Birgit Frauscher

Journal Article Neurology · January 27, 2026 BACKGROUND AND OBJECTIVES: Epilepsy surgery outcomes after intracranial EEG remain suboptimal necessitating the discovery of additional biomarkers to define the epileptogenic zone. Fast ripples (FRs) are a promising, new interictal epilepsy biomarker. By a ... Full text Link to item Cite

Timing is everything: Expert opinion on researching epilepsy rhythms by the ILAE Task Force on Chronobiology.

Journal Article Epilepsia · January 3, 2026 Recurrent seizures, the hallmark of epilepsy, are influenced by rhythms operating over multiple timescales. Chronobiology is the study of biological timing that aims to explain temporal patterns of events like seizures. Fueled by recent advances in genetic ... Full text Link to item Cite

Seminars in epileptology: Presurgical epilepsy evaluation.

Journal Article Epileptic Disord · December 2025 All patients with drug-resistant seizures benefit from a comprehensive evaluation to confirm their seizure diagnosis and explore surgical treatment options. This seminar in epileptology discusses advancements in the field and provides specific didactic mat ... Full text Link to item Cite

Sleep Related Movement Disorders: What's New and Changing Clinical Practice.

Journal Article J Sleep Res · December 2025 Restless legs syndrome (RLS) is a common sensorimotor disorder, and the most common sleep-related movement disorder with a prevalence of up to 15% in the European and US population. This review addresses key aspects of RLS, focusing on novel data that have ... Full text Link to item Cite

A practical guide to the updated seizure classification 2025.

Journal Article Epileptic Disord · December 2025 This paper provides a practical guide to applying the updated seizure classification in clinical settings. The updated classification, published by the International League Against Epilepsy in 2025, builds on the operational classification introduced in 20 ... Full text Link to item Cite

Personalized biomarkers of multiscale functional alterations in temporal lobe epilepsy.

Journal Article Nat Commun · November 19, 2025 Temporal lobe epilepsy (TLE) is the most common pharmacoresistant epilepsy in adults, yet few patients receive curative surgery due to diagnostic and prognostic uncertainty. In a multicenter cohort, we analyzed multimodal MRI and clinical data from 282 TLE ... Full text Link to item Cite

Updated classification of epileptic seizures: position paper of the International League Against Epilepsy

Journal Article Clinical Epileptology · November 1, 2025 The International League Against Epilepsy (ILAE) has updated the operational classification of epileptic seizures, building upon the framework established in 2017. This revision included the published experiences with the implementation of the classificati ... Full text Cite

Response to the comment on: Reduction of interictal epileptic burden by pulsatile corticoid therapy in children with drug-resistant epilepsy-How stable is the effect?

Journal Article Epileptic Disord · October 30, 2025 Full text Link to item Cite

Dreaming in patients with epilepsy: a cross-sectional cohort study.

Journal Article J Sleep Res · October 2025 Epilepsy impacts cognition during wakefulness. As epileptic activity is present and even augmented during sleep, epilepsy could also influence sleep-related cognitive processes. However, whether epilepsy modulates sleep-related experiences like dreaming re ... Full text Link to item Cite

Responsive neurostimulation detections: "Recognizing the unseen".

Journal Article Epileptic Disord · October 2025 BACKGROUND: Closed-loop responsive neurostimulation (RNS) is an established non-resective neuromodulatory therapy for individuals with drug-resistant epilepsy (DRE). RNS systems are typically programmed to detect and respond to predefined seizure onset pat ... Full text Open Access Link to item Cite

Seminar in Epileptology: Normal awake and sleep patterns, interictal abnormalities, and ictal patterns on scalp EEG.

Journal Article Epileptic Disord · October 2025 The accurate interpretation of scalp EEG remains an instrumental diagnostic component of epilepsy care. Knowledge of what constitutes normal EEG findings, non-epileptiform abnormalities, and epileptiform patterns-both ictal and interictal-is essential for ... Full text Link to item Cite

HippoMaps: multiscale cartography of human hippocampal organization.

Journal Article Nat Methods · October 2025 The hippocampus has a specialized microarchitecture, is situated at the nexus of multiple macroscale functional networks, contributes to numerous cognitive as well as affective processes and is highly susceptible to brain pathology across common disorders. ... Full text Link to item Cite

Visual Features in Stereo-Electroencephalography to Predict Surgical Outcome: A Multicenter Study.

Journal Article Ann Neurol · September 2025 OBJECTIVE: Epilepsy surgery needs predictive features that are easily implemented in clinical practice. Previous studies are limited by small sample sizes, lack of external validation, and complex computational approaches. We aimed to identify and validate ... Full text Open Access Link to item Cite

The state of vigilance and not antiseizure medication dosage drive variability in interictal epilepsy biomarkers.

Journal Article Clin Neurophysiol · September 2025 OBJECTIVE: During presurgical intracranial electroencephalography (iEEG) investigation, anti-seizure medication (ASM) is typically tapered to record seizures. Interictal biomarkers are critical for epileptogenic zone (EZ) localization. This study examines ... Full text Link to item Cite

Spectral and network investigation reveals distinct power and connectivity patterns between phasic and tonic REM sleep.

Journal Article Sleep · August 14, 2025 Although rapid eye movement (REM) sleep is often thought of as a singular state, it consists of two substates, phasic and tonic REM, defined by the presence (respectively absence) of bursts of rapid eye movements. These two substates have distinct EEG sign ... Full text Link to item Cite

Reduction of interictal epileptic burden by pulsatile corticoid therapy in children with drug-resistant epilepsy-How stable is the effect?

Journal Article Epileptic Disord · August 2025 OBJECTIVE: The systematic use of pulsatile corticosteroid therapy (PCT) in children with drug-resistant epilepsy has been shown to reduce epileptic activity. However, it remains unclear how long this effect will last. The objective of this study was theref ... Full text Link to item Cite

Widespread decoupling of spindles and slow waves in temporal lobe epilepsy.

Journal Article Epilepsia · July 2025 OBJECTIVE: Memory impairment is common in people with temporal lobe epilepsy (TLE). Recent studies in healthy subjects showed a positive correlation between sleep spindles coupled to slow waves (SWs) and memory performance. We aimed to determine difference ... Full text Link to item Cite

The class imbalance problem in automatic localization of the epileptogenic zone for epilepsy surgery: a systematic review.

Journal Article J Neural Eng · June 26, 2025 Objective.Accurate localization of the epileptogenic zone (EZ) is crucial for epilepsy surgery, but the class imbalance of epileptogenic vs. non-epileptogenic electrode contacts in intracranial electroencephalography (iEEG) data poses significant challenge ... Full text Link to item Cite

Alterations in Cortical Microstructure, Morphology, and Intrinsic Local Function in Spiking Tissue in Patients With Focal Epilepsy.

Journal Article Neurology · June 24, 2025 BACKGROUND AND OBJECTIVES: Epilepsy is increasingly conceptualized as a network disorder, and advancing methods for its diagnosis and treatment requires characterizing both the epileptic generator and related networks. Previous research has highlighted alt ... Full text Link to item Cite

Updated classification of epileptic seizures: Position paper of the International League Against Epilepsy.

Journal Article Epilepsia · June 2025 The International League Against Epilepsy (ILAE) has updated the operational classification of epileptic seizures, building upon the framework established in 2017. This revision, informed by the implementation experience, involved a working group appointed ... Full text Link to item Cite

Multicentre analysis of seizure outcome predicted by removal of high-frequency oscillations.

Journal Article Brain · May 13, 2025 In drug-resistant focal epilepsy, planning surgical resection can involve presurgical intracranial EEG (iEEG) recordings to detect seizures and other iEEG patterns to improve postsurgical seizure outcome. We hypothesized that resection of tissue generating ... Full text Link to item Cite

The Awakening Brain is Characterized by a Widespread and Spatiotemporally Heterogeneous Increase in High Frequencies.

Journal Article Adv Sci (Weinh) · May 2025 Morning awakening is part of everyday life. Surprisingly, information remains scarce on its underlying neurophysiological correlates. Here simultaneous polysomnography and stereo-electroencephalography recordings from 18 patients are used to assess the spe ... Full text Link to item Cite

Mechanistic insights into the interaction between epilepsy and sleep.

Journal Article Nat Rev Neurol · April 2025 Epidemiological evidence has demonstrated associations between sleep and epilepsy, but we lack a mechanistic understanding of these associations. If sleep affects the pathophysiology of epilepsy and the risk of seizures, as suggested by correlative evidenc ... Full text Link to item Cite

Thank you to our reviewers in 2024

Journal Article Epileptic Disorders International Epilepsy Journal with Videotape · April 1, 2025 Full text Cite

Temporal Lobe Epilepsy Perturbs the Brain-Wide Excitation-Inhibition Balance: Associations with Microcircuit Organization, Clinical Parameters, and Cognitive Dysfunction.

Journal Article Adv Sci (Weinh) · March 2025 Excitation-inhibition (E/I) imbalance is theorized as a key mechanism in the pathophysiology of epilepsy, with ample research focusing on elucidating its cellular manifestations. However, few studies investigate E/I imbalance at the macroscale, whole-brain ... Full text Link to item Cite

American Clinical Neurophysiology Society Technical Standards for Electrical Stimulation With Intracranial Electrodes for Functional Brain Mapping and Seizure Induction.

Journal Article J Clin Neurophysiol · March 1, 2025 PURPOSE: These American Clinical Neurophysiology Society technical standards suggest best practices for electrical stimulation mapping (ESM) with subdural and stereotactic depth electrodes for seizure induction and mapping of brain function. METHODS: A wor ... Full text Link to item Cite

Metrics for evaluation of automatic epileptogenic zone localization in intracranial electrophysiology.

Journal Article Clin Neurophysiol · January 2025 INTRODUCTION: Precise localization of the epileptogenic zone is critical for successful epilepsy surgery. However, imbalanced datasets in terms of epileptic vs. normal electrode contacts and a lack of standardized evaluation guidelines hinder the consisten ... Full text Link to item Cite

Leveraging interictal multimodal features and graph neural networks for automated planning of epilepsy surgery.

Journal Article Brain Commun · 2025 Precise localization of the epileptogenic zone is pivotal for planning minimally invasive surgeries in drug-resistant epilepsy. Here, we present a graph neural network (GNN) framework that integrates interictal intracranial EEG features, electrode topology ... Full text Link to item Cite

Sleep-related hypermotor seizures originating from the occipital lobe.

Journal Article Epileptic Disord · December 2024 We present two unique cases of sleep-related hypermotor epilepsy (SHE) originating from the occipital lobe. Patients with sleep-related seizures and drug-resistant occipital lobe epilepsy were identified from the ANPHY lab stereo-electroencephalography (SE ... Full text Link to item Cite

Differential reorganization of episodic and semantic memory systems in epilepsy-related mesiotemporal pathology.

Journal Article Brain : a journal of neurology · November 2024 Declarative memory encompasses episodic and semantic divisions. Episodic memory captures singular events with specific spatiotemporal relationships, whereas semantic memory houses context-independent knowledge. Behavioural and functional neuroimaging studi ... Full text Cite

Development of a stereo-EEG based seizure matching system for clinical decision making in epilepsy surgery.

Journal Article J Neural Eng · October 4, 2024 Objective.The proportion of patients becoming seizure-free after epilepsy surgery has stagnated. Large multi-center stereo-electroencephalography (SEEG) datasets can allow comparing new patients to past similar cases and making clinical decisions with the ... Full text Link to item Cite

Explaining slow seizure propagation with white matter tractography.

Journal Article Brain · October 3, 2024 Epileptic seizures recorded with stereo-EEG can take a fraction of a second or several seconds to propagate from one region to another. What explains such propagation patterns? We combine tractography and stereo-EEG to determine the relationship between se ... Full text Link to item Cite

Generalizability of electroencephalographic interpretation using artificial intelligence: An external validation study.

