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Daniel Carl Sullivan

Professor Emeritus of Radiology
Radiology
Box 3302 DUMC, Durham, NC 27710
311 Research Dr, Rm 161D Bryan Research Bldg., Durham, NC 27710

Selected Publications


Delivering a Quantitative Imaging Agenda.

Journal Article Cancers (Basel) · August 23, 2023 In a digital image, each voxel contains quantitative information dependent on the technique used to generate the image [...]. ... Full text Link to item Cite

An Online Repository for Pre-Clinical Imaging Protocols (PIPs).

Journal Article Tomography · March 27, 2023 Providing method descriptions that are more detailed than currently available in typical peer reviewed journals has been identified as an actionable area for improvement. In the biochemical and cell biology space, this need has been met through the creatio ... Full text Open Access Link to item Cite

QIBA guidance: Computed tomography imaging for COVID-19 quantitative imaging applications.

Journal Article Clin Imaging · September 2021 As the COVID-19 pandemic impacts global populations, computed tomography (CT) lung imaging is being used in many countries to help manage patient care as well as to rapidly identify potentially useful quantitative COVID-19 CT imaging biomarkers. Quantitati ... Full text Open Access Link to item Cite

Incorporating radiomics into clinical trials: expert consensus endorsed by the European Society of Radiology on considerations for data-driven compared to biologically driven quantitative biomarkers.

Journal Article Eur Radiol · August 2021 Existing quantitative imaging biomarkers (QIBs) are associated with known biological tissue characteristics and follow a well-understood path of technical, biological and clinical validation before incorporation into clinical trials. In radiomics, novel da ... Full text Open Access Link to item Cite

Magnetic resonance biomarkers in radiation oncology: The report of AAPM Task Group 294.

Journal Article Medical physics · July 2021 PurposeA magnetic resonance (MR) biologic marker (biomarker) is a measurable quantitative characteristic that is an indicator of normal biological and pathogenetic processes or a response to therapeutic intervention derived from the MR imaging pro ... Full text Open Access Cite

Current and future cancer staging after neoadjuvant treatment for solid tumors.

Journal Article CA Cancer J Clin · March 2021 Until recently, cancer registries have only collected cancer clinical stage at diagnosis, before any therapy, and pathological stage after surgical resection, provided no treatment has been given before the surgery, but they have not collected stage data a ... Full text Open Access Link to item Cite

The International Association for the Study of Lung Cancer Early Lung Imaging Confederation.

Journal Article JCO Clin Cancer Inform · February 2020 PURPOSE: To improve outcomes for lung cancer through low-dose computed tomography (LDCT) early lung cancer detection. The International Association for the Study of Lung Cancer is developing the Early Lung Imaging Confederation (ELIC) to serve as an open-s ... Full text Open Access Link to item Cite

The impact of respiratory gating on improving volume measurement of murine lung tumors in micro-CT imaging.

Journal Article PLoS One · 2020 Small animal imaging has become essential in evaluating new cancer therapies as they are translated from the preclinical to clinical domain. However, preclinical imaging faces unique challenges that emphasize the gap between mouse and man. One example is t ... Full text Open Access Link to item Cite

The impact of respiratory gating on improving volume measurement of murine lung tumors in micro-CT imaging

Journal Article · October 29, 2019 ABSTRACTSmall animal imaging has become essential in evaluating new cancer therapies as they are translated from the preclinical to clinical domain. However, preclinical imaging faces unique challenges that emphasize the ga ... Full text Open Access Cite

Task Group 174 Report: Utilization of [18 F]Fluorodeoxyglucose Positron Emission Tomography ([18 F]FDG-PET) in Radiation Therapy.

Journal Article Med Phys · October 2019 The use of positron emission tomography (PET) in radiation therapy (RT) is rapidly increasing in the areas of staging, segmentation, treatment planning, and response assessment. The most common radiotracer is 18 F-fluorodeoxyglucose ([18 F]FDG), a glucose ... Full text Open Access Link to item Cite

Recommendations towards standards for quantitative MRI (qMRI) and outstanding needs.

Journal Article J Magn Reson Imaging · June 2019 5 Technical Efficacy: Stage 5 J. Magn. Reson. Imaging 2019. ... Full text Open Access Link to item Cite

Implementing diffusion-weighted MRI for body imaging in prospective multicentre trials: current considerations and future perspectives.

Journal Article Eur Radiol · March 2018 UNLABELLED: For body imaging, diffusion-weighted MRI may be used for tumour detection, staging, prognostic information, assessing response and follow-up. Disease detection and staging involve qualitative, subjective assessment of images, whereas for progno ... Full text Open Access Link to item Cite

Imaging biomarker roadmap for cancer studies.

Journal Article Nat Rev Clin Oncol · March 2017 Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs used daily in oncology include clinical TNM stage, objective response and left ventricular ejection fraction. Other CT, MRI, PET and ultrasonography biomarkers are ... Full text Open Access Link to item Cite

Critical Review of Current Approaches for Echocardiographic Reproducibility and Reliability Assessment in Clinical Research.

Journal Article J Am Soc Echocardiogr · December 2016 BACKGROUND: There is no broadly accepted standard method for assessing the quality of echocardiographic measurements in clinical research reports, despite the recognized importance of this information in assessing the quality of study results. METHODS: Twe ... Full text Open Access Link to item Cite

Response

Journal Article Radiology · August 1, 2016 Full text Open Access Cite

Statistical Issues in Testing Conformance with the Quantitative Imaging Biomarker Alliance (QIBA) Profile Claims.

