Scholars@Duke
Chetan B. Patel

Chetan B. Patel

Associate Professor of Medicine
Medicine, Cardiology
chetan.patel@duke.edu
DUMC 3034, Durham, NC 27710

Selected Publications

Donor Heart Recovery and Preservation Modalities in 2024.

Journal Article JACC Heart Fail · March 2024 Historically, heart transplantation (HT) has relied on the use of traditional cold storage for donor heart preservation. This organ preservation modality has several limitations, including the risk for ischemic and cold-induced graft injuries that may cont ... Full text Link to item Cite

Increasing Utilization of Extended Criteria Donor Hearts for Transplantation: The OCS Heart EXPAND Trial.

Journal Article JACC Heart Fail · March 2024 BACKGROUND: Extended criteria donor (ECD) hearts available with donation after brain death (DBD) are underutilized for transplantation due to limitations of cold storage. OBJECTIVES: This study evaluated use of an extracorporeal perfusion system on donor h ... Full text Link to item Cite

Epidemiology, management, and clinical outcomes of extrapulmonary Mycobacterium abscessus complex infections in heart transplant and ventricular assist device recipients.

Journal Article Am J Transplant · July 2023 Nontuberculous mycobacteria are emerging pathogens, yet data on the epidemiology and management of extrapulmonary nontuberculous mycobacteria infections in orthotopic heart transplantation (OHT) and ventricular assist device (VAD) recipients are scarce. We ... Full text Link to item Cite

Trends in cardiovascular medicine: Update on cardiac transplantation.

Journal Article Trends Cardiovasc Med · January 2023 Advanced heart failure affects more than 250,000 people in the United States alone and is associated with high risk of morbidity and mortality. Cardiac transplantation provides a cure for patients with advanced disease but has historically been limited by ... Full text Link to item Cite

Predictive capabilities of the European registry for patients with mechanical circulatory support right-sided heart failure risk score after left ventricular assist device implantation.

Journal Article J Cardiothorac Vasc Anesth · October 2022 OBJECTIVES: The prediction of right heart failure (RHF) after left ventricular assist device (LVAD) implantation remains a challenge. Recently, risk scores were derived from analysis of the European Registry for Patients with Mechanical Circulatory Support ... Full text Link to item Cite

Pericardial Adipose Tissue Volume and Left Ventricular Assist Device-Associated Outcomes.

Journal Article J Card Fail · January 2022 BACKGROUND: Pericardial adipose tissue (PAT) is associated with adverse cardiovascular outcomes in those with and without established heart failure (HF). However, it is not known whether PAT is associated with adverse outcomes in patients with end-stage HF ... Full text Link to item Cite

Proteomic profiling identifies CLEC4C expression as a novel biomarker of primary graft dysfunction after heart transplantation.

Journal Article J Heart Lung Transplant · December 2021 PURPOSE: Clinical models to identify patients at high risk of primary graft dysfunction (PGD) after heart transplantation (HT) are limited, and the underlying pathophysiology of this common post-transplant complication remains poorly understood. We sought ... Full text Link to item Cite

Electrical storm in patients with left ventricular assist devices: Risk factors, incidence, and impact on survival.

Journal Article Heart Rhythm · August 2021 BACKGROUND: Ventricular arrhythmias (VAs) and electrical storm (ES) are recognized complications following left ventricular assist device (LVAD) implantation; however, their association with long term-outcomes remains poorly understood. OBJECTIVE: The purp ... Full text Link to item Cite

A Case for Re-Gifting.

Journal Article JACC Case Rep · July 7, 2021 Many patients die while waiting for a heart transplant. Therefore, it is vital that all suitable organs are used for transplantation. We present a case of an allograft that was transplanted twice and outline considerations regarding tissue typing, the impa ... Full text Link to item Cite

Splanchnic Nerve Block Mediated Changes in Stressed Blood Volume in Heart Failure.

Journal Article JACC Heart Fail · April 2021 OBJECTIVES: The authors estimated changes of stressed blood volume (SBV) induced by splanchnic nerve block (SNB) in patients with either decompensated or ambulatory heart failure with reduced ejection fraction (HFrEF). BACKGROUND: The splanchnic vascular c ... Full text Link to item Cite

Cardiac computed tomography improves the identification of cardiomechanical complications among patients with suspected left ventricular assist device malfunction.

Journal Article J Cardiovasc Comput Tomogr · 2021 BACKGROUND: Left ventricular assist devices (LVAD) are increasingly used for durable mechanical circulatory support in advanced heart failure. While LVAD therapy provides substantial improvement in mortality and quality of life, long-term therapy confers i ... Full text Link to item Cite

Splanchnic Nerve Block for Chronic Heart Failure.

Journal Article JACC Heart Fail · September 2020 OBJECTIVES: We hypothesized that splanchnic nerve blockade (SNB) would attenuate increased exercise-induced cardiac filling pressures in patients with chronic HF. BACKGROUND: Chronic heart failure (HF) is characterized by limited exercise capacity driven i ... Full text Link to item Cite

Cardiovascular Implantable Electronic Device Surgery Following Left Ventricular Assist Device Implantation.

Journal Article JACC Clin Electrophysiol · September 2020 OBJECTIVES: This study sought to determine the indications, characteristics, and outcomes of cardiovascular implantable electronic device (CIED) surgery in patients with LVAD. BACKGROUND: Many patients with a left ventricular assist device (LVAD) will requ ... Full text Link to item Cite

Renal Outcomes in Patients Bridged to Heart Transplant With a Left Ventricular Assist Device.

Journal Article Ann Thorac Surg · August 2020 BACKGROUND: Patients with end-stage heart failure are increasingly being bridged to heart transplant (BTT) with mechanical circulatory support; however the association between a left ventricular assist device (LVAD) BTT strategy and posttransplant renal ou ... Full text Link to item Cite

Left ventricular assist systems and infection-related outcomes: A comprehensive analysis of the MOMENTUM 3 trial.

Journal Article J Heart Lung Transplant · August 2020 BACKGROUND: In a randomized controlled trial (MOMENTUM 3), the HeartMate 3 (HM3) fully magnetically levitated centrifugal-flow left ventricular assist device (LVAD) demonstrated superiority over the HeartMate II (HMII) axial-flow LVAD. These findings were ... Full text Link to item Cite

Association between primary graft dysfunction and acute kidney injury after orthotopic heart transplantation - a retrospective, observational cohort study.

Journal Article Transpl Int · August 2020 Acute kidney injury (AKI) and primary graft dysfunction (PGD) are serious complications after heart transplantation (HT). The relationship between AKI and PGD is poorly understood. We sought to examine the incidence of AKI and identify risk factors associa ... Full text Link to item Cite

Early outcomes with durable left ventricular assist device replacement using the HeartMate 3.