Journal Article Epilepsia · October 2024 OBJECTIVE: The automated interpretation of clinical electroencephalograms (EEGs) using artificial intelligence (AI) holds the potential to bridge the treatment gap in resource-limited settings and reduce the workload at specialized centers. However, to fac ... Full text Link to item Cite

Oscillatory and nonoscillatory sleep electroencephalographic biomarkers of the epileptic network.

Journal Article Epilepsia · October 2024 OBJECTIVE: In addition to the oscillatory brain activity, the nonoscillatory (scale-free) components of the background electroencephalogram (EEG) may provide further information about the complexity of the underlying neuronal network. As epilepsy is consid ... Full text Link to item Cite

Interictal stereo-electroencephalography features below 45 Hz are sufficient for correct localization of the epileptogenic zone and postsurgical outcome prediction.

Journal Article Epilepsia · October 2024 OBJECTIVE: Evidence suggests that the most promising results in interictal localization of the epileptogenic zone (EZ) are achieved by a combination of multiple stereo-electroencephalography (SEEG) biomarkers in machine learning models. These biomarkers us ... Full text Link to item Cite

Brain Networks for Cortical Atrophy and Responsive Neurostimulation in Temporal Lobe Epilepsy.

Journal Article JAMA Neurol · September 30, 2024 IMPORTANCE: Drug-resistant temporal lobe epilepsy (TLE) has been associated with hippocampal pathology. Most surgical treatment strategies, including resection and responsive neurostimulation (RNS), focus on this disease epicenter; however, imaging alterat ... Full text Link to item Cite

Investigating current clinical opinions in stereoelectroencephalography-informed epilepsy surgery.

Journal Article Epilepsia · September 2024 OBJECTIVE: Stereoelectroencephalography (SEEG) is increasingly utilized worldwide in epilepsy surgery planning. International guidelines for SEEG terminology and interpretation are yet to be proposed. There are worldwide differences in SEEG definitions, ap ... Full text Link to item Cite

ANPHY-Sleep: an Open Sleep Database from Healthy Adults Using High-Density Scalp Electroencephalogram.

Journal Article Sci Data · August 17, 2024 Well-documented sleep datasets from healthy adults are important for sleep pattern analysis and comparison with a wide range of neuropsychiatric disorders. Currently, available sleep datasets from healthy adults are acquired using low-density arrays with a ... Full text Link to item Cite

Associations of Cerebral Blood Flow Patterns With Gray and White Matter Structure in Patients With Temporal Lobe Epilepsy.

Journal Article Neurology · August 13, 2024 BACKGROUND AND OBJECTIVES: Neuroimaging studies in patients with temporal lobe epilepsy (TLE) show widespread brain network alterations beyond the mesiotemporal lobe. Despite the critical role of the cerebrovascular system in maintaining whole-brain struct ... Full text Link to item Cite

Pulsatile corticoid therapy reduces interictal epileptic activity burden in children with genetic drug-resistant epilepsy.

Journal Article Epilepsia Open · August 2024 OBJECTIVE: Corticosteroids and adrenocorticotropic hormone (ACTH) are the therapy of choice to treat infantile spasms. However, systematic studies about their use in other types of childhood epilepsies remain rare and ACTH can have serious side effects. Th ... Full text Link to item Cite

EEG/MEG source imaging of deep brain activity within the maximum entropy on the mean framework: Simulations and validation in epilepsy.

Journal Article Hum Brain Mapp · July 15, 2024 Electro/Magneto-EncephaloGraphy (EEG/MEG) source imaging (EMSI) of epileptic activity from deep generators is often challenging due to the higher sensitivity of EEG/MEG to superficial regions and to the spatial configuration of subcortical structures. We p ... Full text Link to item Cite

Spike ripples localize the epileptogenic zone best: an international intracranial study.

Journal Article Brain · July 5, 2024 We evaluated whether spike ripples, the combination of epileptiform spikes and ripples, provide a reliable and improved biomarker for the epileptogenic zone compared with other leading interictal biomarkers in a multicentre, international study. We first v ... Full text Link to item Cite

Connectome reorganization associated with temporal lobe pathology and its surgical resection.

Journal Article Brain · July 5, 2024 Network neuroscience offers a unique framework to understand the organizational principles of the human brain. Despite recent progress, our understanding of how the brain is modulated by focal lesions remains incomplete. Resection of the temporal lobe is t ... Full text Link to item Cite

Systematic review of seizure-onset patterns in stereo-electroencephalography: Current state and future directions.

Journal Article Clin Neurophysiol · July 2024 OBJECTIVE: Increasing evidence suggests that the seizure-onset pattern (SOP) in stereo-electroencephalography (SEEG) is important for localizing the "true" seizure onset. Specifically, SOPs with low-voltage fast activity (LVFA) are associated with seizure- ... Full text Link to item Cite

Clinical Utility of Sleep Recordings During Presurgical Epilepsy Evaluation With Stereo-Electroencephalography: A Systematic Review.

Journal Article J Clin Neurophysiol · July 1, 2024 Although the role of sleep in modulating epileptic activity is well established, many epileptologists overlook the significance of considering sleep during presurgical epilepsy evaluations in cases of drug-resistant epilepsy. Here, we conducted a comprehen ... Full text Link to item Cite

The SEEG Wave.

Journal Article J Clin Neurophysiol · July 1, 2024 Full text Link to item Cite

A spatial perturbation framework to validate implantation of the epileptogenic zone.

Journal Article Nat Commun · June 19, 2024 Stereo-electroencephalography (SEEG) is the gold standard to delineate surgical targets in focal drug-resistant epilepsy. SEEG uses electrodes placed directly into the brain to identify the seizure-onset zone (SOZ). However, its major constraint is limited ... Full text Link to item Cite

Differential relational memory impairment in temporal lobe epilepsy.

Journal Article Epilepsy Behav · June 2024 OBJECTIVE: Temporal lobe epilepsy (TLE) is typically associated with pathology of the hippocampus, a key structure involved in relational memory, including episodic, semantic, and spatial memory processes. While it is widely accepted that TLE-associated hi ... Full text Link to item Cite

Grading system for assessing the confidence in the epileptogenic zone reported in published studies: A Delphi consensus study.

Journal Article Epilepsia · May 2024 OBJECTIVE: This study was undertaken to develop a standardized grading system based on expert consensus for evaluating the level of confidence in the localization of the epileptogenic zone (EZ) as reported in published studies, to harmonize and facilitate ... Full text Link to item Cite

Timing matters for accurate identification of the epileptogenic zone.

Journal Article Clin Neurophysiol · May 2024 OBJECTIVE: Interictal biomarkers of the epileptogenic zone (EZ) and their use in machine learning models open promising avenues for improvement of epilepsy surgery evaluation. Currently, most studies restrict their analysis to short segments of intracrania ... Full text Link to item Cite

Atypical connectome topography and signal flow in temporal lobe epilepsy.

Journal Article Prog Neurobiol · May 2024 Temporal lobe epilepsy (TLE) is the most common pharmaco-resistant epilepsy in adults. While primarily associated with mesiotemporal pathology, recent evidence suggests that brain alterations in TLE extend beyond the paralimbic epicenter and impact macrosc ... Full text Link to item Cite

Intracerebral Dynamics of Sleep Arousals: A Combined Scalp-Intracranial EEG Study.

Journal Article J Neurosci · April 17, 2024 As an intrinsic component of sleep architecture, sleep arousals represent an intermediate state between sleep and wakefulness and are important for sleep-wake regulation. They are defined in an all-or-none manner, whereas they actually present a wide range ... Full text Link to item Cite

Recent advances in clinical electroencephalography.

Journal Article Curr Opin Neurol · April 1, 2024 PURPOSE OF REVIEW: Clinical electroencephalography (EEG) is a conservative medical field. This explains likely the significant gap between clinical practice and new research developments. This narrative review discusses possible causes of this discrepancy ... Full text Link to item Cite

Scalp and hippocampal sleep correlates of memory function in drug-resistant temporal lobe epilepsy.

Journal Article Sleep · February 8, 2024 Seminal animal studies demonstrated the role of sleep oscillations such as cortical slow waves, thalamocortical spindles, and hippocampal ripples in memory consolidation. In humans, whether ripples are involved in sleep-related memory processes is less cle ... Full text Link to item Cite

Learn how to interpret and use intracranial EEG findings.

Journal Article Epileptic Disord · February 2024 Epilepsy surgery is the therapy of choice for many patients with drug-resistant focal epilepsy. Recognizing and describing ictal and interictal patterns with intracranial electroencephalography (EEG) recordings is important in order to most efficiently lev ... Full text Link to item Cite

Consistency of electrical source imaging in presurgical evaluation of epilepsy across different vigilance states.

Journal Article Ann Clin Transl Neurol · February 2024 OBJECTIVE: The use of electrical source imaging (ESI) in assessing the source of interictal epileptic discharges (IEDs) is gaining increasing popularity in presurgical work-up of patients with drug-resistant focal epilepsy. While vigilance affects the abil ... Full text Link to item Cite

Prognostic value of the 5-SENSE Score to predict focality of the seizure-onset zone as assessed by stereoelectroencephalography: a prospective international multicentre validation study.

Journal Article BMJ Neurol Open · 2024 INTRODUCTION: Epilepsy surgery is the only curative treatment for patients with drug-resistant focal epilepsy. Stereoelectroencephalography (SEEG) is the gold standard to delineate the seizure-onset zone (SOZ). However, up to 40% of patients are subsequent ... Full text Open Access Link to item Cite

Quantifying epileptic networks: every data point brings us a step closer to an optimized surgery.

Journal Article Brain Commun · 2024 This scientific commentary refers to 'The sixth sense: how much does interictal intracranial EEG add to determining the focality of epileptic networks?', by Gallagher et al. (https://doi.org/10.1093/braincomms/fcae320). ... Full text Link to item Cite

Targeted density electrode placement achieves high concordance with traditional high-density EEG for electrical source imaging in epilepsy.

Journal Article Clin Neurophysiol · December 2023 OBJECTIVE: High-density (HD) electroencephalography (EEG) is increasingly used in presurgical epilepsy evaluation, but it is demanding in time and resources. To overcome these issues, we compared EEG source imaging (ESI) solutions with a targeted density a ... Full text Link to item Cite

Sleep, oscillations, and epilepsy.

Journal Article Epilepsia · December 2023 Sleep and wake are defined through physiological and behavioral criteria and can be typically separated into non-rapid eye movement (NREM) sleep stages N1, N2, and N3, rapid eye movement (REM) sleep, and wake. Sleep and wake states are not homogenous in ti ... Full text Link to item Cite

Stimulation to probe, excite, and inhibit the epileptic brain.

Journal Article Epilepsia · December 2023 Direct cortical stimulation has been applied in epilepsy for nearly a century and has experienced a renaissance, given unprecedented opportunities to probe, excite, and inhibit the human brain. Evidence suggests stimulation can increase diagnostic and ther ... Full text Link to item Cite

Rapid eye movement sleep affects interictal epileptic activity differently in mesiotemporal and neocortical areas.

Journal Article Epilepsia · November 2023 OBJECTIVE: Rapid eye movement (REM) sleep reduces the rate and extent of interictal epileptiform discharges (IEDs). Breakthrough epileptic activity during REM sleep is therefore thought to best localize the seizure onset zone (SOZ). We utilized polysomnogr ... Full text Link to item Cite

Interictal high-frequency oscillations, spikes, and connectivity profiles: A fingerprint of epileptogenic brain pathologies.

Journal Article Epilepsia · November 2023 OBJECTIVE: Focal cortical dysplasia (FCD), hippocampal sclerosis (HS), nonspecific gliosis (NG), and normal tissue (NT) comprise the majority of histopathological results of surgically treated drug-resistant epilepsy patients. Epileptic spikes, high-freque ... Full text Link to item Cite

The Differing Effects of Sleep on Ictal and Interictal Network Dynamics in Drug-Resistant Epilepsy.

