Scholars@Duke
Daniel William Bradford

Daniel William Bradford

Professor of Psychiatry and Behavioral Sciences
Psychiatry, Child & Family Mental Health & Community Psychiatry
daniel.bradford@duke.edu
Durham VAMC, 508 Fulton Street, MHSL 116D, Durham, NC 27705

Selected Publications

Implementation of Cognitive Behavioral Therapy for psychosis via telehealth: An expert consultation and clinical service model.

Journal Article Psychol Serv · August 2024 Individuals living with psychosis are often underserved in the United States, partly due to the dearth of providers trained in evidence-based practices for this population. One such practice is Cognitive Behavioral Therapy for psychosis, which the Substanc ... Full text Link to item Cite

Mortality and suicidality in veterans health administration patients with newly-identified early episode psychosis.

Journal Article Schizophr Res · February 2024 Within the Veterans Affairs (VA), management of self-harm is a major clinical priority. However, there is limited information on risks for self-harm among VA patients with emerging psychotic disorders relative to VA patients with other emerging mental heal ... Full text Link to item Cite

Lived Experience-Led Research Agenda to Address Early Death in People With a Diagnosis of a Serious Mental Illness: A Consensus Statement.

Journal Article JAMA Netw Open · May 1, 2023 IMPORTANCE: People with serious mental illness (SMI), defined as a diagnosis of schizophrenia spectrum disorder, bipolar disorder, or disabling major depressive disorder) die approximately 10 to 25 years earlier than the general population. OBJECTIVE: To d ... Full text Link to item Cite

Predictors of High-Intensity Psychiatric Service Utilization by Veterans Health Administration Patients With Early Psychosis.

Journal Article Psychiatr Serv · March 1, 2022 OBJECTIVE: People with early episode psychosis (EEP) have more negative care outcomes than do people with later episode psychosis (LEP), including higher levels of high-intensity psychiatric service use. It is unclear whether these differences are best exp ... Full text Link to item Cite

Psychosocial protective factors and suicidal ideation: Results from a national longitudinal study of veterans.

Journal Article J Affect Disord · January 1, 2020 BACKGROUND: This study investigates the empirical association between psychosocial protective factors and subsequent suicidal ideation in veterans. METHODS: We conducted a national longitudinal survey in which participants were randomly drawn from over one ... Full text Link to item Cite

Changing Rates of Mental Health Disorders Among Veterans Treated in the VHA During Troop Drawdown, 2007-2013.

Journal Article Community Ment Health J · October 2019 Nationally representative data on mental health disorder prevalence are critical to set informed mental health priorities and policies. Data indicating mental health diagnoses within our nation's veteran population treated at the Veterans Health Administra ... Full text Link to item Cite

Effects of social support and resilient coping on violent behavior in military veterans.

Journal Article Psychol Serv · May 2018 Violence toward others has been identified as a serious postdeployment adjustment problem in a subset of Iraq- and Afghanistan-era veterans. In the current study, we examined the intricate links between posttraumatic stress disorder (PTSD), commonly cited ... Full text Link to item Cite

Promoting mental health recovery and improving clinical assessment using video technology.

Journal Article Psychiatr Rehabil J · December 2017 TOPIC: Although individuals with medical problems (e.g., diabetes, hypertension) can monitor their symptoms using objective measures (e.g., blood glucose, blood pressure), objective measures are not typically used by individuals with psychotic disorders to ... Full text Link to item Cite

Clinical Factors Associated with Successful Discharge from Assertive Community Treatment.

Journal Article Community Ment Health J · November 2017 We sought to explore clinical factors associated with successful transition from Assertive Community Treatment to less intensive clinical services. Mixed-method observational follow up study of veterans discharged from three VA-affiliated ACT teams to less ... Full text Link to item Cite

A Cohort Study of Mortality in Individuals With and Without Schizophrenia After Diagnosis of Lung Cancer.

Journal Article J Clin Psychiatry · December 2016 OBJECTIVE: Individuals with serious mental illness have increased mortality relative to those without these illnesses. Although cancer is a leading cause of death, few studies have evaluated potential disparities relative to mortality for individuals with ... Full text Link to item Cite

A pilot randomized placebo-controlled trial of adjunctive aripiprazole for chronic PTSD in US military Veterans resistant to antidepressant treatment.

Journal Article Int Clin Psychopharmacol · May 2015 Many individuals with post-traumatic stress disorder (PTSD) experience persistent symptoms despite pharmacological treatment with antidepressants. Several open-label monotherapy and adjunctive studies have suggested that aripiprazole (a second-generation a ... Full text Link to item Cite

Exploratory investigation of biomarker candidates for suicide in schizophrenia and bipolar disorder.