Journal Article J Thorac Cardiovasc Surg · July 2020 BACKGROUND: The HeartMate 3 (HM3) left ventricular assist device (LVAD) (Abbott, Inc, Chicago, Ill) is a fully magnetically levitated centrifugal implantable pump used to treat patients with chronic heart failure. The MOMENTUM (Multicenter Study of MagLev ... Full text Link to item Cite

Assessment of Limitations to Optimization of Guideline-Directed Medical Therapy in Heart Failure From the GUIDE-IT Trial: A Secondary Analysis of a Randomized Clinical Trial.

Journal Article JAMA Cardiol · July 1, 2020 IMPORTANCE: Despite evidence that guideline-directed medical therapy (GDMT) improves outcomes in patients with heart failure (HF) and reduced ejection fraction, many patients are undertreated. The Guiding Evidence-Based Therapy Using Biomarker Intensified ... Full text Link to item Cite

Reassessing Recipient Mortality Under the New Heart Allocation System: An Updated UNOS Registry Analysis.

Journal Article JACC Heart Fail · July 2020 BACKGROUND: An early report of recipient heart transplantation outcomes under the new U.S. heart allocation system introduced in late 2018 found a lower post-transplant survival rate compared with that of the prior system. OBJECTIVES: The aim of this study ... Full text Link to item Cite

Biomarkers in Advanced Heart Failure: Implications for Managing Patients With Mechanical Circulatory Support and Cardiac Transplantation.

Journal Article Circ Heart Fail · July 2020 Biomarkers have a well-defined role in the diagnosis and management of chronic heart failure, but their role in patients with left ventricular assist devices and cardiac transplant is uncertain. In this review, we summarize the available literature in this ... Full text Link to item Cite

Transplant Center Variability in Organ Offer Acceptance and Mortality Among US Patients on the Heart Transplant Waitlist.

Journal Article JAMA Cardiol · June 1, 2020 IMPORTANCE: Under the current Centers for Medicare & Medicaid Services guidelines, there is incentivization to optimize posttransplant outcomes regardless of mortality among patients on the waitlist and transplant rates; few data exist with regard to trans ... Full text Link to item Cite

Increasing the United States heart transplant donor pool with donation after circulatory death.

Journal Article J Thorac Cardiovasc Surg · May 2020 DCD heart donation has the potential to significantly increase the pool of available donor allografts in the US, by as much as 30%, and will lead to a substantial decrease in waiting list mortality. ... Full text Link to item Cite

PredischaRge initiation of Ivabradine in the ManagEment of Heart Failure: Results of the PRIME-HF Trial.

Journal Article Am Heart J · May 2020 BACKGROUND: Ivabradine is guideline-recommended to reduce heart failure (HF) hospitalization in patients with stable chronic HF with reduced ejection fraction (EF). Ivabradine initiation following acute HF has had limited evaluation, and there are few rand ... Full text Link to item Cite

Stellate Ganglion Blockade for the Treatment of Refractory Ventricular Arrhythmias.

Journal Article JACC Clin Electrophysiol · May 2020 OBJECTIVES: This study sought to describe our institutional experience with establishing a neurocardiology service in an attempt to provide autonomic modulation as a treatment for ventricular arrhythmias (VAs). BACKGROUND: Treatment-refractory VAs are comm ... Full text Link to item Cite

Influence of donor brain death duration on outcomes following heart transplantation: A United Network for Organ Sharing Registry analysis.

Journal Article J Thorac Cardiovasc Surg · April 2020 OBJECTIVES: We hypothesized that an increased duration of donor brain death may worsen survival following orthotopic heart transplantation. METHODS: The United Network for Organ Sharing Registry was queried for first-time, adult recipients of heart transpl ... Full text Link to item Cite

Sex Differences in Quality of Life and Clinical Outcomes in Patients With Advanced Heart Failure: Insights From the PAL-HF Trial.

Journal Article Circ Heart Fail · April 2020 BACKGROUND: Palliative care improves quality of life in patients with heart failure. Whether men and women with heart failure derive similar benefit from palliative care interventions remains unknown. METHODS: In a secondary analysis of the PAL-HF trial (P ... Full text Link to item Cite

Impact of Tricuspid Valve Repair for Moderate Tricuspid Regurgitation at the Time of Left Ventricular Assist Device Implantation on the Occurrence of Right Heart Failure

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Significant tricuspid regurgitation (TR) in patients undergoing durable left ventricular assist device (LVAD) implantation has been associated with increased incidence of right heart failure (RHF). There is great surgical practice variability rela ... Full text Cite

Pre-Formed Donor-Specific Antibodies Impact Long Term Survival of Heart Transplants

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: We previously reported that heart transplant (HTx) recipients with pre-formed, anti-HLA antibodies at low titer had one-year survival that was comparable to patients without any anti-HLA antibodies. As a result, we defined unacceptable HLA antigen ... Full text Cite

Predictors and Outcomes of Hemodynamic and Functional LVAD Non-Responders: An Analysis of the INTERMACS Registry

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Despite recent advancements in left ventricular assist device (LVAD) technology, there remains a population of patients who experience ongoing signs and symptoms of heart failure during LVAD support. We sought to describe risk factors and outcomes ... Full text Cite

More Money and More Miles: The Hidden Costs of Donor Procurement with the New Heart Allocation System

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: In October 2018, the United Network for Organ Sharing (UNOS) implemented extensive changes to the adult heart allocation policy. These changes were developed to better stratify medically urgent patients and provide more equitable geographic distri ... Full text Cite

Infection-Related Morbidity with Continuous-Flow Left Ventricular Assist Systems: A Comprehensive Analysis of the Randomized MOMENTUM 3 Trial

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: The MOMENTUM 3 trial established superiority of a fully magnetically-levitated HeartMate 3 (HM3) centrifugal pump over the axial flow HeartMate II (HMII) pump on hemocompatibility-related outcomes. Infection-related outcomes were no different betw ... Full text Cite

Decision Aid Implementation among Left Ventricular Assist Device Programs Participating in the DECIDE-LVAD Stepped-Wedge Trial.

Journal Article Med Decis Making · April 2020 Background. Despite demonstrated efficacy, patient decision aids (DAs) are rarely used in clinical practice in the absence of coverage mandates. Deciding whether to pursue a left ventricular assist device (LVAD) is a major, preference-sensitive decision-id ... Full text Link to item Cite

Percutaneous Intervention for Left Ventricular Assist Device Outflow Obstruction.