Journal Article Ann Neurol · September 15, 2023 OBJECTIVE: Sleep has important influences on focal interictal epileptiform discharges (IEDs), and the rates and spatial extent of IEDs are increased in non-rapid eye movement (NREM) sleep. In contrast, the influence of sleep on seizures is less clear, and ... Full text Link to item Cite

Cortical microstructural gradients capture memory network reorganization in temporal lobe epilepsy.

Journal Article Brain · September 1, 2023 Temporal lobe epilepsy (TLE), one of the most common pharmaco-resistant epilepsies, is associated with pathology of paralimbic brain regions, particularly in the mesiotemporal lobe. Cognitive dysfunction in TLE is frequent, and particularly affects episodi ... Full text Link to item Cite

Large muscle group movements during sleep in healthy people: normative values and correlation to sleep features.

Journal Article Sleep · August 14, 2023 STUDY OBJECTIVES: To investigate the frequency and characteristics of large muscle group movements (LMMs) during sleep in healthy adults. METHODS: LMMs were scored following the International Restless Legs Syndrome Study Group criteria in 100 healthy parti ... Full text Link to item Cite

Validating MEG source imaging of resting state oscillatory patterns with an intracranial EEG atlas.

Journal Article Neuroimage · July 1, 2023 BACKGROUND: Magnetoencephalography (MEG) is a widely used non-invasive tool to estimate brain activity with high temporal resolution. However, due to the ill-posed nature of the MEG source imaging (MSI) problem, the ability of MSI to identify accurately un ... Full text Link to item Cite

Regional variability in intracerebral properties of NREM to REM sleep transitions in humans.

Journal Article Proc Natl Acad Sci U S A · June 27, 2023 Transitions between wake and sleep states show a progressive pattern underpinned by local sleep regulation. In contrast, little evidence is available on non-rapid eye movement (NREM) to rapid eye movement (REM) sleep boundaries, considered as mainly reflec ... Full text Link to item Cite

Enhanced thalamocortical functional connectivity during rapid-eye-movement sleep sawtooth waves.

Journal Article Sleep · June 13, 2023 Full text Link to item Cite

Neurophysiology, Neuropsychology, and Epilepsy, in 2022: Hills We Have Climbed and Hills Ahead. Neurophysiology in epilepsy.

Journal Article Epilepsy Behav · June 2023 Since the discovery of the human electroencephalogram (EEG), neurophysiology techniques have become indispensable tools in our armamentarium to localize epileptic seizures. New signal analysis techniques and the prospects of artificial intelligence and big ... Full text Link to item Cite

Response: Can biomarkers of the epileptogenic zone be characterized in patients rendered seizure free alone?

Journal Article Epilepsia · June 2023 Full text Link to item Cite

SEEGAtlas: A framework for the identification and classification of depth electrodes using clinical images.

Journal Article J Neural Eng · May 31, 2023 Objective.Accurate localization, classification, and visualization of intracranial electrodes are fundamental for analyzing intracranial electrographic recordings. While manual contact localization is the most common approach, it is time-consuming, prone t ... Full text Link to item Cite

Relative entropy is an easy-to-use invasive electroencephalographic biomarker of the epileptogenic zone.

Journal Article Epilepsia · April 2023 OBJECTIVE: High-frequency oscillations are considered among the most promising interictal biomarkers of the epileptogenic zone in patients suffering from pharmacoresistant focal epilepsy. However, there is no clear definition of pathological high-frequency ... Full text Link to item Cite

Atypical intrinsic neural timescales in temporal lobe epilepsy.

Journal Article Epilepsia · April 2023 OBJECTIVE: Temporal lobe epilepsy (TLE) is the most common pharmacoresistant epilepsy in adults. Here we profiled local neural function in TLE in vivo, building on prior evidence that has identified widespread structural alterations. Using resting-state fu ... Full text Link to item Cite

A Subpopulation of Spikes Predicts Successful Epilepsy Surgery Outcome.

Journal Article Ann Neurol · March 2023 OBJECTIVE: Epileptic spikes are the traditional interictal electroencephalographic (EEG) biomarker for epilepsy. Given their low specificity for identifying the epileptogenic zone (EZ), they are given only moderate attention in presurgical evaluation. This ... Full text Link to item Cite

Focal epilepsy impacts rapid eye movement sleep microstructure.

Journal Article Sleep · February 8, 2023 STUDY OBJECTIVES: Whereas there is plenty of evidence on the influence of epileptic activity on non-rapid eye movement (NREM) sleep macro- and micro-structure, data on the impact of epilepsy on rapid eye movement (REM) sleep remains sparse. Using high-dens ... Full text Link to item Cite

Integration of white matter architecture to stereo-EEG better describes epileptic spike propagation.

Journal Article Clin Neurophysiol · February 2023 OBJECTIVE: Stereo-electroencephalography (SEEG)-derived epilepsy networks are used to better understand a patient's epilepsy; however, a unimodal approach provides an incomplete picture. We combine tractography and SEEG to determine the relationship betwee ... Full text Link to item Cite

Analysis of sleep, daytime sleepiness, and autonomic function in multiple system atrophy and Parkinson disease: a prospective study.

Journal Article J Clin Sleep Med · January 1, 2023 STUDY OBJECTIVES: Sleep disorders, daytime sleepiness, and autonomic dysfunction are commonly reported among patients with multiple system atrophy and Parkinson disease (PD). We aimed to assess sleep and autonomic function in these patients to evaluate the ... Full text Link to item Cite

Does epileptic activity impair sleep-related memory consolidation in epilepsy? A critical and systematic review.

Journal Article J Clin Sleep Med · October 1, 2022 STUDY OBJECTIVES: People with epilepsy often complain about disturbed sleep and cognitive impairment. Beyond seizures, the occurrence of interictal epileptic activity during sleep is also increasingly recognized to negatively impact cognitive functioning, ... Full text Link to item Cite

An Open MRI Dataset For Multiscale Neuroscience.

Journal Article Sci Data · September 15, 2022 Multimodal neuroimaging grants a powerful window into the structure and function of the human brain at multiple scales. Recent methodological and conceptual advances have enabled investigations of the interplay between large-scale spatial trends (also refe ... Full text Link to item Cite

Interictal sleep recordings during presurgical evaluation: Bidirectional perspectives on sleep related network functioning.

Journal Article Rev Neurol (Paris) · September 2022 Sleep recordings are an integral part of presurgical evaluation in drug-resistant focal epilepsy. Physiological network functioning is substantially different between wakefulness and sleep and thus may add further complexity to the task of determining the ... Full text Link to item Cite

Sleep and epilepsy: A snapshot of knowledge and future research lines.

Journal Article J Sleep Res · August 2022 Sleep and epilepsy have a reciprocal relationship, and have been recognized as bedfellows since antiquity. However, research on this topic has made a big step forward only in recent years. In this narrative review we summarize the most stimulating discover ... Full text Link to item Cite

Focal epilepsy disrupts spindle structure and function.

Journal Article Sci Rep · July 1, 2022 Sleep spindles are the hallmark of N2 sleep and are attributed a key role in cognition. Little is known about the impact of epilepsy on sleep oscillations underlying sleep-related functions. This study assessed changes in the global spindle rate in patient ... Full text Link to item Cite

Clinical Yield of Electromagnetic Source Imaging and Hemodynamic Responses in Epilepsy: Validation With Intracerebral Data.

Journal Article Neurology · June 13, 2022 BACKGROUND AND OBJECTIVES: Accurate delineation of the seizure-onset zone (SOZ) in focal drug-resistant epilepsy often requires stereo-EEG (SEEG) recordings. Our aims were to propose a truly objective and quantitative comparison between EEG/magnetoencephal ... Full text Link to item Cite

SleepSEEG: automatic sleep scoring using intracranial EEG recordings only.

Journal Article J Neural Eng · May 3, 2022 Objective.To perform automatic sleep scoring based only on intracranial electroencephalography (iEEG), without the need for scalp EEG), electrooculography (EOG) and electromyography (EMG), in order to study sleep, epilepsy, and their interaction.Approach. ... Full text Link to item Cite

Provocative Hyperventilation in a Patient With Stroke-Like Migraine Attacks After Radiation Therapy.

Journal Article JAMA Neurol · May 1, 2022 Full text Link to item Cite

Barques are generated in posterior hippocampus and phase reverse over lateral posterior hippocampal surface.

Journal Article Clin Neurophysiol · April 2022 OBJECTIVE: To investigate whether barques can be localized across the hippocampal longitudinal axis with sufficient specificity. METHODS: We identified 51 focal epilepsy patients implanted with a minimum of two electrodes - unilateral anterior and posterio ... Full text Link to item Cite

Risk Factors for Phenoconversion in Rapid Eye Movement Sleep Behavior Disorder.

Journal Article Ann Neurol · March 2022 OBJECTIVE: This study was undertaken to follow up predictive factors for α-synuclein-related neurodegenerative diseases in a multicenter cohort of idiopathic/isolated rapid eye movement sleep behavior disorder (iRBD). METHODS: Patients with iRBD from 12 ce ... Full text Link to item Cite

Spatio-temporal spike dynamics predict surgical outcome in adult focal epilepsy.

Journal Article Clin Neurophysiol · February 2022 OBJECTIVE: We hypothesized that spatio-temporal dynamics of interictal spikes reflect the extent and stability of epileptic sources and determine surgical outcome. METHODS: We studied 30 consecutive patients (14 good outcome). Spikes were detected in prolo ... Full text Link to item Cite

Correcting for physiological ripples improves epileptic focus identification and outcome prediction.

Journal Article Epilepsia · February 2022 OBJECTIVE: The integration of high-frequency oscillations (HFOs; ripples [80-250 Hz], fast ripples [250-500 Hz]) in epilepsy evaluation is hampered by physiological HFOs, which cannot be reliably differentiated from pathological HFOs. We evaluated whether ... Full text Link to item Cite

Future of Neurology & Technology: Stereoelectroencephalography in Presurgical Epilepsy Evaluation.

Journal Article Neurology · January 24, 2022 Stereoelectroencephalography (SEEG) is not only a sophisticated and highly technological investigation but a new and better way to conceptualize the spatial and temporal dynamics of epileptic activity. The first intracranial investigations with SEEG were p ... Full text Link to item Cite

Region-specific complexity of the intracranial EEG in the sleeping human brain.

Journal Article Sci Rep · January 10, 2022 As the brain is a complex system with occurrence of self-similarity at different levels, a dedicated analysis of the complexity of brain signals is of interest to elucidate the functional role of various brain regions across the various stages of vigilance ... Full text Link to item Cite

Protocol for multicentre comparison of interictal high-frequency oscillations as a predictor of seizure freedom

Journal Article Brain Communications · January 1, 2022 In drug-resistant focal epilepsy, interictal high-frequency oscillations (HFOs) recorded from intracranial EEG (iEEG) may provide clinical information for delineating epileptogenic brain tissue. The iEEG electrode contacts that contain HFO are hypothesized ... Full text Cite

Development and Validation of the 5-SENSE Score to Predict Focality of the Seizure-Onset Zone as Assessed by Stereoelectroencephalography.

Journal Article JAMA Neurol · January 1, 2022 IMPORTANCE: Stereoelectroencephalography (SEEG) has become the criterion standard in case of inconclusive noninvasive presurgical epilepsy workup. However, up to 40% of patients are subsequently not offered surgery because the seizure-onset zone is less fo ... Full text Link to item Cite

Hippocampal spindles and barques are normal intracranial electroencephalographic entities.

Journal Article Clin Neurophysiol · December 2021 OBJECTIVE: To assess whether hippocampal spindles and barques are markers of epileptogenicity. METHODS: Focal epilepsy patients that underwent stereo-electroencephalography implantation with at least one electrode in their hippocampus were selected (n = 75 ... Full text Link to item Cite

Relationship Between Epilepsy and Dreaming: Current Knowledge, Hypotheses, and Perspectives

Journal Article Frontiers in Neuroscience · September 6, 2021 The interactions between epilepsy and sleep are numerous and the impact of epilepsy on cognition is well documented. Epilepsy is therefore likely to influence dreaming as one sleep-related cognitive activity. The frequency of dream recall is indeed decreas ... Full text Cite

Atypical neural topographies underpin dysfunctional pattern separation in temporal lobe epilepsy.

