) and type 2 diabetes mellitus (T2DM). Evidence is needed to support the use of t ... Full text Link to item Cite

Conversion to Thoracotomy During Thoracoscopic vs Robotic Lobectomy: Predictors and Outcomes.

Journal Article Ann Thorac Surg · August 2022 BACKGROUND: Conversion to thoracotomy during minimally invasive lobectomy for lung cancer is occasionally necessary. Differences between video-assisted thoracoscopic surgery (VATS) and robotic-assisted thoracoscopic surgery (RATS) lobectomy conversion have ... Full text Link to item Cite

Cardiac resynchronization therapy outcomes with left ventricular lead concordant with latest mechanical activation: A meta-analysis.

Journal Article Pacing Clin Electrophysiol · August 2022 BACKGROUND: For cardiac resynchronization therapy (CRT), image-guided approaches targeting left ventricular (LV) lead placement at the site of latest mechanical activation had inconsistent outcomes. We examined evidence for improved CRT outcomes when LV le ... Full text Link to item Cite

In vivo fluid transport in human intervertebral discs varies by spinal level and disc region.

Journal Article JOR Spine · June 2022 BACKGROUND: The lumbar discs are large, dense tissues that are primarily avascular, and cells residing in the central region of the disc are up to 6-8 mm from the nearest blood vessel in adults. To maintain homeostasis, disc cells rely on nutrient transpor ... Full text Link to item Cite

Palliative Care Always: Hepatology-Virtual Primary Palliative Care Training for Hepatologists.

Journal Article Hepatol Commun · April 2022 Palliative care (PC) benefits patients with serious illness including end-stage liver disease (ESLD). As part of a cluster randomized trial, hepatologists were trained to deliver primary palliative care to patients with ESLD using an online course, Palliat ... Full text Link to item Cite

Practice Patterns and Outcomes of Transcatheter Aortic Valve Replacement in the United States and Japan: A Report From Joint Data Harmonization Initiative of STS/ACC TVT and J-TVT.

Journal Article J Am Heart Assoc · March 15, 2022 Background The practice pattern and outcome of medical devices following their regulatory approval may differ by country. The aim of this study is to compare postapproval national clinical registry data on transcatheter aortic valve replacement between the ... Full text Link to item Cite

Patient-reported vs. physician-estimated symptoms before and after transcatheter aortic valve replacement.

Journal Article Eur Heart J Qual Care Clin Outcomes · March 2, 2022 AIMS: In contrast to patient-reported health status measures (such as the Kansas City Cardiomyopathy Questionnaire), the New York Heart Association class is based on a physician's assessment of heart failure symptoms and functional limitations on behalf of ... Full text Link to item Cite

Effectiveness of Quality Improvement Coaching on Process Outcomes in Health Care Settings: A Systematic Review.

Journal Article J Gen Intern Med · March 2022 BACKGROUND: A culture of improvement is an important feature of high-quality health care systems. However, health care teams often need support to translate quality improvement (QI) activities into practice. One method of support is consultation from a QI ... Full text Link to item Cite

Lumbar intervertebral disc diurnal deformations and T2 and T1rho relaxation times vary by spinal level and disc region.

Journal Article Eur Spine J · March 2022 PURPOSE: Magnetic resonance imaging (MRI) is routinely used to evaluate spine pathology; however, standard imaging findings weakly correlate to low back pain. Abnormal disc mechanical function is implicated as a cause of back pain but is not assessed using ... Full text Open Access Link to item Cite

Hydroxychloroquine in the pregnancies of women with lupus: a meta-analysis of individual participant data.

Journal Article Lupus Sci Med · March 2022 OBJECTIVE: Multiple guidelines recommend continuing hydroxychloroquine (HCQ) for SLE during pregnancy based on observational data. The goal of this individual patient data meta-analysis was to identify the potential benefits and harms of HCQ use within lup ... Full text Link to item Cite

Use of Direct Oral Anticoagulant and Outcomes in Patients With Atrial Fibrillation after Transcatheter Aortic Valve Replacement: Insights From the STS/ACC TVT Registry.

Journal Article J Am Heart Assoc · January 4, 2022 Background Clinical evidence on the safety and effectiveness of using direct oral anticoagulants (DOACs) in patients with atrial fibrillation after transcatheter aortic valve replacement (TAVR) remains limited. The aim of this study was to investigate the ... Full text Link to item Cite

Outcomes of Cardiac Resynchronization Therapy with Image-Guided Left Ventricular Lead Placement at the Site of Latest Mechanical Activation: A Systematic Review and Meta-Analysis.

Journal Article J Interv Cardiol · 2022 AIM: To assess evidence for an image-guided approach for cardiac resynchronization therapy (CRT) that targets left ventricular (LV) lead placement at the segment of latest mechanical activation. METHODS: A systematic review of EMBASE and PubMed was perform ... Full text Open Access Link to item Cite

Community Size and Lung Cancer Resection Outcomes: Studying The Society of Thoracic Surgeons Database.

Journal Article Ann Thorac Surg · October 2021 BACKGROUND: Socioeconomic factors play key roles in surgical outcomes. Socioeconomic data within The Society of Thoracic Surgeons (STS) General Thoracic Surgery Database (GTSD) are limited. Therefore, we utilized community size as a surrogate to understand ... Full text Link to item Cite

Adjustment Disorders in U.S. Active Duty Military Women: A Scoping Review for the Years 2000 to 2018.

Journal Article Womens Health Issues · August 25, 2021 BACKGROUND: Adjustment disorder (AD) is the most common mental health diagnosis in the U.S. military and is more than twice as likely to be diagnosed in active duty servicewomen as compared with male servicemembers. The literature on ADs, particularly in f ... Full text Link to item Cite

Dissemination of Transcatheter Aortic Valve Replacement in the United States.

Journal Article J Am Coll Cardiol · August 24, 2021 BACKGROUND: Societal guidelines and payor coverage decisions for transcatheter aortic valve replacement (TAVR) attempt to strike a balance between providing access and maintaining quality. The extent to which dissemination of TAVR has achieved these ideals ... Full text Link to item Cite

Readmission After Lobectomy for Lung Cancer: Not All Complications Contribute Equally.

Journal Article Ann Surg · July 1, 2021 OBJECTIVE: The aim of this study was to identify independent predictors of hospital readmission for patients undergoing lobectomy for lung cancer. SUMMARY BACKGROUND DATA: Hospital readmission after lobectomy is associated with increased mortality. Greater ... Full text Link to item Cite

Factors Associated With Successful Postoperative Day One Discharge After Anatomic Lung Resection.

Journal Article Ann Thorac Surg · July 2021 BACKGROUND: There are no criteria to estimate the risk of early discharge after anatomic lung resection. We hypothesized that demographic, clinical, and surgical variables could be used to predict successful postoperative day 1 (POD1) discharge after anato ... Full text Link to item Cite

Cerebral Embolic Protection and Outcomes of Transcatheter Aortic Valve Replacement: Results From the Transcatheter Valve Therapy Registry.

Journal Article Circulation · June 8, 2021 BACKGROUND: Stroke remains a devastating complication of transcatheter aortic valve replacement (TAVR), which has persisted despite refinements in technique and increased operator experience. While cerebral embolic protection devices (EPDs) have been devel ... Full text Link to item Cite

Initial and Longitudinal Cost of Surgical Resection for Lung Cancer.

Journal Article Ann Thorac Surg · June 2021 BACKGROUND: The longitudinal cost of treating patients with non-small cell lung cancer (NSCLC) undergoing surgical resection has not been evaluated. We describe initial and 4-year resource use and cost for NSCLC patients aged 65 years of age or greater who ... Full text Link to item Cite

Variability in Smoking Status for Lobectomy Among Society of Thoracic Surgeons Database Participants.

Journal Article Ann Thorac Surg · June 2021 BACKGROUND: Current smokers undergoing lobectomy are at greater risk of complications than are former smokers. The Society of Thoracic Surgeons (STS) composite score for rating program performance for lobectomy adjusts for smoking status, a modifiable risk ... Full text Link to item Cite

Costs Associated With Lobectomy for Lung Cancer: An Analysis Merging STS and Medicare Data.

Journal Article Ann Thorac Surg · June 2021 BACKGROUND: Costs related to care of patients who undergo lobectomy for lung cancer may vary depending on patient, disease, and treating facility characteristics. We aimed to identify underlying case mix factors that contribute to variability of 90-day cos ... Full text Link to item Cite

Complications after Ravitch versus Nuss repair of pectus excavatum: A Society of Thoracic Surgeons (STS) General Thoracic Surgery Database analysis.

Journal Article Surgery · June 2021 BACKGROUND: There are conflicting reports in the literature comparing outcomes after open Ravitch and minimally invasive Nuss procedures for pectus excavatum repair, and there is relatively little data available comparing the outcomes of these procedures p ... Full text Link to item Cite

Impact of short-term complications of transcatheter aortic valve replacement on longer-term outcomes: results from the STS/ACC Transcatheter Valve Therapy Registry.

Journal Article Eur Heart J Qual Care Clin Outcomes · March 15, 2021 AIMS: While complications of transcatheter aortic valve replacement (TAVR) have decreased, they still occur commonly and may negatively impact both short- and long-term outcomes. We sought to examine the association of complications after TAVR with surviva ... Full text Link to item Cite

Response to: The paradox of implantable cardioverter-defibrillator: When guidelines play against care improvement.

Journal Article Am Heart J · March 2021 Full text Link to item Cite

Evaluating Out-of-Hospital 30-Day Mortality After Transfemoral Transcatheter Aortic Valve Replacement: An STS/ACC TVT Analysis.

Journal Article JACC Cardiovasc Interv · February 8, 2021 OBJECTIVES: This study sought to better understand out-of-hospital 30-day mortality following transfemoral transcatheter aortic valve replacement (TAVR) and identify factors associated with poor outcomes. BACKGROUND: Despite improvements in outcomes with T ... Full text Link to item Cite

Risk stratification using late gadolinium enhancement on cardiac magnetic resonance imaging in patients with hypertrophic cardiomyopathy: A systematic review and meta-analysis.

Journal Article Prog Cardiovasc Dis · 2021 Background The role of late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (c-MRI) for predicting outcomes of patients with hypertrophic cardiomyopathy (HCM) has been debated. Methods We searched PubMed and Embase and various published ... Full text Link to item Cite

Right ventricular lead location and outcomes among patients with cardiac resynchronization therapy: A meta-analysis.

Journal Article Prog Cardiovasc Dis · 2021 BACKGROUND: Cardiac resynchronization therapy (CRT) has been demonstrated to improve heart failure (HF) symptoms, reverse LV remodeling, and reduce mortality and HF hospitalization (HFH) in patients with a reduced left ventricular (LV) ejection fraction (L ... Full text Link to item Cite

Echo-Guided vs. Device-Based Strategies for Optimization of Cardiac Resynchronization Therapy and Long-Term Clinical Outcomes: A Meta-Analysis

Conference CIRCULATION · 2021 Cite

Cardiac Resynchronization Therapy Outcomes with Image-Guided Left Ventricular Lead Placement: A Meta-Analysis

Conference CIRCULATION · 2021 Cite

Is Left Ventricular Lead Placement at Site of Latest Mechanical Activation Associated with Cardiac Resynchronization Therapy Outcomes? Results of a Meta-Analysis

Conference CIRCULATION · 2021 Cite

Equivalent Survival Between Lobectomy and Segmentectomy for Clinical Stage IA Lung Cancer.

Journal Article Ann Thorac Surg · December 2020 BACKGROUND: The oncologic efficacy of segmentectomy is controversial. We compared long-term survival in clinical stage IA (T1N0) Medicare patients undergoing lobectomy and segmentectomy in The Society of Thoracic Surgeons database. METHODS: The Society of ... Full text Link to item Cite

Site-Level Variability in 30-Day Patient Outcomes After Transcatheter Mitral Valve Repair in the United States.

