Scholars@Duke
Daniel Philip Nussbaum

Daniel Philip Nussbaum

Assistant Professor of Surgery
Surgical Oncology
daniel.nussbaum@duke.edu
DUMC 2612, Durham, NC 27710
DUMC 2612, Durham, NC 27710

Selected Publications

Interobserver Variability in the International Study Group for Pancreatic Surgery (ISGPS)-Defined Complications After Pancreatoduodenectomy: An International Cross-Sectional Multicenter Study.

Journal Article Ann Surg · November 1, 2024 OBJECTIVE: To determine the interobserver variability for complications of pancreatoduodenectomy as defined by the International Study Group for Pancreatic Surgery (ISGPS) and others. BACKGROUND: Good interobserver variability for the definitions of surgic ... Full text Link to item Cite

Evolution of Initial Treatment for Desmoid Tumors.

Journal Article Ann Surg Oncol · November 2024 INTRODUCTION: Desmoid tumors (DTs) are rare, fibroblastic cell proliferations that can exhibit locally aggressive behavior but lack metastatic potential. Initial management has traditionally involved upfront resection; however, contemporary guidelines and ... Full text Link to item Cite

Mediator kinase inhibition impedes transcriptional plasticity and prevents resistance to ERK/MAPK-targeted therapy in KRAS-mutant cancers.

Journal Article NPJ Precis Oncol · May 31, 2024 Acquired resistance remains a major challenge for therapies targeting oncogene activated pathways. KRAS is the most frequently mutated oncogene in human cancers, yet strategies targeting its downstream signaling kinases have failed to produce durable treat ... Full text Link to item Cite

Are enhanced recovery protocols after pancreatoduodenectomy still efficient when applied in elderly patients? A systematic review and individual patient data meta-analysis.

Journal Article J Hepatobiliary Pancreat Sci · May 2024 BACKGROUND: This meta-analysis investigated the effects of enhanced recovery after surgery (ERAS) protocols compared to conventional care on postoperative outcomes in patients aged 70 years or older undergoing pancreatoduodenectomy (PD). METHODS: Five data ... Full text Link to item Cite

Contemporary trends and outcomes after liver transplantation and resection for intrahepatic cholangiocarcinoma.

Journal Article J Gastrointest Surg · May 2024 BACKGROUND: Liver transplantation (LT) has been shown to be superior to resection in highly selected patients with perihilar cholangiocarcinoma (CCA), yet has traditionally been contraindicated for intrahepatic CCA (iCCA). Herein, we aimed to examine conte ... Full text Link to item Cite

Simple versus radical cholecystectomy and survival for pathologic stage T1B gallbladder cancer.

Journal Article HPB (Oxford) · April 2024 BACKGROUND: Radical cholecystectomy is recommended for T1B and greater gallbladder cancer, however, there are conflicting reports on the utility of extended resection for T1B disease. Herein, we characterize outcomes following simple and radical cholecyste ... Full text Link to item Cite

Initial Report: Personalized Circulating Tumor DNA and Survival in Patients with Resectable Pancreatic Cancer.

Journal Article Ann Surg Oncol · March 2024 ABSTRACT: BACKGROUND: Pancreatic adenocarcinoma (PDAC) is highly lethal with up to 80% of resected patients experiencing disease recurrence within 2 years (Watanabe, Nakamura, Kimura et al in Int J Mol Sci 23(19):11521, 2022). Cross-sectional imaging and ... Full text Link to item Cite

Abstract B022: A platform to characterize hepatic immunity reveals variation in hepatic infiltration of tumor expanded T cells in “localized” PDAC

Conference Cancer Research · January 16, 2024 AbstractEven in its earliest stages, pancreatic ductal adenocarcinoma (PDAC) is an essentially incurable disease due to the presence of disseminated, yet radiographically occult cancer cells in the setting o ... Full text Cite

Fragmented Care in Stage II and III Gastric and Esophageal Cancer

Conference ANNALS OF SURGICAL ONCOLOGY · 2024 Cite

Tumor size and survival in intrahepatic cholangiocarcinoma treated with surgical resection or ablation.

