Scholars@Duke
Christine Elissa Eyler

Christine Elissa Eyler

Butler Harris Assistant Professor in Radiation Oncology
Radiation Oncology
Box 103659, Durham, NC 27710
LSRC B327C, Box 103659, Durham, NC 27710

Selected Publications

Rewiring cancer: 3D genome determinants of cancer hallmarks.

Journal Article Curr Opin Genet Dev · April 2025 In modern cancer biology, Hanahan and Weinberg's classic depiction of the Hallmarks of Cancer serves as a heuristic for understanding malignant phenotypes [1]. Genetic determinants of these phenotypes promote cancer induction and progression, and these mut ... Full text Link to item Cite

Circulating Tumor DNA Predicts Pathologic and Clinical Outcomes Following Neoadjuvant Chemoradiation and Surgery for Patients With Locally Advanced Rectal Cancer.

Journal Article JCO Precis Oncol · 2021 PURPOSE: This study was designed to assess the ability of perioperative circulating tumor DNA (ctDNA) to predict surgical outcome and recurrence following neoadjuvant chemoradiation for locally advanced rectal cancer (LARC). MATERIALS AND METHODS: Twenty-n ... Full text Link to item Cite

Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisions.

Journal Article Cell Death Dis · September 1, 2011 Malignant gliomas contain a population of self-renewing tumorigenic stem-like cells; however, it remains unclear how these glioma stem cells (GSCs) self-renew or generate cellular diversity at the single-cell level. Asymmetric cell division is a proposed m ... Full text Link to item Cite

Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2.

Journal Article Cell · July 8, 2011 Malignant gliomas are aggressive brain tumors with limited therapeutic options, and improvements in treatment require a deeper molecular understanding of this disease. As in other cancers, recent studies have identified highly tumorigenic subpopulations wi ... Full text Link to item Cite

Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3.

Journal Article Cancer Cell · April 12, 2011 Glioblastomas display cellular hierarchies containing tumor-propagating glioblastoma stem cells (GSCs). STAT3 is a critical signaling node in GSC maintenance but molecular mechanisms underlying STAT3 activation in GSCs are poorly defined. Here we demonstra ... Full text Link to item Cite

Bacterial flavohemoglobin: a molecular tool to probe mammalian nitric oxide biology.

Journal Article Biotechniques · January 2011 A wide range of mammalian signaling and stress pathways are mediated by nitric oxide (NO), which is synthesized in vivo by the nitric oxide synthase (NOS) family of enzymes. Experimental manipulations of NO are frequently achieved by either inhibition or a ... Full text Link to item Cite

Integrin alpha 6 regulates glioblastoma stem cells.

Journal Article Cell Stem Cell · May 7, 2010 Cancer stem cells (CSCs) are a subpopulation of tumor cells suggested to be critical for tumor maintenance, metastasis, and therapeutic resistance. Prospective identification and targeting of CSCs are therefore priorities for the development of novel thera ... Full text Link to item Cite

Targeting A20 decreases glioma stem cell survival and tumor growth.

Journal Article PLoS Biol · February 23, 2010 Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs). GSCs are regulated by molecular pathways distinct from the bulk tumor that may be useful therapeutic targets. We deter ... Full text Open Access Link to item Cite

Erythropoietin Receptor Signaling Through STAT3 Is Required For Glioma Stem Cell Maintenance.

Journal Article Genes Cancer · January 1, 2010 Recombinant erythropoietin (EPO) is a growth factor used in the treatment of chemotherapy-induced anemia, but recent studies suggest that EPO may accelerate cancer growth. Although several cancers express EPO receptors (EPORs), the mechanism by which EPOR ... Full text Link to item Cite

Effects of Single Nucleotide Polymorphisms of the β2 Adrenergic Receptor and of Adenylate Cyclase on Sickle Red Cell Adhesion to Laminin.

Conference Blood · November 16, 2004 AbstractSingle nucleotide polymorphisms (SNPs) of the β2 adrenergic receptor (β2AR) gene (ADRB2) on chromosome 5 have been implicated in clinical variability of several cardiopulmonary disorders. Also, Hoppe ... Full text Cite

B-CAM/LU expression and the role of B-CAM/LU activation in binding of low- and high-density red cells to laminin in sickle cell disease.

Journal Article Am J Hematol · February 2004 Red blood cells from patients with sickle cell disease (SS RBC) adhere to laminin and over-express the high-affinity laminin receptor basal cell adhesion molecule/Lutheran protein (B-CAM/LU). This receptor has recently been shown to undergo activation in v ... Full text Link to item Cite

[Current perspectives of orthogonal polarization spectral imaging in plastic surgery].

Journal Article Chirurg · August 2002 The technology of Orthogonal Polarization Spectral Imaging (OPSI), patented in the United States in 1999, has been heralded as an alternative to conventional intravital microscopy for several reasons, including ease of application and ability to perform co ... Full text Link to item Cite