Journal Article Circ Cardiovasc Qual Outcomes · December 2020 BACKGROUND: Clinical trials have demonstrated health status benefit of transcatheter mitral valve repair (TMVr) with MitraClip in patients with mitral valve regurgitation. Real-world site-level variability in health status outcomes for TMVr, and factors as ... Full text Link to item Cite

Prognostic value of myocardial fibrosis on cardiac magnetic resonance imaging in patients with ischemic cardiomyopathy: A systematic review.

Journal Article Am Heart J · November 2020 UNLABELLED: The use of cardiac magnetic resonance imaging (c-MRI) in risk stratification for clinical outcomes of patients with ischemic cardiomyopathy (ICM) remains low. This systematic review investigated the prognostic value of myocardial fibrosis as as ... Full text Link to item Cite

Volume Pledge is Not Associated with Better Short-Term Outcomes After Lung Cancer Resection.

Journal Article J Clin Oncol · October 20, 2020 PURPOSE: We examined the relationship between short-term outcomes and hospitals and surgeons who met minimum volume thresholds for lung cancer resection based on definitions provided by the Volume Pledge. A secondary aim was to evaluate the volume-outcome ... Full text Link to item Cite

Outcomes of transcatheter aortic valve replacement for patients with severe aortic stenosis and concomitant aortic insufficiency: Insights from the TVT Registry.

Journal Article Am Heart J · October 2020 AIMS: Data regarding outcomes for patients with severe aortic stenosis (AS) with concomitant aortic insufficiency (AI), undergoing transcatheter aortic valve replacement (TAVR) are limited. This study aimed to analyze the prevalence of severe AS with conco ... Full text Link to item Cite

Recurrent thrombosis in patients with antiphospholipid antibodies and an initial venous or arterial thromboembolic event: A systematic review and meta-analysis.

Journal Article J Thromb Haemost · September 2020 BACKGROUND: Patients with antiphospholipid antibodies (aPL) and thromboembolism (TE) are at risk for recurrent TE. Few studies, however, distinguish patients based on the initial event. OBJECTIVES: We performed a systematic review and meta-analysis to inve ... Full text Link to item Cite

Geographic Access to Transcatheter Aortic Valve Replacement Centers in the United States: Insights From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal Article JAMA Cardiol · September 1, 2020 IMPORTANCE: Geographic access to transcatheter aortic replacement (TAVR) centers varies in the United States as a result of controlled expansion through minimum volume requirements. OBJECTIVE: To describe the current geographic access to TAVR centers in th ... Full text Link to item Cite

Concomitant carotid endarterectomy and cardiac surgery does not decrease postoperative stroke rates.

Journal Article J Vasc Surg · August 2020 OBJECTIVE: The timing of operative revascularization for patients with concomitant carotid artery stenosis and coronary artery disease remains controversial. We examined the Society of Thoracic Surgeons (STS) Adult Cardiac Surgery Database to evaluate the ... Full text Link to item Cite

Risk for Nephrogenic Systemic Fibrosis After Exposure to Newer Gadolinium Agents: A Systematic Review.

Journal Article Ann Intern Med · July 21, 2020 BACKGROUND: The risk for nephrogenic systemic fibrosis (NSF) after exposure to newer versus older gadolinium-based contrast agents (GBCAs) remains unclear. PURPOSE: To synthesize evidence about NSF risk with newer versus older GBCAs across the spectrum of ... Full text Link to item Cite

Effectiveness of Acute Care Remote Triage Systems: a Systematic Review.

Journal Article J Gen Intern Med · July 2020 BACKGROUND: Technology-based systems can facilitate remote decision-making to triage patients to the appropriate level of care. Despite technologic advances, the effects of implementation of these systems on patient and utilization outcomes are unclear. We ... Full text Open Access Link to item Cite

A Phase II Randomized Clinical Trial of the Safety and Efficacy of Intravenous Umbilical Cord Blood Infusion for Treatment of Children with Autism Spectrum Disorder.

Journal Article J Pediatr · July 2020 OBJECTIVE: To evaluate whether umbilical cord blood (CB) infusion is safe and associated with improved social and communication abilities in children with autism spectrum disorder (ASD). STUDY DESIGN: This prospective, randomized, placebo-controlled, doubl ... Full text Open Access Link to item Cite

Geographic Access to Transcatheter Aortic Valve Replacement Centers in the United States: Insights From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal Article JAMA Cardiol · June 10, 2020 Importance: Geographic access to transcatheter aortic replacement (TAVR) centers varies in the United States as a result of controlled expansion through minimum volume requirements. Objective: To describe the current geographic access to TAVR centers in th ... Full text Link to item Cite

Demographics, Procedural Characteristics, and Clinical Outcomes When Cardiogenic Shock Precedes TAVR in the United States.

Journal Article JACC Cardiovasc Interv · June 8, 2020 OBJECTIVES: This paper details trends and outcomes in U.S. patients undergoing transcatheter aortic valve replacement (TAVR) who present pre-procedurally with cardiogenic shock. BACKGROUND: Demographic, procedural characteristics, and clinical outcomes in ... Full text Link to item Cite

Conscious Sedation Versus General Anesthesia for Transcatheter Aortic Valve Replacement: Variation in Practice and Outcomes.

Journal Article JACC Cardiovasc Interv · June 8, 2020 OBJECTIVES: The aims of this study were to examine variation in the use of conscious sedation (CS) for transcatheter aortic valve replacement (TAVR) across hospitals and over time and to evaluate outcomes of CS compared with general anesthesia (GA) using i ... Full text Link to item Cite

Assessment of conservative dietary management as a method for normalization of 24-h urine pH in stone formers.

Journal Article Urolithiasis · April 2020 Low urine pH is a metabolic risk factor for stone formation. While medical therapy is typically prescribed (as urinary alkalinization), patients typically prefer dietary modifications. We aimed to assess capacity to alter urine pH with dietary management a ... Full text Link to item Cite

Thrombolytic therapy in older acute ischemic stroke patients with gastrointestinal malignancy or recent bleeding.

Journal Article Eur Stroke J · March 2020 BACKGROUND: There are limited data on the safety of intravenous recombinant tissue plasminogen activator (rtPA) for treating acute ischemic stroke in patients with gastrointestinal malignancy or recent gastrointestinal bleeding within 21 days of their inde ... Full text Link to item Cite

The Society of Thoracic Surgeons Composite Score Rating for Pulmonary Resection for Lung Cancer.

Journal Article Ann Thorac Surg · March 2020 BACKGROUND: The Society of Thoracic Surgeons (STS) General Thoracic Surgery Database (GTSD) has developed composite quality measures for lobectomy and esophagectomy. This study sought to develop a composite measure including all resections for lung cancer. ... Full text Link to item Cite

Videos to reduce racial disparities in ICD therapy Via Innovative Designs (VIVID) trial: Rational, design and methodology.

Journal Article Am Heart J · February 2020 BACKGROUND: Despite a higher prevalence of sudden cardiac death (SCD), black individuals are less likely than whites to have an implantable cardioverter defibrillator (ICD) implanted. Racial differences in ICD utilization is in part explained by higher ref ... Full text Link to item Cite

The Effect and Relationship of Frailty Indices on Survival After Transcatheter Aortic Valve Replacement.

Journal Article JACC Cardiovasc Interv · January 27, 2020 OBJECTIVES: This study sought to evaluate the ability of individual markers of frailty to predict outcomes after transcatheter aortic valve replacement (TAVR) and of their discriminatory value in different age groups. BACKGROUND: Appropriate patient select ... Full text Link to item Cite

Safety and Outcomes of Intravenous tPA in Acute Ischemic Stroke Patients With Prior Stroke Within 3 Months: Findings From Get With The Guidelines-Stroke.

Journal Article Circ Cardiovasc Qual Outcomes · January 2020 Background Guidelines recommend against the use of intravenous tPA (tissue-type plasminogen activator; IV tPA) in acute ischemic stroke patients with prior ischemic stroke within 3 months. However, there are limited data on the safety of IV tPA in this pop ... Full text Link to item Cite

Transformational Coaching: Effect on Process of Care Outcomes and Determinants of Uptake

Report · 2020 High-quality health care is a priority for patients and clinicians alike. Quality improvement (QI) is a framework that guides health system actions to improve the delivery of high-quality health care. Quality improvement activities seek to promote high-qua ... Link to item Cite

Operator Experience and Outcomes of Transcatheter Mitral Valve Repair in the United States.

Journal Article J Am Coll Cardiol · December 17, 2019 BACKGROUND: Transcatheter mitral valve repair (TMVr) for the treatment of mitral regurgitation (MR) is a complex procedure that requires development of a unique skillset. OBJECTIVES: The purpose of this study was to examine the relationship between operato ... Full text Link to item Cite

Pre- Versus Post-Procedure Health Care Resource Utilization in Patients Undergoing Commercial Transcatheter Mitral Valve Repair.

Journal Article JACC Cardiovasc Interv · December 9, 2019 OBJECTIVES: The aim of this study was to assess the real-world impact of transcatheter mitral valve repair (TMVR) on hospitalizations and Medicare costs pre- versus post-TMVR. BACKGROUND: TMVR is effective in degenerative mitral regurgitation (MR) and appr ... Full text Link to item Cite

Factors Associated With and Outcomes of Aborted Procedures During Elective Transcatheter Aortic Valve Replacement.

Journal Article JACC Cardiovasc Interv · September 23, 2019 OBJECTIVES: This study sought to evaluate the outcomes and factors associated with aborted procedures among patients undergoing elective transcatheter aortic valve replacement (TAVR). BACKGROUND: Elective TAVR procedures can be aborted because of device li ... Full text Link to item Cite

Relation of Postdischarge Care Fragmentation and Outcomes in Transcatheter Aortic Valve Implantation from the STS/ACC TVT Registry.

Journal Article Am J Cardiol · September 15, 2019 Fragmented care following elective surgery has been associated with poor outcomes. The association between fragmented care and outcomes in patients undergoing transcatheter aortic valve implantation (TAVI) is unknown. We examined patients who underwent TAV ... Full text Link to item Cite

Introducing Palliative Care within the Treatment of End-Stage Liver Disease: The Study Protocol of a Cluster Randomized Controlled Trial.

Journal Article J Palliat Med · September 2019 Introduction: Patients with end-stage liver disease (ESLD) suffer from myriad symptoms due to the systemic effects of the disease and unpredictable acute episodes, which contribute to progressive deterioration in quality of life (QOL). Despite clear eviden ... Full text Link to item Cite

Association of Smoking Status With Long-Term Mortality and Health Status After Transcatheter Aortic Valve Replacement: Insights From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal Article J Am Heart Assoc · August 20, 2019 Background Smoking is a significant risk factor for aortic stenosis but its impact on clinical and health status outcomes after transcatheter aortic valve replacement (TAVR) has not been described. Methods and Results Patients (n=72 165) undergoing TAVR at ... Full text Link to item Cite

Recent Myocardial Infarction is Associated With Increased Risk in Older Adults With Acute Ischemic Stroke Receiving Thrombolytic Therapy.

Journal Article J Am Heart Assoc · August 6, 2019 Background Intravenous recombinant tissue-type plasminogen activator (rtPA) remains the only medical therapy to improve outcomes for acute ischemic stroke (AIS), but the safety of rtPA in AIS patients with a history of recent myocardial infarction (MI) rem ... Full text Open Access Link to item Cite

Intravenous Tissue Plasminogen Activator in Stroke Mimics.

