Daniel William Bradford
Associate Professor of Psychiatry and Behavioral Sciences
Dr. Bradford's clinical and administrative work, research, and teaching is all in the area of mental health services for individuals with serious mental illnesses, particularly psychotic disorders. Since 2012, he has served as the National Director of Intensive Case Management Services for the Department of Veterans Affairs. In this role, he is responsible for policy development and oversight of over 170 assertive community treatment-based clinical teams serving approximately 14,000 Veterans annually. In his clinical role at Durham VA Medical Center, he is the Division Chief for Psychosocial Rehabilitation and Recovery Services, which provides a broad array of evidence-based treatment for individuals with serious mental illnesses.
Dr. Bradford is board certified in Psychiatry by the American Board of Psychiatry and Neurology and in Addiction Medicine by the American Board of Preventive Medicine. He is a 2013 recipient of an Exemplary Psychiatrist Award from the National Alliance on Mental Illness (NAMI).
Dr. Bradford is board certified in Psychiatry by the American Board of Psychiatry and Neurology and in Addiction Medicine by the American Board of Preventive Medicine. He is a 2013 recipient of an Exemplary Psychiatrist Award from the National Alliance on Mental Illness (NAMI).
Current Appointments & Affiliations
- Associate Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Social and Community Psychiatry, Psychiatry & Behavioral Sciences 2015
Contact Information
- Durham VAMC, 508 Fulton Street, Mhsl 116D, Durham, NC 27705
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daniel.bradford@duke.edu
(919) 286-0411
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Psychiatry Profile
- Background
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Education, Training, & Certifications
- Robert Wood Johnson Clinical Scholars Program, University of North Carolina - Chapel Hill 2003 - 2005
- M.P.H., University of North Carolina - Chapel Hill 2004
- Research Fellow in Psychiatry, Psychiatry, University of North Carolina, Chapel Hill, School of Medicine 2002 - 2003
- General Psychiatry Residency, Psychiatry, University of North Carolina - Chapel Hill 1999 - 2002
- M.D., University of North Carolina - Chapel Hill 1998
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Duke Appointment History
- Assistant Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Social and Community Psychiatry, Psychiatry & Behavioral Sciences 2013 - 2015
- Assistant Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Social and Community Psychiatry, Psychiatry & Behavioral Sciences 2005 - 2013
- Instructor, Temporary in the Department of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2005
- Recognition
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Awards & Honors
- Expertise
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Subject Headings
- Adult
- Affective Disorders, Psychotic
- Aged
- Animals
- Antidepressive Agents
- Antipsychotic Agents
- Behavior Therapy
- Bipolar Disorder
- Brain
- Budgets
- Cerebral Cortex
- Chronic Disease
- Clozapine
- Coercion
- Comorbidity
- Cooperative Behavior
- Corticosterone
- Delivery of Health Care, Integrated
- Desoxycorticosterone
- Dizocilpine Maleate
- Double-Blind Method
- Drug Evaluation, Preclinical
- Drug Resistance
- Drug Synergism
- Evidence-Based Medicine
- Female
- Fluoxetine
- Follow-Up Studies
- Gas Chromatography-Mass Spectrometry
- Health Care Surveys
- Health Services
- Health Services Accessibility
- Health Services Research
- Health Status
- Hippocampus
- Homeless Persons
- Hospitals, Psychiatric
- Hospitals, Veterans
- Humans
- Interviews as Topic
- Learning
- Male
- Memory Disorders
- Mental Disorders
- Mental Health
- Mental Health Services
- Mentally Ill Persons
- Middle Aged
- Models, Psychological
- Neuropsychological Tests
- Neurotransmitter Agents
- Nootropic Agents
- North Carolina
- Patient Care Management
- Patient Education as Topic
- Patient Satisfaction
- Personal Satisfaction
- Personality Assessment
- Pilot Projects
- Piperazines
- Placebos
- Pregnanolone
- Pregnenolone
- Preventive Health Services
- Professional-Patient Relations
- Psychiatric Status Rating Scales
- Psychotherapy
- Psychotic Disorders
- Quality of Life
- Quinolones
- Radioimmunoassay
- Randomized Controlled Trials as Topic
- Rats
- Rats, Sprague-Dawley
- Rehabilitation, Vocational
- Risk Factors
- Schizophrenia
- Serotonin Uptake Inhibitors
- Severity of Illness Index
- Stimulation, Chemical
- Stress Disorders, Post-Traumatic
- Treatment Outcome
- Trust
- United States
- Up-Regulation
- Veterans