Journal Article Acad Radiol · April 2016 A major initiative of the Quantitative Imaging Biomarker Alliance is to develop standards-based documents called "Profiles," which describe one or more technical performance claims for a given imaging modality. The term "actor" denotes any entity (device, ... Full text Open Access Link to item Cite

Delivering a Quantitative Imaging Agenda.

Journal Article Cancers (Basel) · August 23, 2023 In a digital image, each voxel contains quantitative information dependent on the technique used to generate the image [...]. ... Full text Link to item Cite

An Online Repository for Pre-Clinical Imaging Protocols (PIPs).

Journal Article Tomography · March 27, 2023 Providing method descriptions that are more detailed than currently available in typical peer reviewed journals has been identified as an actionable area for improvement. In the biochemical and cell biology space, this need has been met through the creatio ... Full text Open Access Link to item Cite

QIBA guidance: Computed tomography imaging for COVID-19 quantitative imaging applications.

Journal Article Clin Imaging · September 2021 As the COVID-19 pandemic impacts global populations, computed tomography (CT) lung imaging is being used in many countries to help manage patient care as well as to rapidly identify potentially useful quantitative COVID-19 CT imaging biomarkers. Quantitati ... Full text Open Access Link to item Cite

Incorporating radiomics into clinical trials: expert consensus endorsed by the European Society of Radiology on considerations for data-driven compared to biologically driven quantitative biomarkers.

Journal Article Eur Radiol · August 2021 Existing quantitative imaging biomarkers (QIBs) are associated with known biological tissue characteristics and follow a well-understood path of technical, biological and clinical validation before incorporation into clinical trials. In radiomics, novel da ... Full text Open Access Link to item Cite

Magnetic resonance biomarkers in radiation oncology: The report of AAPM Task Group 294.

Journal Article Medical physics · July 2021 PurposeA magnetic resonance (MR) biologic marker (biomarker) is a measurable quantitative characteristic that is an indicator of normal biological and pathogenetic processes or a response to therapeutic intervention derived from the MR imaging pro ... Full text Open Access Cite

Current and future cancer staging after neoadjuvant treatment for solid tumors.

Journal Article CA Cancer J Clin · March 2021 Until recently, cancer registries have only collected cancer clinical stage at diagnosis, before any therapy, and pathological stage after surgical resection, provided no treatment has been given before the surgery, but they have not collected stage data a ... Full text Open Access Link to item Cite

The International Association for the Study of Lung Cancer Early Lung Imaging Confederation.

Journal Article JCO Clin Cancer Inform · February 2020 PURPOSE: To improve outcomes for lung cancer through low-dose computed tomography (LDCT) early lung cancer detection. The International Association for the Study of Lung Cancer is developing the Early Lung Imaging Confederation (ELIC) to serve as an open-s ... Full text Open Access Link to item Cite

The impact of respiratory gating on improving volume measurement of murine lung tumors in micro-CT imaging.

Journal Article PLoS One · 2020 Small animal imaging has become essential in evaluating new cancer therapies as they are translated from the preclinical to clinical domain. However, preclinical imaging faces unique challenges that emphasize the gap between mouse and man. One example is t ... Full text Open Access Link to item Cite

The impact of respiratory gating on improving volume measurement of murine lung tumors in micro-CT imaging

Journal Article · October 29, 2019 ABSTRACTSmall animal imaging has become essential in evaluating new cancer therapies as they are translated from the preclinical to clinical domain. However, preclinical imaging faces unique challenges that emphasize the ga ... Full text Open Access Cite

Task Group 174 Report: Utilization of [18 F]Fluorodeoxyglucose Positron Emission Tomography ([18 F]FDG-PET) in Radiation Therapy.

Journal Article Med Phys · October 2019 The use of positron emission tomography (PET) in radiation therapy (RT) is rapidly increasing in the areas of staging, segmentation, treatment planning, and response assessment. The most common radiotracer is 18 F-fluorodeoxyglucose ([18 F]FDG), a glucose ... Full text Open Access Link to item Cite

Recommendations towards standards for quantitative MRI (qMRI) and outstanding needs.

Journal Article J Magn Reson Imaging · June 2019 5 Technical Efficacy: Stage 5 J. Magn. Reson. Imaging 2019. ... Full text Open Access Link to item Cite

Implementing diffusion-weighted MRI for body imaging in prospective multicentre trials: current considerations and future perspectives.

Journal Article Eur Radiol · March 2018 UNLABELLED: For body imaging, diffusion-weighted MRI may be used for tumour detection, staging, prognostic information, assessing response and follow-up. Disease detection and staging involve qualitative, subjective assessment of images, whereas for progno ... Full text Open Access Link to item Cite

Imaging biomarker roadmap for cancer studies.

Journal Article Nat Rev Clin Oncol · March 2017 Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs used daily in oncology include clinical TNM stage, objective response and left ventricular ejection fraction. Other CT, MRI, PET and ultrasonography biomarkers are ... Full text Open Access Link to item Cite

Critical Review of Current Approaches for Echocardiographic Reproducibility and Reliability Assessment in Clinical Research.

Journal Article J Am Soc Echocardiogr · December 2016 BACKGROUND: There is no broadly accepted standard method for assessing the quality of echocardiographic measurements in clinical research reports, despite the recognized importance of this information in assessing the quality of study results. METHODS: Twe ... Full text Open Access Link to item Cite

Response

Journal Article Radiology · August 1, 2016 Full text Open Access Cite

Statistical Issues in Testing Conformance with the Quantitative Imaging Biomarker Alliance (QIBA) Profile Claims.