Journal Article Heart Lung Circ · March 2020 Left ventricular assist devices (LVADs) are used to support patients with advanced systolic heart failure (HF). These patients might develop LVAD dysfunction and consequent HF symptoms. Occasionally, outflow graft obstruction is responsible for LVAD dysfun ... Full text Link to item Cite

Outcomes of Severely Obese Patients Supported by a Centrifugal-Flow Left Ventricular Assist Device.

Journal Article J Card Fail · February 2020 BACKGROUND: Ventricular assist devices provide improved outcomes for patients with advanced heart failure, but their benefit in the severely obese is not well documented. METHODS: Patients enrolled in the HeartWare ADVANCE trial (n=382) were divided into 2 ... Full text Link to item Cite

Stroke risk following implantation of current generation centrifugal flow left ventricular assist devices.

Journal Article J Card Surg · February 2020 BACKGROUND AND AIM: Stroke remains a significant complication of left ventricular assist device (LVAD) therapy. We performed a single-center retrospective study evaluating patients undergoing first-time HeartWare HVAD (Medtronic Inc) or HeartMate 3 (Abbott ... Full text Link to item Cite

Durability and Efficacy of Tricuspid Valve Repair in Patients Undergoing Left Ventricular Assist Device Implantation.

Journal Article JACC Heart Fail · February 2020 OBJECTIVES: This study sought to determine the durability of tricuspid valve repair (TVr) performed concurrently with left ventricular assist device (LVAD) implantation and its association with the development of late right heart failure (RHF). BACKGROUND: ... Full text Open Access Link to item Cite

Best Practices for Prognostic Evaluation of a Patient With Transthyretin Amyloid Cardiomyopathy.

Journal Article JACC CardioOncol · December 2019 Transthyretin amyloid cardiomyopathy (ATTR-CM) has emerged as an increasingly identified etiology of heart failure. Fortunately, the disease now has an approved therapy, with many others under development. Assessment of prognosis in ATTR-CM is critical to ... Full text Open Access Link to item Cite

Donor and recipient age matching in heart transplantation: analysis of the UNOS Registry.

Journal Article Transpl Int · November 2019 The association of donor and recipient age with survival following adult heart transplantation has not been well characterized. The purpose of this study was to examine the impact of the relationship between donor and recipient age on post-transplant survi ... Full text Link to item Cite

Cardiac Allograft Vasculopathy: A Formidable Foe.

Journal Article J Am Coll Cardiol · July 9, 2019 Full text Link to item Cite

Controlling axillary intra-aortic balloon pump inflation is a viable option for turning an acute heart failure patient into a chronic one.

Journal Article Artif Organs · July 2019 Intra-aortic balloon pump (IABP) is often used to support patients in decompensated heart failure. Placement of the IABP via the axillary artery facilitates long-term support with the device and may allow for the conversion of an acute heart failure (HF) p ... Full text Link to item Cite

Comorbidities and the decision to undergo or forego destination therapy left ventricular assist device implantation: An analysis from the Trial of a Shared Decision Support Intervention for Patients and their Caregivers Offered Destination Therapy for End-Stage Heart Failure (DECIDE-LVAD) study.

Journal Article Am Heart J · July 2019 BACKGROUND: Patients considering destination therapy left ventricular assist devices (DT LVAD) often have high comorbid burden but the association between these comorbidities and post-decision outcomes is unknown. METHODS: We included subjects in DECIDE-LV ... Full text Link to item Cite

Outcomes After Extracorporeal Right Ventricular Assist Device Combined With Durable Left Ventricular Assist Device Support.

Journal Article Ann Thorac Surg · June 2019 BACKGROUND: Right heart failure occurs in 9% to 44% of left ventricular assist device (LVAD) implants, of which less than 10% require right ventricular assist device (RVAD) support either concurrently with the LVAD or staged, as a delayed procedure. We hav ... Full text Link to item Cite

Frailty in the End-Stage Lung Disease or Heart Failure Patient: Implications for the Perioperative Transplant Clinician.

Journal Article J Cardiothorac Vasc Anesth · May 2019 The syndrome of frailty for patients undergoing heart or lung transplantation has been a recent focus for perioperative clinicians because of its association with postoperative complications and poor outcomes. Patients with end-stage cardiac or pulmonary f ... Full text Open Access Link to item Cite

A Fully Magnetically Levitated Left Ventricular Assist Device - Final Report.

Journal Article N Engl J Med · April 25, 2019 BACKGROUND: In two interim analyses of this trial, patients with advanced heart failure who were treated with a fully magnetically levitated centrifugal-flow left ventricular assist device were less likely to have pump thrombosis or nondisabling stroke tha ... Full text Link to item Cite

Outcomes of Laparoscopic Cholecystectomy in Patients Supported with a Left Ventricular Assist Device.

Journal Article J Laparoendosc Adv Surg Tech A · April 2019 BACKGROUND: An increasing number of end-stage heart failure patients are supported with left ventricular assist device (LVAD) implantation and must be maintained on consistent anticoagulation. These patients are experiencing prolonged survival and, in some ... Full text Link to item Cite

Top Ten Tips Palliative Care Clinicians Should Know About Caring for Patients with Left Ventricular Assist Devices.

Journal Article J Palliat Med · April 2019 Advanced heart failure (HF) is a common condition that leads to significant suffering for patients and their families. Left ventricular assist devices (LVADs) can improve both the quantity and quality of life for those suffering with advanced HF. Palliativ ... Full text Link to item Cite

Should Hepatitis C Donors Be Used in Naïve Urgent Status Patients on the Heart Transplant Waitlist?

Journal Article Current Transplantation Reports · March 15, 2019 Purpose of Review: The aim of this commentary is to review contemporary data on the use of hearts from hepatitis C positive donors. Recent Findings: There continues to be a critical shortage of suitable heart donors available for patients with advanced hea ... Full text Cite

Transplanting a heart with a persistent left superior vena cava.

Journal Article J Thorac Cardiovasc Surg · February 2019 Full text Link to item Cite

Cardiac allograft vasculopathy: A review.

Journal Article Catheter Cardiovasc Interv · December 1, 2018 Cardiac allograft vasculopathy (CAV) is a complex disease that remains a significant cause of morbidity and mortality after orthotopic heart transplantation (OHT). Originating as a result of inflammatory response, the development and progression of CAV is ... Full text Link to item Cite

Relation of Volume Overload to Clinical Outcomes in Acute Heart Failure (From ASCEND-HF).

Journal Article Am J Cardiol · November 1, 2018 We aimed to study whether jugular venous distension (JVD) and peripheral edema were associated with worse outcomes in patients with acute heart failure in the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure trial. Of 7,14 ... Full text Link to item Cite

Caregivers of Patients Considering a Destination Therapy Left Ventricular Assist Device and a Shared Decision-Making Intervention: The DECIDE-LVAD Trial.