Journal Article J Surg Oncol · December 2023 OBJECTIVES: We performed a retrospective analysis within a national cancer registry on outcomes following resection or ablation for intrahepatic cholangiocarcinoma (iCCA). METHODS: The National Cancer Database was queried for patients with clinical stage I ... Full text Link to item Cite

Comparing Survival After Resection, Ablation, and Radiation in Small Intrahepatic Cholangiocarcinoma.

Journal Article Ann Surg Oncol · October 2023 BACKGROUND: Hepatectomy is the cornerstone of curative-intent treatment for intrahepatic cholangiocarcinoma (ICC). However, in patients unable to be resected, data comparing efficacy of alternatives including thermal ablation and radiation therapy (RT) rem ... Full text Open Access Link to item Cite

Impact of Tumor Size and Management on Survival in Small Gastric Gastrointestinal Stromal Tumors.

Journal Article J Gastrointest Surg · October 2023 BACKGROUND: Society guidelines remain inconsistent on the role of endoscopic and radiographic surveillance as an alternative to surgical resection of small gastric gastrointestinal stromal tumors (GISTs). Herein, we aimed to assess survival among patients ... Full text Link to item Cite

The Impact of Age in the Treatment of Non-comorbid Patients with Rectal Cancer: Survival Outcomes from the National Cancer Database.

Journal Article World journal of surgery · August 2023 BackgroundMultimodal therapy has improved survival outcomes for rectal cancer (RC) significantly with an exemption for older patients. We sought to assess whether older non-comorbid patients receive substandard oncological treatment for localized ... Full text Cite

Racial disparities in time to laparoscopic cholecystectomy for acute cholecystitis.

Journal Article American journal of surgery · August 2023 BackgroundDisparities in healthcare exist, yet few data are available on racial differences in time from admission to surgery. This study aimed to compare time from admission to laparoscopic cholecystectomy for acute cholecystitis between non-Hisp ... Full text Cite

Trends in Receipt of Adjuvant Chemotherapy and its Impact on Survival in Resected Biliary Tract Cancers.

Journal Article Ann Surg Oncol · August 2023 BACKGROUND: Resection remains the cornerstone of curative-intent treatment for biliary tract cancers (BTCs). However, recent randomized data also support a role for adjuvant chemotherapy (AC). This study aimed to characterize trends in the use of AC and su ... Full text Link to item Cite

Hepatic artery infusion for unresectable colorectal cancer liver metastases: Palliation and conversion.

Journal Article Surgery · August 2023 Patients with unresectable colorectal liver metastases are commonly treated with systemic chemotherapy to convert their disease to an operable state. Unfortunately, many patients remain unresectable after first-line chemotherapy and resort to second- and t ... Full text Link to item Cite

The Impact of Age in the Treatment of Patients with Localized Rectal Cancer - Survival Outcomes from the National Cancer Database

Conference British Journal of Surgery · June 9, 2023 AbstractBackgroundMultimodal therapy for localized rectal cancer (RC), including (neo-)adjuvant systemic therapy and surgery, has impr ... Full text Cite

Digital spatial profiling of intraductal papillary mucinous neoplasms: Toward a molecular framework for risk stratification.

Journal Article Sci Adv · March 15, 2023 The histopathologic heterogeneity of intraductal papillary mucinous neoplasms (IPMN) complicates the prediction of pancreatic ductal adenocarcinoma (PDAC) risk. Intratumoral regions of pancreaticobiliary (PB), intestinal (INT), and gastric foveolar (GF) ep ... Full text Link to item Cite

Multi-institutional Care in Clinical Stage II and III Esophageal Cancer.

Journal Article Ann Thorac Surg · February 2023 BACKGROUND: Management of clinical stage II or III esophageal cancer requires multidisciplinary care. Multi-institutional care has been associated with worse survival in other malignant diseases. This study aimed to determine the impact of multi-institutio ... Full text Link to item Cite

Multidimensional Immunophenotyping of Intraductal Papillary Mucinous Neoplasms Reveals Novel T Cell and Macrophage Signature.