Journal Article Brain · September 4, 2021 Episodic memory is the ability to remember events from our past accurately. The process of pattern separation is hypothesized to underpin this ability and is defined as the capacity to orthogonalize memory traces, to maximize the features that make them un ... Full text Link to item Cite

Interictal spike networks predict surgical outcome in patients with drug-resistant focal epilepsy.

Journal Article Ann Clin Transl Neurol · June 2021 OBJECTIVE: To determine if properties of epileptic networks could be delineated using interictal spike propagation seen on stereo-electroencephalography (SEEG) and if these properties could predict surgical outcome in patients with drug-resistant epilepsy. ... Full text Link to item Cite

Fast oscillations >40 Hz localize the epileptogenic zone: An electrical source imaging study using high-density electroencephalography.

Journal Article Clin Neurophysiol · February 2021 OBJECTIVE: Fast Oscillations (FO) >40 Hz are a promising biomarker of the epileptogenic zone (EZ). Evidence using scalp electroencephalography (EEG) remains scarce. We assessed if electrical source imaging of FO using 256-channel high-density EEG (HD-EEG) ... Full text Link to item Cite

Functional connectivity and topology in patients with restless legs syndrome: a case-control resting-state functional magnetic resonance imaging study.

Journal Article Eur J Neurol · February 2021 BACKGROUND AND PURPOSE: Functional connectivity studies revealed alterations within thalamic, salience, and default mode networks in restless legs syndrome patients. METHODS: Eighty-two patients with restless legs syndrome (untreated, n = 30; on dopaminerg ... Full text Link to item Cite

Sleep modelled as a continuous and dynamic process predicts healthy ageing better than traditional sleep scoring.

Journal Article Sleep Med · January 2021 BACKGROUND: In current clinical practice, sleep is manually scored in discrete stages of 30-s duration. We hypothesize that modelling sleep automatically as continuous and dynamic process predicts healthy ageing better than traditional scoring. METHODS: Sl ... Full text Link to item Cite

Rapid Eye Movement Sleep Sawtooth Waves Are Associated with Widespread Cortical Activations.

Journal Article J Neurosci · November 11, 2020 Sawtooth waves (STW) are bursts of frontocentral slow oscillations recorded in the scalp electroencephalogram (EEG) during rapid eye movement (REM) sleep. Little is known about their cortical generators and functional significance. Stereo-EEG performed for ... Full text Link to item Cite

A multi-scale cortical wiring space links cellular architecture and functional dynamics in the human brain.

Journal Article PLoS Biol · November 2020 The vast net of fibres within and underneath the cortex is optimised to support the convergence of different levels of brain organisation. Here, we propose a novel coordinate system of the human cortex based on an advanced model of its connectivity. Our ap ... Full text Link to item Cite

A prospective controlled study about sleep disorders in drug resistant epilepsy.

Journal Article Sleep Med · November 2020 OBJECTIVE: To evaluate sleep disorders and chronotype in patients with drug resistant focal and generalised epilepsy compared to healthy controls. METHODS: Sixty four patients with focal and six with generalised, drug resistant epilepsy were included and c ... Full text Link to item Cite

Sleep Disruption in Epilepsy: Ictal and Interictal Epileptic Activity Matter.

Journal Article Ann Neurol · November 2020 OBJECTIVE: Disturbed sleep is common in epilepsy. The direct influence of nocturnal epileptic activity on sleep fragmentation remains poorly understood. Stereo-electroencephalography paired with polysomnography is the ideal tool to study this relationship. ... Full text Link to item Cite

Association of fast ripples on intracranial EEG and outcomes after epilepsy surgery.

Journal Article Neurology · October 20, 2020 OBJECTIVE: To examine whether fast ripples (FRs) are an accurate marker of the epileptogenic zone, we analyzed overnight stereo-EEG recordings from 43 patients and hypothesized that FR resection ratio, maximal FR rate, and FR distribution predict postsurgi ... Full text Link to item Cite

Myeloarchitecture gradients in the human insula: Histological underpinnings and association to intrinsic functional connectivity.

Journal Article Neuroimage · August 1, 2020 Insular cortex is a core hub involved in multiple cognitive and socio-affective processes. Yet, the anatomical mechanisms that explain how it is involved in such a diverse array of functions remain incompletely understood. Here, we tested the hypothesis th ... Full text Link to item Cite

Intracranial EEG in the 21st Century

Journal Article Epilepsy Currents · July 1, 2020 Intracranial electroencephalography (iEEG) has been the mainstay of identifying the seizure onset zone (SOZ), a key diagnostic procedure in addition to neuroimaging when considering epilepsy surgery. In many patients, iEEG has been the basis for resective ... Full text Cite

Functional connectome contractions in temporal lobe epilepsy: Microstructural underpinnings and predictors of surgical outcome.

Journal Article Epilepsia · June 2020 OBJECTIVE: Temporal lobe epilepsy (TLE) is the most common drug-resistant epilepsy in adults. Although it is commonly related to hippocampal pathology, increasing evidence suggests structural changes beyond the mesiotemporal lobe. Functional anomalies and ... Full text Link to item Cite

The human K-complex: Insights from combined scalp-intracranial EEG recordings.

Journal Article Neuroimage · June 2020 Sleep spindles and K-complexes (KCs) are a hallmark of N2 sleep. While the functional significance of spindles is comparatively well investigated, there is still ongoing debate about the role of the KC: it is unclear whether it is a cortical response to an ... Full text Link to item Cite

Localizing the epileptogenic zone.

Journal Article Curr Opin Neurol · April 2020 PURPOSE OF REVIEW: Epilepsy surgery is the therapy of choice for 30-40% of people with focal drug-resistant epilepsy. Currently only ∼60% of well selected patients become postsurgically seizure-free underlining the need for better tools to identify the epi ... Full text Link to item Cite

How the Human Brain Sleeps: Direct Cortical Recordings of Normal Brain Activity.

Journal Article Ann Neurol · February 2020 OBJECTIVE: Regional variations in oscillatory activity during human sleep remain unknown. Using the unique ability of intracranial electroencephalography to study in situ brain physiology, this study assesses regional variations of electroencephalographic ... Full text Link to item Cite

A skew-based method for identifying intracranial EEG channels with epileptic activity without detecting spikes, ripples, or fast ripples.

Journal Article Clin Neurophysiol · January 2020 OBJECTIVE: To develop a method for identifying intracranial EEG (iEEG) channels with epileptic activity without the need to detect spikes, ripples, or fast ripples. METHODS: We compared the skew of the distribution of power values from five minutes non-rap ... Full text Link to item Cite

Multimodal Magnetic Resonance Imaging reveals alterations of sensorimotor circuits in restless legs syndrome.

Journal Article Sleep · December 24, 2019 STUDY OBJECTIVES: Integrated information on brain microstructural integrity and iron storage and its impact on the morphometric profile is not available in restless legs syndrome (RLS). We applied multimodal magnetic resonance imaging (MRI) including diffu ... Full text Link to item Cite

NREM sleep is the state of vigilance that best identifies the epileptogenic zone in the interictal electroencephalogram.

Journal Article Epilepsia · December 2019 OBJECTIVE: Interictal epileptiform anomalies such as epileptiform discharges or high-frequency oscillations show marked variations across the sleep-wake cycle. This study investigates which state of vigilance is the best to localize the epileptogenic zone ... Full text Link to item Cite

Association of Cortical Stimulation-Induced Seizure With Surgical Outcome in Patients With Focal Drug-Resistant Epilepsy.

Journal Article JAMA Neurol · September 1, 2019 IMPORTANCE: Cortical stimulation is used during presurgical epilepsy evaluation for functional mapping and for defining the cortical area responsible for seizure generation. Despite wide use of cortical stimulation, the association between cortical stimula ... Full text Link to item Cite

Fast ripple analysis in human mesial temporal lobe epilepsy suggests two different seizure-generating mechanisms.

Journal Article Neurobiol Dis · July 2019 OBJECTIVE: The distinction of hypersynchronous (HYP) and low-voltage fast (LVF) onset seizures in mesial temporal lobe epilepsy (MTLE) is well established, but classifying individual seizures and patients is often challenging. Experimental work indicates a ... Full text Link to item Cite

Sleep, oscillations, interictal discharges, and seizures in human focal epilepsy.

Journal Article Neurobiol Dis · July 2019 Bidirectional interactions between sleep and epilepsy are known since antiquity, however only the introduction of the method of electroencephalography (EEG) in 1929 contributed to objectively investigate and further unravel these obvious clinical relations ... Full text Link to item Cite

Interictal coupling of HFOs and slow oscillations predicts the seizure-onset pattern in mesiotemporal lobe epilepsy.

Journal Article Epilepsia · June 2019 OBJECTIVE: Low-voltage fast activity (LVF) and low-frequency high-amplitude periodic spiking (PS) are the two most common seizure-onset patterns in mesiotemporal lobe epilepsy, with different underlying mechanisms, pathology, and postsurgical outcome. The ... Full text Link to item Cite

Localization of the epileptogenic zone using high frequency oscillations

Journal Article Frontiers in Neurology · January 1, 2019 For patients with drug-resistant focal epilepsy, surgery is the therapy of choice in order to achieve seizure freedom. Epilepsy surgery foremost requires the identification of the epileptogenic zone (EZ), defined as the brain area indispensable for seizure ... Full text Cite

Association of mitochondrial iron deficiency and dysfunction with idiopathic restless legs syndrome.

Journal Article Mov Disord · January 2019 BACKGROUND: Restless legs syndrome is a sensorimotor neurological disorder of the limbs that impairs quality of life and disturbs sleep. However, there has been progress in understanding the disease involving the dopaminergic system as well as iron metabol ... Full text Link to item Cite

Ripples in scalp EEGs of children: co-occurrence with sleep-specific transients and occurrence across sleep stages.

Journal Article Sleep · November 1, 2018 STUDY OBJECTIVES: A dialogue between hippocampal ripples (80-250 Hz) and neocortical sleep-specific transients is important for memory consolidation. Physiological neocortical ripples can be recognized in scalp EEGs of children. We investigated how often s ... Full text Link to item Cite

Diagnosis of REM sleep behavior disorder

Chapter · September 18, 2018 Full text Cite

High-Frequency Oscillations in the Normal Human Brain.

Journal Article Ann Neurol · September 2018 OBJECTIVE: High-frequency oscillations (HFOs) are a promising biomarker for the epileptogenic zone. It has not been possible, however, to differentiate physiological from pathological HFOs, and baseline rates of HFO occurrence vary substantially across bra ... Full text Link to item Cite

Sharply contoured theta waves are the human correlate of ponto-geniculo-occipital waves in the primary visual cortex.

Journal Article Clin Neurophysiol · August 2018 OBJECTIVE: Ponto-geniculo-occipital (PGO) waves occurring along the visual axis are one of the hallmarks of REM sleep in experimental animals. In humans, direct evidence is scarce. There is no systematic study of PGO waves in the primary visual cortex. MET ... Full text Link to item Cite

Corrigendum to "Sparse asynchronous cortical generators can produce measurable scalp EEG signals" [Neuroimage 138 (2016) 123-133].

Journal Article Neuroimage · May 15, 2018 Full text Link to item Cite

Atlas of the normal intracranial electroencephalogram: neurophysiological awake activity in different cortical areas.

Journal Article Brain · April 1, 2018 UNLABELLED: In contrast to scalp EEG, our knowledge of the normal physiological intracranial EEG activity is scarce. This multicentre study provides an atlas of normal intracranial EEG of the human brain during wakefulness. Here we present the results of p ... Full text Link to item Cite

Gender-Specific Differences in Access to Polysomnography and Prevalence of Sleep Disorders.