Journal Article JACC Heart Fail · November 2018 OBJECTIVES: This study aims to characterize caregivers of patients considering destination therapy left ventricular assist device (DT-LVAD) and evaluate the effectiveness of a shared decision-making (SDM) intervention. BACKGROUND: Caregivers play an integr ... Full text Link to item Cite

Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial.

Journal Article Lancet · October 27, 2018 BACKGROUND: Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine t ... Full text Link to item Cite

Long-Chain Omega-3 Fatty Acid Supplements in Depressed Heart Failure Patients: Results of the OCEAN Trial.

Journal Article JACC Heart Fail · October 2018 OBJECTIVES: The goal of this study was to test the effects of long-chain omega-3 fatty acid supplementation on omega-3 levels, depressive symptoms, and other psychosocial factors, as well as other chronic heart failure (CHF)-related functional measures. BA ... Full text Link to item Cite

Management of Patients With Left Ventricular Assist Devices Requiring Teeth Extraction: Is Halting Anticoagulation Appropriate?

Journal Article J Oral Maxillofac Surg · September 2018 PURPOSE: An increasing number of patients with end-stage heart failure are supported with left ventricular assist device (LVAD) implantation and must be maintained on a consistent anticoagulation regimen. Pre-emptive extraction of carious teeth in these pa ... Full text Link to item Cite

Indications for and outcomes of therapeutic plasma exchange after cardiac transplantation: A single center retrospective study.

Journal Article J Clin Apher · August 2018 INTRODUCTION: Limited data are available describing indications for and outcomes of therapeutic plasma exchange (TPE) in cardiac transplantation. METHODS: In a retrospective study of patients who underwent cardiac transplantation at Duke University Medical ... Full text Open Access Link to item Cite

Cangrelor use prior to left ventricular assist device surgery: a case series.

Journal Article J Thromb Thrombolysis · August 2018 Bleeding frequently occurs in patients undergoing placement of a left ventricular assist device (LVAD). Clinical factors that have been identified as contributing to peri-procedural bleeding include LVAD implantation after an acute myocardial infarction an ... Full text Link to item Cite

Blood Pressure Response during Cardiopulmonary Exercise Testing in Heart Failure.

Journal Article Med Sci Sports Exerc · July 2018 INTRODUCTION: The prognostic value of peak V˙O2 and V˙E/V˙CO2 slope measured during cardiopulmonary exercise (CPX) testing has been well established in patients with advanced heart failure, but blood pressure response to exercise is less well characterized ... Full text Open Access Link to item Cite

Primary graft dysfunction after heart transplantation: Incidence, trends, and associated risk factors.

Journal Article Am J Transplant · June 2018 Changes in heart transplantation (HT) donor and recipient demographics may influence the incidence of primary graft dysfunction (PGD). We conducted a retrospective study to evaluate PGD incidence, trends, and associated risk factors by analyzing consecutiv ... Full text Link to item Cite

Risk factors for stroke on left ventricular assist devices.

Journal Article J Card Surg · June 2018 BACKGROUND: Patients with end-stage heart failure on left ventricular assist devices (LVADs) are predisposed to a high incidence of stroke. Preoperative factors associated with increased stroke risk are poorly understood. METHODS: We performed a single-cen ... Full text Link to item Cite

Controversies and Challenges of Ventricular Assist Device Therapy.

Journal Article Am J Cardiol · May 15, 2018 Left ventricular assist device (LVAD) therapy has emerged as an increasingly vital facet of the treatment algorithm for advanced heart failure. Growing experience with LVAD support has led to substantial improvements in outcomes, with 1-year survival rates ... Full text Link to item Cite

Trends and outcomes of cardiac transplantation from donors dying of drug intoxication.

Journal Article Am Heart J · May 2018 BACKGROUND: Deaths from drug intoxication have increased in the United States but outcomes of recipients of orthotopic heart transplantation (OHT) from these donors are not well characterized. METHODS: We performed a retrospective analysis of the United Ne ... Full text Link to item Cite

Two-Year Outcomes with a Magnetically Levitated Cardiac Pump in Heart Failure.

Journal Article N Engl J Med · April 12, 2018 BACKGROUND: In an early analysis of this trial, use of a magnetically levitated centrifugal continuous-flow circulatory pump was found to improve clinical outcomes, as compared with a mechanical-bearing axial continuous-flow pump, at 6 months in patients w ... Full text Link to item Cite

Effectiveness of an Intervention Supporting Shared Decision Making for Destination Therapy Left Ventricular Assist Device: The DECIDE-LVAD Randomized Clinical Trial.

Journal Article JAMA Intern Med · April 1, 2018 IMPORTANCE: Shared decision making helps patients and clinicians elect therapies aligned with patients' values and preferences. This is particularly important for invasive therapies with considerable trade-offs. OBJECTIVE: To assess the effectiveness of a ... Full text Link to item Cite

Long-Term Survival in Patients Receiving a Continuous-Flow Left Ventricular Assist Device.

Journal Article Ann Thorac Surg · March 2018 BACKGROUND: Long-term survivors after implantation of left ventricular assist devices (LVADs) are increasing in prevalence. We describe the characteristics and outcomes in patients surviving longer than 4 years on LVAD support. METHODS: We performed a mult ... Full text Link to item Cite

Assessing Frailty in Patients Undergoing Destination Therapy Left Ventricular Assist Device: Observations from Interagency Registry for Mechanically Assisted Circulatory Support.

Journal Article ASAIO J · 2018 Frailty and heart failure share common pathways with symptoms that often coexist. Assessment of frailty may inform patient selection for left ventricular assist device (LVAD) therapy. Using Interagency Registry for Mechanically Assisted Circulatory Support ... Full text Link to item Cite

Orthostatic Hypotension in Patients With Left Ventricular Assist Devices: Acquired Autonomic Dysfunction.

Journal Article ASAIO J · 2018 Contemporary left ventricular assist device (LVAD) technology uses nonphysiologic continuous flow to deliver blood into the circulation. This results in a reduction of pulsatility, which is implicated in some of the commonly associated side effects with LV ... Full text Link to item Cite

Heartmate III Replacement for Recurring Left Ventricular Assist Device Pump Thrombosis.

Journal Article ASAIO J · 2018 Left ventricular assist devices (LVADs) are being used widely to support patients with advanced systolic heart failure. Some of these patients will need more than one LVAD replacement due to pump thrombosis. The Heartmate III LVAD (Abbott Inc, Chicago, IL) ... Full text Link to item Cite

Migration of Intraaortic Balloon Pump Placed Via the Axillary Artery.