Conference Ann Surg Oncol · November 2022 BACKGROUND: Intraductal papillary mucinous neoplasms (IPMN) are the only radiographically identifiable precursor to pancreatic adenocarcinoma, yet little is known about how these lesions progress to cancer. Inflammation has been associated with dysplastic ... Full text Link to item Cite

Patterns and Impact of Fragmented Care in Stage II and III Gastric Cancer.

Journal Article Ann Surg Oncol · September 2022 BACKGROUND: Optimal management of stage II/III gastric cancer requires multidisciplinary care, often necessitating treatment at more than one facility. We aimed to determine patterns of "fragmented" care and its impact on outcomes, including concordance wi ... Full text Link to item Cite

Impact of enhanced recovery protocols after pancreatoduodenectomy: meta-analysis.

Journal Article Br J Surg · February 24, 2022 BACKGROUND: This individual-patient data meta-analysis investigated the effects of enhanced recovery after surgery (ERAS) protocols compared with conventional care on postoperative outcomes in patients undergoing pancreatoduodenectomy. METHODS: The Cochran ... Full text Link to item Cite

Hospital-level compliance with the commission on cancer's quality of care measures and the association with patient survival.

Journal Article Cancer Med · June 2021 BACKGROUND: Quality measurement has become a priority for national healthcare reform, and valid measures are necessary to discriminate hospital performance and support value-based healthcare delivery. The Commission on Cancer (CoC) is the largest cancer-sp ... Full text Link to item Cite

Surgical management of biliary malignancy.

Journal Article Curr Probl Surg · February 2021 Full text Link to item Cite

Surgical Management of Colorectal Cancer Liver Metastases.

Journal Article Surgical oncology clinics of North America · January 2021 Approximately 50% of colorectal cancer patients develop liver metastases. Hepatic metastases represent the most common cause of colorectal cancer-related mortality. Metastasectomy, if possible, represents the most effective treatment strategy; 20% of patie ... Full text Cite

Textbook Outcomes Among Patients Undergoing Retroperitoneal Sarcoma Resection.

Journal Article Anticancer Res · April 2020 BACKGROUND/AIM: Recently, the concept of textbook outcome (TO) has emerged as a novel effort to develop a benchmark that reflects multiple domains of quality. The aims of the current study were to define TO for retroperitoneal sarcoma (RPS), evaluate the r ... Full text Link to item Cite

Impact of minimally invasive gastrectomy on use of and time to adjuvant chemotherapy for gastric adenocarcinoma.

Conference J Surg Oncol · March 2020 BACKGROUND: Chemotherapy improves outcomes in patients with resectable gastric cancer. Minimally invasive gastrectomy (MIS) rates are increasing, though the impact of MIS on postoperative chemotherapy remains uncertain. This study examines the impact of MI ... Full text Link to item Cite

Role of lymphadenectomy, adjuvant chemotherapy, and treatment at high-volume centers in patients with resected pancreatic cancer-a distinct view on lymph node yield.

Journal Article Langenbecks Arch Surg · February 2020 PURPOSE: While the importance of lymphadenectomy is well-established for patients with resectable pancreatic cancer, its direct impact on survival in relation to other predictive factors is still ill-defined. METHODS: The National Cancer Data Base 2006-201 ... Full text Link to item Cite

No Difference in Survival between Neo-Adjuvant Chemotherapy and Neo-Adjuvant Chemoradiation Therapy in Gastric Cardia Cancer Patients: A Contemporary View from the National Cancer Database.

Journal Article Dig Surg · 2020 INTRODUCTION: Both neo-adjuvant chemoradiation therapy (NACRT) and neo-adjuvant chemotherapy (NAC), in addition to surgical resection of gastric cardia cancer, improves survival outcomes. We assessed whether NACRT or NAC had superior overall survival (OS) ... Full text Link to item Cite

Adjuvant Chemotherapy Improves Survival Following Resection of Locally Advanced Rectal Cancer with Pathologic Complete Response.

Conference J Gastrointest Surg · August 2019 BACKGROUND: Controversy exists over the use of adjuvant chemotherapy for locally advanced (stages II-III) rectal cancer (LARC) patients who demonstrate pathologic complete response (pCR) following neoadjuvant chemoradiation. We conducted a retrospective an ... Full text Link to item Cite

Underutilization of surgical resection in patients with pancreatic acinar cell carcinoma.