Journal Article J Womens Health (Larchmt) · April 2018 BACKGROUND: Previous studies have shown that women have less access or longer waiting times to high-tech medicine compared with men. This study aimed to detect possible gender differences in access to the diagnostic high-tech method of polysomnography (PSG ... Full text Link to item Cite

Prevalence and determinants of rapid eye movement sleep behavior disorder in the general population.

Journal Article Sleep · February 1, 2018 STUDY OBJECTIVES: Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia associated with neurodegenerative synucleinopathies. Its prevalence is largely unknown. This study determined the prevalence and characteristics of RBD in the general ... Full text Link to item Cite

High-frequency oscillations: The state of clinical research.

Journal Article Epilepsia · August 2017 Modern electroencephalographic (EEG) technology contributed to the appreciation that the EEG signal outside the classical Berger frequency band contains important information. In epilepsy, research of the past decade focused particularly on interictal high ... Full text Link to item Cite

Different seizure-onset patterns in mesiotemporal lobe epilepsy have a distinct interictal signature.

Journal Article Clin Neurophysiol · July 2017 OBJECTIVE: Experimental research demonstrated that distinct underlying mechanisms go along with different seizure-onset patterns on EEG. These different mechanisms may reflect different tissue abnormalities which, we hypothesize, could also be reflected in ... Full text Link to item Cite

Physiological and pathological high-frequency oscillations have distinct sleep-homeostatic properties.

Journal Article Neuroimage Clin · 2017 OBJECTIVE: The stage of sleep is a known modulator of high-frequency oscillations (HFOs). For instance, high amplitude slow waves during NREM sleep and the subtypes of REM sleep were shown to contribute to a better separation between physiological and path ... Full text Link to item Cite

Differentiating epileptic from non-epileptic high frequency intracerebral EEG signals with measures of wavelet entropy.

Journal Article Clin Neurophysiol · December 2016 OBJECTIVE: To assess whether there is a difference in the background activity in the ripple band (80-200Hz) between epileptic and non-epileptic channels, and to assess whether this difference is sufficient for their reliable separation. METHODS: We calcula ... Full text Link to item Cite

World Association of Sleep Medicine (WASM) 2016 standards for recording and scoring leg movements in polysomnograms developed by a joint task force from the International and the European Restless Legs Syndrome Study Groups (IRLSSG and EURLSSG).

Journal Article Sleep Med · October 2016 This report presents the results of the work by a joint task force of the International and European Restless Legs Syndrome Study Groups and World Association of Sleep Medicine that revised and updated the current standards for recording and scoring leg mo ... Full text Link to item Cite

Sparse asynchronous cortical generators can produce measurable scalp EEG signals.

Journal Article Neuroimage · September 2016 We investigate to what degree the synchronous activation of a smooth patch of cortex is necessary for observing EEG scalp activity. We perform extensive simulations to compare the activity generated on the scalp by different models of cortical activation, ... Full text Link to item Cite

Phase-amplitude coupling is elevated in deep sleep and in the onset zone of focal epileptic seizures

Journal Article Frontiers in Human Neuroscience · August 3, 2016 The interactions between different EEG frequency bands have been widely investigated in normal and pathologic brain activity. Phase-amplitude coupling (PAC) is one of the important forms of this interaction where the amplitude of higher frequency oscillati ... Full text Cite

Oxygen desaturation during night sleep affects decision-making in patients with obstructive sleep apnea.

Journal Article J Sleep Res · August 2016 This study assessed decision-making and its associations with executive functions and sleep-related factors in patients with obstructive sleep apnea. Thirty patients with untreated obstructive sleep apnea and 20 healthy age- and education-matched controls ... Full text Link to item Cite

The role of the melanoma gene MC1R in Parkinson disease and REM sleep behavior disorder.

Journal Article Neurobiol Aging · July 2016 The MC1R gene, suggested to be involved in Parkinson disease (PD) and melanoma, was sequenced in PD patients (n = 539) and controls (n = 265) from New York, and PD patients (n = 551), rapid eye movement sleep behavior disorder (RBD) patients (n = 351), and ... Full text Link to item Cite

Interaction with slow waves during sleep improves discrimination of physiologic and pathologic high-frequency oscillations (80-500 Hz).

Journal Article Epilepsia · June 2016 OBJECTIVE: To characterize the interaction between physiologic and pathologic high-frequency oscillations (HFOs) and slow waves during sleep, and to evaluate the practical significance of these interactions by automatically classifying channels as recordin ... Full text Link to item Cite

EEG desynchronization during phasic REM sleep suppresses interictal epileptic activity in humans.

Journal Article Epilepsia · June 2016 OBJECTIVE: Rapid eye movement (REM) sleep has a suppressing effect on epileptic activity. This effect might be directly related to neuronal desynchronization mediated by cholinergic neurotransmission. We investigated whether interictal epileptiform dischar ... Full text Link to item Cite

Detectability of Fast Ripples (>250 Hz) on the Scalp EEG: A Proof-of-Principle Study with Subdermal Electrodes.

Journal Article Brain Topogr · May 2016 To evaluate the possibility of detecting fast ripples (FRs) on the surface EEG of patients with focal pharmacoresistant epilepsy, and to investigate the relationship between scalp FRs and localization of the seizure onset zone (SOZ). We included 10 patient ... Full text Link to item Cite

Not Only Sleepwalking But NREM Parasomnia Irrespective of the Type Is Associated with HLA DQB1*05:01.

Journal Article J Clin Sleep Med · April 15, 2016 STUDY OBJECTIVES: Despite the high prevalence and clinical relevance of NREM parasomnias, data on supportive genetic markers are scarce, and mainly refer to sleepwalking only. METHODS: We retrospectively analyzed clinical, polysomnographic, and HLA finding ... Full text Link to item Cite

Quantitative EEG of Rapid-Eye-Movement Sleep: A Marker of Amnestic Mild Cognitive Impairment.

Journal Article Clin EEG Neurosci · April 2016 The basal forebrain cholinergic system, which is impaired in early Alzheimer's disease, is more crucial for the activation of rapid-eye-movement (REM) sleep electroencephalogram (EEG) than it is for wakefulness. Quantitative EEG from REM sleep might thus p ... Full text Link to item Cite

The morphology of high frequency oscillations (HFO) does not improve delineating the epileptogenic zone.

Journal Article Clin Neurophysiol · April 2016 OBJECTIVE: We hypothesized that high frequency oscillations (HFOs) with irregular amplitude and frequency more specifically reflect epileptogenicity than HFOs with stable amplitude and frequency. METHODS: We developed a fully automatic algorithm to detect ... Full text Link to item Cite

When spikes are symmetric, ripples are not: Bilateral spike and wave above 80 Hz in focal and generalized epilepsy.

Journal Article Clin Neurophysiol · March 2016 OBJECTIVE: To evaluate scalp ripples distribution in secondary bilateral synchrony as a tool to lateralize the epileptic focus and to differentiate focal from generalized epilepsy. METHODS: Seventeen EEG recordings with bilateral synchronous discharges of ... Full text Link to item Cite

Relationships between interictal epileptic spikes and ripples in surface EEG.

Journal Article Clin Neurophysiol · January 2016 OBJECTIVE: Ripples (80-250Hz) have been shown to be a more specific biomarker for the epileptogenic zone than epileptic spikes in intracranial EEG and even surface EEG. Ripples often co-occur with spikes. We investigated the spatiotemporal relation between ... Full text Link to item Cite

Interictal Hippocampal Spiking Influences the Occurrence of Hippocampal Sleep Spindles.

Journal Article Sleep · December 1, 2015 OBJECTIVES: The significance of hippocampal sleep spindles and their relation to epileptic activity is still a matter of controversy. Hippocampal spindles have been considered a physiological phenomenon, an evoked response to afferent epileptic discharges, ... Full text Link to item Cite

Enteric nervous system α-synuclein immunoreactivity in idiopathic REM sleep behavior disorder.

Journal Article Neurology · November 17, 2015 OBJECTIVE: To investigate the expression of α-synuclein in colonic biopsies of patients with idiopathic REM sleep behavior disorder (iRBD) and address if α-synuclein immunostaining of tissue obtained via colonic biopsies holds promise as a diagnostic bioma ... Full text Link to item Cite

Long-Term Follow-up Investigation of Isolated Rapid Eye Movement Sleep Without Atonia Without Rapid Eye Movement Sleep Behavior Disorder: A Pilot Study.

Journal Article J Clin Sleep Med · November 15, 2015 STUDY OBJECTIVES: Idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) is a harbinger of synuclein-mediated neurodegenerative diseases. It is unknown if this also applies to isolated REM sleep without atonia (RWA). We performed a long-term fol ... Full text Link to item Cite

Probable RBD and association with neurodegenerative disease markers: A population-based study.

Journal Article Mov Disord · September 2015 BACKGROUND: The prevalence of rapid eye movement sleep behavior disorder (RBD) and its association with markers of neurodegeneration in the general population are poorly defined. METHODS: We assessed the prevalence of probable RBD defined by two validated ... Full text Link to item Cite

A Prospective Video-Polysomnographic Analysis of Movements during Physiological Sleep in 100 Healthy Sleepers.

Journal Article Sleep · September 1, 2015 STUDY OBJECTIVES: Video-polysomnography (v-PSG) is the gold standard for the diagnosis of sleep disorders. Quantitative assessment of type and distribution of physiological movements during sleep for the differentiation between physiological and pathologic ... Full text Link to item Cite

Authors response to "Deficits of attention and cognition in narcoleptic patients--is it hypocretin dependent?".

Journal Article Sleep Med · August 2015 Full text Link to item Cite

Parkinson's Disease Genetic Loci in Rapid Eye Movement Sleep Behavior Disorder.

Journal Article J Mol Neurosci · July 2015 Rapid eye movement (REM) sleep behavior disorder (RBD) is a prodromal condition for Parkinson's disease (PD) and other synucleinopathies, which often occurs many years before the onset of PD. We analyzed 261 RBD patients and 379 controls for nine PD-associ ... Full text Link to item Cite

Sleep influences the intracerebral EEG pattern of focal cortical dysplasia.

Journal Article Epilepsy Res · July 2015 OBJECTIVE: Focal cortical dysplasia (FCD) is able to generate an intrinsic pathological EEG activity characterized by a continuous or near-continuous spiking. Different patterns of discharge were described. We examined quantitatively the distribution of th ... Full text Link to item Cite

Facilitation of epileptic activity during sleep is mediated by high amplitude slow waves.

Journal Article Brain · June 2015 Epileptic discharges in focal epilepsy are frequently activated during non-rapid eye movement sleep. Sleep slow waves are present during this stage and have been shown to include a deactivated ('down', hyperpolarized) and an activated state ('up', depolari ... Full text Link to item Cite

Sleep and Respiration in 100 Healthy Caucasian Sleepers--A Polysomnographic Study According to American Academy of Sleep Medicine Standards.

Journal Article Sleep · June 1, 2015 STUDY OBJECTIVES: Despite differences between American Academy of Sleep Medicine (AASM) and Rechtschaffen and Kales scoring criteria, normative values following the current AASM criteria are lacking. We investigated sleep and respiratory variables in healt ... Full text Link to item Cite

Erratum: HLA-DPB1 and HLA class i confer risk of and protection from narcolepsy (American Journal of Human Genetics (2015) 96 (136-146))

Journal Article American Journal of Human Genetics · May 7, 2015 Full text Cite

Risk factors for neurodegeneration in idiopathic rapid eye movement sleep behavior disorder: a multicenter study.

Journal Article Ann Neurol · May 2015 OBJECTIVE: To assess whether risk factors for Parkinson disease and dementia with Lewy bodies increase rate of defined neurodegenerative disease in idiopathic rapid eye movement (REM) sleep behavior disorder (RBD). METHODS: Twelve centers administered a de ... Full text Link to item Cite

Dreaming furiously? A sleep laboratory study on the dream content of people with Parkinson's disease and with or without rapid eye movement sleep behavior disorder.

