Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of Cincinnati 1997
  • M.S.P.H., Tulane University 1992
• 

  Duke Appointment History

  • Assistant Research Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2002 - 2018
• Research
• 

  Selected Grants

  • Cancer cell intrinsic and extrinsic actions of steroid hormones in breast tumors awarded by Department of Defense 2018 - 2022
  • Optimization of ERalpa-LBD-based CAR-T switch awarded by Cell Design Labs, Inc 2017 - 2018
  • The role of ERRalpha/PGC-1 in disease pathogenesis awarded by National Institutes of Health 2006 - 2018
  • Mechanism-informed combination strategies targeting metabolism in prostate cancer awarded by Department of Defense 2015 - 2016
  • The Androgen Receptor: Cofactor Interface awarded by National Institutes of Health 2002 - 2005
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Andreano, Kaitlyn J., Jennifer G. Baker, Sunghee Park, Rachid Safi, Sandeep Artham, Steffi Oesterreich, Rinath Jeselsohn, et al. “The Dysregulated Pharmacology of Clinically Relevant ESR1 Mutants is Normalized by Ligand-activated WT Receptor.” Mol Cancer Ther 19, no. 7 (July 2020): 1395–1405. https://doi.org/10.1158/1535-7163.MCT-19-1148.
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    • Cocce, Kimberly J., Jeff S. Jasper, Taylor K. Desautels, Logan Everett, Suzanne Wardell, Thomas Westerling, Robert Baldi, et al. “The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer.” Cell Rep 29, no. 4 (October 22, 2019): 889-903.e10. https://doi.org/10.1016/j.celrep.2019.09.032.
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    • Gaillard, Stéphanie L., Kaitlyn J. Andreano, Laurie M. Gay, Meghan Steiner, Matthew S. Jorgensen, Brittany Anne Davidson, Laura J. Havrilesky, et al. “Constitutively active ESR1 mutations in gynecologic malignancies and clinical response to estrogen-receptor directed therapies.” Gynecol Oncol 154, no. 1 (July 2019): 199–206. https://doi.org/10.1016/j.ygyno.2019.04.010.
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    • Park, Sunghee, Rachid Safi, Xiaojing Liu, Robert Baldi, Wen Liu, Juan Liu, Jason W. Locasale, Ching-Yi Chang, and Donald P. McDonnell. “Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer.” Cell Rep 27, no. 12 (June 18, 2019): 3587-3601.e4. https://doi.org/10.1016/j.celrep.2019.05.066.
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    • Racioppi, Luigi, Erik R. Nelson, Wei Huang, Debarati Mukherjee, Scott A. Lawrence, William Lento, Anna Maria Masci, et al. “CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer.” Nat Commun 10, no. 1 (June 4, 2019): 2450. https://doi.org/10.1038/s41467-019-10424-5.
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    • Singh, Brijesh K., Rohit A. Sinha, Madhulika Tripathi, Arturo Mendoza, Kenji Ohba, Jann A. C. Sy, Sherwin Y. Xie, et al. “Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function.” Sci Signal 11, no. 536 (June 26, 2018). https://doi.org/10.1126/scisignal.aam5855.
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    • McLeod, Abigail B., James P. Stice, Suzanne E. Wardell, Holly M. Alley, Ching-Yi Chang, and Donald P. McDonnell. “Validation of histone deacetylase 3 as a therapeutic target in castration-resistant prostate cancer.” Prostate 78, no. 4 (March 2018): 266–77. https://doi.org/10.1002/pros.23467.
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    • McDonnell, Donald P., John D. Norris, and Ching-Yi Chang. “Neomorphic ERα Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery.” Cancer Cell 33, no. 2 (February 12, 2018): 153–55. https://doi.org/10.1016/j.ccell.2018.01.014.
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    • Baek, Amy E., Yen-Rei A. Yu, Sisi He, Suzanne E. Wardell, Ching-Yi Chang, Sanghoon Kwon, Ruchita V. Pillai, et al. “The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells.” Nat Commun 8, no. 1 (October 11, 2017): 864. https://doi.org/10.1038/s41467-017-00910-z.
