Scholars@Duke
Chris Vann

Selected Publications

Different Resistance Exercise Loading Paradigms Similarly Affect Skeletal Muscle Gene Expression Patterns of Myostatin-Related Targets and mTORC1 Signaling Markers.

Journal Article Cells · March 2023 Although transcriptome profiling has been used in several resistance training studies, the associated analytical approaches seldom provide in-depth information on individual genes linked to skeletal muscle hypertrophy. Therefore, a secondary analysis was p ... Full text Open Access Cite

Resistance training in humans and mechanical overload in rodents do not elevate muscle protein lactylation

Journal Article Frontiers in Physiology · January 1, 2023 Although several reports have hypothesized that exercise may increase skeletal muscle protein lactylation, empirical evidence in humans is lacking. Thus, we adopted a multi-faceted approach to examine if acute and subchronic resistance training (RT) altere ... Full text Open Access Cite

Beyond Mechanical Tension: A Review of Resistance Exercise-Induced Lactate Responses & Muscle Hypertrophy

Journal Article Journal of Functional Morphology and Kinesiology · October 4, 2022 The present review aims to explore and discuss recent research relating to the lactate response to resistance training and the potential mechanisms by which lactate may contribute to skeletal muscle hypertrophy or help to prevent muscle atrophy. Fi ... Full text Open Access Cite

Effects of High-Volume Versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations.

Journal Article Frontiers in physiology · January 2022 We evaluated the effects of higher-load (HL) versus (lower-load) higher-volume (HV) resistance training on skeletal muscle hypertrophy, strength, and muscle-level molecular adaptations. Trained men (n = 15, age: 23 ± 3 years; training experience: 7  ... Full text Open Access Cite

Differential microRNA profiles of intramuscular and secreted extracellular vesicles in human tissue-engineered muscle.

Journal Article Front Physiol · 2022 Exercise affects the expression of microRNAs (miR/s) and muscle-derived extracellular vesicles (EVs). To evaluate sarcoplasmic and secreted miR expression in human skeletal muscle in response to exercise-mimetic contractile activity, we utilized a three-di ... Full text Open Access Link to item Cite

Proteasome- and Calpain-Mediated Proteolysis, but Not Autophagy, Is Required for Leucine-Induced Protein Synthesis in C2C12 Myotubes

Journal Article Physiologia · November 8, 2021 Muscle protein synthesis and proteolysis are tightly coupled processes. Given that muscle growth is promoted by increases in net protein balance, it stands to reason that bolstering protein synthesis through amino acids while reducing or inhibiting ... Full text Open Access Cite

Skeletal Muscle Ribosome and Mitochondrial Biogenesis in Response to Different Exercise Training Modalities

Journal Article Frontiers in Physiology · September 10, 2021 Skeletal muscle adaptations to resistance and endurance training include increased ribosome and mitochondrial biogenesis, respectively. Such adaptations are believed to contribute to the notable increases in hypertrophy and aerobic capacity observe ... Full text Open Access Cite

Resistance training rejuvenates the mitochondrial methylome in aged human skeletal muscle

Journal Article The FASEB Journal · September 2021 AbstractResistance training (RT) dynamically alters the skeletal muscle nuclear DNA methylome. However, no study has examined if RT affects the mitochondrial DNA (mtDNA) methylome. Herein, ten older, Caucasian untrained mal ... Full text Open Access Cite

Molecular Differences in Skeletal Muscle After 1 Week of Active vs. Passive Recovery From High-Volume Resistance Training

Journal Article Journal of Strength and Conditioning Research · August 2021 AbstractVann, CG, Haun, CT, Osburn, SC, Romero, MA, Roberson, PA, Mumford, PW, Mobley, CB, Holmes, HM, Fox, CD, Young, KC, and Roberts, MD. Molecular differences in skeletal muscle after 1 week of active vs. pass ... Full text Open Access Cite

An intron variant of the GLI family zinc finger 3 (GLI3) gene differentiates resistance training-induced muscle fiber hypertrophy in younger men.

