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Brandon Augustus Howard

Brandon Augustus Howard

Assistant Professor of Radiology
Radiology, Nuclear Medicine
brandon.howard@duke.edu
Box 3949 Med Ctr, Durham, NC 27710
Dept of Radiology, Durham, NC 27710

Selected Publications

18F-FDG-PET/CT Imaging for Gastrointestinal Malignancies.

Journal Article Radiol Clin North Am · September 2021 Gastrointestinal malignancies encompass a variety of primary tumor sites, each with different staging criteria and treatment approaches. In this review we discuss technical aspects of 18F-FDG-PET/CT scanning to optimize information from both the PET and co ... Full text Open Access Link to item Cite

The utility of initial staging PET-CT as a baseline scan for surveillance imaging in stage II and III melanoma.

Journal Article Surg Oncol · December 2020 BACKGROUND: This study evaluates the utility of whole-body PET-CT for the initial staging and subsequent surveillance imaging of patients with completely resected stage II and stage III melanoma. METHODS: A single-center, retrospective review of patients w ... Full text Link to item Cite

Molecular Imaging in the Head and Neck: Diagnosis and Therapy.

Journal Article Radiol Clin North Am · November 2020 This article is a summary of the most up-to-date applications of radiopharmaceuticals to the diagnosis and therapy of benign and malignant diseases involving endocrine or neuroendocrine organs of the head and neck, focusing on radiotracers approved by the ... Full text Link to item Cite

Predictors of Survival in 211 Patients with Stage IV Pulmonary and Gastroenteropancreatic MIBG-Positive Neuroendocrine Tumors Treated with 131I-MIBG.

Journal Article J Nucl Med · November 2018 This retrospective analysis identifies predictors of survival in a cohort of patients with meta-iodobenzylguanidine (MIBG)-positive stage IV pulmonary and gastroenteropancreatic neuroendocrine tumor (P/GEP-NET) treated with 131I-MIBG therapy, to inform tre ... Full text Open Access Link to item Cite

Utility of Radionuclide Bone Scintigraphy in Complex Regional Pain Syndrome.

Journal Article Curr Pain Headache Rep · February 1, 2018 PURPOSE OF REVIEW: To describe the current understanding of the role of three-phase bone scintigraphy (TPBS) in the diagnosis and management of complex regional pain syndrome (CRPS), discuss its advantages and limitations, and present three examples of TPB ... Full text Link to item Cite

Comparison of Bayesian penalized likelihood reconstruction versus OS-EM for characterization of small pulmonary nodules in oncologic PET/CT.

Journal Article Ann Nucl Med · October 2017 OBJECTIVE: To determine whether the recently introduced Bayesian penalized likelihood PET reconstruction (Q.Clear) increases the visual conspicuity and SUVmax of small pulmonary nodules near the PET resolution limit, relative to ordered subset expectation ... Full text Link to item Cite

Unusual Soft Tissue Uptake of F-18 Sodium Fluoride in Three Patients Undergoing F-18 NaF PET/CT Bone Scans for Prostate Cancer

Journal Article Nuclear Medicine and Molecular Imaging · September 1, 2017 Three males aged 71 to 80 years with known stage IV metastatic prostate cancer underwent F-18 sodium fluoride (NaF) PET/CT to assess osseous metastatic disease burden and stability. In addition to F-18 NaF avid known osseous metastases, each patient also e ... Full text Cite

A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearance.

Journal Article SAGE Open Med Case Rep · 2017 In thyroid cancer patients with renal impairment or other complicating factors, it is important to maximize I-131 therapy efficacy while minimizing bone marrow and lung damage. We developed a web-based calculator based on a modified Benua and Leeper method ... Full text Open Access Link to item Cite

Patient and tumor characteristics predictive of an elevated hepatopulmonary shunt fraction before radioembolization of hepatic tumors.

Journal Article Nucl Med Commun · September 2016 OBJECTIVE: To determine whether any patient or hepatic tumor characteristics are predictive of hepatopulmonary shunt fraction when performed before radioembolization. MATERIALS AND METHODS: A retrospective review was performed on 190 patients who underwent ... Full text Link to item Cite

Difference in appearance between prone and supine myocardial perfusion images obtained on a high-efficiency cadmium zinc telluride SPECT camera.

Journal Article Nucl Med Commun · May 2016 OBJECTIVE: The recent introduction of high-efficiency solid-state gamma cameras for myocardial perfusion single photon emission computed tomography has enabled lower patient radiation dose, faster imaging, and improved image quality. However, artifacts sti ... Full text Link to item Cite

Isolated recto-sigmoid colitis: a new imaging pattern of ipilimumab-associated colitis.