Journal Article Acad Radiol · April 2016 A major initiative of the Quantitative Imaging Biomarker Alliance is to develop standards-based documents called "Profiles," which describe one or more technical performance claims for a given imaging modality. The term "actor" denotes any entity (device, ... Full text Open Access Link to item Cite

Do Radiologists Have Stage Fright? Tumor Staging and How We Can Add Value to the Care of Patients with Cancer.

Journal Article Radiology · January 2016 With current shifts in our health care system and a growing national discussion around the concept of the value of imaging, it is time for radiologists and nuclear medicine physicians to recognize and accept our role in the multidisciplinary oncology team. ... Full text Open Access Link to item Cite

Metrology Standards for Quantitative Imaging Biomarkers.

Journal Article Radiology · December 2015 Although investigators in the imaging community have been active in developing and evaluating quantitative imaging biomarkers (QIBs), the development and implementation of QIBs have been hampered by the inconsistent or incorrect use of terminology or metho ... Full text Open Access Link to item Cite

Role of the Quantitative Imaging Biomarker Alliance in optimizing CT for the evaluation of lung cancer screen-detected nodules.

Journal Article J Am Coll Radiol · April 2015 The Quantitative Imaging Biomarker Alliance (QIBA) is a multidisciplinary consortium sponsored by the RSNA to define processes that enable the implementation and advancement of quantitative imaging methods described in a QIBA profile document that outlines ... Full text Link to item Cite

Quantitative imaging biomarkers: a review of statistical methods for computer algorithm comparisons.

Journal Article Stat Methods Med Res · February 2015 Quantitative biomarkers from medical images are becoming important tools for clinical diagnosis, staging, monitoring, treatment planning, and development of new therapies. While there is a rich history of the development of quantitative imaging biomarker ( ... Full text Link to item Cite

The emerging science of quantitative imaging biomarkers terminology and definitions for scientific studies and regulatory submissions.

Journal Article Stat Methods Med Res · February 2015 The development and implementation of quantitative imaging biomarkers has been hampered by the inconsistent and often incorrect use of terminology related to these markers. Sponsored by the Radiological Society of North America, an interdisciplinary group ... Full text Open Access Link to item Cite

Quantitative imaging biomarkers: a review of statistical methods for technical performance assessment.

Journal Article Stat Methods Med Res · February 2015 Technological developments and greater rigor in the quantitative measurement of biological features in medical images have given rise to an increased interest in using quantitative imaging biomarkers to measure changes in these features. Critical to the pe ... Full text Link to item Cite

Introduction to metrology series.

Journal Article Stat Methods Med Res · February 2015 Full text Open Access Link to item Cite

Foreword

Chapter · June 1, 2013 Full text Cite

The imaging viewpoint: how imaging affects determination of progression-free survival.

Journal Article Clin Cancer Res · May 15, 2013 Tumor measurements on computed tomgoraphic or MRI scans and/or the appearance of new lesions on any of a variety of imaging studies including positron emission tomographic scans are key determinants for assessing progression-free survival as an endpoint in ... Full text Open Access Link to item Cite

American Cancer Society lung cancer screening guidelines.

Journal Article CA: a cancer journal for clinicians · March 1, 2013 Findings from the National Cancer Institute's National Lung Screening Trial established that lung cancer mortality in specific high-risk groups can be reduced by annual screening with low-dose computed tomography. These findings indicate that the adoption ... Open Access Cite

American Cancer Society lung cancer screening guidelines.

Journal Article CA Cancer J Clin · 2013 Findings from the National Cancer Institute's National Lung Screening Trial established that lung cancer mortality in specific high-risk groups can be reduced by annual screening with low-dose computed tomography. These findings indicate that the adoption ... Full text Link to item Cite

Quantitative imaging test approval and biomarker qualification: interrelated but distinct activities.

Journal Article Radiology · June 2011 UNLABELLED: Quantitative imaging biomarkers could speed the development of new treatments for unmet medical needs and improve routine clinical care. However, it is not clear how the various regulatory and nonregulatory (eg, reimbursement) processes (often ... Full text Open Access Link to item Cite

A collaborative enterprise for multi-stakeholder participation in the advancement of quantitative imaging.

Journal Article Radiology · March 2011 Medical imaging has seen substantial and rapid technical advances during the past decade, including advances in image acquisition devices, processing and analysis software, and agents to enhance specificity. Traditionally, medical imaging has defined anato ... Full text Open Access Link to item Cite

The National Lung Screening Trial: overview and study design.

Journal Article Radiology · January 2011 The National Lung Screening Trial (NLST) is a randomized multicenter study comparing low-dose helical computed tomography (CT) with chest radiography in the screening of older current and former heavy smokers for early detection of lung cancer, which is th ... Full text Link to item Cite

Quantitative imaging in oncology patients: Part 2, oncologists' opinions and expectations at major U.S. cancer centers.

Journal Article AJR Am J Roentgenol · July 2010 OBJECTIVE: The purpose of this article is to examine oncologists' opinions and expectations concerning imaging and tumor measurements in patients with cancer. MATERIALS AND METHODS: An electronic mail survey was sent to 2,400 medical, gynecologic, and radi ... Full text Link to item Cite

Quantitative imaging in oncology patients: Part 1, radiology practice patterns at major U.S. cancer centers.

Journal Article AJR Am J Roentgenol · July 2010 OBJECTIVE: The objective of our study was to examine radiologists' opinions and practice patterns concerning tumor measurements in cancer patients. MATERIALS AND METHODS: An electronic mail survey was sent to 565 abdominal imaging radiologists at 55 U.S. N ... Full text Open Access Link to item Cite

Volumetric CT in lung cancer: an example for the qualification of imaging as a biomarker.