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    • Kimbung, Siker, Ching-Yi Chang, Pär-Ola Bendahl, Laura Dubois, J Will Thompson, Donald P. McDonnell, and Signe Borgquist. “Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer.” Endocr Relat Cancer 24, no. 7 (July 2017): 339–49. https://doi.org/10.1530/ERC-16-0533.
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    • Alfaqih, Mahmoud A., Erik R. Nelson, Wen Liu, Rachid Safi, Jeffery S. Jasper, Everardo Macias, Joseph Geradts, et al. “CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer.” Cancer Res 77, no. 7 (April 1, 2017): 1662–73. https://doi.org/10.1158/0008-5472.CAN-16-2738.
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    • Park, Sunghee, Ching-Yi Chang, Rachid Safi, Xiaojing Liu, Robert Baldi, Jeff S. Jasper, Grace R. Anderson, et al. “ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer.” Cell Rep 15, no. 2 (April 12, 2016): 323–35. https://doi.org/10.1016/j.celrep.2016.03.026.
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    • McDonnell, D. P., C. -. Y. Chang, and E. R. Nelson. “The estrogen receptor as a mediator of the pathological actions of cholesterol in breast cancer.” Climacteric : The Journal of the International Menopause Society 17 Suppl 2 (December 2014): 60–65. https://doi.org/10.3109/13697137.2014.966949.
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    • Nelson, Erik R., Ching-yi Chang, and Donald P. McDonnell. “Cholesterol and breast cancer pathophysiology.” Trends Endocrinol Metab 25, no. 12 (December 2014): 649–55. https://doi.org/10.1016/j.tem.2014.10.001.
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    • McDonnell, Donald P., Sunghee Park, Matthew T. Goulet, Jeff Jasper, Suzanne E. Wardell, Ching-Yi Chang, John D. Norris, John R. Guyton, and Erik R. Nelson. “Obesity, cholesterol metabolism, and breast cancer pathogenesis.” Cancer Res 74, no. 18 (September 15, 2014): 4976–82. https://doi.org/10.1158/0008-5472.CAN-14-1756.
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    • Stossi, Fabio, Michael J. Bolt, Radhika D. Dandekar, Vasanta Putluri, Akash K. Kaushik, Ching-yi Chang, Maureen M. Mancini, Arun Sreekumar, Donald P. McDonnell, and Michael Alan Mancini. “Bisphenol AP Is a Novel AR Down-Regulator in Castrate Resistant Prostate Cancer Cells Via Modulation of Nuclear Receptors' Networks.” Endocrine Reviews 35, no. 3 (June 1, 2014).
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    • Weiser, Patrick T., Ching-Yi Chang, Donald P. McDonnell, and Robert N. Hanson. “4,4'-Unsymmetrically substituted 3,3'-biphenyl alpha helical proteomimetics as potential coactivator binding inhibitors.” Bioorg Med Chem 22, no. 2 (January 15, 2014): 917–26. https://doi.org/10.1016/j.bmc.2013.10.051.
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    • Chang, Ching-yi, and Donald P. McDonnell. “Molecular pathways: the metabolic regulator estrogen-related receptor α as a therapeutic target in cancer.” Clinical Cancer Research : An Official Journal of the American Association for Cancer Research 18, no. 22 (November 2012): 6089–95. https://doi.org/10.1158/1078-0432.ccr-11-3221.
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    • Weiser, Patrick T., Anna B. Williams, Ching-Yi Chang, Donald P. McDonnell, and Robert N. Hanson. “3,3'-Disubstituted bipolar biphenyls as inhibitors of nuclear receptor coactivator binding.” Bioorg Med Chem Lett 22, no. 21 (November 1, 2012): 6587–90. https://doi.org/10.1016/j.bmcl.2012.09.007.