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Elbogen, E. B., Molloy, K., Wagner, H. R., Kimbrel, N. A., Beckham, J. C., Van Male, L., … Bradford, D. W. (2020). Psychosocial protective factors and suicidal ideation: Results from a national longitudinal study of veterans. J Affect Disord, 260, 703–709. https://doi.org/10.1016/j.jad.2019.09.062Full Text Link to Item
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Hunt, M. G., Cuddeback, G. S., Bromley, E., Bradford, D. W., & Hoff, R. A. (2019). Changing Rates of Mental Health Disorders Among Veterans Treated in the VHA During Troop Drawdown, 2007-2013. Community Ment Health J, 55(7), 1120–1124. https://doi.org/10.1007/s10597-019-00437-1Full Text Link to Item
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Van Voorhees, E. E., Wagner, H. R., Beckham, J. C., Bradford, D. W., Neal, L. C., Penk, W. E., & Elbogen, E. B. (2018). Effects of social support and resilient coping on violent behavior in military veterans. Psychol Serv, 15(2), 181–190. https://doi.org/10.1037/ser0000187Full Text Link to Item
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Bradford, D. W., Cuddeback, G., & Elbogen, E. B. (2017). Promoting mental health recovery and improving clinical assessment using video technology. Psychiatr Rehabil J, 40(4), 412–414. https://doi.org/10.1037/prj0000267Full Text Link to Item
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Bromley, E., Mikesell, L., Whelan, F., Hellemann, G., Hunt, M., Cuddeback, G., … Young, A. S. (2017). Clinical Factors Associated with Successful Discharge from Assertive Community Treatment. Community Ment Health J, 53(8), 916–921. https://doi.org/10.1007/s10597-017-0083-1Full Text Link to Item
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Bradford, D. W., Goulet, J., Hunt, M., Cunningham, N. C., & Hoff, R. (2016). A Cohort Study of Mortality in Individuals With and Without Schizophrenia After Diagnosis of Lung Cancer. J Clin Psychiatry, 77(12), e1626–e1630. https://doi.org/10.4088/JCP.15m10281Full Text Link to Item
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Bradford, D. W., & Cunningham, N. (2016). Psychotic disorders cause the greatest mortality disparity among mental disorders, though more deaths are attributable overall to mood and anxiety disorders. Evid Based Ment Health, 19(2), 58. https://doi.org/10.1136/eb-2015-102100Full Text Link to Item
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Naylor, J. C., Kilts, J. D., Bradford, D. W., Strauss, J. L., Capehart, B. P., Szabo, S. T., … Marx, C. E. (2015). A pilot randomized placebo-controlled trial of adjunctive aripiprazole for chronic PTSD in US military Veterans resistant to antidepressant treatment. Int Clin Psychopharmacol, 30(3), 167–174. https://doi.org/10.1097/YIC.0000000000000061Full Text Link to Item
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Youssef, N. A., Bradford, D. W., Kilts, J. D., Szabo, S. T., Naylor, J. C., Allen, T. B., … Marx, C. E. (2015). Exploratory investigation of biomarker candidates for suicide in schizophrenia and bipolar disorder. Crisis, 36(1), 46–54. https://doi.org/10.1027/0227-5910/a000280Full Text Link to Item
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Cunningham, N. T., Dennis, N., Dattilo, W., Hunt, M., & Bradford, D. W. (2014). Continuation of clozapine during chemotherapy: a case report and review of literature. Psychosomatics, 55(6), 673–679. https://doi.org/10.1016/j.psym.2014.05.007Full Text Link to Item
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Gierisch, J. M., Nieuwsma, J. A., Bradford, D. W., Wilder, C. M., Mann-Wrobel, M. C., McBroom, A. J., … Williams, J. W. (2014). Pharmacologic and behavioral interventions to improve cardiovascular risk factors in adults with serious mental illness: a systematic review and meta-analysis. J Clin Psychiatry, 75(5), e424–e440. https://doi.org/10.4088/JCP.13r08558Full Text Link to Item
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Szabo, S. T., Kilts, J. D., Naylor, J. C., Youssef, N. A., Strauss, J. L., Morey, R. A., … Marx, C. E. (2014). Amino acids as biomarker candidates for suicidality in male OEF/OIF Veterans: relevance to NMDA receptor modulation and nitric oxide signaling. Mil Med, 179(5), 486–491. https://doi.org/10.7205/MILMED-D-13-00337Full Text Link to Item
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Bradford, D. W., Cunningham, N. T., Slubicki, M. N., McDuffie, J. R., Kilbourne, A. M., Nagi, A., & Williams, J. W. (2013). An evidence synthesis of care models to improve general medical outcomes for individuals with serious mental illness: a systematic review. J Clin Psychiatry, 74(8), e754–e764. https://doi.org/10.4088/JCP.12r07666Full Text Link to Item