Journal Article Circ Cardiovasc Qual Outcomes · August 2019 BACKGROUND: The necessity for rapid evaluation and treatment of acute ischemic stroke with intravenous tPA (tissue-type plasminogen activator) may increase the risk of administrating tPA to patients presenting with noncerebrovascular conditions that closel ... Full text Link to item Cite

Institutional Experience With Transcatheter Mitral Valve Repair and Clinical Outcomes: Insights From the TVT Registry.

Journal Article JACC Cardiovasc Interv · July 22, 2019 OBJECTIVES: The aim of this study was to examine the relation between institutional experience and procedural results of transcatheter mitral valve repair. BACKGROUND: Transcatheter mitral valve repair for the treatment of mitral regurgitation (MR) is a co ... Full text Link to item Cite

Self-management of Epilepsy: A Systematic Review.

Journal Article Ann Intern Med · July 16, 2019 BACKGROUND: Although self-management is recommended for persons with epilepsy, its optimal strategies and effects are uncertain. PURPOSE: To evaluate the components and efficacy of self-management interventions in the treatment of epilepsy in community-dwe ... Full text Open Access Link to item Cite

Emergency Department Interventions for Older Adults: A Systematic Review.

Journal Article J Am Geriatr Soc · July 2019 OBJECTIVES: To evaluate the effect of emergency department (ED) interventions on clinical, utilization, and care experience outcomes for older adults. DESIGN: A conceptual model informed, protocol-based systematic review. SETTING: Emergency Department (ED) ... Full text Link to item Cite

Procedural Volume and Outcomes for Transcatheter Aortic-Valve Replacement.

Journal Article N Engl J Med · June 27, 2019 BACKGROUND: During the introduction of transcatheter aortic-valve replacement (TAVR) in the United States, requirements regarding procedural volume were mandated by the Centers for Medicare and Medicaid Services as a condition of reimbursement. A better un ... Full text Link to item Cite

Systematic Review for the 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.

Journal Article J Am Coll Cardiol · June 25, 2019 BACKGROUND: The 2013 American College of Cardiology/American Heart Association guidelines for the treatment of blood cholesterol found little evidence to support the use of nonstatin lipid-modifying medications to reduce atherosclerotic cardiovascular dise ... Full text Link to item Cite

Systematic Review for the 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.

Journal Article Circulation · June 18, 2019 BACKGROUND: The 2013 American College of Cardiology/American Heart Association guidelines for the treatment of blood cholesterol found little evidence to support the use of nonstatin lipid-modifying medications to reduce atherosclerotic cardiovascular dise ... Full text Link to item Cite

Association Between Transcatheter Aortic Valve Replacement and Early Postprocedural Stroke.

Journal Article JAMA · June 18, 2019 IMPORTANCE: Reducing postprocedural stroke is important to improve the safety of transcatheter aortic valve replacement (TAVR). OBJECTIVE: This study evaluated the trends of stroke occurring within 30 days after the procedure during the first 5 years TAVR ... Full text Link to item Cite

Intravenous Tissue-Type Plasminogen Activator in Acute Ischemic Stroke Patients With History of Stroke Plus Diabetes Mellitus.

Journal Article Stroke · June 2019 Background and Purpose- Acute ischemic stroke patients with history of prior ischemic stroke plus concomitant diabetes mellitus (DM) were excluded from the ECASS III trial (European Cooperative Acute Stroke Study) because of safety concerns. However, there ... Full text Link to item Cite

Racial Disparities in the Utilization and Outcomes of TAVR: TVT Registry Report.

Journal Article JACC Cardiovasc Interv · May 27, 2019 OBJECTIVES: This study sought to evaluate racial disparities in the performance and outcomes of transcatheter aortic valve replacement (TAVR). BACKGROUND: Racial disparities in cardiovascular diseases are well described. Whether the racial disparities obse ... Full text Link to item Cite

Lack of correlation between short- and long-term performance after lung cancer surgery.

Journal Article J Thorac Cardiovasc Surg · April 2019 OBJECTIVE: Outcomes for lung cancer surgery are currently measured according to perioperative morbidity and mortality. However, the oncologic efficacy of the surgery is reflected by long-term survival. We examined correlation between measures of short-term ... Full text Link to item Cite

The Prevalence and Impact of Atrial Fibrillation on 1-Year Outcomes in Patients Undergoing Transcatheter Mitral Valve Repair: Results From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal Article JACC Cardiovasc Interv · March 25, 2019 OBJECTIVES: The aim of this study was to compare 1-year outcomes following transcatheter mitral valve (MV) repair in patients with and without atrial fibrillation (AF). BACKGROUND: The development of AF in degenerative mitral regurgitation (MR) is consider ... Full text Link to item Cite

Penetration, Completeness, and Representativeness of The Society of Thoracic Surgeons General Thoracic Surgery Database for Lobectomy.

Journal Article Ann Thorac Surg · March 2019 BACKGROUND: Not all surgeons performing lobectomy in the United States report outcomes to The Society of Thoracic Surgeons General Thoracic Surgery Database (STS GTSD). We examined penetration, completeness, and representativeness of the STS GTSD for lobec ... Full text Link to item Cite

Morbidity and 30-day mortality after decortication for parapneumonic empyema and pleural effusion among patients in the Society of Thoracic Surgeons' General Thoracic Surgery Database.

Journal Article J Thorac Cardiovasc Surg · March 2019 OBJECTIVE: We analyzed the Society of Thoracic Surgeons' Database to describe the results of surgical decortication. METHODS: A review of patients undergoing pulmonary decortication, excluding hemothorax and malignancy, from 2009 to 2016 was performed. Pre ... Full text Link to item Cite

Left Ventricular Hypertrophy Does Not Affect 1-Year Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement.

Journal Article JACC Cardiovasc Interv · February 25, 2019 OBJECTIVES: The aim of this study was to evaluate the association between pre-procedural left ventricular hypertrophy (LVH) patterns and clinical outcomes after transcatheter aortic valve replacement (TAVR). BACKGROUND: The association between pre-procedur ... Full text Link to item Cite

Integrated outpatient palliative care for patients with advanced cancer: A systematic review and meta-analysis.

Journal Article Palliat Med · February 2019 BACKGROUND:: Despite increasing emphasis on integration of palliative care with disease-directed care for advanced cancer, the nature of this integration and its effects on patient and caregiver outcomes are not well-understood. AIM:: We evaluated the effe ... Full text Link to item Cite

Defining Proficiency for The Society of Thoracic Surgeons Participants Performing Thoracoscopic Lobectomy.

Journal Article Ann Thorac Surg · January 2019 BACKGROUND: Parameters defining attainment and maintenance of proficiency in thoracoscopic video-assisted thoracic surgery (VATS) lobectomy remain unknown. To address this knowledge gap, this study investigated the institutional performance curve for VATS ... Full text Link to item Cite

Using a society database to evaluate a patient safety collaborative: the Cardiovascular Surgical Translational Study.

Journal Article J Comp Eff Res · January 2019 AIM: To assess the utility of using external databases for quality improvement (QI) evaluations in the context of an innovative QI collaborative aimed to reduce three infections and improve patient safety across the cardiac surgery service line. METHODS: W ... Full text Link to item Cite

Effectiveness of Remote Triage: A Systematic Review

Report · 2019 The US health care system currently faces several challenges including caring for an increasing elderly population, a large numbers of patients with multiple chronic conditions, and an uneven distribution of primary care providers across the country. The f ... Link to item Cite

Prosthesis-Patient Mismatch in Patients Undergoing Transcatheter Aortic Valve Replacement: From the STS/ACC TVT Registry.

Journal Article J Am Coll Cardiol · December 4, 2018 BACKGROUND: Prosthesis-patient mismatch (PPM) after surgical aortic valve replacement (AVR) for aortic stenosis is generally associated with worse outcomes. Transcatheter AVR (TAVR) can achieve a larger valve orifice and the effects of PPM after TAVR are l ... Full text Link to item Cite

Interventions for Preventing Thromboembolic Events in Patients With Atrial Fibrillation: A Systematic Review.

Journal Article Ann Intern Med · December 4, 2018 BACKGROUND: The comparative safety and effectiveness of treatments to prevent thromboembolic complications in atrial fibrillation (AF) remain uncertain. PURPOSE: To compare the effectiveness of medical and procedural therapies in preventing thromboembolic ... Full text Link to item Cite

Association of Renin-Angiotensin Inhibitor Treatment With Mortality and Heart Failure Readmission in Patients With Transcatheter Aortic Valve Replacement.

Journal Article JAMA · December 4, 2018 IMPORTANCE: Data are lacking on the effect of a renin-angiotensin system (RAS) inhibitor prescribed after transcatheter aortic valve replacement (TAVR). Treatment with a RAS inhibitor may reverse left ventricular remodeling and improve function. OBJECTIVE: ... Full text Link to item Cite

Predicting Thromboembolic and Bleeding Event Risk in Patients with Non-Valvular Atrial Fibrillation: A Systematic Review.

Journal Article Thromb Haemost · December 2018 BACKGROUND: Atrial fibrillation (AF) is a common cardiac arrhythmia that increases the risk of stroke. Medical therapy for decreasing stroke risk involves anticoagulation, which may increase bleeding risk for certain patients. In determining the optimal t ... Full text Link to item Cite

Association of Transcatheter Mitral Valve Repair With Quality of Life Outcomes at 30 Days and 1 Year: Analysis of the Transcatheter Valve Therapy Registry.

Journal Article JAMA Cardiol · December 1, 2018 IMPORTANCE: Improvements in symptoms, functional capacity, and quality of life are among the key goals of edge-to-edge transcatheter mitral valve repair (TMVR) for mitral regurgitation. OBJECTIVE: To examine health status outcomes among patients undergoing ... Full text Link to item Cite

Invasive Mediastinal Staging for Lung Cancer by The Society of Thoracic Surgeons Database Participants.

Journal Article Ann Thorac Surg · October 2018 BACKGROUND: Prior studies suggest underutilization of invasive mediastinal staging for lung cancer. We hypothesized that The Society of Thoracic Surgeons General Thoracic Surgery Database (STS-GTSD) participants would have higher rates of invasive staging ... Full text Link to item Cite

Minimally Invasive Lung Cancer Surgery Performed by Thoracic Surgeons as Effective as Thoracotomy.

Journal Article J Clin Oncol · August 10, 2018 Purpose The prevalence of minimally invasive lung cancer surgery using video-assisted thoracic surgery (VATS) has increased dramatically over the past decade, yet recent studies have suggested that the lymph node evaluation during VATS lobectomy is inadequ ... Full text Link to item Cite

Interventions That Support or Involve Caregivers or Families of Patients with Traumatic Injury: a Systematic Review.

Journal Article J Gen Intern Med · July 2018 BACKGROUND: Almost 40 million family caregivers care for a loved one with severe physical or cognitive impairments. The purpose of this review is to summarize evidence about the benefits of interventions to support or involve family members/caregivers of p ... Full text Link to item Cite

Usefulness and Cost-Effectiveness of Universal Echocardiographic Contrast to Detect Left Ventricular Thrombus in Patients with Heart Failure and Reduced Ejection Fraction.

Journal Article Am J Cardiol · July 1, 2018 Contrast is a recommended but frequently unused tool in transthoracic echocardiography to improve detection of left ventricular thrombus in patients with ejection fraction (EF) ≤35%. The clinical and economic outcomes of a possible solution (i.e., universa ... Full text Link to item Cite

Nonpharmacologic Treatments for Attention-Deficit/Hyperactivity Disorder: A Systematic Review.

Journal Article Pediatrics · June 2018 CONTEXT: Nonpharmacologic treatments for attention-deficit/hyperactivity disorder (ADHD) encompass a range of care approaches from structured behavioral interventions to complementary medicines. OBJECTIVES: To assess the comparative effectiveness of nonpha ... Full text Link to item Cite

Management of Menopause Symptoms with Acupuncture: An Umbrella Systematic Review and Meta-Analysis.

