Scholars@Duke
Christopher Mosher

Christopher Mosher

Assistant Professor of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
christopher.mosher@duke.edu
DCRI - Durham Centre Building, 300 West Morgan St., Office 833, Durham, NC 27701

Selected Publications

Aspirin Dosing for Secondary Prevention of Atherosclerotic Cardiovascular Disease in Chronic Obstructive Pulmonary Disease and Asthma: Insights From ADAPTABLE.

Journal Article J Am Heart Assoc · December 2, 2025 BACKGROUND: Guidelines recommend aspirin (75-100 mg daily) for the secondary prevention of atherosclerotic cardiovascular disease (ASCVD). However, it is unknown if people with a history of ASCVD and chronic obstructive pulmonary disease (COPD) or asthma, ... Full text Link to item Cite

New horizons in advancing lifestyle medicine for older adults utilizing a transdisciplinary approach: gaps and opportunities.

Journal Article Age Ageing · May 31, 2025 Nearly half of premature deaths can be prevented with healthy lifestyle behaviours. However, most older adults do not adhere to established guidelines to promote a healthy lifestyle. We propose a tailored framework of lifestyle medicine that acknowledges t ... Full text Link to item Cite

Risk of Atherosclerotic Cardiovascular Disease After Chronic Obstructive Pulmonary Disease Hospitalization among Primary and Secondary Prevention Older Adults.

Journal Article J Am Heart Assoc · January 21, 2025 BACKGROUND: Meta-analyses have suggested that the risk of cardiovascular disease events is significantly higher after a chronic obstructive pulmonary disease (COPD) exacerbation, but the populations at highest risk have not been well characterized to date. ... Full text Link to item Cite

Feasibility, Usability, and Pilot Efficacy Study of a Software-Enabled, Virtual Pulmonary Rehabilitation with Remote Therapeutic Monitoring.

Journal Article Int J Chron Obstruct Pulmon Dis · 2025 OBJECTIVE: Fewer than 3% of adults with Chronic Obstructive Pulmonary Disease (COPD) attend in-person, center-based pulmonary rehabilitation (PR) despite demonstrated health benefits and reduction in mortality. This study evaluated the feasibility and usab ... Full text Link to item Cite

"A good day is just being able to breathe": Aligning COPD research with patient needs, a qualitative study.

Journal Article PLoS One · 2025 BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a common and impactful disease that is the target of a large portfolio of clinical research. However, there is limited understanding of how individuals with COPD perceive trial designs, outcomes, ... Full text Link to item Cite

Risk of Atherosclerotic Cardiovascular Disease Hospitalizations after Chronic Obstructive Pulmonary Disease Hospitalization among Older Adults.

Journal Article Ann Am Thorac Soc · November 2024 Rationale: Meta-analyses have suggested the risk of cardiovascular disease (CVD) events is significantly higher after a chronic obstructive pulmonary disease (COPD) exacerbation. However, many of these studies have included a broad array of CVD events or h ... Full text Link to item Cite

Telehealth Pulmonary Rehabilitation: A Call for Minimum Standards.

Journal Article Am J Respir Crit Care Med · July 15, 2024 Full text Link to item Cite

Review of the Evidence for Pulmonary Rehabilitation in COPD: Clinical Benefits and Cost-Effectiveness.

Journal Article Respir Care · May 28, 2024 COPD is a common and lethal chronic condition, recognized as a leading cause of death worldwide. COPD is associated with significant morbidity and disability, particularly among older adults. The disease course is marked by periods of stability and disease ... Full text Link to item Cite

Timing of Treatment Outcomes and Risk Factors for Failure of BPAP in Patients Hospitalized for COPD Exacerbation.

Journal Article Respir Care · December 2022 BACKGROUND: Patients hospitalized for COPD exacerbation have an increased risk of mortality, particularly among those who fail bi-level positive airway pressure (BPAP) for hypercapnic respiratory failure subsequently requiring invasive mechanical ventilati ... Full text Link to item Cite

Cost-effectiveness of Pulmonary Rehabilitation Among US Adults With Chronic Obstructive Pulmonary Disease.

Journal Article JAMA Netw Open · June 1, 2022 IMPORTANCE: Pulmonary rehabilitation (PR) after exacerbation of chronic obstructive pulmonary disease (COPD) is effective in reducing COPD hospitalizations and mortality while improving health-related quality of life, yet use of PR remains low. Estimates o ... Full text Link to item Cite

Risk factors for mortality in lung transplant recipients aged ≥65 years: A retrospective cohort study of 5,815 patients in the scientific registry of transplant recipients.

Journal Article J Heart Lung Transplant · January 2021 BACKGROUND: Lung transplantation is increasingly performed in recipients aged ≥65 years. However, the risk factors for mortality specific to this population have not been well studied. In lung transplant recipients aged ≥65 years, we sought to determine po ... Full text Link to item Cite

Electronic Cigarettes: A Role in Smoking Cessation?

Journal Article Am J Respir Crit Care Med · August 15, 2020 Full text Link to item Cite

Cardiovascular implications of idiopathic pulmonary fibrosis: A way forward together?

Journal Article Am Heart J · August 2020 Cardiovascular disease has an increased prevalence among patients with idiopathic pulmonary fibrosis (IPF). Cardiovascular disease and IPF share similar symptoms with overlapping demographics and risk factors for disease development. Common cellular mediat ... Full text Link to item Cite

Time to diagnosis of idiopathic pulmonary fibrosis in the IPF-PRO Registry.

Journal Article BMJ Open Respir Res · July 2020 BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive disease with high mortality. Patient characteristics associated with diagnostic delays are not well described. METHODS: Subjects who had not been diagnosed with IPF prior to referral and rece ... Full text Link to item Cite

Post-Intensive Care Unit Psychiatric Comorbidity and Quality of Life.

Journal Article J Hosp Med · October 2017 The prevalence of psychiatric symptoms ranges from 17% to 44% in intensive care unit (ICU) survivors. The relationship between the comorbidity of psychiatric symptoms and quality of life (QoL) in ICU survivors has not been carefully examined. This study ex ... Full text Link to item Cite

Antidepressant Use and Depressive Symptoms in Intensive Care Unit Survivors.

Journal Article J Hosp Med · September 2017 Nearly 30% of intensive care unit (ICU) survivors have depressive symptoms 2-12 months after hospital discharge. We examined the prevalence of depressive symptoms and risk factors for depressive symptoms in 204 patients at their initial evaluation in the C ... Full text Link to item Cite