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    • Michalek, Ryan D., Valerie A. Gerriets, Amanda G. Nichols, Makoto Inoue, Dmitri Kazmin, Ching-Yi Chang, Mary A. Dwyer, et al. “Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation.” Proc Natl Acad Sci U S A 108, no. 45 (November 8, 2011): 18348–53. https://doi.org/10.1073/pnas.1108856108.
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    • Chang, Ching-yi, Dmitri Kazmin, Jeff S. Jasper, Rebecca Kunder, William J. Zuercher, and Donald P. McDonnell. “The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer.” Cancer Cell 20, no. 4 (October 18, 2011): 500–510. https://doi.org/10.1016/j.ccr.2011.08.023.
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    • Yang, Jun, Ching-yi Chang, Rachid Safi, James Morgan, Donald P. McDonnell, Peter J. Fuller, Colin D. Clyne, and Morag J. Young. “Identification of ligand-selective peptide antagonists of the mineralocorticoid receptor using phage display.” Mol Endocrinol 25, no. 1 (January 2011): 32–43. https://doi.org/10.1210/me.2010-0193.
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    • Kobayashi, Sakiko, James P. Stice, Dmitri Kazmin, Bryan M. Wittmann, Erin A. Kimbrel, Dean P. Edwards, Ching-Yi Chang, and Donald P. McDonnell. “Mechanisms of progesterone receptor inhibition of inflammatory responses in cellular models of breast cancer.” Mol Endocrinol 24, no. 12 (December 2010): 2292–2302. https://doi.org/10.1210/me.2010-0289.
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    • Dwyer, Mary A., James D. Joseph, Hilary E. Wade, Matthew L. Eaton, Rebecca S. Kunder, Dmitri Kazmin, Ching-yi Chang, and Donald P. McDonnell. “WNT11 expression is induced by estrogen-related receptor alpha and beta-catenin and acts in an autocrine manner to increase cancer cell migration.” Cancer Res 70, no. 22 (November 15, 2010): 9298–9308. https://doi.org/10.1158/0008-5472.CAN-10-0226.
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    • Michalek, Ryan, Sarah Jacobs, Ching-yi Chang, Olga Ilkayeva, Nancie Maciver, Russell Jones, Vincent Giguere, Donald McDonnell, and Jeffrey Rathmell. “Estrogen related receptor-alpha is a global metabolic and fate determinant for T lymphocytes.” Journal of Immunology 184 (April 1, 2010).
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    • Alaynick, William A., James M. Way, Stephanie A. Wilson, William G. Benson, Liming Pei, Michael Downes, Ruth Yu, et al. “ERRgamma regulates cardiac, gastric, and renal potassium homeostasis.” Mol Endocrinol 24, no. 2 (February 2010): 299–309. https://doi.org/10.1210/me.2009-0114.
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    • Norris, John D., Ching-Yi Chang, Bryan M. Wittmann, Rebecca S. Kunder, Huaxia Cui, Daju Fan, James D. Joseph, and Donald P. McDonnell. “The homeodomain protein HOXB13 regulates the cellular response to androgens.” Mol Cell 36, no. 3 (November 13, 2009): 405–16. https://doi.org/10.1016/j.molcel.2009.10.020.
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    • Grasfeder, Linda L., Stephanie Gaillard, Stephen R. Hammes, Olga Ilkayeva, Christopher B. Newgard, Richard B. Hochberg, Mary A. Dwyer, Ching-Yi Chang, and Donald P. McDonnell. “Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha.” Mol Endocrinol 23, no. 8 (August 2009): 1171–82. https://doi.org/10.1210/me.2009-0024.
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    • Norris, John David, James David Joseph, Andrea Barreto Sherk, Dalia Juzumiene, Philip Stewart Turnbull, Stephen William Rafferty, Huaxia Cui, et al. “Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ligands.” Chem Biol 16, no. 4 (April 24, 2009): 452–60. https://doi.org/10.1016/j.chembiol.2009.01.016.
