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Trends and outcomes of cardiac transplantation from donors dying of drug intoxication.

Publication ,  Journal Article
Warraich, HJ; Lu, D; Cobb, S; Cooper, LB; DeVore, A; Patel, CB; Rosenberg, PB; Schroder, JN; Daneshmand, MA; Milano, CA; Hernandez, AF ...
Published in: Am Heart J
May 2018

BACKGROUND: Deaths from drug intoxication have increased in the United States but outcomes of recipients of orthotopic heart transplantation (OHT) from these donors are not well characterized. METHODS: We performed a retrospective analysis of the United Network for Organ Sharing's STAR database between January 2000 and March 2014 and assessed mortality and retransplantation using adjusted Cox models by mechanism of donor death. RESULTS: Of the 31,660 OHTs from 2000 to 2014, 1233 (3.9%) were from drug intoxication. These donors were more likely to be female, white, with greater tobacco use and higher BMI compared to donors who died of other mechanisms. Drug intoxication accounted for 1.1% of OHT donors in 2000 and 6.2% in March 2014. No significant difference was observed in 10-year mortality (adjusted hazard ratio [HR], 95% confidence interval [CI]: 0.99, 0.87-1.13), 10-year retransplantation (adjusted HR 0.84, 0.49-1.41) or 1-year and 3-year rehospitalization with other mechanisms of death compared to drug intoxication. CONCLUSION: There has been a large increase in OHT donors who die of drug intoxication in the United States. OHT outcomes from these donors are similar to those dying from other mechanisms. These data have important implications for donor selection in context of the ongoing opioid epidemic.

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Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

May 2018

Volume

199

Start / End Page

92 / 96

Location

United States

Related Subject Headings

  • United States
  • Tissue and Organ Procurement
  • Tissue Donors
  • Survival Rate
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Registries
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Warraich, H. J., Lu, D., Cobb, S., Cooper, L. B., DeVore, A., Patel, C. B., … Mentz, R. J. (2018). Trends and outcomes of cardiac transplantation from donors dying of drug intoxication. Am Heart J, 199, 92–96. https://doi.org/10.1016/j.ahj.2018.02.003
Warraich, Haider J., Di Lu, Stacy Cobb, Lauren B. Cooper, Adam DeVore, Chetan B. Patel, Paul B. Rosenberg, et al. “Trends and outcomes of cardiac transplantation from donors dying of drug intoxication.Am Heart J 199 (May 2018): 92–96. https://doi.org/10.1016/j.ahj.2018.02.003.
Warraich HJ, Lu D, Cobb S, Cooper LB, DeVore A, Patel CB, et al. Trends and outcomes of cardiac transplantation from donors dying of drug intoxication. Am Heart J. 2018 May;199:92–6.
Warraich, Haider J., et al. “Trends and outcomes of cardiac transplantation from donors dying of drug intoxication.Am Heart J, vol. 199, May 2018, pp. 92–96. Pubmed, doi:10.1016/j.ahj.2018.02.003.
Warraich HJ, Lu D, Cobb S, Cooper LB, DeVore A, Patel CB, Rosenberg PB, Schroder JN, Daneshmand MA, Milano CA, Hernandez AF, Rogers JG, Mentz RJ. Trends and outcomes of cardiac transplantation from donors dying of drug intoxication. Am Heart J. 2018 May;199:92–96.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

May 2018

Volume

199

Start / End Page

92 / 96

Location

United States

Related Subject Headings

  • United States
  • Tissue and Organ Procurement
  • Tissue Donors
  • Survival Rate
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Registries
  • Middle Aged
  • Male