Journal Article Sleep Med · March 2015 OBJECTIVE: Rapid eye movement (REM) sleep behavior disorder (RBD) has been related to altered, action-filled, vivid, and aggressive dream content, but research comparing the possible differences in dreams of Parkinson's disease (PD) patients with and witho ... Full text Link to item Cite

Olfactory dysfunction predicts early transition to a Lewy body disease in idiopathic RBD.

Journal Article Neurology · February 17, 2015 OBJECTIVE: The aim of the present study was to determine the predictive value of olfactory dysfunction for the early development of a synuclein-mediated neurodegenerative disease in subjects with idiopathic REM sleep behavior disorder (iRBD) over an observ ... Full text Link to item Cite

Sleep disorders and circadian rhythm in epilepsy revisited: a prospective controlled study.

Journal Article Sleep Med · February 2015 OBJECTIVE: Sleep disturbance is reported to be frequent in epilepsy. The role of comorbidity, which is frequently accompanied by sleep disturbance, has not been investigated. The present study assessed sleep disorders and circadian rhythm in patients with ... Full text Link to item Cite

Pain perception in narcolepsy with cataplexy patients.

Journal Article Sleep Med · February 2015 Full text Link to item Cite

Scalp spindles are associated with widespread intracranial activity with unexpectedly low synchrony.

Journal Article Neuroimage · January 15, 2015 In humans, the knowledge of intracranial correlates of spindles is mainly gathered from noninvasive neurophysiologic and functional imaging studies which provide an indirect estimate of neuronal intracranial activity. This potential limitation can be overc ... Full text Link to item Cite

HLA-DPB1 and HLA class I confer risk of and protection from narcolepsy.

Journal Article Am J Hum Genet · January 8, 2015 Type 1 narcolepsy, a disorder caused by a lack of hypocretin (orexin), is so strongly associated with human leukocyte antigen (HLA) class II HLA-DQA1(∗)01:02-DQB1(∗)06:02 (DQ0602) that very few non-DQ0602 cases have been reported. A known triggering factor ... Full text Link to item Cite

Erratum to: Autonomic symptoms in idiopathic REM behavior disorder: a multicentre case–control study (J Neurol, (2014), 261, (1112-1118), 10.1007/s00415-014-7317-8)

Journal Article Journal of Neurology · January 1, 2015 Full text Cite

Quality control for diagnosis of REM sleep behavior disorder: Criteria, questionnaires, video, and polysomnography

Chapter · January 1, 2015 The diagnosis of REM sleep behavior disorder (RBD) is based on clinical criteria, which include history and information from video/polysomnography. While probable RBD can be diagnosed from questionnaires, for a definite diagnosis polysomnography demonstrat ... Full text Cite

Subjective deficits of attention, cognition and depression in patients with narcolepsy.

Journal Article Sleep Med · January 2015 OBJECTIVE: Patients with narcolepsy often complain about attention deficits in everyday situations. In comparison with these subjective complaints, deficits in objective testing are subtler. The present study assessed the relationships between subjective c ... Full text Link to item Cite

Diagnostic value of the REM sleep behavior disorder screening questionnaire in Parkinson's disease.

Journal Article Sleep Med · January 2015 OBJECTIVE: We aimed to validate the rapid eye movement (REM) sleep behavior disorder (RBD) screening questionnaire (RBDSQ) in 2 independent samples of patients with Parkinson's disease (PD) using different settings when performing the investigations. METHO ... Full text Link to item Cite

Review of diagnostic instruments for the restless legs syndrome/Willis-Ekbom Disease (RLS/WED): critique and recommendations.

Journal Article J Clin Sleep Med · December 15, 2014 OBJECTIVES: Over the last decade, increased research on therapy, pathogenesis, epidemiological and genetic aspects of restless legs syndrome/Willis-Ekbom Disease (RLS/WED) has necessitated development of diagnostic instruments specific to RLS. The Movement ... Full text Link to item Cite

Review of quality of life instruments for the restless legs syndrome/Willis-Ekbom Disease (RLS/WED): critique and recommendations.

Journal Article J Clin Sleep Med · December 15, 2014 OBJECTIVES: Over the last decade therapeutic, pathogenetic, epidemiological and genetic research in restless legs syndrome/Willis-Ekbom Disease (RLS/WED) has required the development of specific quality of life scales and sleep scales. A Movement Disorder ... Full text Link to item Cite

Review of Severity Rating Scales for Restless Legs Syndrome: Critique and Recommendations

Journal Article Movement Disorders Clinical Practice · December 1, 2014 Over the last decade, research in restless legs syndrome (RLS; also known as Willis-Ekbom disease) has increased dramatically. The International Parkinson and Movement Disorder Society commissioned a task force to formally evaluate the available evidence o ... Full text Cite

Five-year follow-up of substantia nigra echogenicity in idiopathic REM sleep behavior disorder.

Journal Article Mov Disord · December 2014 Hyperechogenicity of the substantia nigra visualized by transcranial sonography occurs in most Parkinson's disease (PD) patients. Idiopathic rapid eye movement (REM) sleep behavior disorder (IRBD) subjects eventually develop PD and other synucleinopathies. ... Full text Link to item Cite

C9orf72 repeat expansions in rapid eye movement sleep behaviour disorder.

Journal Article Can J Neurol Sci · November 2014 BACKGROUND: A large hexanucleotide repeat expansion in C9orf72 has been identified as the most common genetic cause in familial amyotrophic lateral sclerosis and frontotemporal dementia. Rapid Eye Movement Sleep Behavior Disorder (RBD) is a sleep disorder ... Full text Link to item Cite

Is there a polysomnographic signature of augmentation in restless legs syndrome?

Journal Article Sleep Med · October 2014 OBJECTIVE: Augmentation of restless legs syndrome (RLS) is a potentially severe side-effect of dopaminergic treatment. Data on objective motor characteristics in augmentation are scarce. The aim of this study was to investigate in detail different variable ... Full text Link to item Cite

Validation of an integrated software for the detection of rapid eye movement sleep behavior disorder.

Journal Article Sleep · October 1, 2014 STUDY OBJECTIVES AND DESIGN: Rapid eye movement sleep without atonia (RWA) is the polysomnographic hallmark of REM sleep behavior disorder (RBD). To partially overcome the disadvantages of manual RWA scoring, which is time consuming but essential for the a ... Full text Link to item Cite

Do periodic arm movements during sleep exist in healthy subjects? A polysomnographic study.

Journal Article Sleep Med · September 2014 BACKGROUND: Despite several polysomnographic studies on periodic leg movements (PLM) in healthy sleep, data on the prevalence and characteristics of periodic arm movements (PAM) in normal subjects are lacking. We aimed to investigate PAM and their associat ... Full text Link to item Cite

Quantitative assessment of isolated rapid eye movement (REM) sleep without atonia without clinical REM sleep behavior disorder: clinical and research implications.

Journal Article Sleep Med · September 2014 BACKGROUND: Rapid eye movement (REM) sleep without atonia (RWA) is observed in some patients without a clinical history of REM sleep behavior disorder (RBD). It remains unknown whether these patients meet the refined quantitative electromyographic (EMG) cr ... Full text Link to item Cite

Targeted resequencing and systematic in vivo functional testing identifies rare variants in MEIS1 as significant contributors to restless legs syndrome.

Journal Article Am J Hum Genet · July 3, 2014 Restless legs syndrome (RLS) is a common neurologic condition characterized by nocturnal dysesthesias and an urge to move, affecting the legs. RLS is a complex trait, for which genome-wide association studies (GWASs) have identified common susceptibility a ... Full text Link to item Cite

A prospective questionnaire study in 100 healthy sleepers: non-bothersome forms of recognizable sleep disorders are still present.

Journal Article J Clin Sleep Med · June 15, 2014 STUDY OBJECTIVES: Despite several polysomnographic normative studies and multiple surveys of sleep disorders in the general population, few data have been collected on healthy sleepers. We aimed to survey the characteristics of healthy sleep. METHODS: We p ... Full text Link to item Cite

Autonomic symptoms in idiopathic REM behavior disorder: a multicentre case-control study.

Journal Article J Neurol · June 2014 Patients with idiopathic REM sleep behavior disorder (iRBD) are at very high risk of developing neurodegenerative synucleinopathies, which are disorders with prominent autonomic dysfunction. Several studies have documented autonomic dysfunction in iRBD, bu ... Full text Link to item Cite

Motor events during healthy sleep: a quantitative polysomnographic study.

Journal Article Sleep · April 1, 2014 STUDY OBJECTIVES: Many sleep disorders are characterized by increased motor activity during sleep. In contrast, studies on motor activity during physiological sleep are largely lacking. We quantitatively investigated a large range of motor phenomena during ... Full text Link to item Cite

Comorbidity and medication in REM sleep behavior disorder: a multicenter case-control study.

Journal Article Neurology · March 25, 2014 OBJECTIVE: This controlled study investigated associations between comorbidity and medication in patients with polysomnographically confirmed idiopathic REM sleep behavior disorder (iRBD), using a large multicenter clinic-based cohort. METHODS: Data of a s ... Full text Link to item Cite

Blood cis-eQTL analysis fails to identify novel association signals among sub-threshold candidates from genome-wide association studies in restless legs syndrome.

Journal Article PLoS One · 2014 Restless legs syndrome (RLS) is a common neurologic disorder characterized by nightly dysesthesias affecting the legs primarily during periods of rest and relieved by movement. RLS is a complex genetic disease and susceptibility factors in six genomic regi ... Full text Link to item Cite

DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe.

Journal Article Sleep · January 1, 2014 STUDY OBJECTIVE: Prior research has identified five common genetic variants associated with narcolepsy with cataplexy in Caucasian patients. To replicate and/or extend these findings, we have tested HLA-DQB1, the previously identified 5 variants, and 10 ot ... Full text Link to item Cite

Corrigendum to "Rapid eye movement sleep behavior disorder: Devising controlled active treatment studies for symptomatic and neuroprotective therapy-a consensus statement from the International Rapid Eye Movement Sleep Behavior Disorder Study Group" [Sleep Med 14(8) (2013) 795-806]

Journal Article Sleep Medicine · January 1, 2014 Full text Cite

Restless legs syndrome (Willis-Ekbom disease) and growing pains: are they the same thing? A side-by-side comparison of the diagnostic criteria for both and recommendations for future research.

Journal Article Sleep Med · December 2013 There has been no previous side-by-side comparison of the diagnostic criteria for restless legs syndrome (RLS) (Willis-Ekbom disease) and growing pains. In our review, we explore this comparison emphasizing overlaps and disconnects, summarize recent litera ... Full text Link to item Cite

Narcolepsy and pregnancy: a retrospective European evaluation of 249 pregnancies.

Journal Article J Sleep Res · October 2013 In a retrospective cohort study undertaken in 12 European countries, 249 female narcoleptic patients with cataplexy (n = 216) and without cataplexy (n = 33) completed a self-administrated questionnaire regarding pregnancy and childbirth. The cohort was div ... Full text Link to item Cite

Delayed diagnosis, range of severity, and multiple sleep comorbidities: a clinical and polysomnographic analysis of 100 patients of the innsbruck narcolepsy cohort.

Journal Article J Clin Sleep Med · August 15, 2013 STUDY OBJECTIVES: Narcolepsy is reported to affect 26-56/100,000 in the general population. We aimed to describe clinical and polysomnographic features of a large narcolepsy cohort in order to comprehensively characterize the narcoleptic spectrum. METHODS: ... Full text Link to item Cite

Defining muscle activities for assessment of rapid eye movement sleep behavior disorder: from a qualitative to a quantitative diagnostic level.