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    • Clyne, Colin D., Ching-Yi Chang, Rachid Safi, Peter J. Fuller, Donald P. McDonnell, and Morag J. Young. “Purification and characterization of recombinant human mineralocorticoid receptor.” Mol Cell Endocrinol 302, no. 1 (April 10, 2009): 81–85. https://doi.org/10.1016/j.mce.2008.11.030.
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    • Stein, Rebecca A., Ching-Yi Chang, Dmitri A. Kazmin, James Way, Thies Schroeder, Melanie Wergin, Mark W. Dewhirst, and Donald P. McDonnell. “Estrogen-related receptor alpha is critical for the growth of estrogen receptor-negative breast cancer.” Cancer Res 68, no. 21 (November 1, 2008): 8805–12. https://doi.org/10.1158/0008-5472.CAN-08-1594.
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    • Zella, Lee A., Ching-Yi Chang, Donald P. McDonnell, and J Wesley Pike. “The vitamin D receptor interacts preferentially with DRIP205-like LxxLL motifs.” Arch Biochem Biophys 460, no. 2 (April 15, 2007): 206–12. https://doi.org/10.1016/j.abb.2006.12.016.
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    • Klokk, Tove I., Piotr Kurys, Cem Elbi, Akhilesh K. Nagaich, Anindya Hendarwanto, Thomas Slagsvold, Ching-Yi Chang, Gordon L. Hager, and Fahri Saatcioglu. “Ligand-specific dynamics of the androgen receptor at its response element in living cells.” Mol Cell Biol 27, no. 5 (March 2007): 1823–43. https://doi.org/10.1128/MCB.01297-06.
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    • Gaillard, Stéphanie, Linda L. Grasfeder, Christiane L. Haeffele, Edward K. Lobenhofer, Tzu-Ming Chu, Russ Wolfinger, Dmitri Kazmin, et al. “Receptor-selective coactivators as tools to define the biology of specific receptor-coactivator pairs.” Mol Cell 24, no. 5 (December 8, 2006): 797–803. https://doi.org/10.1016/j.molcel.2006.10.012.
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    • Kazmin, Dmitri, Tatiana Prytkova, C Edgar Cook, Russell Wolfinger, Tzu-Ming Chu, David Beratan, J. D. Norris, Ching-yi Chang, and Donald P. McDonnell. “Linking ligand-induced alterations in androgen receptor structure to differential gene expression: a first step in the rational design of selective androgen receptor modulators.” Mol Endocrinol 20, no. 6 (June 2006): 1201–17. https://doi.org/10.1210/me.2005-0309.
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    • Chang, Ching-Yi, Jennifer Abdo, Tanya Hartney, and Donald P. McDonnell. “Development of peptide antagonists for the androgen receptor using combinatorial peptide phage display.” Mol Endocrinol 19, no. 10 (October 2005): 2478–90. https://doi.org/10.1210/me.2005-0072.
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    • Chang, Ching-yi, and Donald P. McDonnell. “Androgen receptor-cofactor interactions as targets for new drug discovery.” Trends Pharmacol Sci 26, no. 5 (May 2005): 225–28. https://doi.org/10.1016/j.tips.2005.03.002.
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    • Juzumiene, Dalia, Ching-yi Chang, Daju Fan, Tanya Hartney, John D. Norris, and Donald P. McDonnell. “Single-step purification of full-length human androgen receptor.” Nucl Recept Signal 3 (2005): e001. https://doi.org/10.1621/nrs.03001.
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    • Kurebayashi, Shogo, Takeshi Nakajima, Seong-Chul Kim, Ching-Yi Chang, Donald P. McDonnell, Jean-Paul Renaud, and Anton M. Jetten. “Selective LXXLL peptides antagonize transcriptional activation by the retinoid-related orphan receptor RORgamma.” Biochem Biophys Res Commun 315, no. 4 (March 19, 2004): 919–27. https://doi.org/10.1016/j.bbrc.2004.01.131.