Journal Article Crisis · 2015 BACKGROUND: Clozapine and lithium increase neurosteroids in rodents, and both drugs demonstrate antisuicidal actions. We therefore hypothesized that neurosteroid levels may be reduced in patients with schizophrenia or bipolar disorder who completed suicide ... Full text Link to item Cite

Amino acids as biomarker candidates for suicidality in male OEF/OIF Veterans: relevance to NMDA receptor modulation and nitric oxide signaling.

Journal Article Mil Med · May 2014 Veteran populations are exposed to multiple stressful events, and suicidality among veterans is a serious problem. Identifying biomarkers of suicidality may enhance detection, prevention, and treatment. Multiple neurotransmitter systems are implicated in t ... Full text Link to item Cite

Pharmacologic and behavioral interventions to improve cardiovascular risk factors in adults with serious mental illness: a systematic review and meta-analysis.

Journal Article J Clin Psychiatry · May 2014 OBJECTIVE: Individuals with serious mental illness have high rates of cardiovascular disease (CVD) risk factors and mortality. This systematic review was conducted to evaluate pharmacologic and behavioral interventions to reduce CVD risk in adults with ser ... Full text Link to item Cite

Adverse impact of coercive treatments on psychiatric inpatients' satisfaction with care.

Journal Article Community Ment Health J · August 2013 Consumers' satisfaction with inpatient mental health care is recognized as a key quality indicator that prospectively predicts functional and clinical outcomes. Coercive treatment experience is a frequently cited source of dissatisfaction with inpatient ca ... Full text Link to item Cite

An evidence synthesis of care models to improve general medical outcomes for individuals with serious mental illness: a systematic review.

Journal Article J Clin Psychiatry · August 2013 OBJECTIVE: To conduct a systematic review of studies of interventions that integrated medical and mental health care to improve general medical outcomes in individuals with serious mental illness. DATA SOURCES: English-language publications in MEDLINE (via ... Full text Link to item Cite

A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans.

Journal Article Psychiatry Res · April 30, 2013 Subthreshold posttraumatic stress disorder (PTSD) is associated with increased risk for suicidality, depression, and functional impairment. We thus conducted a small (N=12) pilot randomized controlled trial (RCT) with paroxetine for subthreshold PTSD in Op ... Full text Open Access Link to item Cite

Recovery Facilitating Service Planning: An Interdisciplinary Responsibility

Chapter · March 21, 2013 This is the first truly interdisciplinary book that examines how professionals work together within community mental health. ... Cite

A recovery-oriented money management intervention.

Journal Article Psychiatr Serv · January 2013 Full text Link to item Cite

An open-label pilot study of aripiprazole for male and female veterans with chronic post-traumatic stress disorder who respond suboptimally to antidepressants.

Journal Article Int Clin Psychopharmacol · July 2012 Emerging data suggest that second-generation antipsychotics such as aripiprazole may be effective in the treatment of post-traumatic stress disorder (PTSD). However, few clinical trials have used aripiprazole in PTSD, and data are limited on its use in Vet ... Full text Link to item Cite

Building a bridge of trust: collaborative assessment with a person with serious mental illness.

Journal Article J Pers Assess · 2012 Collaborative assessment utilizes psychological testing to help people make positive changes in their lives. Limited research has evaluated the utility of collaborative assessment for persons with serious mental illness. This case example uses the Personal ... Full text Link to item Cite

Issues in defining and measuring veteran community reintegration: proceedings of the Working Group on Community Reintegration, VA Rehabilitation Outcomes Conference, Miami, Florida.

Journal Article J Rehabil Res Dev · 2012 In January 2010, the Department of Veterans Affairs (VA) Rehabilitation Research and Development Service convened a State of the Art (SOTA) conference to advance the field of outcome measurement for rehabilitation-related studies. This article reports on t ... Full text Link to item Cite

Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence.

Journal Article Neuroscience · September 15, 2011 Emerging preclinical and clinical evidence suggests that pregnenolone may be a promising novel therapeutic candidate in schizophrenia. Pregnenolone is a neurosteroid with pleiotropic actions in rodents that include the enhancement of learning and memory, n ... Full text Link to item Cite

Money management, mental health, and psychiatric disability: a recovery-oriented model for improving financial skills.

Journal Article Psychiatr Rehabil J · 2011 TOPIC: Although money management skills are essential for independent functioning in the community, when viewed from the framework of psychosocial rehabilitation, there have been few systematic models for teaching money management skills to consumers with ... Full text Link to item Cite

Assessing trauma, substance abuse, and mental health in a sample of homeless men.