Journal Article HPB (Oxford) · June 2019 BACKGROUND: Pancreatic acinar cell carcinoma (pACC) is a rare malignancy and surgical utilization has been historically low in these patients. Contemporary outcomes for this patient population remain unknown. METHODS: The 1998-2012 National Cancer Data Bas ... Full text Link to item Cite

Soft Tissue Sarcoma of the Extremities: What Is the Value of Treating at High-volume Centers?

Journal Article Clin Orthop Relat Res · April 2019 BACKGROUND: For many cancer types, survival is improved when patients receive management at treatment centers that encounter high numbers of patients annually. This correlation may be more important with less common malignancies such as sarcoma. Existing e ... Full text Link to item Cite

Hospital Volume Threshold for the Treatment of Retroperitoneal Sarcoma.

Journal Article Anticancer Res · April 2019 BACKGROUND: Retroperitoneal sarcomas (RPS) are rare, histologically heterogeneous, and anatomically complex tumors. National Comprehensive Cancer Network guidelines recommend evaluation and management by multidisciplinary teams with experience in sarcoma. ... Full text Link to item Cite

Primary sarcomas of the pancreas: A review of 253 patients from the National Cancer Data Base.

Journal Article Surg Oncol · December 2018 INTRODUCTION: Primary sarcomas of the pancreas are rare, and the limited data regarding their presentation, oncologic profile, and survival have been derived from small case series. METHODS: The National Cancer Data Base (1998-2012) was queried for patient ... Full text Link to item Cite

High rate of positive lymph nodes in T1a gallbladder cancer does not translate to decreased survival: a population-based, propensity score adjusted analysis.

Journal Article HPB (Oxford) · November 2018 BACKGROUND: Current consensus guidelines suggest that gallbladder cancer (GBC) patients with resected T1a disease can be observed while patients with T1b or greater lesions should undergo lymphadenectomy (LNE). The primary aim of this study was to critical ... Full text Link to item Cite

Open versus laparoscopic portal lymphadenectomy in gallbladder cancer: is there a difference in lymph node yield?

Journal Article HPB (Oxford) · June 2018 BACKGROUND: Gallbladder cancer (GBC) is the most common biliary tract malignancy. Because it commonly metastasizes via lymphatics, portal lymphadenectomy should be included in oncologic resections. This study aimed to compare the oncologic equivalence of t ... Full text Link to item Cite

Preoperative radiation therapy in the surgical management of gastric and junctional adenocarcinoma: Should lymph node retrieval guidelines be altered?

Journal Article J Surg Oncol · June 2018 BACKGROUND: Although surgery remains the cornerstone of gastric cancer therapy, the use of radiation therapy (RT) is increasingly being employed to optimize outcomes. We sought to assess outcomes following use of RT for the treatment of gastric adenocarcin ... Full text Link to item Cite

Race is an independent predictor of survival in patients with soft tissue sarcoma of the extremities.

Journal Article BMC Cancer · April 27, 2018 BACKGROUND: In the United States, race and socioeconomic status are well known predictors of adverse outcomes in several different cancers. Existing evidence suggests that race and socioeconomic status may impact survival in soft tissue sarcoma (STS). We i ... Full text Link to item Cite

Selective survival advantage associated with primary tumor resection for metastatic gastric cancer in a Western population.

Journal Article Gastric Cancer · March 2018 BACKGROUND: The prognosis of metastatic gastric cancer (GC) remains dismal, with a median survival of 10 months. Historically, primary tumor resection was not thought to confer any survival benefit. Although high-level data exist guiding treatment of metas ... Full text Link to item Cite

Measuring the Quality of Gastric Cancer Care in the United

Conference ANNALS OF SURGICAL ONCOLOGY · February 1, 2018 Link to item Cite

Adjuvant Chemotherapy Does Not Confer Superior Survival in Patients With Atypical Carcinoid Tumors.