Journal Article J Altern Complement Med · April 2018 OBJECTIVES: Vasomotor symptoms (VMSs) are the most common symptoms reported during menopause. Although hormone therapy is effective for reducing VMSs, its use is restricted in some women. Many women with VMSs thus seek nonhormonal, nonpharmacologic treatme ... Full text Link to item Cite

Differential effects of operative complications on survival after surgery for primary lung cancer.

Journal Article J Thorac Cardiovasc Surg · March 2018 OBJECTIVE: Complications adversely affect survival after lung cancer surgery. We tested the hypothesis that effects of complications after lung cancer surgery on survival vary substantially across the spectrum of postoperative complications. METHODS: The S ... Full text Link to item Cite

Attention Deficit Hyperactivity Disorder:Diagnosis and Treatment in Children and Adolescents. Comparative Effectiveness Review No. 203

Report · January 25, 2018 Full text Cite

Prediction of Long-Term Survival After Lung Cancer Surgery for Elderly Patients in The Society of Thoracic Surgeons General Thoracic Surgery Database.

Journal Article Ann Thorac Surg · January 2018 BACKGROUND: Prior risk models using the STS General Thoracic Surgery database (STS-GTSD) have been limited to 30-day outcomes. We have now linked STS data to Medicare data and sought to create a risk prediction model for long-term mortality after lung canc ... Full text Link to item Cite

Attention Deficit Hyperactivity Disorder: Diagnosis and Treatment in Children and Adolescents. Comparative Effectiveness Review No. 203.

Journal Article · January 2018 Full text Cite

Metformin Use May Moderate the Effect of DPP-4 Inhibitors on Cardiovascular Outcomes.

Journal Article Diabetes Care · December 2017 OBJECTIVE: To explore prevalent metformin use as a potential moderator of the cardiovascular effects of dipeptidyl peptidase 4 inhibitors (DPP-4i). RESEARCH DESIGN AND METHODS: We performed a meta-analysis of the three major cardiovascular outcomes trials ... Full text Link to item Cite

Diagnostic Accuracy of Screening Tests and Treatment for Post-Acute Coronary Syndrome Depression: A Systematic Review.

Journal Article Ann Intern Med · November 21, 2017 BACKGROUND: Patients who have had an acute coronary syndrome (ACS) event have an increased risk for depression. PURPOSE: To evaluate the diagnostic accuracy of depression screening instruments and to compare safety and effectiveness of depression treatment ... Full text Link to item Cite

Geographic Variations in Lung Cancer Lobectomy Outcomes: The General Thoracic Surgery Database.

Journal Article Ann Thorac Surg · November 2017 BACKGROUND: Lung cancer ranks as the top cancer killer in the United States. Using The Society of Thoracic Surgeons General Thoracic Surgery Database (GTSD), the geographic variability of lung cancer lobectomy for operative mortality and major morbidity we ... Full text Link to item Cite

The Society of Thoracic Surgeons General Thoracic Surgery Database: 2017 Update on Research.

Journal Article Ann Thorac Surg · November 2017 The outcomes research efforts based on The Society of Thoracic Surgeons (STS) General Thoracic Surgery Database include two established research programs with dedicated task forces and with data analyses conducted at the STS data analytic center: (1) The S ... Full text Link to item Cite

Improving vasomotor symptoms; psychological symptoms; and health-related quality of life in peri- or post-menopausal women through yoga: An umbrella systematic review and meta-analysis.

Journal Article Complement Ther Med · October 2017 OBJECTIVES: Vasomotor symptoms (VMS), commonly reported during menopausal transition, negatively affect psychological health and health-related quality of life (HRQoL). While hormone therapy is an effective treatment, its use is limited by concerns about p ... Full text Link to item Cite

Mortality and Respiratory Failure After Thoracoscopic Lung Biopsy for Interstitial Lung Disease.

Journal Article Ann Thorac Surg · August 2017 BACKGROUND: Surgical lung biopsy contributes to establishing a specific diagnosis among many patients with interstitial lung disease (ILD). The risks of death and respiratory failure associated with elective thoracoscopic surgical lung biopsy, and patient ... Full text Link to item Cite

Surgically Managed Clinical Stage IIIA-Clinical N2 Lung Cancer in The Society of Thoracic Surgeons Database.

Journal Article Ann Thorac Surg · August 2017 BACKGROUND: The role of surgical resection in patients with clinical stage IIIA-N2 positive (cIIIA-N2) lung cancer is controversial, partly because of the variability in short- and long-term outcomes. The objective of this study was to characterize the man ... Full text Link to item Cite

The Society of Thoracic Surgeons Lung Cancer Resection Risk Model: Higher Quality Data and Superior Outcomes (vol 102, pg 370, 2016)

Journal Article ANNALS OF THORACIC SURGERY · August 1, 2017 Link to item Cite

Prognostic Value of Noninvasive Cardiovascular Testing in Patients With Stable Chest Pain: Insights From the PROMISE Trial (Prospective Multicenter Imaging Study for Evaluation of Chest Pain).

Journal Article Circulation · June 13, 2017 BACKGROUND: Optimal management of patients with stable chest pain relies on the prognostic information provided by noninvasive cardiovascular testing, but there are limited data from randomized trials comparing anatomic with functional testing. METHODS: In ... Full text Link to item Cite

The Society of Thoracic Surgeons Composite Score for Evaluating Esophagectomy for Esophageal Cancer.

Journal Article Ann Thorac Surg · May 2017 BACKGROUND: The Society of Thoracic Surgeons (STS) has developed composite quality measures for cardiac surgical procedures and lobectomy for lung cancer. This study sought to develop a composite measure for esophagectomy for esophageal cancer. METHODS: Th ... Full text Link to item Cite

Use of mindfulness, meditation and relaxation to treat vasomotor symptoms.

Journal Article Climacteric · April 2017 Postmenopausal women with bothersome vasomotor symptoms (VMS) often seek alternatives to hormone-based treatment due to medication risks or personal preference. We sought to identify the effects of meditation, mindfulness, hypnosis and relaxation on VMS an ... Full text Link to item Cite

Clinical Outcomes of Metformin Use in Populations With Chronic Kidney Disease, Congestive Heart Failure, or Chronic Liver Disease: A Systematic Review.

Journal Article Ann Intern Med · February 7, 2017 BACKGROUND: Recent changes to the U.S. Food and Drug Administration boxed warning for metformin will increase its use in persons with historical contraindications or precautions. Prescribers must understand the clinical outcomes of metformin use in these p ... Full text Link to item Cite

The Impact of Interventions that Integrate Accelerometers on Physical Activity and Weight Loss: A Systematic Review.

Journal Article Ann Behav Med · February 2017 BACKGROUND: Regular physical activity is important for improving and maintaining health, but sedentary behavior is difficult to change. Providing objective, real-time feedback on physical activity with wearable motion-sensing technologies (activity monitor ... Full text Link to item Cite

Congenital Heart Disease in Premature Infants 25-32 Weeks' Gestational Age.

Journal Article J Pediatr · February 2017 OBJECTIVE: To determine the birth prevalence of congenital heart defects (CHDs) across the spectrum of common defects in very/extremely premature infants and to compare mortality rates between premature infants with and without CHDs. STUDY DESIGN: The Kids ... Full text Link to item Cite

Comparison of visual assessment of coronary stenosis with independent quantitative coronary angiography: Findings from the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial.

Journal Article Am Heart J · February 2017 BACKGROUND: The outcomes in patients by visual assessment and quantitative coronary angiography (QCA) for obstructive coronary artery disease (CAD) are not known. Our objectives were to compare visual and QCA estimates of obstructive CAD and to assess thei ... Full text Link to item Cite

Features of Autoimmune Hepatitis in Patients With Drug-induced Liver Injury.

Journal Article Clin Gastroenterol Hepatol · January 2017 BACKGROUND & AIMS: Drug-induced liver injury (DILI) has features similar to those of other liver diseases including autoimmune hepatitis (AIH). We aimed to characterize the clinical and autoimmune features of liver injury caused by nitrofurantoin, minocycl ... Full text Link to item Cite

Reply.

Other Clin Gastroenterol Hepatol · December 2016 Full text Link to item Cite

The Society of Thoracic Surgeons General Thoracic Surgery Database: 2016 Update on Research.

Journal Article Ann Thorac Surg · November 2016 The Society of Thoracic Surgeons General Thoracic Surgery Database has grown to more than 500,000 case records. Clinical research supported by the database is increasingly used to advance patient outcomes. This research review from the General Thoracic Sur ... Full text Link to item Cite

The Society of Thoracic Surgeons Lung Cancer Resection Risk Model: Higher Quality Data and Superior Outcomes.

Journal Article Ann Thorac Surg · August 2016 BACKGROUND: The Society of Thoracic Surgeons (STS) creates risk-adjustment models for common cardiothoracic operations for quality improvement purposes. Our aim was to update the lung cancer resection risk model utilizing the STS General Thoracic Surgery D ... Full text Link to item Cite

Time-dependent classification accuracy curve under marker-dependent sampling.

Journal Article Biom J · July 2016 Evaluating the classification accuracy of a candidate biomarker signaling the onset of disease or disease status is essential for medical decision making. A good biomarker would accurately identify the patients who are likely to progress or die at a partic ... Full text Link to item Cite

Predictors of Major Morbidity or Mortality After Resection for Esophageal Cancer: A Society of Thoracic Surgeons General Thoracic Surgery Database Risk Adjustment Model.

Journal Article Ann Thorac Surg · July 2016 BACKGROUND: The purpose of this analysis was to revise the model for perioperative risk for esophagectomy for cancer utilizing The Society of Thoracic Surgeons General Thoracic Surgery Database to provide enhanced risk stratification and quality improvemen ... Full text Link to item Cite

Longitudinal Follow-up of Lung Cancer Resection From the Society of Thoracic Surgeons General Thoracic Surgery Database in Patients 65 Years and Older.

Journal Article Ann Thorac Surg · June 2016 BACKGROUND: The Society of Thoracic Surgeons (STS) General Thoracic Surgery Database (GTSD) does not capture long-term survival after lung cancer surgery. Our objective was to provide longitudinal follow-up to the STS GTSD through linkage to Centers for Me ... Full text Link to item Cite

Minimally Invasive Versus Open Esophagectomy for Esophageal Cancer: A Comparison of Early Surgical Outcomes From The Society of Thoracic Surgeons National Database.

Journal Article Ann Thorac Surg · April 2016 BACKGROUND: Open esophagectomy results in significant morbidity and mortality. Minimally invasive esophagectomy (MIE) has become increasingly popular at specialized centers with the aim of improving perioperative outcomes. Numerous single-institution studi ... Full text Link to item Cite

Liver injury from nonsteroidal anti-inflammatory drugs in the United States.

Journal Article Liver Int · April 2016 BACKGROUND & AIMS: Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used and have been associated with hepatotoxicity. Studies of liver injury from NSAIDs have been retrospective and prospective data are lacking. The aim was to report the feature ... Full text Link to item Cite

The Society of Thoracic Surgeons Composite Score for Rating Program Performance for Lobectomy for Lung Cancer.

Journal Article Ann Thorac Surg · April 2016 BACKGROUND: The Society of Thoracic Surgeons (STS) has developed multidimensional composite quality measures for common cardiac surgery procedures. This first composite measure for general thoracic surgery evaluates STS participant performance for lobectom ... Full text Link to item Cite

Effectiveness of Intermittent Pneumatic Compression Devices for Venous Thromboembolism Prophylaxis in High-Risk Surgical Patients: A Systematic Review.