Journal Article J Invasive Cardiol · January 2018 Axillary artery intraaortic balloon pump (IABP) placement enables those awaiting transplant to ambulate and get stronger, but motion increases risk of IABP migration. The management of a migrated pump in a 44-year-old man with heart failure is described. ... Link to item Cite

Intra-Aortic Balloon Pump Use Before Left Ventricular Assist Device Implantation: Insights From the INTERMACS Registry.

Journal Article ASAIO J · 2018 Use of durable, continuous-flow left ventricular assist devices (LVADs) has expanded rapidly, although data are limited regarding optimization strategies before LVAD implantation. We examined current use of intra-aortic balloon pumps (IABPs) before LVAD im ... Full text Link to item Cite

The impact of a failing right heart in patients supported by intra-aortic balloon counterpulsation.

Journal Article Eur Heart J Acute Cardiovasc Care · December 2017 BACKGROUND: Intra-aortic balloon pumps (IABPs) provide primarily left ventricular support, yet few data detail the efficacy of this temporary mechanical circulatory support device in patients with concomitant right ventricular failure. We compared the effi ... Full text Link to item Cite

Stellate ganglion blockade for the treatment of refractory ventricular arrhythmias: A systematic review and meta-analysis.

Journal Article J Cardiovasc Electrophysiol · December 2017 INTRODUCTION: Treatment refractory ventricular arrhythmias (VAs) are often driven and exacerbated by heightened sympathetic tone. We aim to conduct a systematic review and meta-analysis of published studies of a temporary percutaneous stellate ganglion blo ... Full text Link to item Cite

Medical Management of Patients With a Left Ventricular Assist Device for the Non-Left Ventricular Assist Device Specialist.

Journal Article JACC Heart Fail · September 2017 More than 2,400 continuous-flow left ventricular assist devices (LVADs) are implanted each year in the United States alone. Both the number of patients living with LVADs and the life expectancy of these patients are increasing. As a result, patients with L ... Full text Link to item Cite

Palliative Care in Heart Failure: The PAL-HF Randomized, Controlled Clinical Trial.

Journal Article J Am Coll Cardiol · July 18, 2017 BACKGROUND: Advanced heart failure (HF) is characterized by high morbidity and mortality. Conventional therapy may not sufficiently reduce patient suffering and maximize quality of life. OBJECTIVES: The authors investigated whether an interdisciplinary pal ... Full text Link to item Cite

Long-term outcomes and management of the heart transplant recipient.

Journal Article Best Pract Res Clin Anaesthesiol · June 2017 Cardiac transplantation remains the gold standard in the treatment of advanced heart failure. With advances in immunosuppression, long-term outcomes continue to improve despite older and higher risk recipients. The median survival of the adult after heart ... Full text Open Access Link to item Cite

Hemocompatibility-Related Outcomes in the MOMENTUM 3 Trial at 6 Months: A Randomized Controlled Study of a Fully Magnetically Levitated Pump in Advanced Heart Failure.

Journal Article Circulation · May 23, 2017 BACKGROUND: The HeartMate 3 (HM3) Left Ventricular Assist System (LVAS) (Abbott) is a centrifugal, fully magnetically levitated, continuous-flow blood pump engineered to enhance hemocompatibility and reduce shear stress on blood components. The MOMENTUM 3 ... Full text Link to item Cite

Assessment of cardiac allograft systolic function by global longitudinal strain: From donor to recipient.

Conference Clin Transplant · May 2017 BACKGROUND: Cardiac allografts are routinely evaluated by left ventricular ejection fraction (LVEF) before and after transplantation. However, myocardial deformation analyses with LV global longitudinal strain (GLS) are more sensitive for detecting impaire ... Full text Link to item Cite

Autonomic Modulation for the Treatment of Ventricular Arrhythmias: Therapeutic Use of Percutaneous Stellate Ganglion Blocks.

Journal Article J Cardiovasc Electrophysiol · April 2017 Ventricular tachycardia (VT), ventricular fibrillation (VF), and electrical storm are commonly encountered emergency conditions in cardiac and surgical intensive care units. In most cases, recurrent ventricular arrhythmias or electrical storm are associate ... Full text Link to item Cite

Two-Phase Hospital-Associated Outbreak of Mycobacterium abscessus: Investigation and Mitigation.

Journal Article Clin Infect Dis · April 1, 2017 BACKGROUND: Nontuberculous mycobacteria (NTM) commonly colonize municipal water supplies and cause healthcare-associated outbreaks. We investigated a biphasic outbreak of Mycobacterium abscessus at a tertiary care hospital. METHODS: Case patients had recen ... Full text Link to item Cite

Efficacy and Safety of Tolvaptan in Patients Hospitalized With Acute Heart Failure.

Journal Article J Am Coll Cardiol · March 21, 2017 BACKGROUND: The oral vasopressin-2 receptor antagonist tolvaptan causes aquaresis in patients with volume overload, potentially facilitating decongestion and improving the clinical course of patients with acute heart failure (AHF). OBJECTIVES: The TACTICS- ... Full text Link to item Cite

A Fully Magnetically Levitated Circulatory Pump for Advanced Heart Failure.

Journal Article N Engl J Med · February 2, 2017 BACKGROUND: Continuous-flow left ventricular assist systems increase the rate of survival among patients with advanced heart failure but are associated with the development of pump thrombosis. We investigated the effects of a new magnetically levitated cen ... Full text Link to item Cite

Amiodarone use in patients listed for heart transplant is associated with increased 1-year post-transplant mortality.

Journal Article J Heart Lung Transplant · February 2017 BACKGROUND: Pre-transplant amiodarone use has been postulated as a risk factor for morbidity and mortality after orthotopic heart transplantation (OHT). We assessed pre-OHT amiodarone use and tested the hypothesis that it is associated with impaired post-O ... Full text Link to item Cite

The incidence, risk factors, and outcomes associated with late right-sided heart failure in patients supported with an axial-flow left ventricular assist device.

Journal Article J Heart Lung Transplant · January 2017 BACKGROUND: Early right-sided heart failure (RHF) after left ventricular assist device (LVAD) implantation is associated with increased mortality, but little is known about patients who develop late RHF (LRHF). We evaluated the incidence, risk factors, and ... Full text Link to item Cite

Plasma Levels of MicroRNA-155 Are Upregulated with Long-Term Left Ventricular Assist Device Support.

Journal Article ASAIO J · 2017 Left ventricular assist device (LVAD) therapy unloads the failing heart but exposes the human body to unique pathophysiologic demands such as continuous blood flow and complete univentricular support, which are associated with increased risk of adverse cli ... Full text Link to item Cite

Rethinking papillary muscle resection for refractory ventricular tachycardia in the LVAD era. A case report.

