Scholars@Duke
William Jonathan Parsons

William Jonathan Parsons

Assistant Professor of Medicine
Medicine, Cardiology

Selected Publications

Typhoid fever.

Chapter · December 14, 2023 Typhoid fever is an invasive bacterial disease associated with bloodstream infection that causes a high burden of disease in Africa and Asia. Typhoid primarily affects individuals ranging from infants through to young adults. The causative organism, Salmon ... Full text Link to item Cite

Myocardial oxygenation in dogs during reactive hyperemia.

Journal Article J Biomed Opt · April 1998 The mechanisms of myocardial oxygenation during reactive hyperemia were studied in the beating heart using continuous near infrared (NIR) spectroscopy. In open chest dogs, NIR spectroscopy was used to monitor brief occlusions of the left anterior descendin ... Full text Link to item Cite

Predicting adverse outcome with exercise SPECT technetium-99m sestamibi imaging in patients with suspected or known coronary artery disease.

Journal Article Am J Cardiol · February 1, 1997 The goal of this study was to determine the ability of exercise single-photon emission computed tomographic (SPECT) technetium-99m (Tc-99m) sestamibi imaging to predict adverse events in a population with a comparable distribution of men (n = 114) and wome ... Full text Link to item Cite

Differential sympathetic neural control of oxygenation in resting and exercising human skeletal muscle.

Journal Article J Clin Invest · July 15, 1996 Metabolic products of skeletal muscle contraction activate metaboreceptor muscle afferents that reflexively increase sympathetic nerve activity (SNA) targeted to both resting and exercising skeletal muscle. To determine effects of the increased sympathetic ... Full text Link to item Cite

Developmental regulation of cytochrome oxidase subunit VIa isoforms in cardiac and skeletal muscle.

Journal Article Am J Physiol · February 1996 Physiological requirements for mitochondrial respiration change during fetal and postnatal development of cardiac and skeletal muscle, particularly after the abrupt transition from the hypoxic fetal environment to the oxygen-rich milieu of the neonate. Thi ... Full text Link to item Cite

Subcellular partitioning of MRP RNA assessed by ultrastructural and biochemical analysis.

Journal Article J Cell Biol · March 1994 A small RNA encoded within the nucleus is an essential subunit of a RNA processing endonuclease (RNase MRP) hypothesized to generate primers for mitochondrial DNA replication from the heavy strand origin of replication. Controversy has arisen, however, con ... Full text Link to item Cite

Myocardial oxygenation in dogs during partial and complete coronary artery occlusion.

Journal Article Circ Res · September 1993 Regional myocardial oxygenation was assessed during partial and complete coronary artery occlusion using near infrared spectroscopy. In eight open-chest dogs, partial occlusions resulting in an approximately 42% decrease in left anterior descending coronar ... Full text Link to item Cite

Sequence elements required for transcriptional activity of the human myoglobin promoter in intact myocardium.

Journal Article Circ Res · August 1993 To define sequence elements required for myoglobin gene transcription in the intact heart, we examined the expression of a reporter gene under the control of a 380-bp upstream segment (-373 to +7) from the human myoglobin gene in transgenic mouse embryos a ... Full text Link to item Cite

Gradients of transgene expression directed by the human myoglobin promoter in the developing mouse heart.

Journal Article Proc Natl Acad Sci U S A · March 1, 1993 Prior studies using transient transfection assays in cultured avian and murine skeletal myotubes indicate that the proximal 2-kb segment of the 5' flanking region of the human myoglobin gene contains transcriptional control elements sufficient to direct mu ... Full text Link to item Cite

Reciprocal expression of cytochrome oxidase genes during murine myogenesis (Abstract)

Other Journal of the American College of Cardiology · 1993 Presented at the 42nd ACC National Meeting, Anaheim, CA, 1993. ... Cite

Regional myocardial oxygenation during adenosine-mediated hyperemia (Abstract)

Other Circulation · 1993 Presented at the 66th AHA National Meetings, Atlanta, GA, 1993. ... Cite

The human myoglobin promoter directs chamber-specific and transmurally heterogeneous transcription in hearts of transgenic mice (Abstract)

Other Journal of the American College of Cardiology · 1992 Presented at the 41st ACC National Meeting, Dallas, TX, 1992. ... Cite

The fetal pattern of cytochrome c oxidase isogene expression is recapitulated by tonic exercise (Abstract)

Other Circulation · 1992 Presented at the 65th AHA National Meetings, New Orleans, LA, 1992. ... Cite

Partial coronary occlusion is associated with depletion of tissue oxygen stores (Abstract)

Other Journal of the American College of Cardiology · 1991 Presented at the 40th ACC National Meeting, Atlanta, GA, 1991. ... Cite

In vivo relationship of cardiac 02 consumption to cytochrome a,a3 oxidation level during ischemia and reperfusion (Abstract)

Other The FASEB Journal · 1991 Presented at the National FASEB Meeting, Atlanta, GA, 1991 ... Cite

Dynamic mechanisms of cardiac oxygenation during brief ischemia and reperfusion.