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Strauss, J. L., Zervakis, J. B., Stechuchak, K. M., Olsen, M. K., Swanson, J., Swartz, M. S., … Oddone, E. Z. (2013). Adverse impact of coercive treatments on psychiatric inpatients' satisfaction with care. Community Ment Health J, 49(4), 457–465. https://doi.org/10.1007/s10597-012-9539-5Full Text Link to Item
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Naylor, J. C., Dolber, T. R., Strauss, J. L., Kilts, J. D., Strauman, T. J., Bradford, D. W., … Marx, C. E. (2013). A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans. Psychiatry Res, 206(2–3), 318–320. https://doi.org/10.1016/j.psychres.2012.11.008Full Text Open Access Copy Link to Item
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Elbogen, E. B., Bradford, D. W., & Swartz, M. S. (2013). A recovery-oriented money management intervention. Psychiatr Serv, 64(1), 99. https://doi.org/10.1176/appi.ps.640103Full Text Link to Item
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Youssef, N. A., Marx, C. E., Bradford, D. W., Zinn, S., Hertzberg, M. A., Kilts, J. D., … Strauss, J. L. (2012). An open-label pilot study of aripiprazole for male and female veterans with chronic post-traumatic stress disorder who respond suboptimally to antidepressants. Int Clin Psychopharmacol, 27(4), 191–196. https://doi.org/10.1097/YIC.0b013e328352ef4eFull Text Link to Item
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Resnik, L., Bradford, D. W., Glynn, S. M., Jette, A. M., Johnson Hernandez, C., & Wills, S. (2012). Issues in defining and measuring veteran community reintegration: proceedings of the Working Group on Community Reintegration, VA Rehabilitation Outcomes Conference, Miami, Florida. J Rehabil Res Dev, 49(1), 87–100. https://doi.org/10.1682/jrrd.2010.06.0107Full Text Link to Item
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Tiegreen, J. A., Braxton, L. E., Elbogen, E. B., & Bradford, D. (2012). Building a bridge of trust: collaborative assessment with a person with serious mental illness. J Pers Assess, 94(5), 513–521. https://doi.org/10.1080/00223891.2012.666596Full Text Link to Item
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Marx, C. E., Bradford, D. W., Hamer, R. M., Naylor, J. C., Allen, T. B., Lieberman, J. A., … Kilts, J. D. (2011). Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence. Neuroscience, 191, 78–90. https://doi.org/10.1016/j.neuroscience.2011.06.076Full Text Link to Item
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Elbogen, E. B., Tiegreen, J., Vaughan, C., & Bradford, D. W. (2011). Money management, mental health, and psychiatric disability: a recovery-oriented model for improving financial skills. Psychiatr Rehabil J, 34(3), 223–231. https://doi.org/10.2975/34.3.2011.223.231Full Text Link to Item
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Kim, M. M., Ford, J. D., Howard, D. L., & Bradford, D. W. (2010). Assessing trauma, substance abuse, and mental health in a sample of homeless men. Health Soc Work, 35(1), 39–48. https://doi.org/10.1093/hsw/35.1.39Full Text Link to Item
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Reuland, D. S., Cherrington, A., Watkins, G. S., Bradford, D. W., Blanco, R. A., & Gaynes, B. N. (2009). Diagnostic accuracy of Spanish language depression-screening instruments. Ann Fam Med, 7(5), 455–462. https://doi.org/10.1370/afm.981Full Text Link to Item
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Marx, C. E., Keefe, R. S. E., Buchanan, R. W., Hamer, R. M., Kilts, J. D., Bradford, D. W., … Shampine, L. J. (2009). Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology, 34(8), 1885–1903. https://doi.org/10.1038/npp.2009.26Full Text Link to Item
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Bradford, D. W., Kim, M. M., Braxton, L. E., Marx, C. E., Butterfield, M., & Elbogen, E. B. (2008). Access to medical care among persons with psychotic and major affective disorders. Psychiatr Serv, 59(8), 847–852. https://doi.org/10.1176/ps.2008.59.8.847Full Text Link to Item
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Kim, M. M., Swanson, J. W., Swartz, M. S., Bradford, D. W., Mustillo, S. A., & Elbogen, E. B. (2007). Healthcare barriers among severely mentally ill homeless adults: evidence from the five-site health and risk study. Adm Policy Ment Health, 34(4), 363–375. https://doi.org/10.1007/s10488-007-0115-1Full Text Link to Item
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Marx, C. E., Shampine, L. J., Duncan, G. E., VanDoren, M. J., Grobin, A. C., Massing, M. W., … Morrow, A. L. (2006). Clozapine markedly elevates pregnenolone in rat hippocampus, cerebral cortex, and serum: candidate mechanism for superior efficacy? Pharmacol Biochem Behav, 84(4), 598–608. https://doi.org/10.1016/j.pbb.2006.07.026Full Text Link to Item