Journal Article Acad Radiol · January 2010 RATIONALE AND OBJECTIVES: New ways to understand biology as well as increasing interest in personalized treatments requires new capabilities for the assessment of therapy response. The lack of consensus methods and qualification evidence needed for large-s ... Full text Link to item Cite

TU‐C‐BRC‐02: Infrastructure to Integrate Imaging in Clinical Trials

Conference Medical Physics · January 1, 2009 Imaging biomarkers are increasingly used as primary or secondary endpoints in therapeutic trials. There are many academic units, professional organizations, industry groups and federal agencies addressing one or more components or issues associated with im ... Full text Cite

The Reference Image Database to Evaluate Response to therapy in lung cancer (RIDER) project: a resource for the development of change-analysis software.

Journal Article Clin Pharmacol Ther · October 2008 Critical to the clinical evaluation of effective novel therapies for lung cancer is the early and accurate determination of tumor response, which requires an understanding of the sources of uncertainty in tumor measurement and subsequent attempts to minimi ... Full text Link to item Cite

The Translational Research Working Group developmental pathway for image-based assessment modalities.

Journal Article Clin Cancer Res · September 15, 2008 The Image-based assessment modality (IM) pathway refers to one of six Translational Research Working Group (TRWG) pathways that, together, describe the core domains of early translational cancer research. This pathway focuses on approaches that are based o ... Full text Link to item Cite

Imaging as a quantitative science.

Journal Article Radiology · August 2008 Featured Publication Full text Link to item Cite

Imaging biomarkers roundtable report

Journal Article JOURNAL OF NUCLEAR MEDICINE · July 1, 2008 Link to item Cite

PET/CT in cancer patient management. Commentary.

Journal Article J Nucl Med · January 2007 Link to item Cite

Workshop on imaging science development for cancer prevention and preemption.

Journal Article Cancer Biomark · 2007 The concept of intraepithelial neoplasm (IEN) as a near-obligate precursor of cancers has generated opportunities to examine drug or device intervention strategies that may reverse or retard the sometimes lengthy process of carcinogenesis. Chemopreventive ... Full text Link to item Cite

Commentary

Journal Article Journal of Nuclear Medicine · January 1, 2007 Cite

I2 imaging: cancer biology and the tumor microenvironment.

Journal Article Cancer Res · December 1, 2006 The use of imaging techniques to understand the role of the tumor microenvironment in cancer progression was the topic of a National Cancer Institute (NCI)-sponsored think tank entitled "I2 Imaging: Cancer Biology and the Tumor Microenvironment," held in A ... Full text Link to item Cite

Molecular imaging in oncology.

Journal Article Ann Oncol · September 2006 Full text Link to item Cite

Advancing the boundaries of molecular imaging.

Journal Article Biol Psychiatry · May 15, 2006 Full text Link to item Cite

Advanced imaging and technology in gastrointestinal neoplasia: summary of the AGA-NCI Symposium October 4-5, 2004.

Journal Article Gastroenterology · April 2006 Imaging and other advanced technologies for detection of gastrointestinal cancers are undergoing a major revolution on several fronts. This is facilitated by convergence of key technologies including advanced endoscopic-detection systems, more specific con ... Full text Link to item Cite

Lung-cancer screening.

Journal Article N Engl J Med · November 17, 2005 Full text Link to item Cite

The progress and promise of molecular imaging probes in oncologic drug development.

Journal Article Clin Cancer Res · November 15, 2005 As addressed by the recent Food and Drug Administration Critical Path Initiative, tools are urgently needed to increase the speed, efficiency, and cost-effectiveness of drug development for cancer and other diseases. Molecular imaging probes developed base ... Full text Link to item Cite

Expanding the use of magnetic resonance in the assessment of tumor response to therapy: workshop report.

Journal Article Cancer Res · August 15, 2005 Although dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and magnetic resonance spectroscopy (MRS) have great potential to provide routine assessment of cancer treatment response, their widespread application has been hampered by a lack of s ... Full text Link to item Cite

Clinical practice. Lung cancer screening.

Journal Article N Engl J Med · June 30, 2005 Featured Publication Full text Link to item Cite

Functional imaging in lung cancer.

Journal Article J Clin Oncol · May 10, 2005 Accurate detection of the presence and extent of disease is vital in the management of non-small-cell lung cancer. While computed tomography and magnetic resonance imaging tend to be the routine diagnostic modalities used in the management of lung cancer, ... Full text Link to item Cite

Progress and promise of FDG-PET imaging for cancer patient management and oncologic drug development.

Journal Article Clin Cancer Res · April 15, 2005 2-[(18)F]Fluoro-2-deoxyglucose positron emission tomography (FDG-PET) assesses a fundamental property of neoplasia, the Warburg effect. This molecular imaging technique offers a complementary approach to anatomic imaging that is more sensitive and specific ... Full text Link to item Cite

Seeing into cells. The promise of in vivo molecular imaging in oncology.

Journal Article EMBO Rep · April 2005 Featured Publication The promise of in vivo molecular imaging in oncology ... Full text Link to item Cite

Meeting report: high-throughput technologies for in vivo imaging agents.

Journal Article Mol Imaging · 2005 Combinatorial chemistry and high-throughput screening have become standard tools for discovering new drug candidates with suitable pharmacological properties. Now, those same technologies are starting to be applied to the problem of discovering novel in vi ... Full text Link to item Cite

Nanotechnology and tumor imaging: seizing an opportunity.