Journal Article J Electrocardiol · 2017 We report the case of a 57-year-old man with a history of ischemic cardiomyopathy who presented to the hospital with recurrent episodes of ventricular tachycardia refractory to antiarrhythmic medications. Mapping identified a deep premature ventricular con ... Full text Link to item Cite

The Axillary Intra-Aortic Balloon Pump as a Bridge to Recovery Allows Early Ambulation in Long-Term Use: Case Series and Literature Review.

Journal Article Innovations (Phila) · 2017 We evaluated the feasibility, tolerability, and efficacy of a strategy for transaxillary artery intra-aortic balloon pump placement for extended mechanical circulatory support of patients with postcardiotomy shock as a bridge to recovery. Patients requirin ... Full text Link to item Cite

Thyroid hormone use during cardiac transplant organ procurement.

Journal Article Clin Transplant · December 2016 BACKGROUND: Acute hypothyroidism after brain death results in hemodynamic impairments that limit availability of donor hearts. Thyroid hormone infusions can halt that process and lead to increased utilization of donor organs, but prolonged use of thyroid r ... Full text Link to item Cite

Positive Impact of Continuous-Flow Left Ventricular Assist Device Implantation on Glycemic Control in Patients with Type 2 Diabetes Mellitus and Advanced Chronic Systolic Heart Failure.

Journal Article Pharmacotherapy · December 2016 STUDY OBJECTIVE: To evaluate the impact of continuous-flow left ventricular assist device (LVAD) implantation on glycemic control in patients with type 2 diabetes mellitus and advanced chronic systolic heart failure. DESIGN: Retrospective medical record re ... Full text Link to item Cite

INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) Profiling Identifies Ambulatory Patients at High Risk on Medical Therapy After Hospitalizations for Heart Failure.

Journal Article Circ Heart Fail · November 2016 BACKGROUND: INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) profiles provide important prognostic information for patients with advanced heart failure (HF) receiving mechanical support. The value of INTERMACS profiling has no ... Full text Link to item Cite

Use of Heart Failure Medical Therapies Among Patients With Left Ventricular Assist Devices: Insights From INTERMACS.

Journal Article J Card Fail · September 2016 BACKGROUND: Use of left ventricular assist devices (LVADs) for treatment of advanced heart failure has expanded significantly over the past decade. However, concomitant use of heart failure medical therapies after implant is poorly characterized. METHODS A ... Full text Link to item Cite

Usefulness of Palliative Care to Complement the Management of Patients on Left Ventricular Assist Devices.

Journal Article Am J Cardiol · September 1, 2016 Within the last decade, advancements in left ventricular assist device therapy have allowed patients with end-stage heart failure (HF) to live longer and with better quality of life. Like other life-saving interventions, however, there remains the risk of ... Full text Link to item Cite

The Diagnostic Yield of Repeated Endoscopic Evaluation in Patients with Gastrointestinal Bleeding and Left Ventricular Assist Devices.

Journal Article Dig Dis Sci · June 2016 INTRODUCTION: Left ventricular assist devices (LVADs) are increasingly common in patients with advanced heart failure. GI bleeding (GIB) occurs in 20-30 % of these patients and can arise anywhere in the GI tract. Given the high rates of GIB in this populat ... Full text Link to item Cite

Trends and outcomes of patients with adult congenital heart disease and pulmonary hypertension listed for orthotopic heart transplantation in the United States.

Journal Article J Heart Lung Transplant · May 2016 BACKGROUND: Heart transplantation is increasing in patients with adult congenital heart disease (ACHD). In this population, the association of pulmonary hypertension (PH) with post-transplant outcomes is not well-defined. METHODS: Using data from the Unite ... Full text Link to item Cite

Liver function tests in patients with acute heart failure and associated outcomes: insights from ASCEND-HF.

Journal Article Eur J Heart Fail · April 2016 AIMS: We aimed to characterize abnormal liver function tests in patients with heart failure (HF), as they are commonly encountered yet poorly defined. METHODS AND RESULTS: We used data from ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide in ... Full text Link to item Cite

Hemodynamic Predictors of Heart Failure Morbidity and Mortality: Fluid or Flow?

Journal Article J Card Fail · March 2016 BACKGROUND: Patients with advanced heart failure may continue for prolonged times with persistent hemodynamic abnormalities; intermediate- and long-term outcomes of these patients are unknown. METHODS AND RESULTS: We used ESCAPE (Evaluation Study of Conges ... Full text Link to item Cite

Elevated Cardiac Troponin I in Preservation Solution Is Associated With Primary Graft Dysfunction.

Journal Article J Card Fail · February 2016 BACKGROUND: Although primary graft dysfunction (PGD) is a leading cause of mortality and morbidity early post-heart transplant, relatively little is known regarding mechanisms involved in PGD development. METHODS AND RESULTS: We examined the relationship b ... Full text Link to item Cite

Prognostic Implications of Long-Chain Acylcarnitines in Heart Failure and Reversibility With Mechanical Circulatory Support.

Journal Article J Am Coll Cardiol · January 26, 2016 BACKGROUND: Heart failure (HF) is characterized by perturbations in energy homeostasis and metabolism. The reversibility and prognostic value of circulating markers associated with these changes remain unclear. OBJECTIVES: This study sought to describe the ... Full text Link to item Cite

Assessing Consequences of Intraaortic Balloon Counterpulsation Versus Left Ventricular Assist Devices at the Time of Heart Transplantation.

Journal Article ASAIO J · 2016 The proportion of heart transplant recipients bridged with durable, intracorporeal left ventricular assist devices (dLVADs) has dramatically increased; however, concern exists regarding obligate repeat sternotomy, increased bleeding risk because of anticoa ... Full text Link to item Cite

Clinical Implications of Cluster Analysis-Based Classification of Acute Decompensated Heart Failure and Correlation with Bedside Hemodynamic Profiles.

Journal Article PLoS One · 2016 BACKGROUND: Classification of acute decompensated heart failure (ADHF) is based on subjective criteria that crudely capture disease heterogeneity. Improved phenotyping of the syndrome may help improve therapeutic strategies. OBJECTIVE: To derive cluster an ... Full text Link to item Cite

A Multicenter Trial of a Shared Decision Support Intervention for Patients and Their Caregivers Offered Destination Therapy for Advanced Heart Failure: DECIDE-LVAD: Rationale, Design, and Pilot Data.

Journal Article J Cardiovasc Nurs · 2016 BACKGROUND: Shared decision making is important to ensure that patients receive therapies aligned with their goals and values. Based upon a detailed needs assessment with diverse stakeholders, pamphlet and video decision aids for destination therapy left v ... Full text Link to item Cite

Pulmonary Hypertension in the Era of Mechanical Circulatory Support.

