Scholars@Duke
Brian Bishop Hughley

Brian Bishop Hughley

Associate Professor of Head and Neck Surgery & Communication Sciences
Head & Neck Surgical Oncology

Selected Publications

P16/HPV-negative oropharyngeal squamous cell carcinoma survival: Comparing primary surgery to primary chemoradiotherapy. A systematic review and meta-analysis.

Journal Article Eur J Surg Oncol · July 2025 OBJECTIVES: This study investigated differences in survival for p16/HPV-negative OPSCC patients treated with primary surgery versus primary (chemo-)radiation therapy (CRT). MATERIALS AND METHODS: PubMed, CINAHL and Web of Science databases and the online C ... Full text Link to item Cite

Clinician feedback using a shared decision-making tool for the evaluation of patients with thyroid nodules-an observational study.

Journal Article Endocrine · February 2024 BackgroundWe pilot-tested an encounter conversation aid to support shared decision making (SDM) between patients with thyroid nodules and their clinicians.ObjectiveCharacterize the clinician feedback after providing care to patients with ... Full text Cite

The beavertail modified radial forearm free flap: Retrospective review of a versatile technique to increase flap bulk in the head and neck.

Journal Article Microsurgery · November 2023 OBJECTIVE: Utilization of free tissue transfers in head and neck reconstruction has greatly increased due to their dependability and reliability. Anterolateral thigh (ALT) and rectus abdominus (RA) free flaps may provide too much soft tissue bulk, especial ... Full text Link to item Cite

Tumor volume as a predictor of survival in advanced laryngeal cancer treated with total laryngectomy.

Journal Article Head Neck · June 2023 BACKGROUND: Recent literature shows that tumor volume (TV) in T3 laryngeal squamous cell carcinoma (LSCC) is associated with response to radiation therapy. The aim of this study was to evaluate the effect of TV on survival outcomes in patients undergoing t ... Full text Link to item Cite

Patient feedback receiving care using a shared decision making tool for thyroid nodule evaluation-an observational study.

Journal Article Endocrine · April 2023 PURPOSE: To characterize the feedback of patients with thyroid nodules receiving care using a shared decision making (SDM) tool designed to improve conversations with their clinicians related to diagnostic options (e.g. thyroid biopsy, ultrasound surveilla ... Full text Link to item Cite

American Head and Neck Society position statement on the use of PD-1 inhibitors for treatment of advanced cutaneous squamous cell carcinoma.

Journal Article Head Neck · January 2023 BACKGROUND: A position statement put forth by the American Head and Neck Society (AHNS) was constructed to provide evidence-based treatment recommendations for PD-1 inhibitor use in advanced cutaneous squamous cell carcinoma (cSCC). Secondarily, we sought ... Full text Link to item Cite

Non-HPV-Related Head and Neck Squamous Cell Carcinoma in a Young Patient Cohort.

Journal Article Ear Nose Throat J · December 2021 OBJECTIVES: Head and neck squamous cell carcinoma (HNSCC) is rare in patients younger than 40 years. Many practitioners suspect HNSCC is a more aggressive disease in this age group, and perhaps increasing in incidence; however, there are scant and conflict ... Full text Link to item Cite

Sinking skin flap syndrome in head and neck reconstruction: A case report

Journal Article Otolaryngology Case Reports · November 1, 2021 We describe the first documented case of sinking skin flap syndrome (SSFS) following head and neck cancer resection with free flap reconstruction. This rare syndrome, also known as “syndrome of the trephined,” is an uncommon complication typically seen aft ... Full text Cite

Ethical Considerations for Elderly Patients with Cutaneous Malignancy.

Journal Article Otolaryngol Clin North Am · April 2021 Discussions of ethics in surgery generally focus on the principles of beneficence, nonmalfeasance, autonomy, and justice. Caring for elderly patients with advanced cutaneous malignancies often requires the added consideration of narrative ethics to account ... Full text Link to item Cite

Shift in the timing of microvascular free tissue transfer failures in head and neck reconstruction.

Journal Article Laryngoscope · February 2020 OBJECTIVE: Analyze the cause and significance of a shift in the timing of free flap failures in head and neck reconstruction. STUDY DESIGN: Retrospective multi-institutional review of prospectively collected databases at tertiary care centers. METHODS: Inc ... Full text Link to item Cite

Cutaneous Head and Neck Malignancies in the Elderly.

Journal Article Clin Geriatr Med · May 2018 Cutaneous malignancy of the head and neck affects a large proportion of elderly patients. The severity ranges from small, easily treatable lesions to large, invasive, potentially metastatic tumors. Surgical treatment is the primary treatment of most skin c ... Full text Link to item Cite

Survival outcomes in elderly patients with untreated upper aerodigestive tract cancer.

Journal Article Head Neck · February 2017 BACKGROUND: This study is an evaluation of survival in patients with upper aerodigestive tract (UADT) cancer who did not receive guideline-directed therapy. METHODS: The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) databas ... Full text Link to item Cite

Antiangiogenic antibody improves melanoma detection by fluorescently labeled therapeutic antibodies.

Journal Article Laryngoscope · December 2016 OBJECTIVE: Evaluate if vascular normalization with an antiangiogenic monoclonal antibody improves detection of melanoma using fluorescently labeled antibody-based imaging. STUDY DESIGN: Preclinical. METHODS: Panitumumab and control IgG were covalently link ... Full text Link to item Cite

The promotion of mandibular defect healing by the targeting of S1P receptors and the recruitment of alternatively activated macrophages.

Journal Article Biomaterials · December 2013 Endogenous signals originating at the site of injury are involved in the paracrine recruitment, proliferation, and differentiation of circulating progenitor and diverse inflammatory cell types. Here, we investigate a strategy to exploit endogenous cell rec ... Full text Link to item Cite

Multilayer cell-seeded polymer nanofiber constructs for soft-tissue reconstruction.

Journal Article JAMA Otolaryngol Head Neck Surg · September 2013 IMPORTANCE: Cell seeding throughout the thickness of a nanofiber construct allows for patient-specific implant alternatives with long-lasting effects, earlier integration, and reduced inflammation when compared with traditional implants. Cell seeding may i ... Full text Link to item Cite

Revision of the functionally devastated nasal airway.

Journal Article Facial Plast Surg · August 2012 Functional rhinoplasty can be especially challenging in a patient who has had previous surgery, trauma, anatomic abnormalities, or systemic disease affecting the nasal mucosa. A thorough analysis of the type and location of the obstruction is critical, and ... Full text Link to item Cite

Revision aural atresia surgery: indications and outcomes.

Conference Otol Neurotol · February 2011 OBJECTIVE: To determine the most common indications for revision congenital aural atresia (CAA) surgery and the postoperative healing and hearing outcomes of revision surgery. STUDY DESIGN: Retrospective case review. SETTING: Tertiary care academic otologi ... Full text Link to item Cite

Construct validity of a simulator for myringotomy with ventilation tube insertion.

Journal Article Otolaryngol Head Neck Surg · November 2009 OBJECTIVES: To establish construct validity of an anatomic model as a simulator for myringotomy with ventilation tube insertion and to assess its subjective appeal. STUDY DESIGN: Cross-sectional, repeated-measures comparative evaluation of simulator. SETTI ... Full text Link to item Cite

Complications with forehead flaps in nasal reconstruction.

Journal Article Laryngoscope · June 2009 OBJECTIVES/HYPOTHESIS: To determine what characteristics and comorbidities are associated with a higher rate of complications in patients undergoing nasal reconstruction with a forehead flap. STUDY DESIGN: Retrospective chart review. METHODS: Chart review ... Full text Link to item Cite