Journal Article Sleep Med · August 2013 Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by dream enacting behavior. Its polysomnographic hallmark is loss of physiological REM muscle atonia. Current diagnostic criteria require both a typical history of RBD or ... Full text Link to item Cite

Rapid eye movement sleep behavior disorder: devising controlled active treatment studies for symptomatic and neuroprotective therapy--a consensus statement from the International Rapid Eye Movement Sleep Behavior Disorder Study Group.

Journal Article Sleep Med · August 2013 OBJECTIVES: We aimed to provide a consensus statement by the International Rapid Eye Movement Sleep Behavior Disorder Study Group (IRBD-SG) on devising controlled active treatment studies in rapid eye movement sleep behavior disorder (RBD) and devising stu ... Full text Link to item Cite

Family history of idiopathic REM behavior disorder: a multicenter case-control study.

Journal Article Neurology · June 11, 2013 OBJECTIVE: To compare the frequency of proxy-reported REM sleep behavior disorder (RBD) among relatives of patients with polysomnogram-diagnosed idiopathic RBD (iRBD) in comparison to controls using a large multicenter clinic-based cohort. METHODS: A total ... Full text Link to item Cite

Is a diagnosis of ancillary restless legs syndrome reproducible over time? Experience with the Wayne Hening telephone diagnostic interview.

Journal Article Sleep Med · June 2013 OBJECTIVE: The Hening telephone diagnostic interview (HTDI) is a validated structured diagnostic instrument for restless legs syndrome (RLS). A diagnosis of ancillary RLS is defined as RLS with non bothering or only sporadic occurrence of RLS symptoms. The ... Full text Link to item Cite

Dilution of candidates: the case of iron-related genes in restless legs syndrome.

Journal Article Eur J Hum Genet · April 2013 Restless legs syndrome (RLS) is a common multifactorial disease. Some genetic risk factors have been identified. RLS susceptibility also has been related to iron. We therefore asked whether known iron-related genes are candidates for association with RLS a ... Full text Link to item Cite

On “polysomnography reveals unexpectedly high rates of organic sleep disorders in patients with prediagnosed primary insomnia” (Sleep Breath 2011 doi 10.1007/s11325-011-0608-8).

Journal Article Sleep Breath · March 2013 Full text Link to item Cite

ImmunoChip study implicates antigen presentation to T cells in narcolepsy.

Journal Article PLoS Genet · 2013 Recent advances in the identification of susceptibility genes and environmental exposures provide broad support for a post-infectious autoimmune basis for narcolepsy/hypocretin (orexin) deficiency. We genotyped loci associated with other autoimmune and inf ... Full text Link to item Cite

Validation of the Innsbruck REM sleep behavior disorder inventory.

Journal Article Mov Disord · November 2012 A diagnosis of definite REM sleep behavior disorder requires both a positive history for REM sleep behavior disorder and polysomnographic demonstration of REM sleep without atonia. To improve and facilitate screening for REM sleep behavior disorder, there ... Full text Link to item Cite

Narcolepsy-cataplexy: deficient prepulse inhibition of blink reflex suggests pedunculopontine involvement.

Journal Article J Sleep Res · October 2012 Hypocretin (orexin) deficiency plays a major role in the pathophysiology of narcolepsy-cataplexy. In animal models, hypocretinergic projections to the pedunculopontine nucleus are directly involved in muscle tone regulation mediating muscle atonia - a hall ... Full text Link to item Cite

Environmental risk factors for REM sleep behavior disorder: A multicenter case-control study

Journal Article Neurology · July 31, 2012 Objective: Idiopathic REM sleep behavior disorder is a parasomnia characterized by dream enactment and is commonly a prediagnostic sign of parkinsonism and dementia. Since risk factors have not been defined, we initiated a multicenter case-control study to ... Full text Cite

Investigation of autonomic function in idiopathic REM sleep behavior disorder.

Journal Article J Neurol · June 2012 Idiopathic REM sleep behavior disorder (iRBD) has been suggested as an early "pre-motor" stage of Parkinson's disease (PD) in a significant proportion of cases. We investigated autonomic function in 15 consecutive iRBD patients and compared these findings ... Full text Link to item Cite

A single-question screen for rapid eye movement sleep behavior disorder: a multicenter validation study.

Journal Article Mov Disord · June 2012 BACKGROUND: Idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia that is an important risk factor for Parkinson's disease (PD) and Lewy body dementia. Its prevalence is unknown. One barrier to determining prevalence is that cur ... Full text Link to item Cite

Normative EMG values during REM sleep for the diagnosis of REM sleep behavior disorder.

Journal Article Sleep · June 1, 2012 BACKGROUND: Correct diagnosis of rapid eye movement sleep behavior disorder (RBD) is important because it can be the first manifestation of a neurodegenerative disease, it may lead to serious injury, and it is a well-treatable disorder. We evaluated the el ... Full text Link to item Cite

Decision making and executive functions in REM sleep behavior disorder.

Journal Article Sleep · May 1, 2012 STUDY OBJECTIVES: This study was designed to assess decision making and executive functions in patients with idiopathic REM sleep behavior disorder (iRBD). IRBD is often seen as an early sign of later evolving neurodegenerative disease, most importantly Pa ... Full text Link to item Cite

White and gray matter abnormalities in narcolepsy with cataplexy.

Journal Article Sleep · March 1, 2012 STUDY OBJECTIVES: The authors applied diffusion-tensor imaging including measurements of mean diffusivity (MD), which is a parameter of brain tissue integrity, fractional anisotropy (FA), which is a parameter of neuronal fiber integrity, and voxel-based mo ... Full text Link to item Cite

Can observers link dream content to behaviours in rapid eye movement sleep behaviour disorder? A cross-sectional experimental pilot study.

Journal Article J Sleep Res · February 2012 Motor activity in rapid eye movement (REM) sleep behaviour disorder (RBD) has been linked to dream content. Systematic and controlled sleep laboratory studies directly assessing the relation between RBD behaviours and experienced dream content are, however ... Full text Link to item Cite

Sleep-related movement disorders

Chapter · January 1, 2012 Introduction Nocturnal sleep disturbances, excessive daytime sleepiness, sleep-related breathing disorders, and sleep-related movement disorders are major non-motor key features of many movement disorders. Most research has focussed on Parkinson’s disease, ... Full text Cite

Prevalence of restless legs syndrome in a Georgian primary healthcare setting: a pilot study.

Journal Article Eur Neurol · 2012 BACKGROUND: The prevalence of restless legs syndrome (RLS) is approximately 10% in Western Europe, but unknown in Georgia. This pilot study aimed to assess RLS prevalence in a focused Georgian population. METHODS: An RLS epidemiological questionnaire [Alle ... Full text Link to item Cite

Measurement of endogenous acetone and isoprene in exhaled breath during sleep

Journal Article Physiological Measurement · January 1, 2012 This explorative study aims at characterizing the breath behavior of two prototypic volatile organic compounds, acetone and isoprene, during normal human sleep and to possibly relate changes in the respective concentration time courses to the underlying sl ... Full text Cite

Motor disturbances during non-REM and REM sleep in narcolepsy-cataplexy: a video-polysomnographic analysis.

Journal Article J Sleep Res · December 2011 Motor events during sleep can be frequently observed in patients with narcolepsy-cataplexy. We hypothesized that increased motor events and related arousals contribute to sleep fragmentation in this disease. We aimed to perform a detailed whole-night video ... Full text Link to item Cite

Erratum: Common variants in P2RY11 are associated with narcolepsy (Nature Genetics (2011) 43 (66-71))

Journal Article Nature Genetics · October 1, 2011 Full text Cite

Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.

Journal Article PLoS Genet · July 2011 Restless legs syndrome (RLS) is a sensorimotor disorder with an age-dependent prevalence of up to 10% in the general population above 65 years of age. Affected individuals suffer from uncomfortable sensations and an urge to move in the lower limbs that occ ... Full text Link to item Cite

Executive functions, information sampling, and decision making in narcolepsy with cataplexy.

Journal Article Neuropsychology · July 2011 OBJECTIVE: Narcolepsy with cataplexy (NC) affects neurotransmitter systems regulating emotions and cognitive functions. This study aimed to assess executive functions, information sampling, reward processing, and decision making in NC. METHOD: Twenty-one N ... Full text Link to item Cite

Fragmentary myoclonus in sleep revisited: a polysomnographic study in 62 patients.

Journal Article Sleep Med · April 2011 STUDY OBJECTIVES: To investigate the frequency of fragmentary myoclonus (FM) in a sleep-disorder population, to analyze its distribution across sleep stages and to examine potential associations with clinical correlates and night-to-night variability. DESI ... Full text Link to item Cite

Parkinson's disease sleep scale--validation of the revised version PDSS-2.

Journal Article Mov Disord · March 2011 BACKGROUND: The previous Parkinson's disease sleep scale (PDSS) is a 15-item visual analogue scale that assesses the profile of nocturnal disturbances in Parkinson's disease (PD) patients. OBJECTIVE: To extend the scale so that it becomes a frequency measu ... Full text Link to item Cite

Usefulness of the SINBAR electromyographic montage to detect the motor and vocal manifestations occurring in REM sleep behavior disorder.

Journal Article Sleep Med · March 2011 OBJECTIVE: In a previous study we showed that simultaneous electromyographic (EMG) recording of the mentalis, flexor digitorum superficialis and extensor digitorum brevis (SINBAR EMG montage) detected the highest rates of rapid eye movement (REM) sleep pha ... Full text Link to item Cite

Restless legs syndrome in Friedreich ataxia: a polysomnographic study.

Journal Article Mov Disord · February 1, 2011 Friedreich ataxia (FA) is the most common type of hereditary ataxia. Frataxin deficiency due to a GAA expansion in the first intron of chromosome 9 results in intramitochondrial iron accumulation. On the basis of the patients' complaints about sleep distur ... Full text Link to item Cite

White and gray matter abnormalities in idiopathic rapid eye movement sleep behavior disorder: a diffusion-tensor imaging and voxel-based morphometry study.

Journal Article Ann Neurol · February 2011 OBJECTIVE: We applied diffusion-tensor imaging (DTI) including measurements of mean diffusivity (MD), a parameter of brain tissue integrity, fractional anisotropy (FA), a parameter of neuronal fiber integrity, as well as voxel-based morphometry (VBM), a me ... Full text Link to item Cite

Common variants in P2RY11 are associated with narcolepsy.

Journal Article Nat Genet · January 2011 Growing evidence supports the hypothesis that narcolepsy with cataplexy is an autoimmune disease. We here report genome-wide association analyses for narcolepsy with replication and fine mapping across three ethnic groups (3,406 individuals of European anc ... Full text Link to item Cite

A descriptive analysis of neck myoclonus during routine polysomnography.

Journal Article Sleep · August 2010 STUDY OBJECTIVES: Although episodes of neck myoclonus (head jerks) in REM sleep have a characteristic appearance, they have so far not been described systematically in video-polysomnography. This study assesses the occurrence, frequency, and characteristic ... Full text Link to item Cite

Reply: "Restless legs syndrome and Parkinson's disease"

Journal Article Movement Disorders · July 15, 2010 Full text Cite

Restless Legs Syndrome

Chapter · May 18, 2010 Full text Cite

Excessive daytime sleepiness in Austria: Prevalence and risk factors

Journal Article Somnologie · March 1, 2010 Background: The prevalence of excessive daytime sleepiness has been studied in many countries. Results differ remarkably depending on the definition and methods used. The objective of the present study was to evaluate the prevalence of excessive daytime sl ... Full text Cite

REM sleep behavior disorder in 703 sleep-disorder patients: the importance of eliciting a comprehensive sleep history.

Journal Article Sleep Med · February 2010 OBJECTIVES: The aim of our study was to evaluate the frequency of REM sleep behavior disorder (RBD) in a mixed sleep laboratory population and to assess potential associations. Moreover, we investigated referral diagnoses of patients subsequently diagnosed ... Full text Link to item Cite

Progressive development of augmentation during long-term treatment with levodopa in restless legs syndrome: results of a prospective multi-center study.