Journal Article ASAIO J · 2016 Left heart disease (LHD) represents the most common cause of pulmonary hypertension (PH), and is associated with worse prognosis compared with LHD without PH. In addition, PH due to LHD may prevent patients from receiving heart transplantation, because of ... Full text Link to item Cite

Scedosporium apiosermum infection of the "Native" valve: Fungal endocarditis in an orthotopic heart transplant recipient.

Journal Article Med Mycol Case Rep · September 2015 Scedosporium apiospermum is an increasingly appreciated pathogen in immunosuppressed patients. We present a case of S. apiospermum endocarditis in a 70-year-old male who had undergone orthotopic heart transplant. Echocardiogram demonstrated a 1.4 cm tricus ... Full text Link to item Cite

Tolvaptan in Patients Hospitalized With Acute Heart Failure: Rationale and Design of the TACTICS and the SECRET of CHF Trials.

Journal Article Circ Heart Fail · September 2015 Congestion is a primary reason for hospitalization in patients with acute heart failure (AHF). Despite inpatient diuretics and vasodilators targeting decongestion, persistent congestion is present in many AHF patients at discharge and more severe congestio ... Full text Link to item Cite

Comparison of 2-Year Outcomes of Extended Criteria Cardiac Transplantation Versus Destination Left Ventricular Assist Device Therapy Using Continuous Flow.

Journal Article Am J Cardiol · August 15, 2015 Alternatives have emerged for patients ineligible for cardiac transplantation under standard criteria. The purpose of our study was to compare outcomes in patients ineligible for cardiac transplantation under standard criteria, treated either with extended ... Full text Link to item Cite

Bridge to long-term mechanical circulatory support with a left ventricular assist device: novel use of transcatheter aortic valve replacement.

Journal Article Ann Thorac Surg · April 2015 We describe the use of transcatheter aortic valve replacement to allow for bridging to a left ventricular assist device in a patient with end-stage heart failure, secondary to nonischemic cardiomyopathy and severe bioprosthetic aortic valve regurgitation. ... Full text Link to item Cite

The heart is just a muscle.

Journal Article Circulation · March 10, 2015 Full text Link to item Cite

Improved early survival with a nonsternotomy approach for continuous-flow left ventricular assist device replacement.

Journal Article Ann Thorac Surg · February 2015 BACKGROUND: Even in the modern era of continuous-flow left ventricular assist devices (CF LVADs), device replacement may be required. Nonsternotomy (NS) approaches are being used more commonly for replacement procedures. Outcomes after this less invasive a ... Full text Link to item Cite

Effects of left ventricular assist device support on biomarkers of cardiovascular stress, fibrosis, fluid homeostasis, inflammation, and renal injury.

Journal Article JACC Heart Fail · January 2015 OBJECTIVES: The purpose of this study was to examine changes in a broad panel of biomarkers following left ventricular assist device (LVAD) support in advanced heart failure (HF). BACKGROUND: LVAD therapy mechanically unloads the failing heart and may resu ... Full text Link to item Cite

Cardiac implantable electronic device removal in patients with left ventricular assist device associated infections.

Journal Article J Cardiovasc Electrophysiol · November 2014 INTRODUCTION: Heart failure patients with left ventricular assist devices (LVADs) are at risk for infection. Cardiac implantable electronic devices (CIEDs) are commonly present in these patients. The course of infections in patients with an LVAD and a CIED ... Full text Link to item Cite

The palliative care in heart failure trial: rationale and design.

Journal Article Am Heart J · November 2014 BACKGROUND: The progressive nature of heart failure (HF) coupled with high mortality and poor quality of life mandates greater attention to palliative care as a routine component of advanced HF management. Limited evidence exists from randomized, controlle ... Full text Link to item Cite

Characteristics and outcomes of patients with heart failure and discordant findings by right-sided heart catheterization and cardiopulmonary exercise testing.

Journal Article Am J Cardiol · October 1, 2014 There are limited data integrating findings on right-sided cardiac catheterization and cardiopulmonary exercise testing in ambulatory patients with heart failure. In this study, 187 outpatients with HF referred to the Duke Medical Center for consideration ... Full text Link to item Cite

Efficacy and durability of central oversewing for treatment of aortic insufficiency in patients with continuous-flow left ventricular assist devices.

Conference J Heart Lung Transplant · September 2014 BACKGROUND: Aortic insufficiency (AI) in patients supported with continuous-flow left ventricular assist devices (CF-LVAD) results in regurgitant volume returning from the aorta to the left ventricle, increased LVAD pump volume and reduced systemic cardiac ... Full text Link to item Cite

A contemporary review of mechanical circulatory support.

Journal Article J Heart Lung Transplant · July 2014 Mechanical circulatory support has seen numerous advances in the recent years, with important observations made to guide patient selection for the therapy, indications for use, and management of devices after implantation. There is rapid growth in the use ... Full text Link to item Cite

Proceedings from Duke resistant hypertension think tank.

Journal Article Am Heart J · June 2014 To identify patients at increased risk for cardiovascular outcomes, apparent treatment resistant hypertension (aTRH) is defined as having a blood pressure (BP) above goal despite the use of ≥3 antihypertensive therapies of different classes at maximally to ... Full text Link to item Cite

Trends in the use and outcomes of ventricular assist devices among medicare beneficiaries, 2006 through 2011.

Journal Article J Am Coll Cardiol · April 15, 2014 OBJECTIVES: This study sought to examine trends in mortality, readmission, and costs among Medicare beneficiaries receiving ventricular assist devices (VADs) and associations between hospital-level procedure volume and outcomes. BACKGROUND: VADs are an opt ... Full text Link to item Cite

Patient selection for advanced heart failure therapy referral.

Journal Article Crit Pathw Cardiol · March 2014 Despite advances in medical therapy for chronic heart failure (HF), advanced HF carries a dismal prognosis. Options such as transplantation and durable mechanical circulatory support have greatly improved outcomes for these patients, but their introduction ... Full text Link to item Cite

Representativeness of RELAX-AHF clinical trial population in acute heart failure.

Journal Article Circ Cardiovasc Qual Outcomes · March 2014 BACKGROUND: The Relaxin for the Treatment of Acute Heart Failure (RELAX-AHF) trial enrolled 1161 patients admitted to the hospital for acute heart failure (AHF) to evaluate the therapeutic efficacy of serelaxin, a recombinant form of human relaxin-2. We ch ... Full text Link to item Cite

Thrombolytic therapy for thrombosis of continuous flow ventricular assist devices.

Journal Article J Card Fail · February 2014 BACKGROUND: Despite chronic systemic anticoagulation, advanced heart failure patients treated with a continuous-flow left ventricular assist device (LVAD) remain at risk for pump thrombosis. Pump thrombosis may initially be suspected in the setting of clin ... Full text Link to item Cite

Medical management of patients with continuous-flow left ventricular assist devices.