Journal Article Ann Thorac Surg · October 2017 BACKGROUND: Although the use of adjuvant chemotherapy in patients with pathologically node-positive (pN+) atypical carcinoid tumor of the lung is an accepted practice, controversy exists about its use in pathologically node-negative (pN0) patients. Our aim ... Full text Link to item Cite

Lymph node yield during pancreatic surgery - a distinct view

Conference SWISS MEDICAL WEEKLY · September 12, 2017 Link to item Cite

Minimally invasive gastrectomy for gastric cancer: A national perspective on oncologic outcomes and overall survival.

Journal Article Surgical oncology · September 2017 BackgroundMinimally invasive (MI) gastrectomy has become increasingly common as a resection technique for gastric cancer; however, data are limited regarding peri-operative morbidity, oncologic outcomes and long-term survival, particularly in the ... Full text Cite

Nationwide trends and outcomes associated with neoadjuvant therapy in pancreatic cancer: An analysis of 18 243 patients.

Conference J Surg Oncol · August 2017 BACKGROUND: Neoadjuvant therapy has theoretical benefits for pancreatic cancer; however, its association with perioperative outcomes remains controversial. This study sought to evaluate variation in use of neoadjuvant therapy and outcomes following pancrea ... Full text Link to item Cite

Going the Extra Mile: Improved Survival for Pancreatic Cancer Patients Traveling to High-volume Centers.

Conference Ann Surg · August 2017 OBJECTIVE: This study compares outcomes following pancreaticoduodenectomy (PD) for patients treated at local, low-volume centers and those traveling to high-volume centers. BACKGROUND: Although outcomes for PD are superior at high-volume institutions, not ... Full text Link to item Cite

A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution.

Journal Article Cell Rep · July 25, 2017 Combinatorial inhibition of effector and feedback pathways is a promising treatment strategy for KRAS mutant cancers. However, the particular pathways that should be targeted to optimize therapeutic responses are unclear. Using CRISPR/Cas9, we systematical ... Full text Link to item Cite

Subtotal cholecystectomy for the hostile gallbladder: failure to control the cystic duct results in significant morbidity.

Journal Article HPB (Oxford) · June 2017 BACKGROUND: Outcomes following the inability to control the cystic duct due to a hostile triangle of Calot during cholecystectomy remain unknown. The purpose of this study was to analyze the safety and efficacy of subtotal cholecystectomy, with attention t ... Full text Link to item Cite

PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation.

Journal Article Sci Transl Med · December 14, 2016 Therapies that efficiently induce apoptosis are likely to be required for durable clinical responses in patients with solid tumors. Using a pharmacological screening approach, we discovered that combined inhibition of B cell lymphoma-extra large (BCL-XL) a ... Full text Open Access Link to item Cite

Preoperative or postoperative radiotherapy versus surgery alone for retroperitoneal sarcoma: a case-control, propensity score-matched analysis of a nationwide clinical oncology database.

Journal Article Lancet Oncol · July 2016 BACKGROUND: Recruitment into clinical trials for retroperitoneal sarcoma has been challenging, resulting in termination of the only randomised multicentre trial in the USA investigating perioperative radiotherapy. Nonetheless, use of radiotherapy for retro ... Full text Link to item Cite

Minimally Invasive Versus Open Low Anterior Resection: Equivalent Survival in a National Analysis of 14,033 Patients With Rectal Cancer.

Journal Article Ann Surg · June 2016 OBJECTIVE: To examine survival of patients who underwent minimally invasive versus open low anterior resection (LAR) for rectal cancer. BACKGROUND: Utilization of laparoscopic and robotic LAR for rectal cancer has steadily increased. Short-term outcomes be ... Full text Link to item Cite

Surgical Resection of the Primary Tumor in Stage IV Colorectal Cancer Without Metastasectomy is Associated With Improved Overall Survival Compared With Chemotherapy/Radiation Therapy Alone.

Journal Article Dis Colon Rectum · April 2016 BACKGROUND: Controversy exists over whether resection of the primary tumor in stage IV colorectal cancer with inoperable metastases improves patient outcomes. OBJECTIVE: The purpose of this study was to evaluate whether resection of the primary tumor witho ... Full text Link to item Cite

Minimally Invasive Pancreaticoduodenectomy Does Not Improve Use or Time to Initiation of Adjuvant Chemotherapy for Patients With Pancreatic Adenocarcinoma.