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    • Sathya, Ganesan, Ching-yi Chang, Dmitri Kazmin, C Edgar Cook, and Donald P. McDonnell. “Pharmacological uncoupling of androgen receptor-mediated prostate cancer cell proliferation and prostate-specific antigen secretion.” Cancer Res 63, no. 22 (November 15, 2003): 8029–36.
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    • Pike, J Wesley, Peterman Pathrose, Olga Barmina, Ching-Yi Chang, Donald P. McDonnell, Hironori Yamamoto, and Nirupama K. Shevde. “Synthetic LXXLL peptide antagonize 1,25-dihydroxyvitamin D3-dependent transcription.” J Cell Biochem 88, no. 2 (February 1, 2003): 252–58. https://doi.org/10.1002/jcb.10336.
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    • Chang, Ching-yi, John D. Norris, Michelle Jansen, Huey-Jing Huang, and Donald P. McDonnell. “Application of random peptide phage display to the study of nuclear hormone receptors.” Methods Enzymol 364 (2003): 118–42. https://doi.org/10.1016/s0076-6879(03)64007-3.
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    • Puga, Alvaro, Jennifer Marlowe, Sonya Barnes, Ching-yi Chang, Andrew Maier, Zongqing Tan, J Kevin Kerzee, Xaoqing Chang, Matt Strobeck, and Erik S. Knudsen. “Role of the aryl hydrocarbon receptor in cell cycle regulation.” Toxicology 181–182 (December 27, 2002): 171–77. https://doi.org/10.1016/s0300-483x(02)00276-7.
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    • Pathrose, Peterson, Olga Barmina, Ching-Yi Chang, Donald P. McDonnell, Nirupama K. Shevde, and J Wesley Pike. “Inhibition of 1,25-dihydroxyvitamin D3-dependent transcription by synthetic LXXLL peptide antagonists that target the activation domains of the vitamin D and retinoid X receptors.” J Bone Miner Res 17, no. 12 (December 2002): 2196–2205. https://doi.org/10.1359/jbmr.2002.17.12.2196.
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    • McDonnell, Donald P., Ashini Wijayaratne, Ching-yi Chang, and John D. Norris. “Elucidation of the molecular mechanism of action of selective estrogen receptor modulators.” Am J Cardiol 90, no. 1A (July 3, 2002): 35F-43F. https://doi.org/10.1016/s0002-9149(01)02221-4.
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    • Chang, Ching-Yi, and Donald P. McDonnell. “Evaluation of ligand-dependent changes in AR structure using peptide probes.” Mol Endocrinol 16, no. 4 (April 2002): 647–60. https://doi.org/10.1210/mend.16.4.0818.
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    • Weatherman, R. V., C. -. Y. Chang, N. J. Clegg, D. C. Carroll, R. N. Day, J. D. Baxter, D. P. McDonnell, T. S. Scanlan, and F. Schaufele. “Ligand-selective interactions of ER detected in living cells by fluorescence resonance energy transfer.” Mol Endocrinol 16, no. 3 (March 2002): 487–96. https://doi.org/10.1210/mend.16.3.0813.
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    • McDonnell, Donald P., Caroline E. Connor, Ashini Wijayaratne, Ching-Yi Chang, and John D. Norris. “Definition of the molecular and cellular mechanisms underlying the tissue-selective agonist/antagonist activities of selective estrogen receptor modulators.” Recent Prog Horm Res 57 (2002): 295–316. https://doi.org/10.1210/rp.57.1.295.
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    • Chang, C. Y., P. J. Walther, and D. P. McDonnell. “Glucocorticoids manifest androgenic activity in a cell line derived from a metastatic prostate cancer.” Cancer Res 61, no. 24 (December 15, 2001): 8712–17.
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    • McDonnell, D. P., C. Y. Chang, and J. D. Norris. “Capitalizing on the complexities of estrogen receptor pharmacology in the quest for the perfect SERM.” Ann N Y Acad Sci 949 (December 2001): 16–35. https://doi.org/10.1111/j.1749-6632.2001.tb03999.x.