Journal Article J Arthroplasty · February 2016 BACKGROUND: Thromboprophylaxis regimens include pharmacologic and mechanical options such as intermittent pneumatic compression devices (IPCDs). There are a wide variety of IPCDs available, but it is uncertain if they vary in effectiveness or ease of use. ... Full text Link to item Cite

Use of Intravenous Tissue Plasminogen Activator in Patients Without a Stroke (Stroke Mimics): Findings From the get With the Guidelines Stroke Registry

Conference STROKE · February 1, 2016 Link to item Cite

Epidemiology and Mortality of Very and Extremely Preterm Infants With Congenital Heart Defects

Journal Article CIRCULATION · November 10, 2015 Link to item Cite

Racial and Ethnic Differences in Lung Cancer Surgical Stage: An STS Database Study.

Journal Article Thorac Cardiovasc Surg · October 2015 BACKGROUND: Racial and ethnic differences in lung cancer care have been previously documented. These differences may be related to access to care, cultural differences, or fewer patients presenting with operable lung cancer. The relationship between race a ... Full text Link to item Cite

TCT-284 Comparison of Visual Assessment of Coronary Stenosis with Independent Quantitative Coronary Angiography: Findings from the PROMISE Trial (PROspective Multicenter Imaging Study for Evaluation of chest pain)

Conference Journal of the American College of Cardiology · October 2015 Full text Cite

Electronic Interventions for Alcohol Misuse and Alcohol Use Disorders: A Systematic Review.

Journal Article Ann Intern Med · August 4, 2015 BACKGROUND: The use of electronic interventions (e-interventions) may improve treatment of alcohol misuse. PURPOSE: To characterize treatment intensity and systematically review the evidence for efficacy of e-interventions, relative to controls, for reduci ... Full text Link to item Cite

Outcomes of anatomical versus functional testing for coronary artery disease.

Journal Article N Engl J Med · April 2, 2015 BACKGROUND: Many patients have symptoms suggestive of coronary artery disease (CAD) and are often evaluated with the use of diagnostic testing, although there are limited data from randomized trials to guide care. METHODS: We randomly assigned 10,003 sympt ... Full text Link to item Cite

P1131 : Autoimmune hepatitis-like drug induced liver injury

Conference Journal of Hepatology · April 2015 Full text Cite

Implications of ventricular arrhythmia "bursts" with normal epicardial flow, myocardial blush, and ST-segment recovery in anterior ST-elevation myocardial infarction reperfusion: a biosignature of direct myocellular injury "downstream of downstream".

Journal Article Eur Heart J Acute Cardiovasc Care · February 2015 AIMS: Establishing epicardial flow with percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) is necessary but not sufficient to ensure nutritive myocardial reperfusion. We evaluated whether adding myocardial blush ... Full text Link to item Cite

Noninvasive fractional flow on MRA predicts stroke risk of intracranial stenosis.

Journal Article J Neuroimaging · 2015 BACKGROUND AND PURPOSE: Fractional flow may identify hemodynamic effects and ischemic risk beyond percent stenosis of an artery. We hypothesized that diminished TOF-MRA signal intensity distal to an intracranial stenosis predicts stroke risk. METHODS: TOF- ... Full text Link to item Cite

The Impact of Wearable Motion Sensing Technologies on Physical Activity: A Systematic Review.

Report · 2015 Cite

Effect of the CT table strap on radiation exposure and image quality during cervical spine CT.

Journal Article AJNR Am J Neuroradiol · October 2014 BACKGROUND AND PURPOSE: The CT table strap may impair shoulder lowering during cervical spine CT. The purpose of this investigation was to evaluate the effect of the CT table strap on radiation exposure and image quality during CT of the cervical spine. MA ... Full text Link to item Cite

Relationship between characteristics of medications and drug-induced liver disease phenotype and outcome.

Journal Article Clin Gastroenterol Hepatol · September 2014 BACKGROUND & AIMS: It is not known whether specific characteristics of medication are associated with type of drug-induced liver injury (DILI) or outcome. We examined the relationships among select characteristics of medications and DILI phenotype and outc ... Full text Link to item Cite

Fewer complications result from a video-assisted approach to anatomic resection of clinical stage I lung cancer.

Journal Article J Thorac Cardiovasc Surg · August 2014 OBJECTIVES: Anatomic resection is currently the standard of care for clinical stage I lung cancer, yet clinicians increasingly pursue nonsurgical, ablative therapies to avoid the morbidity of thoracotomy. The video-assisted thoracic surgery (VATS) approach ... Full text Link to item Cite

Computed Tomography Angiography in the Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) Study.

Journal Article Interv Neurol · August 2014 BACKGROUND: The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) study validated noninvasive imaging tests of intracranial atherosclerosis against catheter angiography in a prospective, blinded, multicenter setting. Critical evaluat ... Full text Link to item Cite

Effects of nurse-managed protocols in the outpatient management of adults with chronic conditions: a systematic review and meta-analysis.

Journal Article Ann Intern Med · July 15, 2014 BACKGROUND: Changes in federal health policy are providing more access to medical care for persons with chronic disease. Providing quality care may require a team approach, which the American College of Physicians calls the "medical home." One new model ma ... Full text Link to item Cite

Malignant pleural mesothelioma and the Society of Thoracic Surgeons Database: an analysis of surgical morbidity and mortality.

Journal Article J Thorac Cardiovasc Surg · July 2014 BACKGROUND: To date, reported surgical morbidity and mortality for pleurectomy/decortication and extrapleural pneumonectomy performed for malignant pleural mesothelioma primarily represent the experience of a few specialized centers. For comparison, we exa ... Full text Link to item Cite

Sex differences in early outcomes after lung cancer resection: analysis of the Society of Thoracic Surgeons General Thoracic Database.

Journal Article J Thorac Cardiovasc Surg · July 2014 OBJECTIVES: Women with lung cancer have superior long-term survival outcomes compared with men, independent of stage. The cause of this disparity is unknown. For patients undergoing lung cancer resection, these survival differences could be due, in part, t ... Full text Link to item Cite

Thoracoscopic lobectomy is associated with acceptable morbidity and mortality in patients with predicted postoperative forced expiratory volume in 1 second or diffusing capacity for carbon monoxide less than 40% of normal.

Journal Article J Thorac Cardiovasc Surg · July 2014 OBJECTIVE: A predicted postoperative (ppo) forced expiratory volume in 1 second (FEV1%) or diffusing capacity of the lung for carbon monoxide (DLCO%) of <40% has traditionally been considered to convey a high risk of lobectomy owing to elevated postoperati ... Full text Link to item Cite

Rate- and rhythm-control therapies in patients with atrial fibrillation: a systematic review.

Journal Article Ann Intern Med · June 3, 2014 BACKGROUND: The comparative effectiveness of treatments for atrial fibrillation (AF) is uncertain. PURPOSE: To evaluate the comparative effectiveness of rate- and rhythm-control therapies. DATA SOURCES: English-language studies in PubMed, EMBASE, and the C ... Full text Link to item Cite

PROspective Multicenter Imaging Study for Evaluation of chest pain: rationale and design of the PROMISE trial.

Journal Article Am Heart J · June 2014 BACKGROUND: Suspected coronary artery disease (CAD) is one of the most common, potentially life-threatening diagnostic problems clinicians encounter. However, no large outcome-based randomized trials have been performed to guide the selection of diagnostic ... Full text Link to item Cite

Comparative effectiveness and safety of drug therapy for pulmonary arterial hypertension: a systematic review and meta-analysis.

Journal Article Chest · May 2014 BACKGROUND: Current treatments for pulmonary arterial hypertension (PAH) have been shown to improve dyspnea, 6-min walk distance (6MWD), and pulmonary hemodynamics, but few studies were designed to compare treatment regimens or assess the impact of treatme ... Full text Link to item Cite

Predictors of anastomotic leak after esophagectomy: an analysis of the society of thoracic surgeons general thoracic database.

Journal Article Ann Thorac Surg · December 2013 BACKGROUND: Anastomotic leak is an important cause of morbidity and mortality after esophagectomy. Few studies have targeted risk factors for the development of leak after esophagectomy. The purpose of this study is to use The Society of Thoracic Surgeons ... Full text Link to item Cite

Does treatment readiness enhance the response of African American substance users to Motivational Enhancement Therapy?

Journal Article Psychol Addict Behav · September 2013 The development of effective treatments for African Americans and other ethnic minorities is essential for reducing health disparities in substance use. Despite research suggesting that Motivational Enhancement Therapy (MET) may reduce substance use among ... Full text Link to item Cite

Evaluation of the reliability of clinical staging of T2 N0 esophageal cancer: a review of the Society of Thoracic Surgeons database.

Journal Article Ann Thorac Surg · August 2013 BACKGROUND: Clinical staging of esophageal cancer has improved with positron-emission tomography/computed tomography and endoscopic ultrasound imaging. Despite such progress, small single-center studies have questioned the reliability of clinical staging o ... Full text Link to item Cite

Treatment of Atrial Fibrillation. Comparative Effectiveness Review 119

Report · June 28, 2013 Cite

Following unenhanced MRI assessment for local recurrence after surgical resection of mesenchymal soft tissue tumors, do additional gadolinium-enhanced images change reader confidence or diagnosis?

Journal Article Eur J Radiol · May 2013 PURPOSE: Evaluate if gadolinium enhanced MR imaging (GeMRI) improves confidence, changes the final diagnosis, or improves accuracy in the assessment of musculoskeletal (MSK) tumor residual or recurrence following surgical resection. We also assess if diffe ... Full text Link to item Cite

Elbow MR imaging findings in patients with synovial fringe syndrome.

Journal Article Skeletal Radiol · May 2013 OBJECTIVE: To describe imaging findings in patients with synovial fringe (SF) syndrome of the elbow and to compare with a control population. MATERIALS AND METHODS: Nine patients (5 men, 4 women) whose mean age was 35.7 years were diagnosed with SF syndrom ... Full text Link to item Cite

A weighted generalized score statistic for comparison of predictive values of diagnostic tests.

Journal Article Stat Med · March 15, 2013 Featured Publication Positive and negative predictive values are important measures of a medical diagnostic test performance. We consider testing equality of two positive or two negative predictive values within a paired design in which all patients receive two diagnostic test ... Full text Link to item Cite

Clinical trials in sudden cardiac death prevention: Principles and endpoints

Chapter · January 1, 2013 A properly designed and conducted randomized clinical trial is the most objective approach for definitive comparison of medical therapies. However, a clinical trial is a complex collaborative undertaking and requires substantial multidisciplinary planning ... Full text Cite

Thoracoscopic lobectomy has increasing benefit in patients with poor pulmonary function: a Society of Thoracic Surgeons Database analysis.

Journal Article Ann Surg · September 2012 OBJECTIVE: Using a national database, we asked whether video-assisted thoracoscopic surgery (VATS) lobectomy is beneficial in high-risk pulmonary patients. BACKGROUND: Single-institution series demonstrated benefit of VATS lobectomy over lobectomy via thor ... Full text Link to item Cite

Lymph node evaluation by open or video-assisted approaches in 11,500 anatomic lung cancer resections.

Journal Article Ann Thorac Surg · August 2012 BACKGROUND: Unsuspected lymph node metastases are found in the surgical specimens of 10% to 25% clinical stage I lung cancers. Video-assisted thoracic surgery (VATS) is a minimally invasive alternative to thoracotomy. Because detection of clinically occult ... Full text Link to item Cite

Implementing rapid HIV testing with or without risk-reduction counseling in drug treatment centers: results of a randomized trial.

Journal Article Am J Public Health · June 2012 OBJECTIVES: We examined the effectiveness of risk reduction counseling and the role of on-site HIV testing in drug treatment. METHODS: Between January and May 2009, we randomized 1281 HIV-negative (or status unknown) adults who reported no past-year HIV te ... Full text Link to item Cite

Rationale for Using Exercise in the Treatment of Stimulant Use Disorders.