Journal Article Abdom Radiol (NY) · February 2016 PURPOSE: The purpose of this study is to describe typical CT findings and distinct imaging patterns of ipilimumab-associated colitis in immunotherapeutic treatment of melanoma. MATERIALS AND METHODS: This HIPAA-compliant retrospective study included 86 pat ... Full text Link to item Cite

FDG Uptake on Positron Emission Tomography Correlates with Survival and Time to Recurrence in Patients with Stage I Non-Small-Cell Lung Cancer.

Journal Article J Thorac Oncol · June 2015 INTRODUCTION: Patients with stage I non-small-cell lung cancer (NSCLC) have a wide variation in outcomes, most likely because there are undetected metastases at presentation. We retrospectively reviewed patients with early stage lung cancer to determine if ... Full text Link to item Cite

Definitive diagnosis of cerebrospinal fluid leak into the pleural space using 111In-DTPA cisternography.

Journal Article Clin Nucl Med · March 2015 A 58-year-old woman with a calcified disk extrusion causing severe spinal stenosis underwent T8 to T9 diskectomy and spinal fusion. A postoperative pseudomeningocele was treated with lumbar drain and fibrin glue. Performed for persistent right pleural effu ... Full text Link to item Cite

PET-CT: current applications and new developments in the thorax.

Journal Article Semin Respir Crit Care Med · February 2014 Positron emission tomography computed tomography(PET-CT) imaging has emerged as an essential clinical diagnostic tool in the evaluation of thoracic abnormalities. Currently, its primary role is for tumor imaging; it helps to differentiate benign from malig ... Full text Link to item Cite

Murine CD7 shares antigenic cross-reactivity with HSP-60.

Journal Article Hybridoma (Larchmt) · April 2008 Human (h) CD7 is a 40 kDa single chain Ig superfamily molecule that is expressed on thymocytes, a major subunit of peripheral T cells, and most natural killer cells. Ligands for hCD7 include the epithelial cell-produced molecule, K-12, and galectin. Mice d ... Full text Link to item Cite

Stable RNA interference-mediated suppression of cyclophilin A diminishes non-small-cell lung tumor growth in vivo.

Journal Article Cancer Res · October 1, 2005 Cyclophilin A (CypA) was recently reported to be overexpressed in non-small-cell lung cancer, and represents a potentially novel therapeutic target. To determine the role of CypA in oncogenesis, stable RNA interference (RNAi)-mediated knockdown of CypA was ... Full text Link to item Cite

Translating biomarkers into clinical practice: prognostic implications of cyclophilin A and macrophage migratory inhibitory factor identified from protein expression profiles in non-small cell lung cancer.

Journal Article Lung Cancer · December 2004 Biomarkers have the potential to significantly change diagnostic strategies and influence therapeutic management. We developed a MALDI-TOF protein expression profiling platform for biomarker discovery and a proof-of-principle study identified two proteins, ... Full text Link to item Cite

Thermodynamic analysis of cyclosporin a binding to cyclophilin a in a lung tumor tissue lysate.

Journal Article Anal Chem · August 1, 2004 We report on the application of SUPREX (stability of unpurified proteins from rates of H/D exchange) to the analysis of a protein-ligand binding interaction under the ex vivo solution conditions of a human lung tumor tissue lysate. A SUPREX-derived binding ... Full text Link to item Cite

Identification and validation of a potential lung cancer serum biomarker detected by matrix-assisted laser desorption/ionization-time of flight spectra analysis.

Journal Article Proteomics · September 2003 Many abnormalities detected in the thorax by routine conventional imaging studies are benign, yet all require further evaluation because of the concern for cancer. To address this deficiency and develop a serum biomarker for lung cancer, we designed a matr ... Full text Link to item Cite

Analysis of human serum proteins by liquid phase isoelectric focusing and matrix-assisted laser desorption/ionization-mass spectrometry.

Journal Article Proteomics · September 2003 Direct matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) analysis of human serum yielded ion signals from only a fraction of the total number of peptides and proteins expected to be in the sample. We increased the ... Full text Link to item Cite

Protein expression profiling identifies macrophage migration inhibitory factor and cyclophilin a as potential molecular targets in non-small cell lung cancer.

Journal Article Cancer Res · April 1, 2003 Current diagnostic and therapeutic strategies for lung cancer have had no significant impact on lung cancer mortality over the last several decades. This study used a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF M ... Link to item Cite

Use of mixture models in MALDI-TOF proteomic data for peak registration

Conference PROCEEDINGS OF THE 7TH JOINT CONFERENCE ON INFORMATION SCIENCES · January 1, 2003 Link to item Cite

A fractionation protocol to reduce signal suppression effects in the MALDI analysis of blood proteins

Journal Article Proceedings 50th Asms Conference on Mass Spectrometry and Allied Topics · December 1, 2002 A protocol involving the combination of liquid-phase isoelectric focusing and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) was developed. Liquid-phase isoelectric focusing was used to separate serum peptides a ... Cite

Sweet the sound. Music in medicine.

Journal Article N C Med J · 2001 Link to item Cite