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    • Norris, J. D., C. Chang, and D. P. McDonnell. “Estrogen receptor-cofactor interactions as targets for novel drug discovery.” Ernst Schering Res Found Workshop, no. 34 (2001): 181–201. https://doi.org/10.1007/978-3-662-04645-6_10.
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    • Hall, J. M., C. Y. Chang, and D. P. McDonnell. “Development of peptide antagonists that target estrogen receptor beta-coactivator interactions.” Mol Endocrinol 14, no. 12 (December 2000): 2010–23. https://doi.org/10.1210/mend.14.12.0561.
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    • Schaufele, F., C. Y. Chang, W. Liu, J. D. Baxter, S. K. Nordeen, Y. Wan, R. N. Day, and D. P. McDonnell. “Temporally distinct and ligand-specific recruitment of nuclear receptor-interacting peptides and cofactors to subnuclear domains containing the estrogen receptor.” Mol Endocrinol 14, no. 12 (December 2000): 2024–39. https://doi.org/10.1210/mend.14.12.0572.
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    • McDonnell, D. P., C. Y. Chang, and J. D. Norris. “Development of peptide antagonists that target estrogen receptor-cofactor interactions.” J Steroid Biochem Mol Biol 74, no. 5 (November 30, 2000): 327–35. https://doi.org/10.1016/s0960-0760(00)00109-6.
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    • Puga, A., S. J. Barnes, C. Chang, H. Zhu, K. P. Nephew, S. A. Khan, and H. G. Shertzer. “Activation of transcription factors activator protein-1 and nuclear factor-kappaB by 2,3,7,8-tetrachlorodibenzo-p-dioxin.” Biochem Pharmacol 59, no. 8 (April 15, 2000): 997–1005. https://doi.org/10.1016/s0006-2952(99)00406-2.
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    • Puga, A., S. J. Barnes, T. P. Dalton, C. Y. Chang, E. S. Knudsen, and M. A. Maier. “Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest.” J Biol Chem 275, no. 4 (January 28, 2000): 2943–50. https://doi.org/10.1074/jbc.275.4.2943.
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    • Chang, C. Y., J. D. Norris, H. Grøn, L. A. Paige, P. T. Hamilton, D. J. Kenan, D. Fowlkes, and D. P. McDonnell. “Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta.” Mol Cell Biol 19, no. 12 (December 1999): 8226–39. https://doi.org/10.1128/mcb.19.12.8226.
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    • Shertzer, H. G., A. Puga, C. Chang, P. Smith, D. W. Nebert, K. D. Setchell, and T. P. Dalton. “Inhibition of CYP1A1 enzyme activity in mouse hepatoma cell culture by soybean isoflavones.” Chem Biol Interact 123, no. 1 (November 15, 1999): 31–49. https://doi.org/10.1016/s0009-2797(99)00121-0.
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    • Norris, J. D., L. A. Paige, D. J. Christensen, C. Y. Chang, M. R. Huacani, D. Fan, P. T. Hamilton, D. M. Fowlkes, and D. P. McDonnell. “Peptide antagonists of the human estrogen receptor.” Science 285, no. 5428 (July 30, 1999): 744–46. https://doi.org/10.1126/science.285.5428.744.
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    • Paige, L. A., D. J. Christensen, H. Grøn, J. D. Norris, E. B. Gottlin, K. M. Padilla, C. Y. Chang, et al. “Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta.” Proc Natl Acad Sci U S A 96, no. 7 (March 30, 1999): 3999–4004. https://doi.org/10.1073/pnas.96.7.3999.
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    • Maier, A., J. Micka, K. Miller, T. Denko, C. Y. Chang, D. W. Nebert, and D. W. Alvaro Puga. “Aromatic hydrocarbon receptor polymorphism: development of new methods to correlate genotype with phenotype.” Environ Health Perspect 106, no. 7 (July 1998): 421–26. https://doi.org/10.1289/ehp.106-1533118.