Journal Article Mol Imaging · October 2004 Nanoparticles, labeled with a signaling moiety for in vivo imaging, and one or more ligands for molecularly targeted specificity, hold considerable promise in oncology. Nanoparticles can serve as modular platforms, from which a wide variety of highly sensi ... Full text Link to item Cite

Challenges and opportunities for in vivo imaging in oncology.

Journal Article Technol Cancer Res Treat · December 2002 Advances in genomics, proteomics and technology are changing medicine in fundamental ways. There are increasing clinical and laboratory requirements to obtain cellular and molecular information in vivo. This is particularly true in oncology, where the beha ... Full text Link to item Cite

Factors affecting patient enrollment in radiology clinical trials: a case study of the American College of Radiology Imaging Network.

Journal Article Acad Radiol · July 2002 RATIONALE AND OBJECTIVES: This study was designed to identify factors that affect the enrollment of patients into American College of Radiology Imaging Network clinical trials. MATERIALS AND METHODS: A quality improvement study was performed. Brainstorming ... Full text Link to item Cite

Breast tissue density quantification via digitized mammograms.

Journal Article IEEE Trans Med Imaging · August 2001 Studies reported in the literature indicate that breast cancer risk is associated with mammographic densities. An objective, repeatable, and a quantitative measure of risk derived from mammographic densities will be of considerable use in recommending alte ... Full text Link to item Cite

NCI image archive management workshop: a preliminary report.

Journal Article Acad Radiol · July 2001 The National Cancer Institute organized a workshop entitled "Image Archive Management" that was presented on August 28 and 29, 2000, at the Natcher Conference Center on the National Institutes of Health (NIH) campus. The purpose of this workshop was to sol ... Full text Link to item Cite

National Cancer Institute initiative: Lung image database resource for imaging research.

Journal Article Acad Radiol · May 2001 Preliminary clinical studies suggest that spiral computed tomography (CT) of the lungs can improve early detection of lung cancer in high-risk individuals. More clinical studies are needed, however, before public health recommendations can be proposed for ... Full text Link to item Cite

In vivo imaging of gene expression.

Journal Article Semin Radiat Oncol · January 2001 Featured Publication Imaging of gene expression is increasingly essential for cancer diagnosis, prediction of tumor response to various available therapies, and for monitoring response to therapy, whether it is gene or nongene therapy. Most of the work on developing techniques ... Full text Link to item Cite

NCI initiative: development of novel imaging technologies.

Journal Article IEEE Trans Med Imaging · June 2000 Full text Link to item Cite

How experience and training influence mammography expertise.

Journal Article Acad Radiol · October 1999 RATIONALE AND OBJECTIVES: The authors evaluated the influence of perceptual and cognitive skills in mammography detection and interpretation by testing three groups representing different levels of mammography expertise in terms of experience, training, an ... Full text Link to item Cite

BI-RADS categorization as a predictor of malignancy.

Journal Article Radiology · June 1999 PURPOSE: To determine the positive predictive value (PPV) of the American College of Radiology Breast Imaging Reporting and Data System (BI-RADS) categories 0, 2, 3, 4, and 5 by using BI-RADS terminology and by auditing data on needle localizations. MATERI ... Full text Link to item Cite

A sequential chart for the audit-based evaluation of screening mammogram interpretation.

Journal Article Acad Radiol · April 1999 RATIONALE AND OBJECTIVES: Auditing has received much attention recently as a method for radiologists to use to evaluate their interpretation of screening mammograms. U.S. Food and Drug Administration regulations require that some sort of audit be in place ... Full text Link to item Cite

Intermediate outcomes: diagnostic and therapeutic impact.

Journal Article Acad Radiol · January 1999 The conceptual basis for intermediate outcomes has been established, and scientifically sound methods are available for assessment of these short-term outcomes. While modest intermediate outcomes research experience assessing imaging technology has accumul ... Full text Link to item Cite

Combined ultrasound and near infrared diffused light imaging in a test object

Journal Article IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control · January 1, 1999 We have investigated the use of combining near infrared (NIR) diffuse light and ultrasound imaging methods to increase the detection sensitivity and to reduce the false alarm rate in small target detection. A line-of-sight optical projection through a test ... Full text Cite

Disparity mapping applied to sonography of the breast: technical note.

Journal Article Radiology · May 1998 A two-dimensional sonoelastographic technique called "disparity mapping" was applied to breast sonographic examinations in eight patients to test discrimination between benign and malignant lesions. With probe compression, pairs of gray-scale sonographic s ... Full text Link to item Cite

Combined ultrasound and near infrared diffused light imaging

Journal Article Proceedings of the IEEE Ultrasonics Symposium · December 1, 1997 We have investigated the use of combining near infrared (NIR) diffuse light and ultrasound methods to increase detection sensitivity and specificity of small targets by ultrasound. A line-of-sight optical projection through a test phantom is identified fro ... Cite

Optically guided ultrasound imaging system

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · December 1, 1997 This study investigates the potential use of combining near infrared (NIR) diffuse light and ultrasound methods for early detection of small breast tumors. A novel imaging system which combines these two methods has been introduced. A NIR phased array posi ... Full text Cite

Breast carcinoma: MR imaging before re-excisional biopsy.

Journal Article Radiology · November 1997 PURPOSE: To investigate the role of magnetic resonance (MR) imaging in the examination of patients after excisional biopsy of breast carcinoma before re-excision. MATERIALS AND METHODS: Forty-seven patients underwent contrast material-enhanced MR imaging a ... Full text Link to item Cite

Diagnostic performance characteristics of architectural features revealed by high spatial-resolution MR imaging of the breast.