Journal Article Am J Physiol · November 1990 Myocardial oxygenation may be altered markedly by changes in tissue blood flow. During brief ischemia and reperfusion produced by transient occlusion of the left anterior descending artery in 10 open-chest dogs, changes in the oxygenation of tissue hemoglo ... Full text Link to item Cite

Left ventricular end diastolic wall thickness and tissue blood volume during brief ischemia and reperfusion (Abstract)

Other Journal of the American College of Cardiology · 1990 Presented at the 39th ACC National Meeting, New Orleans, LA, 1990. ... Cite

Reactive hyperemia is closely associated with repayment of myocardial oxygen debt (Abstract)

Other Circulation · 1990 Presented at the 63rd AHA National Meetings, Dallas, TX, 1990. ... Cite

In vivo near infrared monitoring of myocardial oxygenation during ischemia and reperfusion (Abstract)

Other Journal of the American College of Cardiology · 1989 Presented at the 38th ACC National Meeting, Anaheim, CA, 1989. ... Cite

Increased extraction of tissue oxygen stores: An in vivo mechanism of myocardial oxygenation during early ischemia (Abstract)

Other Clinical Research · 1989 Presented at the National AFCR Meeting, Washington, D.C., 1989. ... Cite

Dynamic mechanisms of cardiac oxygenation during brief ischemia and reperfusion (Abstract)

Other Circulation · 1989 Presented at the 62nd AHA National Meetings, New Orleans, LA, 1989. ... Cite

Isobutylmethylxanthine stimulates adenylate cyclase by blocking the inhibitory regulatory protein, Gi.

Journal Article Mol Pharmacol · July 1988 The methylxanthines, such as caffeine and theophylline, are an important and widely used class of drugs, which are believed to mediate many of their physiological effects by increasing intracellular concentrations of cAMP. These agents are known to inhibit ... Link to item Cite

The new cardiotonic agent sulmazole is an A1 adenosine receptor antagonist and functionally blocks the inhibitory regulator, Gi.

Journal Article Mol Pharmacol · April 1988 Although many of the new cardiotonic agents are known to increase cAMP and to inhibit with variable potency a low Km cAMP phosphodiesterase, there is still debate as to the mechanism(s) by which these agents act. In a rat adipocyte membrane model we demons ... Link to item Cite

High dose urokinase for acute myocardial infarction results in high rate of sustained infarct artery patency (Abstract)

Other Circulation · 1988 Presented at the 61st AHA National Meetings, Washington, D.C., 1988. ... Cite

Heterologous desensitization of the inhibitory A1 adenosine receptor-adenylate cyclase system in rat adipocytes. Regulation of both Ns and Ni.

Journal Article J Biol Chem · January 15, 1987 Adenosine, acting via A1 adenosine receptors, can inhibit adenylate cyclase activity in adipocytes. To assess the effects of chronic adenosine agonist exposure on the A1 adenosine receptor system of adipocytes, rats were infused with (-)-phenylisopropylade ... Link to item Cite

Salmonella Infections

Chapter · 1987 Cite

The methylxanthines stimulate adenylate cyclase by blocking the inhibitory regulator, Gi (Abstract)

Other Clinical Research · 1987 Presented at the AFCR National Meeting, San Diego, CA, 1987. ... Cite

The new positive inotropes inhibit guanine nucleotide binding proteins (Abstract)

Other Circulation · 1987 Presented at the 60th AHA National Meetings, Anaheim, CA, 1987. ... Cite

The rat testicular A1 adenosine receptor-adenylate cyclase system.

Journal Article Endocrinology · October 1986 When adenosine interacts with membrane-bound A1 receptors, it is capable of inhibiting the enzyme adenylate cyclase in brain and fat tissue. In this paper we characterize the A1 adenosine receptor-adenylate cyclase system of the rat testes. The agonist rad ... Full text Link to item Cite

Heterologous desensitization of the A1 adenosine receptor adenylate cyclase system (Abstract)

Other Circulation · 1986 Presented at the 59th AHA National Meetings, Dallas, TX, 1986. ... Cite

Methylxanthines as adenosine receptor antagonists.

Journal Article Ann Intern Med · October 1985 Full text Link to item Cite

Acute cholecystitis due to Aeromonas hydrophila

Journal Article New York state journal of medicine · 1985 Cite

Separation and partial characterization of fractions derived from frog lung homogenates. A possible marker system for amphibian pulmonary surfactant.

Journal Article Journal of Histochemistry & Cytochemistry · December 1977 The purpose of this study is to determine if inframammalian vertebrate (amphibian) lung contains certain nonspecific esterases that have been identified as enzyme markers for mammalian (rat and mouse) pulmonary surfactant. Density gradient centrif ... Full text Cite