Conference Ann Surg Oncol · March 2016 BACKGROUND: The modifiable variable best proven to improve survival after resection of pancreatic adenocarcinoma is the addition of adjuvant chemotherapy. A theoretical advantage of minimally invasive pancreaticoduodenectomy (MI-PD) is the potential for gr ... Full text Link to item Cite

Determining the Optimal Timing for Initiation of Adjuvant Chemotherapy After Resection for Stage II and III Colon Cancer.

Journal Article Dis Colon Rectum · February 2016 BACKGROUND: Several reports suggest that the efficacy of adjuvant chemotherapy on survival diminishes over time for colon cancer; however, precise timing of its loss of benefit has not been established. OBJECTIVE: This study aimed to determine the relation ... Full text Link to item Cite

Lymph Node Yield Between Open and Laparoscopic Portal Lymphadenectomy

Conference ANNALS OF SURGICAL ONCOLOGY · February 1, 2016 Link to item Cite

Feeding jejunostomy tube placement during resection of gastric cancers.

Journal Article J Surg Res · January 2016 BACKGROUND: Feeding tube placement is common among patients undergoing gastrectomy, and national guidelines currently recommend consideration of a feeding jejunostomy tube (FJT) for all patients undergoing resection for gastric cancer. However, data are li ... Full text Link to item Cite

Robotic Low Anterior Resection for Rectal Cancer: A National Perspective on Short-term Oncologic Outcomes.

Journal Article Ann Surg · December 2015 OBJECTIVE: This study examines short-term outcomes and pathologic surrogates of oncologic results among patients undergoing robotic versus laparoscopic low anterior resection for rectal cancer. A total of 6403 patients met inclusion criteria. Although the ... Full text Link to item Cite

Laparoscopic Total Gastrectomy in the Western Patient Population: Tips, Techniques, and Evidence-based Practice.

Journal Article Surg Laparosc Endosc Percutan Tech · December 2015 Gastric cancer is the second most common malignancy worldwide, and surgical resection is the only curative treatment. Traditionally, open total gastrectomy has been the procedure of choice for large and proximal carcinomas. Over the past decade, however, l ... Full text Link to item Cite

Optimal timing of tracheostomy after trauma without associated head injury.

Journal Article J Surg Res · October 2015 BACKGROUND: Controversy exists over optimal timing of tracheostomy in patients with respiratory failure after blunt trauma. The study aimed to determine whether the timing of tracheostomy affects mortality in this population. METHODS: The 2008-2011 Nationa ... Full text Link to item Cite

The use of radiation therapy in localized high-grade soft tissue sarcoma and potential impact on survival.

Journal Article Ann Surg Oncol · September 2015 BACKGROUND: It is a consensus that radiation therapy (RT) should be applied for all large, deep, high-grade soft tissue sarcomas (STS). Therefore, we investigated the National Cancer Database (NCDB) to study how these guidelines are being followed, to dete ... Full text Link to item Cite

Analysis of perioperative radiation therapy in the surgical treatment of primary and recurrent retroperitoneal sarcoma.

Journal Article J Surg Oncol · September 2015 BACKGROUND: Radiation therapy (RT) is increasingly utilized in conjunction with surgery for the treatment of retroperitoneal soft tissue sarcomas (RPS). Despite multiple theoretical advantages of RT, its role in the surgical management of this disease rema ... Full text Link to item Cite

Leukopenia is associated with worse but not prohibitive outcomes following emergent abdominal surgery.

Journal Article J Trauma Acute Care Surg · September 2015 BACKGROUND: There are little data currently available to guide surgical decision making regarding emergent surgical interventions in leukopenic patients. The purpose of this study was to investigate the impact of leukopenia among patients undergoing emerge ... Full text Link to item Cite

Improving Outcomes in Colorectal Surgery by Sequential Implementation of Multiple Standardized Care Programs.