Journal Article J Glob Drug Policy Pract · 2012 Novel approaches to the treatment of stimulant abuse and dependence are needed. Clinical data examining the use of exercise as a treatment for the abuse of nicotine, alcohol, and other substances suggest that exercise may be a beneficial treatment for stim ... Link to item Cite

Adjunctive counseling during brief and extended buprenorphine-naloxone treatment for prescription opioid dependence: a 2-phase randomized controlled trial.

Journal Article Arch Gen Psychiatry · December 2011 CONTEXT: No randomized trials have examined treatments for prescription opioid dependence, despite its increasing prevalence. OBJECTIVE: To evaluate the efficacy of brief and extended buprenorphine hydrochloride-naloxone hydrochloride treatment, with diffe ... Full text Link to item Cite

Motivational enhancement therapy for African American substance users: a randomized clinical trial.

Journal Article Cultur Divers Ethnic Minor Psychol · October 2011 Limited empirical evidence concerning the efficacy of substance abuse treatments among African Americans reduces opportunities to evaluate and improve program efficacy. The current study, conducted as a secondary analysis of a randomized clinical trial con ... Full text Link to item Cite

Stimulant reduction intervention using dosed exercise (STRIDE) - CTN 0037: study protocol for a randomized controlled trial.

Journal Article Trials · September 19, 2011 BACKGROUND: There is a need for novel approaches to the treatment of stimulant abuse and dependence. Clinical data examining the use of exercise as a treatment for the abuse of nicotine, alcohol, and other substances suggest that exercise may be a benefici ... Full text Link to item Cite

Sample size calculations for evaluating a diagnostic test when the gold standard is missing at random.

Journal Article Stat Med · January 30, 2011 Full text Link to item Cite

Sample size calculations for evaluating a diagnostic test when the gold standard is missing at random.

Journal Article Stat Med · July 10, 2010 Performance of a diagnostic test is ideally evaluated by a comparison of the test results to a gold standard for all the patients in a study. In practice, however, it is common for a subset of study patients to have the gold standard not verified (missing) ... Full text Link to item Cite

Evaluation of a new heparin agent in percutaneous coronary intervention: results of the phase 2 evaluation of M118 IN pErcutaNeous Coronary intErvention (EMINENCE) Trial.

Journal Article Circulation · April 20, 2010 BACKGROUND: Factor Xa and factor IIa (thrombin) play roles in thrombotic complications after percutaneous coronary intervention. M118 is a novel low-molecular-weight heparin that has been rationally designed to capture the desired attributes of unfractiona ... Full text Link to item Cite

Effect of improving the quality of radiographic interpretation on the ability to predict pulmonary tuberculosis relapse.

Journal Article Acad Radiol · February 2010 Featured Publication RATIONALE AND OBJECTIVES: Chest radiographic findings are important for diagnosis and management of tuberculosis. The reliability of these findings is therefore of interest. We sought to describe interobserver reliability of chest radiographic findings in ... Full text Link to item Cite

RR-interval irregularity precedes ventricular fibrillation in ST elevation acute myocardial infarction.

Journal Article Heart Rhythm · January 2010 BACKGROUND: Sudden cardiac arrest is a leading cause of death in industrialized countries, and ischemic ventricular fibrillation (VF) is a frequent cause. OBJECTIVE: The purpose of this study was to determine whether patients with ST elevation myocardial i ... Full text Link to item Cite

Design and rationale of the Evaluation of M118 IN pErcutaNeous Coronary intErvention (EMINENCE) trial.

Journal Article Am Heart J · November 2009 Featured Publication BACKGROUND: Currently recommended anticoagulant agents used in the setting of percutaneous coronary intervention (PCI) inhibit, with varying degrees of intensity, 2 critical targets (factor Xa and/or IIa) of the coagulation cascade, yet they carry signific ... Full text Link to item Cite

Coronary artery bypass surgery compared with percutaneous coronary interventions for multivessel disease: a collaborative analysis of individual patient data from ten randomised trials.

Journal Article Lancet · April 4, 2009 Featured Publication BACKGROUND: Coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI) are alternative treatments for multivessel coronary disease. Although the procedures have been compared in several randomised trials, their long-term effects on mo ... Full text Link to item Cite

Reperfusion ventricular arrhythmia 'bursts' predict larger infarct size despite TIMI 3 flow restoration with primary angioplasty for anterior ST-elevation myocardial infarction.

Journal Article Eur Heart J · April 2009 Featured Publication Aims Successful epicardial reperfusion with primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI) can paradoxically evoke myocardial reperfusion injury, which may be signalled by temporally associated ventricular a ... Full text Link to item Cite

Clinical trials in sudden cardiac death prevention: Principles and endpoints

Journal Article · December 1, 2008 Research questions can be approached by means of observational studies, case-control studies, or randomized controlled trials (RCTs). Observational studies are often useful for developing research ideas, but are vulnerable to bias due to an uncontrolled pr ... Full text Cite

Reperfusion ventricular arrhythmia 'bursts' in TIMI 3 flow restoration with primary angioplasty for anterior ST-elevation myocardial infarction: a more precise definition of reperfusion arrhythmias.

Journal Article Europace · August 2008 Featured Publication AIMS: We sought to define reperfusion-induced ventricular arrhythmias (VAs) more precisely through simultaneous angiography, continuous ST-segment recovery, and beat-to-beat Holter analyses in subjects with anterior ST-elevation myocardial infarction (STEM ... Full text Link to item Cite

The role of RR-interval variability preceding ventricular fibrillation in ST elevation acute myocardial infarction

Conference CIRCULATION · October 16, 2007 Link to item Cite

Mechanistic and prognostic implications of "Burst" ventricular arrhythmias and their precise timing after TIMI 3 reperfusion in anterior ST elevation myocardial infarction

Journal Article CIRCULATION · October 16, 2007 Link to item Cite

Computer programs for the concordance correlation coefficient.

Journal Article Comput Methods Programs Biomed · October 2007 Featured Publication The CCC macro is presented for computation of the concordance correlation coefficient (CCC), a common measure of reproducibility. The macro has been produced in both SAS and R, and a detailed presentation of the macro input and output for the SAS program i ... Full text Link to item Cite

The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) trial.

Journal Article Neurology · June 12, 2007 BACKGROUND: Transcranial Doppler ultrasound (TCD) and magnetic resonance angiography (MRA) can identify intracranial atherosclerosis but have not been rigorously validated against the gold standard, catheter angiography. The WASID trial (Warfarin Aspirin S ... Full text Link to item Cite

CT angiography in the Stroke Outcomes and Neuroirnaging of Intracranial Atherosclerosis (SONIA) study

Conference JOURNAL OF NEUROSURGERY · May 1, 2007 Link to item Cite

Ventricular arrhythmia "bursts" in the setting of acute anterior infarct artery recanalization: A re-definition of "reperfusion arrhythmias"

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 6, 2007 Link to item Cite

Reperfusion "BURST" arrhythmias as a biomarker of myocellular damage despite TIMI 3 epicardial flow

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 6, 2007 Link to item Cite

CT angiography in the stroke outcomes and neuroimaging of intracranial atherosclerosis (SONIA) study

Conference STROKE · February 1, 2007 Link to item Cite

Decreasing CD4+ T-cell count during suppressed or low-level viraemia in patients with HIV infection.

Journal Article Antivir Ther · 2007 Featured Publication BACKGROUND: Suboptimal improvement in CD4+ T-cell count is not uncommon in HIV-infected patients with suppressed plasma HIV RNA levels, and a decrease in CD4+ T-cell count in patients with suppressed or low-level viraemia has been observed. METHODS: Our ob ... Link to item Cite

Comparison of concordance correlation coefficient and coefficient of individual agreement in assessing agreement.

Journal Article J Biopharm Stat · 2007 Featured Publication In method comparison and reliability studies, it is often important to assess agreement between multiple measurements made by different methods, devices, laboratories, observers, or instruments. For continuous data, the concordance correlation coefficient ... Full text Link to item Cite

Assessing individual agreement.

Journal Article J Biopharm Stat · 2007 Featured Publication Evaluating agreement between measurement methods or between observers is important in method comparison studies and in reliability studies. Often we are interested in whether a new method can replace an existing invasive or expensive method, or whether mul ... Full text Link to item Cite

The weighted generalized estimating equations approach for the evaluation of medical diagnostic test at subunit level.

Journal Article Biom J · August 2006 Featured Publication Sensitivity and specificity are common measures used to evaluate the performance of a diagnostic test. A diagnostic test is often administrated at a subunit level, e.g. at the level of vessel, ear or eye of a patient so that the treatment can be targeted a ... Full text Link to item Cite

A global sensitivity analysis of performance of a medical diagnostic test when verification bias is present.

Journal Article Stat Med · September 15, 2003 Featured Publication Current advances in technology provide less invasive or less expensive diagnostic tests for identifying disease status. When a diagnostic test is evaluated against an invasive or expensive gold standard test, one often finds that not all patients undergo t ... Full text Link to item Cite

Evaluating medical diagnostic tests at the subunit level in the presence of verification bias.

Journal Article Stat Med · July 15, 2003 Featured Publication We advocate that medical diagnostic tests should be evaluated at the subunit level instead of the patient level if a disease can occur in multiple parts/units within a patient, for example, vessels, segments, ears, eyes etc. When a non-invasive test is com ... Full text Link to item Cite

An estimated score method for missing and auxiliary covariates in two stage studies

Journal Article Journal of Statistical Planning and Inference · July 1, 2003 We consider the following type of two stage studies. First, a full scale study is conducted by observing an outcome Y, imperfect surrogate measure T of the unobserved covariate of interest X, and covariates U for all members of a cohort, where the cohort i ... Full text Cite

Accounting for nonignorable verification bias in assessment of diagnostic tests.

Journal Article Biometrics · March 2003 Featured Publication A "gold" standard test, providing definitive verification of disease status, may be quite invasive or expensive. Current technological advances provide less invasive, or less expensive, diagnostic tests. Ideally, a diagnostic test is evaluated by comparing ... Full text Link to item Cite

Prediction of native coronary artery disease progression following PTCA or CABG in the Emory Angioplasty Versus Surgery Trial.

Journal Article Med Sci Monit · February 2003 Featured Publication BACKGROUND: The natural history of atherosclerosis progression following revascularization procedures (PTCA or CABG) limits the long-term benefits of these procedures and requires continuation of risk management. MATERIAL/METHODS: Of 392 patients with mult ... Link to item Cite

Design, progress and challenges of a double-blind trial of warfarin versus aspirin for symptomatic intracranial arterial stenosis.

Journal Article Neuroepidemiology · 2003 Full text Link to item Cite

"Ignorance region" of sensitivity and specificity of a diagnostic test when not all patients are verified with a gold standard

Conference AMERICAN HEART JOURNAL · November 1, 2002 Link to item Cite

Cost and cost-effectiveness of an early invasive vs conservative strategy for the treatment of unstable angina and non-ST-segment elevation myocardial infarction.

Journal Article JAMA · October 16, 2002 Featured Publication CONTEXT: In the Treat Angina with Aggrastat and Determine Cost of Therapy with an Invasive or Conservative Strategy (TACTICS)-Thrombolysis in Myocardial Infarction (TIMI) 18 trial, patients with either unstable angina or non-ST-segment elevation myocardial ... Full text Link to item Cite

Intravascular radiation therapy after balloon angioplasty of narrowed femoropopliteal arteries to prevent restenosis: results of the PARIS feasibility clinical trial.