Journal Article AJR Am J Roentgenol · August 1997 OBJECTIVE: Our objective was twofold: to determine which architectural features revealed by high spatial-resolution MR imaging of the breast contribute to diagnostic accuracy and to evaluate the diagnostic performance characteristics of those architectural ... Full text Link to item Cite

MR imaging of ductal carcinoma in situ.

Journal Article Radiology · February 1997 PURPOSE: To investigate the ability of magnetic resonance (MR) imaging to depict ductal carcinoma in situ (DCIS). MATERIALS AND METHODS: Between January 1992 and April 1996, 330 women underwent MR imaging before excisional biopsy. Of these, 101 women had c ... Full text Link to item Cite

High-resolution MR imaging of the breast: clinical context.

Journal Article Radiographics · November 1996 Preliminary investigation into magnetic resonance (MR) imaging as a breast imaging technique has demonstrated several promising roles for this modality when used as an adjunct to mammography for the detection and diagnosis of breast cancer. There are many ... Full text Link to item Cite

Effect of human variability on independent double reading in screening mammography.

Journal Article Acad Radiol · November 1996 RATIONALE AND OBJECTIVES: To demonstrate the range of gains and losses that radiologists might experience from independent double reading in screening mammography. METHODS: From a national random sample of radiologists, the authors formed 131 pairs. For ea ... Full text Link to item Cite

Variability in mammogram interpretation.

Journal Article Adm Radiol J · September 1996 Link to item Cite

Film screen mammography and sonography in the evaluation of breast prosthesis integrity

Journal Article Breast Disease · March 1, 1996 The purpose of this study was to determine the sensitivity and specificity of film screen mammography and sonography in detecting implant rupture and identify findings significantly associated with rupture, The sensitivity and specificity of preoperative m ... Cite

Variability in the interpretation of screening mammograms by US radiologists. Findings from a national sample.

Journal Article Arch Intern Med · January 22, 1996 Featured Publication OBJECTIVE: To evaluate the effectiveness of screening mammography by estimating the variability in radiologists' ability to detect breast cancer within the US population of radiologists at mammography centers accredited by the American College of Radiology ... Link to item Cite

Seromas in residual fibrous capsules after explantation: mammographic and sonographic appearances.

Journal Article Radiology · March 1995 PURPOSE: To evaluate the mammographic and sonographic findings associated with seromas that develop in residual fibrous capsules after explantation of breast prostheses. MATERIALS AND METHODS: Preoperative and postoperative mammograms were reviewed in 86 p ... Full text Link to item Cite

Periprosthetic mycobacterial infection. CT and mammographic findings.

Journal Article Clin Imaging · 1995 Organisms of the Mycobacterium fortuitum complex are an uncommon but important cause of periprosthetic infection following augmentation mammoplasty or other breast surgery. This etiological agent must be considered in the particular case of periprosthetic ... Full text Link to item Cite

Needle core biopsy of mammographic lesions.

Journal Article AJR Am J Roentgenol · January 1995 Full text Link to item Cite

Prediction of breast cancer malignancy using an artificial neural network.

Journal Article Cancer · December 1, 1994 BACKGROUND: An artificial neural network (ANN) was developed to predict breast cancer from mammographic findings. This network was evaluated in a retrospective study. METHODS: For a set of patients who were scheduled for biopsy, radiologists interpreted th ... Full text Link to item Cite

Needle core biopsy of mammographic lesions.

Journal Article AJR Am J Roentgenol · March 1994 Needle core biopsy and fine-needle aspiration cytology (FNAC) provide histologic diagnoses in a wide variety of clinical settings. In breast disease, surgeons have used these techniques to evaluate palpable masses for many years. In recent years, radiologi ... Full text Link to item Cite

PREDICTION OF BREAST-CANCER MALIGNANCY FOR DIFFICULT CASES USING AN ARTIFICIAL NEURAL-NETWORK

Conference WORLD CONGRESS ON NEURAL NETWORKS-SAN DIEGO - 1994 INTERNATIONAL NEURAL NETWORK SOCIETY ANNUAL MEETING, VOL 1 · January 1, 1994 Link to item Cite

Impact of patient-controlled compression on the mammography experience.

Journal Article Radiology · January 1993 The authors tested the hypothesis that giving women control over the compression portion of the mammography examination results in a less painful experience, greater overall patient satisfaction, and a radiographic image as good as that produced by means o ... Full text Link to item Cite

The natural history of mammographic calcifications subjected to interval follow-up.

Journal Article Arch Surg · November 1992 The purpose of this investigation was to determine the natural history and risk of malignancy associated with isolated indeterminate microcalcifications subjected to interval follow-up. During a 2-year study, 91 patients were identified with indeterminate ... Full text Link to item Cite

Two dimensional ultrasonic beam distortion in the breast: in vivo measurements and effects.

Journal Article Ultrason Imaging · October 1992 Two dimensional arrival time data was obtained for the propagation of ultrasound across the breasts of 7 female volunteers. These profiles were extracted through the use of cross-correlation measurements and a simulated annealing process that maintained ph ... Full text Link to item Cite

Large aperture phase error measurement and effects

Conference Proceedings - IEEE Ultrasonics Symposium · January 1, 1992 Clinical measurements and computer simulations were conducted to determine the effects of phase errors on image quality in large aperture systems. Using a 3.5MHz 24.5mm receive aperture, phase errors were measured across the left breasts of 6 female volunt ... Full text Cite

Measurement of force applied during mammography.

Journal Article Radiology · November 1991 The discomfort that patients experience during mammography is probably related to a variety of factors, one of which might be the amount of compression used. The authors measured the amount of force applied to the breasts during mammography and the resulti ... Full text Link to item Cite

The impact of acoustic velocity variations on target detectability in ultrasonic images of the breast.

