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Bryan O'Sullivan-Murphy

Bryan O'Sullivan-Murphy

Assistant Professor of Radiology
Radiology, Cardiothoracic Imaging
bryan.osullivanmurphy@duke.edu
Duke Hospital North, 2301 Erwin Rd Box 3808, Durham, NC 27710

Selected Publications

Radiographic Imaging of Community-Acquired Pneumonia: A Case-Based Review.

Journal Article Infect Dis Clin North Am · March 2024 The chest radiograph is the most common imaging examination performed in most radiology departments, and one of the more common indications for these studies is suspected infection. Radiologists must therefore be aware of less common radiographic patterns ... Full text Link to item Cite

Image quality of photon counting and energy integrating chest CT - Prospective head-to-head comparison on same patients.

Journal Article Eur J Radiol · September 2023 PURPOSE: To prospectively compare the image quality of high-resolution, low-dose photon-counting detector CT (PCD-CT) with standard energy-integrating-detector CT (EID) on the same patients. METHOD: IRB-approved, prospective study; patients received same-d ... Full text Open Access Link to item Cite

MR Imaging for the Evaluation of Diffuse Lung Disease: Where Are We?

Journal Article Radiol Clin North Am · November 2022 Patients with diffuse lung diseases require thorough medical and social history and physical examinations, coupled with a multitude of laboratory tests, pulmonary function tests, and radiologic imaging to discern and manage the specific disease. This revie ... Full text Link to item Cite

Radiographic Imaging of Community-Acquired Pneumonia: A Case-Based Review.

Journal Article Radiol Clin North Am · May 2022 The chest radiograph is the most common imaging examination performed in most radiology departments, and one of the more common indications for these studies is suspected infection. Radiologists must therefore be aware of less common radiographic patterns ... Full text Link to item Cite

Role of ultrasound in the evaluation of first-trimester pregnancies in the acute setting.

Journal Article Ultrasonography · April 2020 In patients presenting for an evaluation of pregnancy in the first trimester, transvaginal ultrasound is the modality of choice for establishing the presence of an intrauterine pregnancy; evaluating pregnancy viability, gestational age, and multiplicity; d ... Full text Link to item Cite

Pancreaticobiliary Trauma: A Multimodality Imaging Update.

Journal Article Semin Ultrasound CT MR · August 2018 Pancreaticobiliary injury is an uncommon entity which more often occurs in the setting of blunt than penetrating trauma. We present cases of pancreaticobiliary traumatic injuries from our Level 1 trauma center to illustrate an imaging update on the spectru ... Full text Link to item Cite

Pathological ER stress in β cells

Chapter · March 1, 2014 Diabetes mellitus is a global chronic disease, major cause of morbidity and mortality, and significantly decreases both quality of life and life expectancy. The reduction in functional β cell mass due to increased β cell apoptosis and decreased β cell prol ... Full text Cite

Pathological endoplasmic reticulum stress mediated by the IRE1 pathway contributes to pre-insulitic beta cell apoptosis in a virus-induced rat model of type 1 diabetes.

Journal Article Diabetologia · December 2013 AIMS/HYPOTHESIS: We hypothesised that pathological endoplasmic reticulum (ER) stress contributes to beta cell death during development of type 1 diabetes. In this study, we investigated the occurrence of beta cell ER stress and the signalling pathways invo ... Full text Link to item Cite

KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance.

Journal Article PLoS One · 2013 Obesity places major demands on the protein folding capacity of the endoplasmic reticulum (ER), resulting in ER stress, a condition that promotes hepatic insulin resistance and steatosis. Here we identify the transcription factor, Kruppel-like factor 15 (K ... Full text Link to item Cite

Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome.

Journal Article Cell Metab · August 8, 2012 Recent clinical and experimental evidence suggests that endoplasmic reticulum (ER) stress contributes to the life-and-death decisions of β cells during the progression of type 1 and type 2 diabetes. Although crosstalk between inflammation and ER stress has ... Full text Link to item Cite

Cytoplasmic polyadenylation element binding protein deficiency stimulates PTEN and Stat3 mRNA translation and induces hepatic insulin resistance.

Journal Article PLoS Genet · January 2012 The cytoplasmic polyadenylation element binding protein CPEB1 (CPEB) regulates germ cell development, synaptic plasticity, and cellular senescence. A microarray analysis of mRNAs regulated by CPEB unexpectedly showed that several encoded proteins are invol ... Full text Link to item Cite

A novel role for the centrosomal protein, pericentrin, in regulation of insulin secretory vesicle docking in mouse pancreatic beta-cells.

Journal Article PLoS One · July 27, 2010 The centrosome is important for microtubule organization and cell cycle progression in animal cells. Recently, mutations in the centrosomal protein, pericentrin, have been linked to human microcephalic osteodysplastic primordial dwarfism (MOPD II), a rare ... Full text Link to item Cite

CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells.

Journal Article PLoS One · 2009 Gimap5 (GTPase of the immunity-associated protein 5) has been linked to the regulation of T cell survival, and polymorphisms in the human GIMAP5 gene associate with autoimmune disorders. The BioBreeding diabetes-prone (BBDP) rat has a mutation in the Gimap ... Full text Link to item Cite

Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response.

Journal Article Cell Stress Chaperones · December 2008 T cell receptor (TCR) ligation (signal one) in the presence of co-stimulation (signal two) results in downstream signals that increase protein production enabling naïve T cells to fully activate and gain effector function. Enhanced production of proteins b ... Full text Link to item Cite

Specific chemopreventive agents trigger proteasomal degradation of G1 cyclins: implications for combination therapy.

Journal Article Clin Cancer Res · April 1, 2004 PURPOSE: There is a need to identify cancer chemoprevention mechanisms. We reported previously that all-trans-retinoic acid (RA) prevented carcinogenic transformation of BEAS-2B immortalized human bronchial epithelial cells by causing G(1) arrest, permitti ... Full text Link to item Cite