Journal Article FASEB journal : official publication of the Federation of American Societies for Experimental Biology · May 2021 We examined the association between genotype and resistance training-induced changes (12 wk) in dual x-ray energy absorptiometry (DXA)-derived lean soft tissue mass (LSTM) as well as muscle fiber cross-sectional area (fCSA; vastus lateralis; n = 109; age = ... Full text Open Access Cite

Effects of Resistance Training on the Redox Status of Skeletal Muscle in Older Adults

Journal Article Antioxidants · February 26, 2021 The aim of this study was to investigate the effects of resistance training (RT) on the redox status of skeletal muscle in older adults. Thirteen males aged 64 ± 9 years performed full-body RT 2x/week for 6 weeks. Muscle biopsies were obtained from ... Full text Open Access Cite

LAT1 Protein Content Increases Following 12 Weeks of Resistance Exercise Training in Human Skeletal Muscle

Journal Article Frontiers in Nutrition · January 14, 2021 Introduction: Amino acid transporters are essential for cellular amino acid transport and promoting protein synthesis. While previous literature has demonstrated the association of amino acid transporters and protein synthesi ... Full text Open Access Cite

An optimized procedure for isolation of rodent and human skeletal muscle sarcoplasmic and myofibrillar proteins

Journal Article Journal of Biological Methods · February 24, 2020 Several published protocols exist for isolating contractile or myofibrillar (MF) proteins from skeletal muscle, however, achieving complete resuspension of the myofibril pellet can be technically challenging. We performed several previously publish ... Full text Open Access Cite

Synergist ablation-induced hypertrophy occurs more rapidly in the plantaris than soleus muscle in rats due to different molecular mechanisms

Journal Article American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · February 1, 2020 We examined molecular mechanisms that were altered during rapid soleus (type I fiber-dominant) and plantaris (type II fiber-dominant) hypertrophy in rats. Twelve Wistar rats (3.5 mo old; 6 female, 6 male) were subjected to surgical right-leg soleu ... Full text Open Access Cite

Skeletal Muscle Myofibrillar Protein Abundance Is Higher in Resistance-Trained Men, and Aging in the Absence of Training May Have an Opposite Effect

Journal Article Sports · January 10, 2020 Resistance training generally increases skeletal muscle hypertrophy, whereas aging is associated with a loss in muscle mass. Interestingly, select studies suggest that aging, as well as resistance training, may lead to a reduction in the abundance ... Full text Open Access Cite

Skeletal muscle LINE-1 ORF1 mRNA is higher in older humans but decreases with endurance exercise and is negatively associated with higher physical activity

Journal Article Journal of Applied Physiology · October 1, 2019 The long interspersed nuclear element-1 (L1) is a retrotransposon that constitutes 17% of the human genome and is associated with various diseases and aging. Estimates suggest that ~100 L1 copies are capable of copying and pasting into other regio ... Full text Open Access Cite

Skeletal muscle LINE-1 retrotransposon activity is upregulated in older versus younger rats

Journal Article American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · September 1, 2019 Long interspersed element-1 (LINE-1) is a retrotransposon capable of replicating and inserting LINE-1 copies into the genome. Others have reported skeletal muscle LINE-1 markers are higher in older versus younger mice, but data are lacking in othe ... Full text Open Access Cite

Skeletal muscle mitochondrial volume and myozenin-1 protein differences exist between high versus low anabolic responders to resistance training

Journal Article PeerJ · July 27, 2018 BackgroundWe sought to examine how 12 weeks of resistance exercise training (RET) affected skeletal muscle myofibrillar and sarcoplasmic protein levels along with markers of mitochondrial physiology in high versus ... Full text Open Access Cite

Soy protein supplementation is not androgenic or estrogenic in college-aged men when combined with resistance exercise training

Journal Article Scientific Reports · July 24, 2018 AbstractIt is currently unclear as to whether sex hormones are significantly affected by soy or whey protein consumption. Additionally, estrogenic signaling may be potentiated via soy protein supplementation due to the pres ... Full text Open Access Cite

Effects of Whey, Soy or Leucine Supplementation with 12 Weeks of Resistance Training on Strength, Body Composition, and Skeletal Muscle and Adipose Tissue Histological Attributes in College-Aged Males

Journal Article Nutrients · September 4, 2017 We sought to determine the effects of L-leucine (LEU) or different protein supplements standardized to LEU (~3.0 g/serving) on changes in body composition, strength, and histological attributes in skeletal muscle and adipose tissue. Seventy-five un ... Full text Open Access Cite