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    • Chang, C. Y., and A. Puga. “Constitutive activation of the aromatic hydrocarbon receptor.” Mol Cell Biol 18, no. 1 (January 1998): 525–35. https://doi.org/10.1128/mcb.18.1.525.
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    • Hoffer, A., C. Y. Chang, and A. Puga. “Dioxin induces transcription of fos and jun genes by Ah receptor-dependent and -independent pathways.” Toxicology and Applied Pharmacology 141, no. 1 (November 1996): 238–47. https://doi.org/10.1006/taap.1996.0280.
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    • Puga, A., J. Micka, C. Y. Chang, H. C. Liang, and D. W. Nebert. “Role of molecular biology in risk assessment.” Adv Exp Med Biol 387 (1996): 395–404. https://doi.org/10.1007/978-1-4757-9480-9_48.
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    • Vasiliou, V., A. Puga, C. Y. Chang, M. W. Tabor, and D. W. Nebert. “Interaction between the Ah receptor and proteins binding to the AP-1-like electrophile response element (EpRE) during murine phase II [Ah] battery gene expression.” Biochem Pharmacol 50, no. 12 (December 22, 1995): 2057–68. https://doi.org/10.1016/0006-2952(95)02108-6.
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    • Carrier, F., C. Y. Chang, J. L. Duh, D. W. Nebert, and A. Puga. “Interaction of the regulatory domains of the murine Cyp1a1 gene with two DNA-binding proteins in addition to the Ah receptor and the Ah receptor nuclear translocator (ARNT).” Biochem Pharmacol 48, no. 9 (November 1, 1994): 1767–78. https://doi.org/10.1016/0006-2952(94)90463-4.
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    • Chang, C., D. R. Smith, V. S. Prasad, C. L. Sidman, D. W. Nebert, and A. Puga. “Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice.” Pharmacogenetics 3, no. 6 (December 1993): 312–21. https://doi.org/10.1097/00008571-199312000-00005.
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  • Conference Papers

    • Chakraborty, Binita, Jovita Bymerwa, Robert Baldi, Wen Liu, Ching-Yi Chang, and Donald McDonnell. “Pharmacologic targeting of estrogen receptor in melanoma to enhance antitumor immunity.” In Cancer Immunology Research, 8:53–53. AMER ASSOC CANCER RESEARCH, 2020.
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    • Mukherjee, Debarati, Robert Baldi, Ching-Yi Chang, Luigi Racioppi, and Donald P. McDonnell. “Impact of CaMKK2 inhibition in tumor-associated myeloid cells on CD8+cytotoxic T-cell recruitment into mammary tumors.” In Cancer Immunology Research, 8:56–57. AMER ASSOC CANCER RESEARCH, 2020.
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    • Gaillard, Stephanie, Laurie M. Gay, Meghan Steiner, Kaitlyn Andreano, Brittany Anne Davidson, Laura Jean Havrilesky, Angeles Alvarez Secord, et al. “Assessment of activating estrogen receptor 1 (ESR1) mutations in gynecologic malignancies.” In Journal of Clinical Oncology, 36:5590–5590. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.15_suppl.5590.
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    • Alfaqih, Mahmoud A., Erik R. Nelson, Rachid Safi, Jeff Jasper, Ching-yi Chang, Stephen J. Freedland, and Donald P. McDonnell. “Abstract 3311: The cholesterol/ 27-hydroxycholesterol axis is a novel therapeutic target in castrate resistant prostate cancer.” In Molecular and Cellular Biology. American Association for Cancer Research, 2014. https://doi.org/10.1158/1538-7445.am2014-3311.
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    • Stevens, Ellen V., Regina Whitaker, Audrey Guinet, Ching-Yi Chang, Carole Grenier, Jeffrey Marks, Donald P. McDonnell, Susan K. Murphy, Andrew Berchuck, and Stephanie Gaillard. “Abstract 4570: Role of ERRalpha in ovarian cancer.” In Experimental and Molecular Therapeutics. American Association for Cancer Research, 2014. https://doi.org/10.1158/1538-7445.am2014-4570.
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