Journal Article J Vasc Interv Radiol · August 2001 Featured Publication PURPOSE: To conduct a feasibility study to assess the feasibility, safety, and outcome of endoluminal gamma radiation therapy after balloon angioplasty of superficial femoral artery (SFA) lesions. MATERIALS AND METHODS: Forty patients with claudication wer ... Full text Link to item Cite

Association of LDL heterogeneity and native coronary disease progression at 3 years following PTCA or CABG in EAST

Journal Article CIRCULATION · October 31, 2000 Link to item Cite

Association of total plasma homocyst(e)ine levels and 8-years mortality following PTCA or CABG in EAST

Journal Article CIRCULATION · October 31, 2000 Link to item Cite

Costs of revascularization over eight years in the randomized and eligible patients in the Emory Angioplasty versus Surgery Trial (EAST).

Journal Article Am J Cardiol · October 1, 2000 Featured Publication The Emory Angioplasty versus Surgery Trial (EAST) was a randomized trial that compared, by intention to treat, the clinical outcome and costs of percutaneous transluminal coronary angioplasty (PTCA) and coronary bypass grafting (CABG) for multivessel coron ... Full text Link to item Cite

Targeting patients undergoing angioplasty for thrombus inhibition: a cost-effectiveness and decision support model.

Journal Article Circulation · July 25, 2000 Featured Publication BACKGROUND: In recent clinical trials, glycoprotein IIb/IIIa blockers have demonstrated effectiveness in preventing adverse events after angioplasty in high-risk patients. However, uncertainty exists regarding the cost-effective selection of patients to re ... Full text Link to item Cite

Eight-year mortality in the Emory Angioplasty versus Surgery Trial (EAST).

Journal Article J Am Coll Cardiol · April 2000 Featured Publication OBJECTIVES: To evaluate the long-term outcome of patients randomized to coronary bypass surgery or coronary angioplasty. BACKGROUND: The Emory Angioplasty versus Surgery Trial (EAST) is a single center randomized comparison of a strategy of initial coronar ... Full text Link to item Cite

Applying the resource-based relative value scale to the Emory angioplasty versus surgery trial.

Journal Article Am J Cardiol · March 15, 2000 Featured Publication The resource-based relative value scale developed for use in the Medicare fee schedule can also be very useful in profiling and comparing physicians' cardiovascular utilization across different medical activities. This article applies relative value units ... Full text Link to item Cite

One year follow-up after intravascular radiation therapy following balloon angioplasty of narrowed femoral-popliteal arteries. Results of the PARIS feasibility clinical trial

Journal Article JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · February 1, 2000 Link to item Cite

Prognostic value of thallium-201 single-photon emission computed tomography for patients with multivessel coronary artery disease after revascularization (the Emory Angioplasty versus Surgery Trial [EAST]).

Journal Article Am J Cardiol · December 15, 1999 Featured Publication The aim of this study was to investigate the relation between reversible thallium single-photon emission computed tomography (SPECT) myocardial perfusion defects at 1-year after revascularization and quantitative indexes in Emory Angioplasty versus Surgery ... Full text Link to item Cite

Comparison of outcome after coronary angioplasty and coronary surgery for multivessel coronary artery disease in persons with diabetes.

Journal Article Am Heart J · November 1999 Full text Link to item Cite

Evaluating the exposure and disease relationship with adjustment for different types of exposure misclassification: a regression approach.

Journal Article Stat Med · October 30, 1999 Featured Publication Misclassification of exposure can lead to biased results in the epidemiologic research. Available methods accounting for misclassification often require the use of a gold standard or assume non-differential misclassification of exposure. We present a regre ... Full text Link to item Cite

Economic impact of GPIIB/IIIA blockade after high-risk angioplasty: results from the RESTORE trial. Randomized Efficacy Study of Tirofiban for Outcomes and Restenosis.

Journal Article J Am Coll Cardiol · October 1999 Featured Publication OBJECTIVE: This study was conducted to assess the impact of GPIIb/IIIa blockade with tirofiban on costs during the initial hospitalization and at 30 days among patients undergoing high-risk coronary angioplasty. BACKGROUND: GPIIb/IIIa blockers are a new cl ... Full text Link to item Cite

Can cardiovascular clinical characteristics be identified and outcome models be developed from an in-patient claims database?

Journal Article Am J Cardiol · July 15, 1999 The objective of this study was to assess whether administrative (claims) databases can be used to assess clinical variables and predict outcome. Although administrative databases are useful for assessing resource utilization, their utility for assessing c ... Full text Link to item Cite

A comparison of the Charlson comorbidity index derived from medical record data and administrative billing data.

Journal Article J Clin Epidemiol · February 1999 Featured Publication The objective of this article is to compare the Charlson comorbidity index derived from medical record data (Chart Index) with the same index derived from billing data (ICD-9 Index) to determine how well each predicted inpatient and 30-day mortality, lengt ... Full text Link to item Cite

Economics, health-related quality of life, and cost-effectiveness methods for the TACTICS (Treat Angina With Aggrastat [tirofiban]] and Determine Cost of Therapy with Invasive or Conservative Strategy)-TIMI 18 trial.

Journal Article Am J Cardiol · February 1, 1999 Concern over escalating health care costs has led to increasing focus on economics and assessment of outcome measures for expensive forms of therapy. This is being investigated in the Treat Angina With Aggrastat [tirofiban] and Determine Cost of Therapy wi ... Full text Link to item Cite

A regression model for multivariate random length data.

Journal Article Stat Med · January 30, 1999 Featured Publication Multivariate random length data occur when we observe multiple measurements of a quantitative variable and the variable number of these measurements is also an observed outcome for each experimental unit. For example, for a patient with coronary artery dis ... Full text Link to item Cite

A procedure for the detection of multivariate outliers

Journal Article Computational Statistics and Data Analysis · December 28, 1998 Single case diagnostics are susceptible to a masking effect. This has led to the development of methods for detecting of multiple multivariate outliers. The available methods work well but may not be able to always detect outliers in data with contaminatio ... Full text Cite

Association of plasma homocyst(e)ine levels and atherogenic risk factors with native coronary new lesion formation and graft disease after PTCA or CABG in EAST

Journal Article CIRCULATION · October 27, 1998 Link to item Cite

Eight year outcome in the emory angioplasty vs surgery trial

Journal Article CIRCULATION · October 27, 1998 Link to item Cite

Prospective, randomized trial comparing blood and oxygenated crystalloid cardioplegia in reoperative coronary artery bypass grafting.

Journal Article J Thorac Cardiovasc Surg · May 1998 Featured Publication OBJECTIVES: Reoperative coronary artery bypass grafting presents unique challenges for myocardial preservation. The purpose of this study was to compare oxygenated blood cardioplegia with oxygenated crystalloid cardioplegia during reoperative coronary arte ... Full text Link to item Cite

Concomitant aortic and renal artery reconstruction in patients on an intensive antihypertensive medical regimen: long-term outcome.

Journal Article Ann Vasc Surg · May 1998 Featured Publication A beneficial effect in blood pressure control is presumed for patients on an intensive preoperative antihypertensive regimen who undergo empiric renal revascularization. Nonetheless, a noticeable decline in surgical cure rates for hypertension has been rec ... Full text Link to item Cite

Power considerations when a continuous outcome variable is dichotomized.

Journal Article J Biopharm Stat · May 1998 Featured Publication An investigator can compare two groups with respect to a continuous outcome variable, Y, by comparing the means of Y or by collapsing that variable into categories. For example, antihypertensive treatments can be compared on the basis of blood pressure mea ... Full text Link to item Cite

Angiogenesis as a predictor of survival after surgical resection for stage I non-small-cell lung cancer.

Journal Article J Thorac Cardiovasc Surg · March 1998 Featured Publication OBJECTIVES: Some patients with surgically resected stage I non-small-cell lung cancer eventually have metastatic disease. A histologic marker of metastatic potential and diminished survival for stage I non-small-cell lung cancer may distinguish this patien ... Full text Link to item Cite

Aggressive lipid lowering in postcoronary angioplasty patients with elevated cholesterol (the Lovastatin Restenosis Trial).

Journal Article Am J Cardiol · March 1, 1998 Featured Publication A substudy of the Lovastatin Restenosis Trial in patients with elevated cholesterol (>200 mg/dl) showed no evidence of an effect of aggressive lipid lowering on restenosis, confirming the results of the main trial. ... Full text Link to item Cite

Effect of Plasma Homocyst(e)ine Levels on Adverse Cardiovascular Outcomes After PTCA or CABG in EAST

Journal Article Journal of the American College of Cardiology · February 1998 Full text Cite

ANOVA for repeated ordinal data with small sample size? A comparison of ANOVA, MANOVA, WLS and GEE methods by simulation

Journal Article Communications in Statistics Part B Simulation and Computation · January 1, 1998 Repeated ordinal outcomes are common in behavioral and medical sciences. Due to the familiarity, simplicity and robustness of ANOVA methodology, this approach has been frequently used for repeated ordinal data. Weighted least squares (WLS) and generalized ... Full text Cite

An Evaluation of the Utility of Intravascular Ultrasound in an Endovascular Practice

Journal Article Vascular and Endovascular Surgery · January 1, 1998 Intravascular ultrasound (IVUS) has been shown to be superior to arteriography for measuring luminal stenosis and characterizing plaque morphology and content. However, IVUS has not been routinely adopted during endovascular interventions, which may be due ... Full text Cite

Outcome of coronary bypass surgery versus coronary angioplasty in diabetic patients with multivessel coronary artery disease.

Journal Article J Am Coll Cardiol · January 1998 OBJECTIVES: This study sought to compare the outcome of percutaneous transluminal coronary angioplasty (PTCA) (n = 834) and coronary artery bypass graft surgery (CABG) (n = 1805) in diabetic patients with multivessel coronary disease from an observational ... Full text Link to item Cite

Late survival after valve operation in patients with left ventricular dysfunction.

Journal Article Ann Thorac Surg · October 1997 Featured Publication BACKGROUND: Left ventricular dysfunction is a predictor of hospital mortality after cardiac valve operation. We evaluated late survival in a large cohort of these patients. METHODS: From 1980 to 1993, 257 patients with a preoperative ejection fraction of 0 ... Full text Link to item Cite

Angioplasty or surgery for multivessel coronary artery disease: comparison of eligible registry and randomized patients in the EAST trial and influence of treatment selection on outcomes. Emory Angioplasty versus Surgery Trial Investigators.

Journal Article Am J Cardiol · June 1, 1997 Featured Publication The Emory Angioplasty versus Surgery Trial (EAST) showed that multivessel patients eligible for both percutaneous transluminal coronary angioplasty (PTCA) and coronary bypass surgery (CABG) had equivalent 3-year outcomes regarding survival, myocardial infa ... Full text Link to item Cite

A new method for analysis of case-control studies that involve misclassified exposures.

Journal Article AMERICAN JOURNAL OF EPIDEMIOLOGY · June 1, 1997 Link to item Cite

Economic winners and losers after introduction of an effective new therapy depend on the type of payment system.

Journal Article Am J Manag Care · May 1997 An effective therapy for a costly illness has economic consequences. There may also be differences between provider costs and payer costs and initial versus long-term costs; costs may also vary with the reimbursement scheme. Consider the case of an effecti ... Link to item Cite

Tubal ligation and fatal ovarian cancer in a large prospective cohort study.

Journal Article Am J Epidemiol · February 15, 1997 Featured Publication Several studies suggest that tubal sterilization may decrease the risk of ovarian cancer. Data from the Cancer Prevention Study II were analyzed to examine the relation between tubal ligation and ovarian cancer mortality in a large prospective study. A tot ... Full text Link to item Cite

Is there a bias against performing coronary revascularization in women?

Journal Article Am J Cardiol · November 15, 1996 Featured Publication This study compares referral to coronary revascularization after diagnostic cardiac catheterization in 8,133 women and 25,785 men. Although gender played a role, angiographic severity of coronary disease was the most important determinant of the selection ... Link to item Cite

Long term survival after aortic or mitral valve operation in patients with left ventricular dysfunction

Journal Article CIRCULATION · October 15, 1996 Link to item Cite

Empirical reconstruction of the renal artery: long-term outcome.