Journal Article Health Soc Work · February 2010 This study examined the impact of physical and sexual trauma on a sample of 239 homeless men. Study participants completed a self-administered survey that collected data on demographics, exposure to psychological trauma, physical health and mental health p ... Full text Link to item Cite

Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia.

Journal Article Neuropsychopharmacology · July 2009 The neurosteroid pregnenolone and its sulfated derivative enhance learning and memory in rodents. Pregnenolone sulfate also positively modulates NMDA receptors and could thus ameliorate hypothesized NMDA receptor hypofunction in schizophrenia. Furthermore, ... Full text Link to item Cite

Diagnostic accuracy of Spanish language depression-screening instruments.

Journal Article Ann Fam Med · 2009 PURPOSE: To make decisions about implementing systematic depression screening, primary care physicians who serve Spanish-speaking populations need to know whether Spanish language depression-screening instruments are accurate. We aimed to review systematic ... Full text Link to item Cite

Access to medical care among persons with psychotic and major affective disorders.

Journal Article Psychiatr Serv · August 2008 OBJECTIVE: People with serious mental illness have higher mortality rates than the general population, and this difference is not explained by such causes as suicide or accidents. This study therefore examined access and barriers to medical care among pers ... Full text Link to item Cite

Healthcare barriers among severely mentally ill homeless adults: evidence from the five-site health and risk study.

Journal Article Adm Policy Ment Health · July 2007 UNLABELLED: Few studies have examined barriers to physical and mental healthcare among homeless mentally adults. METHODS: This study examined physical and mental healthcare barriers reported by 154 recently homeless mentally ill persons. RESULTS: Practical ... Full text Link to item Cite

Clozapine markedly elevates pregnenolone in rat hippocampus, cerebral cortex, and serum: candidate mechanism for superior efficacy?

Journal Article Pharmacol Biochem Behav · August 2006 Clozapine demonstrates superior efficacy in patients with schizophrenia, but the precise mechanisms contributing to this clinical advantage are not clear. Clozapine and olanzapine increase the GABAergic neuroactive steroid (NS) allopregnanolone, and it has ... Full text Link to item Cite

Olanzapine and fluoxetine administration and coadministration increase rat hippocampal pregnenolone, allopregnanolone and peripheral deoxycorticosterone: implications for therapeutic actions.

Journal Article Pharmacol Biochem Behav · August 2006 Olanzapine and fluoxetine elevate the GABAergic neuroactive steroid allopregnanolone to physiologically relevant concentrations in rodent cerebral cortex. It is unknown if these agents also alter pregnenolone or deoxycorticosterone. Since olanzapine and fl ... Full text Link to item Cite

Can shelter-based interventions improve treatment engagement in homeless individuals with psychiatric and/or substance misuse disorders?: a randomized controlled trial.

Journal Article Med Care · August 2005 BACKGROUND: High proportions of homeless individuals have mental illness and substance use disorders. Few of these individuals engage in consistent treatment, although they are likely to benefit from it. Shelter-based interventions to help this population ... Full text Link to item Cite

Duration of illness and treatment effects on hippocampal volume in male patients with schizophrenia.

Journal Article Br J Psychiatry · January 2005 BACKGROUND: Reduced hippocampal volume is a consistently described structural abnormality in schizophrenia but its cause and timing are not known. AIMS: To examine the relationship of duration of schizophrenic illness and treatment effects with hippocampal ... Full text Link to item Cite

Schizophrenia, drug therapy, and monitoring.

Journal Article N Engl J Med · January 22, 2004 Link to item Cite

Pharmacological management of first-episode schizophrenia and related nonaffective psychoses.

Journal Article Drugs · 2003 Schizophrenia is a severe mental illness characterised by abnormalities of thought and perception that affects 1-2% of the population. Patients who experience a first episode of schizophrenia should be treated early and optimally with antipsychotic agents ... Full text Link to item Cite

Effectiveness of second-generation antipsychotics in patients with treatment-resistant schizophrenia: a review and meta-analysis of randomized trials.

Journal Article Am J Psychiatry · April 2001 OBJECTIVE: The authors conducted a review and meta-analysis of studies that compared the efficacy and tolerability of typical and second-generation antipsychotics for patients with treatment-resistant schizophrenia. METHOD: A systematic search revealed 12 ... Full text Link to item Cite

Atypical antipsychotic drugs in treatment-refractory schizophrenia

Journal Article Psychiatric Annals · January 1, 1998 Full text Cite