Journal Article J Am Coll Surg · August 2015 BACKGROUND: The purpose of this study was to examine the impact of the sequential implementation of the enhanced recovery program (ERP) and surgical site infection bundle (SSIB) on short-term outcomes in colorectal surgery (CRS) to determine if the presenc ... Full text Open Access Link to item Cite

Abstract 5465: Systematic interrogation of druggable pathways in pancreatic adenocarcinomas using pooled gene-knockdown lentiviral libraries

Conference Cancer Research · August 1, 2015 AbstractDespite significant advances in the development of cancer treatment in the last 20 years the best available therapies have marginally improved the survival rate of treated pancreatic cancer patients ... Full text Cite

Long-term Oncologic Outcomes After Neoadjuvant Radiation Therapy for Retroperitoneal Sarcomas.

Journal Article Ann Surg · July 2015 OBJECTIVE: To evaluate long-term survival among patients undergoing radiation therapy (RT), followed by surgical resection of retroperitoneal sarcomas (RPS). BACKGROUND: Despite a lack of level 1 evidence supporting neoadjuvant RT for RPS, its use has incr ... Full text Link to item Cite

Neoadjuvant radiation therapy does not increase perioperative morbidity among patients undergoing gastrectomy for gastric cancer.

Journal Article J Surg Oncol · July 2015 BACKGROUND: Neoadjuvant radiation therapy (RT) as a component of the multimodality treatment of gastric cancer has demonstrated promising results. Data regarding its effect on perioperative safety are limited. METHODS: Adults undergoing gastrectomy for gas ... Full text Link to item Cite

Management of 1- to 2-cm Carcinoid Tumors of the Appendix: Using the National Cancer Data Base to Address Controversies in General Surgery.

Journal Article J Am Coll Surg · May 2015 BACKGROUND: The management of 1- to 2-cm appendiceal carcinoid tumors remains controversial. Here we use the National Cancer Data Base (NCDB) to compare long-term outcomes for patients treated via resection of the primary tumor alone vs right hemicolectomy ... Full text Link to item Cite

Defining the role of adjuvant chemotherapy after lobectomy for typical bronchopulmonary carcinoid tumors.

Journal Article Ann Thorac Surg · February 2015 BACKGROUND: Treatment guidelines for typical bronchopulmonary carcinoid tumors recommend observation alone after resection of stage I-IIIA disease, but there are limited data related to the use of adjuvant chemotherapy in the setting of nodal metastases fo ... Full text Link to item Cite

A standardized care plan is associated with shorter hospital length of stay in patients undergoing pancreaticoduodenectomy.

Journal Article J Surg Res · January 2015 BACKGROUND: In this retrospective review, we evaluate a standardized care plan (SCP) for patients undergoing pancreaticoduodenectomy, which included selective placement of feeding jejunostomy tubes (FJTs) and a perioperative fast-track recovery pathway (FT ... Full text Link to item Cite

Laparoscopic versus open low anterior resection for rectal cancer: results from the national cancer data base.

Journal Article J Gastrointest Surg · January 2015 BACKGROUND: While the use of laparoscopy has increased among patients undergoing colorectal surgery, there is ongoing debate regarding the oncologic equivalence of laparoscopy compared to open low anterior resection (LAR) for rectal cancer. METHODS: The 20 ... Full text Link to item Cite

The Use of Radiation Therapy in Well-Differentiated Soft Tissue Sarcoma of the Extremities: An NCDB Review.

Journal Article Sarcoma · 2015 Objective. This study investigated patterns of utilization of radiation therapy (RT) and correlated this with overall survival by assessing patients with well-differentiated soft tissue sarcoma of the extremity (STS-E) in the National Cancer Database (NCDB ... Full text Link to item Cite

Informed consent and other ethical and regulatory considerations in emergency research

Chapter · January 1, 2015 Complex mechanisms are in place to protect research subjects and to ensure that participants are informed of the risks, benefits, and alternatives available to them prior to enrolling in a research study. However, the process for obtaining informed consent ... Cite

Wound classification reporting in HPB surgery: can a single word change public perception of institutional performance?