Journal Article J Vasc Surg · September 1996 Featured Publication PURPOSE: Unequivocal indications for renal artery reconstruction remain the presence of significant underlying renal insufficiency or severe hypertension. Thus surgical intervention for renal artery stenosis in the absence of this clinical picture may well ... Full text Link to item Cite

Relation of lumen size to restenosis after percutaneous transluminal coronary balloon angioplasty. Lovastatin Restenosis Trial Group.

Journal Article Am J Cardiol · July 15, 1996 Featured Publication The relation between post-percutaneous transluminal balloon angioplasty (post-PTCA) and angiography indexes were investigated in the Lovastatin Restenosis Trial. Post-PTCA percent diameter measured by the operator was found to be a weak predictor of angiog ... Link to item Cite

The importance of work-up (verification) bias correction in assessing the accuracy of SPECT thallium-201 testing for the diagnosis of coronary artery disease.

Journal Article J Clin Epidemiol · July 1996 Featured Publication Noninvasive testing is often evaluated by the sensitivity and specificity in comparison with a more invasive, but more definitive "gold" standard. However, work-up or verification bias, which occurs when the results of a noninvasive test impact the decisio ... Full text Link to item Cite

Effectiveness of revascularization in the Emory angioplasty versus surgery trial. A randomized comparison of coronary angioplasty with bypass surgery.

Journal Article Circulation · June 1, 1996 Featured Publication BACKGROUND: The Emory Angioplasty Versus Surgery Trial (EAST) was designed to determine whether percutaneous transluminal coronary angioplasty (PTCA) is as effective as coronary artery bypass graft surgery (CABG) in restoring arterial perfusion capacity in ... Full text Link to item Cite

Quantitative SPECT Thallium indices predict outcomes in Emory angioplasty versus surgery trial (EAST).

Journal Article JOURNAL OF NUCLEAR MEDICINE · May 1, 1996 Link to item Cite

Stress Thallium SPECT is equally effective for predicting outcomes for women and men in the Emory angioplasty versus surgery trial (EAST).

Journal Article JOURNAL OF NUCLEAR MEDICINE · May 1, 1996 Link to item Cite

Prospective, randomized trial comparing blood and crystalloid cardioplegia in reoperative CABG surgery

Journal Article ANESTHESIA AND ANALGESIA · April 1, 1996 Link to item Cite

Economic winners and losers after introduction of an effective new therapy depend on the type of payment system

Journal Article Journal of Investigative Medicine · January 1, 1996 An effective therapy for a costly illness will have economic consequences. There may also be differences between providers and payers costs, initial versus long term costs, and costs may vary with the reimbursement scheme. Consider the case of an effective ... Cite

A comparison of the costs of and quality of life after coronary angioplasty or coronary surgery for multivessel coronary artery disease. Results from the Emory Angioplasty Versus Surgery Trial (EAST).

Journal Article Circulation · November 15, 1995 Featured Publication BACKGROUND: The Emory Angioplasty Versus Surgery Trial (EAST) is a randomized trial that compares, by intention to treat, the clinical outcome and costs of percutaneous transluminal coronary angioplasty (PTCA) and coronary surgery for multivessel coronary ... Full text Link to item Cite

LONG-TERM FOLLOW-UP IN PATIENTS WITH ABNORMAL THALLIUM SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY (SPECT) AND NORMAL CORONARY-ARTERIES

Journal Article CIRCULATION · October 15, 1995 Link to item Cite

5-YEAR OUTCOME AFTER CORONARY SURGERY OR CORONARY ANGIOPLASTY - RESULTS FROM THE EMORY ANGIOPLASTY VS SURGERY TRIAL (EAST)

Journal Article CIRCULATION · October 15, 1995 Link to item Cite

QUANTITATIVE THALLIUM SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY PREDICTS RISK FOR POOR OUTCOME IN THE EMORY ANGIOPLASTY SURGERY TRIAL

Journal Article CIRCULATION · October 15, 1995 Link to item Cite

Percutaneous transluminal coronary angioplasty as a first revascularization procedure in single-, double- and triple-vessel coronary artery disease.

Journal Article J Am Coll Cardiol · July 1995 Featured Publication OBJECTIVES: We sought to compare in-hospital and long-term outcome after angioplasty in patients with single-, double- and triple-vessel disease. BACKGROUND: Coronary angioplasty is increasingly used in patients with multivessel disease. METHODS: The sourc ... Full text Link to item Cite

Emory Angioplasty Versus Surgery Trial (EAST): design, recruitment, and baseline description of patients.

Journal Article Am J Cardiol · March 23, 1995 Featured Publication In patients with multivessel coronary artery disease who require revascularization there is uncertainty as to the selection of the appropriate patients for percutaneous transluminal coronary angioplasty (PTCA) as opposed to coronary artery bypass grafting ... Link to item Cite

Methodology to correct for differential misclassification.

Journal Article Epidemiology · March 1995 Featured Publication Misclassification of exposure is a serious problem in epidemiology. Methods for addressing misclassification are available, but most are based on limiting assumptions such as availability of a "gold standard" measure of true exposure, or availability of tw ... Full text Link to item Cite

Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease.

Journal Article N Engl J Med · February 23, 1995 Featured Publication BACKGROUND: Impaired endothelium-mediated relaxation contributes to vasospasm and myocardial ischemia in patients with coronary artery disease. We hypothesized that cholesterol-lowering therapy with the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhib ... Full text Link to item Cite

Lack of effect of lovastatin on restenosis after coronary angioplasty. Lovastatin Restenosis Trial Study Group.

Journal Article N Engl J Med · November 17, 1994 Featured Publication BACKGROUND: Experimental and clinical observations suggest that lowering serum lipid levels may reduce the risk of restenosis after coronary angioplasty. We report the results of a prospective, randomized, double-blind trial evaluating whether lowering lip ... Full text Link to item Cite

A randomized trial comparing coronary angioplasty with coronary bypass surgery. Emory Angioplasty versus Surgery Trial (EAST).

Journal Article N Engl J Med · October 20, 1994 Featured Publication BACKGROUND: The clinical benefit of percutaneous transluminal coronary angioplasty (PTCA) as compared with coronary-artery bypass grafting (CABG) for patients with multivessel coronary artery disease has not been established. To determine the outcomes of t ... Full text Link to item Cite

ARTERIOGRAPHICALLY DEFINED REASONS FOR ADDITIONAL PROCEDURES IN EAST

Journal Article CIRCULATION · October 1, 1994 Link to item Cite

Percutaneous transluminal coronary angioplasty in women compared with men.

Journal Article J Am Coll Cardiol · July 1994 Featured Publication OBJECTIVES: This study compares in-hospital and long-term outcome after angioplasty in women and men. BACKGROUND: The recognition that coronary artery disease is the most common cause of death in women has increased interest in outcome studies of coronary ... Full text Link to item Cite

THE IMPORTANCE OF WORK-UP BIAS CORRECTION IN ASSESSING THE ACCURACY OF SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHIC STRESS TL-201 TESTING

Journal Article CLINICAL RESEARCH · April 1, 1994 Link to item Cite

A prospective evaluation of surgically treated groin complications following percutaneous cardiac procedures.

Journal Article Am Surg · February 1994 Featured Publication During an 18-month study period, 100 noncardiac surgical complications of a percutaneous cardiac interventional procedure were treated at Emory University Hospital. These were predominantly pseudoaneurysms (61.2%), groin hematomas (11.2%) arteriovenous fis ... Link to item Cite

Ischemic nephropathy and concomitant aortic disease: a ten-year experience.

Journal Article J Vasc Surg · January 1994 Featured Publication PURPOSE: The durability of renal preservation after surgical intervention has not been well defined, particularly in patients with associated aortic disease. A review of all patients at the Emory University Hospital with renal insufficiency (creatinine lev ... Full text Link to item Cite

Acute lower extremity ischemia after cardiac surgery.

Journal Article Am J Surg · August 1993 Featured Publication A retrospective review during a 5-year period (1987 to 1992) was conducted of all patients manifesting leg ischemia after major cardiac surgery. There were 7,620 procedures performed, and 65 (0.85%) patients (mean age: 65 years) were identified with acute ... Full text Link to item Cite

Use of two data sources to estimate odds ratios in case-control studies.

Journal Article Epidemiology · July 1993 Featured Publication Information bias is among the most serious and common problems in epidemiology. Approaches have been developed to reduce information bias by correcting for known amounts of misclassification. Unfortunately, in most studies, the extent of exposure misclassi ... Full text Link to item Cite

Can restenosis after coronary angioplasty be predicted from clinical variables?

Journal Article J Am Coll Cardiol · January 1993 Featured Publication OBJECTIVES: The purpose of this study was to determine whether variables shown to correlate with restenosis in one group (learning group) could be shown to predict recurrent stenosis in a second group (validation group). BACKGROUND: Restenosis remains a cr ... Full text Link to item Cite

Early mortality of acute myocardial infarction in patients with and without prior coronary revascularization surgery. A Coronary Artery Surgery Study Registry Study.

Journal Article Circulation · June 1992 Featured Publication BACKGROUND: The Coronary Artery Surgery Study (CASS) Registry is used to evaluate the effect of various baseline clinical and angiographic factors on mortality after acute out-of-hospital myocardial infarction (MI) in patients with and without prior corona ... Full text Link to item Cite

Analysing the relationship between change in a risk factor and risk of disease.

Journal Article Stat Med · April 1992 Featured Publication There are numerous examples in the epidemiologic literature of analyses that relate the change in a risk factor, such as serum cholesterol, to the risk of an adverse outcome, such as heart disease. Many of these analyses fit some type of regression model ( ... Full text Link to item Cite

The relationship between cholesterol level and myocardial infarction or mortality risk in patients with coronary artery disease. A report from the Coronary Artery Surgery Study (CASS) registry.

Journal Article Ann Epidemiol · 1992 Featured Publication Using data from the Coronary Artery Surgery Study (CASS) registry, we evaluated the relationship between cholesterol levels measured at enrollment and the following events: all-cause mortality, cardiac death, fatal myocardial infarction (MI), and nonfatal ... Full text Link to item Cite

Improved survival of surgically treated patients with triple vessel coronary artery disease and severe angina pectoris. A report from the Coronary Artery Surgery Study (CASS) registry.

Journal Article J Thorac Cardiovasc Surg · April 1989 Featured Publication We examined survival rates during a 6-year follow-up of patients in the registry of the Coronary Artery Surgery Study who had three vessel coronary artery disease and Canadian Cardiovascular Society class III-IV angina pectoris. All patients had a stenosis ... Link to item Cite

Anomalous coronary arteries: location, degree of atherosclerosis and effect on survival--a report from the Coronary Artery Surgery Study.

Journal Article J Am Coll Cardiol · March 1, 1989 Featured Publication Limited information is available about clinical presentation, degree of atherosclerosis and effect on overall survival in a large series of patients with coronary artery anomalies. From the National Heart, Lung, and Blood Institute Multicenter Coronary Art ... Full text Link to item Cite

Prevalence and significance of atrial fibrillation in coronary artery disease (CASS Registry).

Journal Article Am J Cardiol · April 1, 1988 Featured Publication Estimates of the prevalence of atrial fibrillation (AF) in patients with coronary artery disease have varied from "frequent" to less than 2%. Data on 18,343 patients with angiographically demonstrated CAD in the Coronary Artery Surgery Study (CASS) registr ... Full text Link to item Cite

Utilization of the National Death Index-A classification problem. Impact of changes in the NDI matching criteria evaluated with the Coronary Artery Surgery Study (CASS) data

Journal Article Controlled Clinical Trials · January 1, 1988 Full text Cite