Journal Article Curr Treat Options Cardiovasc Med · February 2014 The prevalence of patients living with advanced heart failure continues to rise. For a subset of these patients, continuous-flow left ventricular assist devices (LVADs) are a life-saving therapy. Given the efficacy and durability of contemporary LVAD devic ... Full text Link to item Cite

Outcomes after implantable left ventricular assist device replacement procedures.

Journal Article ASAIO J · 2014 As the duration of support increases for patients with continuous flow left ventricular assist devices (LVADs), device replacement may still be necessary for a variety of indications. Outcomes after replacement LVAD surgeries have not been extensively desc ... Full text Link to item Cite

Valvular heart disease in patients supported with left ventricular assist devices.

Journal Article Circ Heart Fail · January 2014 Patients with advanced HF and coexisting VHD who undergo LVAD implantation constitute a growing population and pose unique challenges in clinical and surgical management. Contemporary continuous-flow LVADs alter blood flow dynamics and cardiovascular physi ... Full text Link to item Cite

Ten-year experience with extended criteria cardiac transplantation.

Journal Article Circ Heart Fail · November 2013 BACKGROUND: Extended criteria cardiac transplant (ECCT) programs expand the transplant pool by matching donors and recipients typically excluded from the transplant process because of age or comorbidity. There is a paucity of data examining long-term outco ... Full text Link to item Cite

Cardiohepatic interactions in heart failure: an overview and clinical implications.

Journal Article J Am Coll Cardiol · June 18, 2013 Heart failure (HF) is a major public health problem leading to frequent hospitalizations, impaired quality of life, and shortened life expectancy. Heart failure leads to a chronic inability to meet metabolic requirements of end organs or skeletal muscle. C ... Full text Link to item Cite

Natural history and clinical effect of aortic valve regurgitation after left ventricular assist device implantation.

Journal Article J Thorac Cardiovasc Surg · May 2013 OBJECTIVES: Aortic valve regurgitation reduces left ventricular assist device mechanical efficiency. Evidence has also suggested that left ventricular assist device implantation can induce or exacerbate aortic valve regurgitation. However, this has not bee ... Full text Link to item Cite

Relationship of right- to left-sided ventricular filling pressures in advanced heart failure: insights from the ESCAPE trial.

Journal Article Circ Heart Fail · March 2013 BACKGROUND: Although right atrial pressure (RAP) and pulmonary capillary wedge pressure (PCWP) are correlated in heart failure, in a sizeable minority of patients, the RAP and PCWP are not tightly coupled. The basis of this variability in the RAP/PCWP rati ... Full text Link to item Cite

Dysphagia in the setting of left ventricular assist device hemolysis.

Journal Article ASAIO J · 2013 A 69-year-old man with advanced heart failure treated with a continuous-flow left ventricular assist device presented for evaluation of dark urine and severe dysphagia. Because of evidence of ongoing intravascular hemolysis with device dysfunction, there w ... Full text Link to item Cite

A crisis of the heart: an acute reversible cardiomyopathy bridged to recovery in a patient with Addison's disease.

Journal Article ASAIO J · 2013 Primary adrenal insufficiency or Addison's disease is a rare disorder often difficult to diagnose on presentation by the nature of its associated nonspecific symptoms, such as nausea or weakness. Cardiovascular complications of the condition are usually li ... Full text Link to item Cite

Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis.

Journal Article N Engl J Med · December 27, 2012 BACKGROUND: Disorders of mineral metabolism, including secondary hyperparathyroidism, are thought to contribute to extraskeletal (including vascular) calcification among patients with chronic kidney disease. It has been hypothesized that treatment with the ... Full text Link to item Cite

Utility of concomitant tricuspid valve procedures for patients undergoing implantation of a continuous-flow left ventricular device.

Journal Article J Thorac Cardiovasc Surg · November 2012 OBJECTIVE: Patients referred for implantable continuous-flow left ventricular assist devices (cfLVAD) frequently have preoperative right heart failure and tricuspid regurgitation (TR). The objective of this report is to examine early clinical benefits of c ... Full text Link to item Cite

Mechanisms of bleeding and approach to patients with axial-flow left ventricular assist devices.

Journal Article Circ Heart Fail · November 2011 Axial-flow LVADs have become an integral tool in the management of end-stage heart failure. Consequently, nonsurgical bleeding has emerged as a major source of morbidity and mortality in this fragile population. The mechanisms responsible for these adverse ... Full text Link to item Cite

Β-arrestin: a signaling molecule and potential therapeutic target for heart failure.

Journal Article J Mol Cell Cardiol · October 2011 Currently, some of the most effective treatments for heart failure target GPCRs such as the beta-adrenergic receptors (β1AR and β2AR) and angiotensin II type IA receptors (AT1aR). Ligands for these receptors not only function by blocking the deleterious G- ... Full text Link to item Cite

Durable mechanical circulatory support devices.

Journal Article Prog Cardiovasc Dis · 2011 Individuals afflicted with advanced systolic heart failure who have become unresponsive to standard medical and electrical therapies are categorized as having American Heart Association stage D heart failure. The high mortality rates for medically treated ... Full text Link to item Cite

Mechanical circulatory support for advanced heart failure.

Journal Article Curr Treat Options Cardiovasc Med · December 2010 Both acute and chronic systolic heart failure can progress to an advanced phase, resulting in stage D heart failure and even cardiogenic shock. Despite significant progress in the treatment of systolic heart failure using medical and device therapies, this ... Full text Link to item Cite

Functional selectivity in adrenergic and angiotensin signaling systems.

Journal Article Mol Pharmacol · December 2010 β-Adrenergic and angiotensin II type 1A receptors are therapeutic targets for the treatment of a number of common human diseases. Pharmacological agents designed as antagonists for these receptors have positively affected the morbidity and mortality of pat ... Full text Link to item Cite

Thiazolidinediones and risk for atherosclerosis: pleiotropic effects of PPar gamma agonism.

Journal Article Diab Vasc Dis Res · September 2006 Despite advances in the development of anti-hyperglycaemic drugs and a greater focus on cardiovascular risk modification for patients with diabetes, cardiovascular disease remains the most common complication of type 2 diabetes. Since their initial availab ... Full text Link to item Cite

Thiazolidinediones, peripheral oedema and congestive heart failure: what is the evidence?

Journal Article Diab Vasc Dis Res · May 2005 Cardiovascular disease is the most common complication of type 2 diabetes mellitus (type 2 DM), accounting for approximately 80% of deaths. While atherosclerotic vascular disease accounts for much of the cardiovascular morbidity and mortality among diabeti ... Full text Link to item Cite