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Marx, C. E., Shampine, L. J., Khisti, R. T., Trost, W. T., Bradford, D. W., Grobin, A. C., … Morrow, A. L. (2006). Olanzapine and fluoxetine administration and coadministration increase rat hippocampal pregnenolone, allopregnanolone and peripheral deoxycorticosterone: implications for therapeutic actions. Pharmacol Biochem Behav, 84(4), 609–617. https://doi.org/10.1016/j.pbb.2006.07.032Full Text Link to Item
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Bradford, D. W., Gaynes, B. N., Kim, M. M., Kaufman, J. S., & Weinberger, M. (2005). Can shelter-based interventions improve treatment engagement in homeless individuals with psychiatric and/or substance misuse disorders?: a randomized controlled trial. Med Care, 43(8), 763–768. https://doi.org/10.1097/01.mlr.0000170402.35730.eaFull Text Link to Item
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Chakos, M. H., Schobel, S. A., Gu, H., Gerig, G., Bradford, D., Charles, C., & Lieberman, J. A. (2005). Duration of illness and treatment effects on hippocampal volume in male patients with schizophrenia. Br J Psychiatry, 186, 26–31. https://doi.org/10.1192/bjp.186.1.26Full Text Link to Item
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De Socio, G. V. L. (2004). Schizophrenia, drug therapy, and monitoring. N Engl J Med, 350(4), 415–416.Link to Item
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Bradford, D. W., Perkins, D. O., & Lieberman, J. A. (2003). Pharmacological management of first-episode schizophrenia and related nonaffective psychoses. Drugs, 63(21), 2265–2283. https://doi.org/10.2165/00003495-200363210-00001Full Text
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Chakos, M., Lieberman, J., Hoffman, E., Bradford, D., & Sheitman, B. (2001). Effectiveness of second-generation antipsychotics in patients with treatment-resistant schizophrenia: a review and meta-analysis of randomized trials. The American Journal of Psychiatry, 158(4), 518–526. https://doi.org/10.1176/appi.ajp.158.4.518Full Text
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Bradford, D. W., Chakos, M. H., Sheitman, B. B., & Lieberman, J. A. (1998). Atypical antipsychotic drugs in treatment-refractory schizophrenia. Psychiatric Annals, 28(11), 618–626. https://doi.org/10.3928/0048-5713-19981101-06Full Text
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Book Sections
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Farkas, M., Forbess, R., & Bradford, D. W. (2013). Recovery Facilitating Service Planning: An Interdisciplinary Responsibility. In K. Yeager, D. Cutler, D. Svendsen, & G. Sills (Eds.), Modern Community Mental Health An Interdisciplinary Approach. Oxford University Press.
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Conference Papers
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Marx, C. E., Keefe, R. S., Leimone, L. A., Hamer, R. M., Bradford, D. W., Dunn, L., … Shampine, L. J. (2007). Proof-of-concept trial with the neurosterold pregnenolone targeting neurocognitive and negative symptoms in schizophrenia. In Biological Psychiatry (Vol. 61, pp. 13S-13S). San Diego, CA: ELSEVIER SCIENCE INC.Link to Item
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Bradford, D. W., Shampine, L. J., Harris, V. P., Naylor, J. C., Massing, M. W., Lieberman, J. A., … Marx, C. E. (2007). Pregnenolone reductions in parietal cortex are associated with suicide in patients with schizophrenia. In Schizophrenia Bulletin (Vol. 33, pp. 308–308). Savannah, GA: OXFORD UNIV PRESS.Link to Item
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Marx, C. E., Shampine, L. J., Duncan, G. E., VanDoren, M. J., Grobin, A. C., Massing, M. W., … Morrow, A. L. (2007). Clozapine increases the neurosteroid pregnenolone in rat hippocampus, cerebral cortex, and serum: Relevance to superior efficacy? In Schizophrenia Bulletin (Vol. 33, pp. 319–319). Savannah, GA: OXFORD UNIV PRESS.Link to Item
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Bradford, D. W., Shampine, L. J., Harris, V. P., Naylor, J. C., Massing, M. W., Lieberman, J. A., … Marx, C. E. (2006). Pregnenolone alterations in parietat cortex are associated with death by suicide in patients with schizophrenia. In Neuropsychopharmacology (Vol. 31, pp. S118–S119). Hollywood, FL: NATURE PUBLISHING GROUP.Link to Item
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Marx, C. E., Shampine, L. J., Duncan, G. E., VanDoren, M. J., Grobin, A. C., Massing, M. W., … Morrow, A. L. (2006). Clozapine markedly elevates pregnenolone in rat hippocampus, cerebral cortex, and serum: Candidate mechanism for superior efficacy? In Neuropsychopharmacology (Vol. 31, pp. S117–S117). Hollywood, FL: NATURE PUBLISHING GROUP.Link to Item
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