Journal Article Invest Radiol · September 1991 Experimentally obtained ultrasonic phase aberration profiles in the breast were used to investigate the impact of acoustic velocity variations on images of simulated breast lesions. The imaging properties of several phased-array transducers with varying fr ... Full text Link to item Cite

Positron emission tomography in neuropsychiatry.

Journal Article Invest Radiol · February 1991 Positron emission tomography (PET) allows high-resolution, three-dimensional evaluation of regional brain metabolic activity and neurotransmitter function. This imaging technique has been applied increasingly in psychiatric research and may yield new infor ... Full text Link to item Cite

Evaluation of acute renal failure with magnetic resonance imaging using gradient-echo and Gd-DTPA.

Journal Article Invest Radiol · January 1991 Detection of acute renal failure (ARF) using fast-scan magnetic resonance imaging (MRI) with Gd-DTPA was studied in a dog model. ARF was produced in five dogs by infusion of norepinephrine (0.75 micrograms/kg/min) into the renal arteries for 40 minutes. MR ... Full text Link to item Cite

In vivo measurements of ultrasonic beam distortion in the breast.

Journal Article Ultrason Imaging · January 1991 The phase aberrations encountered by ultrasonic pulses propagating through breast tissue in twenty-two female volunteers were measured. The experiments were designed to assess the impact of these aberrations on clinical ultrasonic image quality for a varie ... Full text Link to item Cite

Radiopaque markers on mammary implants.

Journal Article AJR Am J Roentgenol · August 1989 Full text Link to item Cite

Breast skin calcifications: localization with a stereotactic device.

Journal Article Radiology · May 1989 Calcifications that lie within the skin of the breast may be mistakenly thought to be intraparenchymal on mammograms if they are projected over breast tissue in two views. A simple, reliable technique was developed to determine calcification location. It u ... Full text Link to item Cite

Nonpalpable breast lesions at biopsy. A detailed analysis of radiographic features.

Journal Article Ann Surg · August 1988 Several studies have demonstrated that mammographic screening of asymptomatic women results in a lower mortality rate where breast cancer is concerned. Often, screening mammograms reveal a nonpalpable radiographic abnormality and the diagnosis must be dete ... Full text Link to item Cite

Effects of ECT on brain structure: a pilot prospective magnetic resonance imaging study.

Journal Article Am J Psychiatry · June 1988 The authors describe a pilot prospective investigation of the effects of ECT on brain structure using magnetic resonance imaging (MRI). In nine patients with major depression, a course of ECT produced no acute changes in brain structure according to blind ... Full text Link to item Cite

The study of perception.

Journal Article Invest Radiol · January 1988 Full text Link to item Cite

Experience with an alternative curriculum.

Journal Article Invest Radiol · March 1987 Link to item Cite

Science in radiology

Journal Article Investigative Radiology · January 1, 1987 Full text Cite

Distribution of 15- and 137-mu diameter microspheres in the dog lung in the axial plane.

Journal Article Invest Radiol · August 1986 Oleic acid infusion, as a model of fat embolism, produces a predominantly peripheral lesion in the dog lung. The lung injury corresponds to the peripheral distribution of labeled oleic acid. The basis for this distribution of oleic acid is not known. Our h ... Full text Link to item Cite

Regional pulmonary distribution of iodine-125-labeled oleic acid. Its relationship to the pattern of oleic acid edema and pulmonary blood flow.

Journal Article Invest Radiol · February 1986 Oleic acid infusion in dogs produces a patchy, predominantly peripheral lesion on CT scans. This study correlates the pattern of oleic acid injury with the distribution of infused oleic acid and pulmonary blood flow. Radiolabeled oleic acid (I-125, 0.05 ml ... Full text Link to item Cite

Intraperitoneal chromic phosphate P 32 suspension therapy of malignant peritoneal cytology in endometrial carcinoma.

Journal Article Am J Obstet Gynecol · September 15, 1985 Malignant peritoneal cytology in patients with endometrial carcinoma is a poor prognostic feature, identifying patients at high risk for early intra-abdominal recurrence. Between 1977 and January, 1983, 65 women with endometrial carcinoma who had malignant ... Full text Link to item Cite

PERIPHERAL DISTRIBUTION OF LARGE DIAMETER MICROSPHERES IN THE DOG LUNG

Journal Article INVESTIGATIVE RADIOLOGY · January 1, 1985 Link to item Cite

Lymphoscintigraphy for malignant melanoma. Surgical considerations.

Journal Article Am Surg · December 1983 Lymphoscintigraphy using technetium-99m atimony sulfur colloid was performed in 22 patients with melanoma referred to Duke University Comprehensive Cancer Center in an attempt to identify patterns of regional lymphatic drainage. Scans from six patients rev ... Link to item Cite

Lung scan interpretation: effect of different observers and different criteria.

Journal Article Radiology · December 1983 Many nuclear medicine physicians use criteria put forth by McNeil or Biello et al. to interpret lung scintigrams, while others use an integration of these and other reported or personal criteria. Interobserver variation within these schemes has not been as ... Full text Link to item Cite

Observations on the intraperitoneal distribution of chromic phosphate (32P) suspension for intraperitoneal therapy.

Journal Article Radiology · February 1983 Seven patients received intraperitoneal chromic phosphate (32P) suspension in a 3-ml bolus with a saline flush, and another ten patients were given the suspension in a 500-ml infusion of normal saline. During the first six hours after administration, most ... Full text Link to item Cite

Radionuclide studies in lung disease

Journal Article Seminars in Respiratory Medicine · January 1, 1983 Full text Cite

Use of pulmonary angiography for suspected pulmonary embolism: influence of scintigraphic diagnosis.