Journal Article J Neurol · February 2010 The European Restless Legs Syndrome (RLS) Study Group performed the first multi-center, long-term study systematically evaluating RLS augmentation under levodopa treatment. This prospective, open-label 6-month study was conducted in six European countries ... Full text Link to item Cite

Restless legs syndrome in Parkinson's disease.

Journal Article Mov Disord · October 30, 2009 We aimed to investigate the prevalence of restless legs syndrome (RLS) according to essential diagnostic criteria, and to explore potential associations with clinical features, especially motor fluctuations, in a cohort of 113 patients with idiopathic Park ... Full text Link to item Cite

Midbrain hyperechogenicity in idiopathic REM sleep behavior disorder.

Journal Article Mov Disord · October 15, 2009 Recent studies have reported an increased risk to develop Parkinson's disease (PD) in patients with idiopathic RBD (iRBD). Midbrain hyperechogenicity is a common transcranial sonography (TCS) finding in PD and has been suggested as a PD risk-marker in nonp ... Full text Link to item Cite

Cerebral vasoreactivity decreases overnight in severe obstructive sleep apnea syndrome: a study of cerebral hemodynamics.

Journal Article Sleep Med · September 2009 BACKGROUND: OSAS has been associated with surrogate markers of atherosclerosis and is a known risk factor for stroke. However, there is limited data on the effects of recurring apneas in severe OSAS on cerebral circulation and their consequences on cerebro ... Full text Link to item Cite

Erratum: Narcolepsy is strongly associated with the T-cell receptor alpha locus (Nature Genetics (2009) 41 (708-711))

Journal Article Nature Genetics · July 1, 2009 Full text Cite

The severity range of restless legs syndrome (RLS) and augmentation in a prospective patient cohort: association with ferritin levels.

Journal Article Sleep Med · June 2009 OBJECTIVES: The aim of the study was to prospectively examine all patients with a diagnosis of RLS consulting a sleep disorders clinic and to assess RLS severity and augmentation and their associations, including ferritin levels. METHODS: Patients were str ... Full text Link to item Cite

Narcolepsy is strongly associated with the T-cell receptor alpha locus.

Journal Article Nat Genet · June 2009 Narcolepsy with cataplexy, characterized by sleepiness and rapid onset into REM sleep, affects 1 in 2,000 individuals. Narcolepsy was first shown to be tightly associated with HLA-DR2 (ref. 3) and later sublocalized to DQB1*0602 (ref. 4). Following studies ... Full text Link to item Cite

Mode of vagus nerve stimulation differentially affects sleep related breathing in patients with epilepsy.

Journal Article Seizure · June 2009 PURPOSE: We describe the influence of vagus nerve stimulation (VNS) with standard mode and rapid cycling mode on sleep related breathing in two patients with epilepsy. METHODS: Two VNS treated patients underwent digital video-polysomnography for three nigh ... Full text Link to item Cite

Replication of restless legs syndrome loci in three European populations.

Journal Article J Med Genet · May 2009 BACKGROUND: Restless legs syndrome (RLS) is associated with common variants in three intronic and intergenic regions in MEIS1, BTBD9, and MAP2K5/LBXCOR1 on chromosomes 2p, 6p and 15q. METHODS: Our study investigated these variants in 649 RLS patients and 1 ... Full text Link to item Cite

PLM detection by actigraphy compared to polysomnography: a validation and comparison of two actigraphs.

Journal Article Sleep Med · March 2009 OBJECTIVE: To compare periodic leg movement (PLM) counts obtained with polysomnography (PSG) to those obtained from actigraphy with two devices (Actiwatch and PAM-RL). METHODS: Twenty-four patients underwent full night actigraphy with Actiwatch from both l ... Full text Link to item Cite

The relation between abnormal behaviors and REM sleep microstructure in patients with REM sleep behavior disorder.

Journal Article Sleep Med · February 2009 OBJECTIVE: To investigate the temporal relation between rapid eye movement (REM) sleep microstructure (REMs, EMG activity) and motor events in REM sleep behavior disorder (RBD). METHODS: Polysomnographic records of eight patients with RBD were analyzed and ... Full text Link to item Cite

Periodic leg movements during sleep and periodic limb movement disorder in patients presenting with unexplained insomnia.

Journal Article Clin Neurophysiol · February 2009 OBJECTIVE: The aim of this study was to evaluate quantitatively the presence and the characteristics of periodic leg movements during sleep (PLMS) in a group of consecutive patients presenting with daytime impairment related to insomnia of unknown etiology ... Full text Link to item Cite

PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome.

Journal Article Nat Genet · August 2008 We identified association of restless legs syndrome (RLS) with PTPRD at 9p23-24 in 2,458 affected individuals and 4,749 controls from Germany, Austria, Czechia and Canada. Two independent SNPs in the 5' UTR of splice variants expressed predominantly in the ... Full text Link to item Cite

Suggestive evidence for linkage for restless legs syndrome on chromosome 19p13.

Journal Article Neurogenetics · May 2008 Five loci for restless legs syndrome (RLS) on chromosomes 12q, 14q, 9p, 2q, and 20p (RLS1-RLS5) have been mapped in RLS families, with a recessive in the first and autosomal-dominant mode of inheritance in the latter cases. Investigations of further RLS fa ... Full text Link to item Cite

Quantification of electromyographic activity during REM sleep in multiple muscles in REM sleep behavior disorder.

Journal Article Sleep · May 2008 STUDY OBJECTIVES: The aim of our study was to determine which muscle or combination of muscles (either axial or limb muscles, lower or upper limb muscles, or proximal or distal limb muscles) provides the highest rates of rapid eye movement (REM) sleep phas ... Full text Link to item Cite

Validation of the Augmentation Severity Rating Scale (ASRS): a multicentric, prospective study with levodopa on restless legs syndrome.

Journal Article Sleep Med · August 2007 BACKGROUND: Augmentation is the main complication during long-term dopaminergic treatment of restless legs syndrome (RLS) and reflects an overall increase in RLS severity. Its severity varies considerably from a minor problem to a devastating exacerbation ... Full text Link to item Cite

Video analysis of motor events in REM sleep behavior disorder.

Journal Article Mov Disord · July 30, 2007 In REM sleep behavior disorder (RBD), several studies focused on electromyographic characterization of motor activity, whereas video analysis has remained more general. The aim of this study was to undertake a detailed and systematic video analysis. Nine p ... Full text Link to item Cite

Erratum: Auditory startle reaction is disinhibited in idiopathic restless legs syndrome (Sleep (2007) 30, 4, (489-493))

Journal Article Sleep · May 1, 2007 Cite

Auditory startle reaction is disinhibited in idiopathic restless legs syndrome.

Journal Article Sleep · April 2007 STUDY OBJECTIVES: Because the auditory startle reaction is abnormal in disorders with substantia nigra pathology, we hypothesized that auditory startle responses (ASRs) might also be altered in restless legs syndrome (RLS). DESIGN: Neurophysiologic study o ... Full text Link to item Cite

Family-based association study of the restless legs syndrome loci 2 and 3 in a European population.

Journal Article Mov Disord · January 15, 2007 Three loci for the restless legs syndrome (RLS) on chromosomes 12q, 14q, and 9p (RLS1, RLS2, and RLS3) have been mapped, but no gene has been identified as yet. RLS1 has been confirmed in families from three different populations. We conducted a family-bas ... Full text Link to item Cite

The role of laboratory diagnostics in sleep medicine

Journal Article Laboratoriumsmedizin · October 1, 2006 Sleep medicine represents an interdisciplinary science consisting of neurology, psychiatry, pulmonology, internal medicine, pediatry, otorhinolaryngology, and dentistry in which polysomnographic, actigraphic, and ambulatory methods as well as a detailed me ... Full text Cite

Disturbance of rapid eye movement sleep in spinocerebellar ataxia type 2.

Journal Article Mov Disord · October 2006 Five genetically confirmed spinocerebellar ataxia type 2 (SCA2) patients were admitted to our sleep laboratory for two all-night video-polysomnographies. A standard montage was used, including electroencephalography, vertical and horizontal electrooculogra ... Full text Link to item Cite

Restless legs syndrome and motor activity during sleep in spinocerebellar ataxia type 6.

Journal Article Sleep Med · September 2006 BACKGROUND AND PURPOSE: We investigated the frequency of restless legs syndrome (RLS) and sleep disturbance in spinocerebellar ataxia type 6 (SCA6). PATIENTS AND METHODS: Five patients out of three multigenerational SCA6 families underwent a standardized i ... Full text Link to item Cite

Daytime sleepiness and the COMT val158met polymorphism in patients with Parkinson disease.

Journal Article Sleep · January 2006 STUDY OBJECTIVE: A preliminary study by our group suggested an association between daytime sleepiness and the catechol-O-methyltransferase (COMT) val158met polymorphism (rs4680) in patients with Parkinson disease (PD). We sought to confirm this association ... Link to item Cite

Daytime sleepiness is not increased in mild to moderate multiple sclerosis: a pupillographic study.

Journal Article Sleep Med · November 2005 BACKGROUND: Daytime sleepiness has been described in multiple sclerosis (MS); a combination of MS and narcolepsy has also been observed in a few case reports. In this study, we investigated daytime sleepiness in a general sample of MS patients compared to ... Full text Link to item Cite

Voxel-based morphometry in narcolepsy.

Journal Article Sleep Med · November 2005 BACKGROUND AND PURPOSE: Voxel-based morphometry (VBM) is a magnetic resonance imaging (MRI)-based indirect volumetry, which allows the investigation of the entire brain without restriction of predefined regions-of-interest. Recent studies using this techni ... Full text Link to item Cite

Restless legs syndrome: a community-based study of prevalence, severity, and risk factors.

Journal Article Neurology · June 14, 2005 OBJECTIVE: To assess the prevalence and severity of restless legs syndrome (RLS) in the general community and to investigate its potential relationship with iron metabolism and other potential risk factors. METHODS: This was a cross-sectional study of a se ... Full text Link to item Cite

Association of daytime sleepiness with COMT polymorphism in patients with parkinson disease: a pilot study.

Journal Article Sleep · June 15, 2004 STUDY OBJECTIVES: To evaluate an association between catechol-O-methyltransferase (COMT) genotype and subjective daytime sleepiness in patients with Parkinson disease. DESIGN: Structured questionnaire study. SETTING: Tertiary Parkinson disease care center ... Full text Link to item Cite

Increased daytime sleepiness in Parkinson's disease: a questionnaire survey.

Journal Article Mov Disord · March 2003 We evaluated the frequency and severity of excessive daytime sleepiness in an outpatient population with Parkinson's disease in comparison to age-matched controls and examined its relationship with antiparkinsonian drug therapy and sleep history. Increased ... Full text Link to item Cite

Restless legs syndrome: Diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health

Journal Article Sleep Medicine · January 1, 2003 Background: Restless legs syndrome is a common yet frequently undiagnosed sensorimotor disorder. In 1995, the International Restless Legs Syndrome Study Group developed standardized criteria for the diagnosis of restless legs syndrome. Since that time, add ... Full text Cite

Transient restless legs syndrome after spinal anesthesia: a prospective study.

Journal Article Neurology · December 10, 2002 OBJECTIVE: To assess the incidence and time course of new-onset restless legs syndrome (RLS) after spinal anesthesia. METHODS: A total of 202 consecutive patients undergoing spinal anesthesia for various types of surgery were prospectively evaluated regard ... Full text Link to item Cite

Modafinil for the treatment of daytime sleepiness in Parkinson's disease: a double-blind, randomized, crossover, placebo-controlled polygraphic trial.

Journal Article Sleep · December 2002 OBJECTIVES: To assess the therapeutic efficacy of modafinil in the treatment of increased daytime sleepiness in patients with Parkinson's disease (PD). DESIGN: Double-blind, randomized, placebo-controlled crossover study with two 2-week treatment blocks, s ... Link to item Cite