Andrew John Liu
Assistant Professor of Neurology

While striving to provide excellent clinical care, I also have several research interests:

1. Investigate a neurodevelopmental disorder, Tuberous Sclerosis Complex, which has the potential to provide insight into the pathophysiological mechanism of a neurodegenerative disorders, Alzheimer's Disease. 

2. In collaboration with Dr. Cathrine Hoyo, we are investigating an epigenetic mechanism to explain the racial disparities in the development of Alzheimer's disease between underrepresented minorities and European Americans.

3. I am  interested in clinically characterizing the long-term cognitive and behavioral consequences in convalescent COVID-19 patients.

Current Research Interests

Tuberous Sclerosis Complex (TSC) is considered an infantile tauopathy due to mutations in TSC1  and TSC2.  These mutations leads to hyperactivation of a centralized intracellular pathway called mammalian Target of Rapamycin (mTOR). Our publication in 2022 described how TSC patients are accumulation an isotype of phosphorylated tau more commonly seen in Alzheimer's Disease. Further investigating TSC has the potential to lead to a pathophysiological mechanism of phosphorylated tau and novel treatments for both TSC and Alzheimer's Disease patients.

Dr. Cathrine Hoyo and I are investigating the relationship between prenatal stress and epigenetic changes. This relationship may explain why underrepresented minorities develop Alzheimer's Disease dementia at least twice as often when compared to European Americans.

Lastly, I have an interest in comprehensively characterizing convalescent COVID-19 patients to determine the cognitive, psychiatric and behavioral consequences of this disorder longitudinally.

Current Appointments & Affiliations

Contact Information

  • 932 Morreene Rd, Room 258, Durham, NC 27705
  • 932 Morreene Rd., Rm 258, Durham, NC 27705
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