Journal Article HPB (Oxford) · December 2014 INTRODUCTION: The drive to improve outcomes and the inevitability of mandated public reporting necessitate uniform documentation and accurate databases. The reporting of wound classification in patients undergoing hepato-pancreatico-biliary (HPB) surgery a ... Full text Link to item Cite

Systematic interrogation of druggable pathways in pancreatic adenocarcinoma

Conference MOLECULAR BIOLOGY OF THE CELL · December 1, 2014 Link to item Cite

Defining the learning curve for team-based laparoscopic pancreaticoduodenectomy.

Conference Ann Surg Oncol · November 2014 BACKGROUND: The purpose of this study was to define the learning curves for laparoscopic pancreaticoduodenectomy (LPD) with and without laparoscopic reconstruction, using paired surgical teams consisting of advanced laparoscopic-trained surgeons and advanc ... Full text Link to item Cite

Feeding jejunostomy tube placement in patients undergoing pancreaticoduodenectomy: an ongoing dilemma.

Journal Article J Gastrointest Surg · October 2014 BACKGROUND: Concomitant placement of feeding jejunostomy tubes (FJT) during pancreaticoduodenectomy is common, yet there are limited data regarding catheter-specific morbidity and associated outcomes. This information is crucial to appropriately select pat ... Full text Link to item Cite

The effect of neoadjuvant radiation therapy on perioperative outcomes among patients undergoing resection of retroperitoneal sarcomas.

Journal Article Surg Oncol · September 2014 BACKGROUND: Neoadjuvant radiation therapy (RT) has several theoretical benefits in the treatment of retroperitoneal sarcoma (RPS), but concerns remain about treatment toxicity and perioperative morbidity. There are limited data regarding its effect on peri ... Full text Link to item Cite

Ureteral stenting in laparoscopic colorectal surgery.

Journal Article J Surg Res · July 2014 BACKGROUND: Few studies have examined the current status of ureteral stent use or the indications for stenting, particularly in laparoscopic colorectal surgery. This study examines current national trends and predictors of ureteral stenting in patients und ... Full text Link to item Cite

The role of clinical care pathways: an experience with distal pancreatectomy.

Journal Article J Surg Res · July 2014 BACKGROUND: Previous studies have indicated that clinical pathways may shorten hospital length of stay (HLOS) among patients undergoing distal pancreatectomy (DP). Here, we evaluate an institutional standardized care pathway (SCP) for patients undergoing D ... Full text Link to item Cite

Gastroesophageal heterotopia and HER2/neu overexpression in an adenocarcinoma arising from a small bowel duplication.

Journal Article Arch Pathol Lab Med · March 2014 Small bowel duplications are congenital structures commonly lined by heterotopic gastric or pancreatic mucosa. Though benign in children, small bowel duplications have the potential for malignant degeneration in adulthood. Here, we present the first report ... Full text Link to item Cite

Pulmonary homograft monocusp reconstruction of the right ventricular outflow tract: outcomes to the intermediate term.

Journal Article Ann Thorac Surg · July 2010 BACKGROUND: There is limited information on longer-term outcomes of pulmonary homograft monocusp (PHM) reconstruction of the right ventricular outflow tract (RVOT). METHODS: A retrospective review of 131 consecutive patients undergoing RVOT reconstruction ... Full text Link to item Cite

Ascending aortitis and aortic valve endocarditis in an infant.

Journal Article J Thorac Cardiovasc Surg · April 2010 Full text Link to item Cite

Can the Kawashima procedure be performed in younger patients?

Journal Article Ann Thorac Surg · August 2009 BACKGROUND: The prudence of performing early palliative cavopulmonary connection that includes superior vena cava in association with azygous-hemiazygous continuation of the inferior vena cava, Kawashima procedure (KP), has been questioned. We document our ... Full text Link to item Cite

Thoracic duct ligation for persistent chylothorax after pediatric cardiothoracic surgery.

Journal Article Ann Thorac Surg · July 2009 BACKGROUND: There is considerable literature on incidence and medical management of postsurgical chylothorax in children but little is known about outcomes of thoracic duct ligation (TDL) for patients refractory to medical therapy. METHODS: A retrospective ... Full text Link to item Cite