Journal Article AJR Am J Roentgenol · October 1982 The use of pulmonary angiography as related to ventilation-perfusion scintigraphy was studied at two teaching hospitals in 600 patients clinically suspected of having pulmonary embolism, using a combined prospective-retrospective approach. Sixty patients u ... Full text Link to item Cite

Scintigraphic perfusion patterns in patients with diffuse lung disease.

Journal Article Radiology · April 1982 Perfusion scintigrams of 55 patients with radiographic evidence of diffuse lung disease were reviewed. Thirty-nine had acute and/or chronic changes caused by congestive heart failure, and 16 had diffuse reticulonodular disease. A normal or near-normal perf ... Full text Link to item Cite

Localization of I-131-labeled goat and primate anti-carcinoembryonic antigen(CEA) antibodies in patients with cancer.

Journal Article Invest Radiol · 1982 Thirty patients with anti-carcinoembryonic antigen (CEA)-producing cancers of the colon, breast, or thyroid were injected with 1 to 2 mCi of Iodine-131 (131I)-labeled, affinity-purified, goat or baboon anti-CEA antibodies. Images were obtained daily for fo ... Full text Link to item Cite

In vivo tumor localization using tumor-specific monkey xenoantibody, alloantibody, and murine monoclonal xenoantibody.

Journal Article Ann Surg · November 1981 Specific in vivo localization of antibodies reactive with human melanoma cell membrane tumor associated antigens (TAA) has been attempted using congenitally athymic nude mice bearing subcutaneous human melanoma tumor xenografts as the experimental model. I ... Full text Link to item Cite

Lymphoscintigraphy in malignant melanoma: 99mTc antimony sulfur colloid.

Journal Article AJR Am J Roentgenol · October 1981 Lymphoscintigrams were performed using technetium-99m antimony sulfur colloid in 21 patients with cutaneous malignant melanoma. Scintigraphic results were concordant with clinical prediction of lymph drainage in six of 11 patients with trunk melanoma, in f ... Full text Link to item Cite

Computed tomography of primary liver tumors in children.

Journal Article Radiology · May 1981 Computed tomography (CT) was performed in three children with hepatoblastoma, hepatocellular carcinoma, or hemangioendotheliomatosis. In each case the tumor was identified as a mass with a lower attenuation value than surrounding normal liver tissue. Howev ... Full text Link to item Cite

Percutaneous transtubal scintigraphic assessment of patency of peritoneovenous shunts.

Journal Article Clin Nucl Med · February 1981 Peritoneovenous shunts have been widely used in the management of patients with ascites when medical therapy has failed. Shunt malfunction is a frequent complication. Direct injection of a small amount of Tc-99m-sulfur colloid into the afferent limb of the ... Full text Link to item Cite

Accuracy of radionuclide imaging in distinguishing renal masses from normal variants.

Journal Article Radiology · August 1980 To determine the accuracy of scintigraphy in distinguishing true renal masses from normal variants, 40 patients with excretory urographic findings indicating a possible, but not definite, mass lesion were studied. Scintigraphy correctly identified 17 true ... Full text Link to item Cite

Angiographic evaluation of chronic pulmonary embolism.

Journal Article Radiology · August 1980 In some patients acute pulmonary emboli may fail to resolve normally, resulting in chronic pulmonary embolism. This may lead to pulmonary hypertension, respiratory insufficiency, cor pulmonale, and death. The angiographic evaluation in nine patients with c ... Full text Link to item Cite

Problems in the scintigraphic detection of osteomyelitis in children.

Journal Article Radiology · June 1980 99mTc-pyrophosphate studies in 21 children with acute hematogenous osteomyelitis were compared with radiographic, clinical and surgical findings. Eleven 99mTc studies revealed obvious abnormalities, four showed subtle abnormalities, two were misleading, an ... Full text Link to item Cite

The value of radionuclide bone imaging in selected patients with osteogenic sarcoma metastatic to lung.

Journal Article Pediatr Radiol · April 1980 Bone scintigraphic findings are presented in three pediatric patients with osteogenic sarcoma metastatic to lung. The bone imaging radionuclide was concentrated to a variable degree within the pulmonary metastases. Radionuclide bone imaging was valuable in ... Full text Link to item Cite

Properties of chromate phosphate P-32 radiocolloid as a therapeutic agent

Journal Article Investigative Radiology · January 1, 1980 Cite

Integrated imaging for childhood diseases

Journal Article Pediatric Annals · January 1, 1980 Full text Cite

BREMSSTRAHLUNG IMAGING OF INTRAPERITONEAL P-32 DISTRIBUTIONS

Journal Article JOURNAL OF NUCLEAR MEDICINE · January 1, 1980 Link to item Cite

An evaluation of the 24-hour RAIU test performed with an Anger camera and a pinhole collimator

Journal Article Clinical Nuclear Medicine · 1979 RAIU measurements obtained with a conventional thyroid uptake probe have been compared with those obtained with an Anger camera and a pinhole collimator. Although the field distribution for the pinhole collimator deviates markedly from the IAEA recommendat ... Cite

The use of ultrasound to enhance the diagnostic utility of the equivocal liver scintigraph.

Journal Article Radiology · September 1978 Using state-of-the-art technology in nuclear medicine and ultrasound, directed ultrasound examinations were performed with attention to equivocal areas identified on hepatic isotope studies. In 100 patients studied prospectively, 100 equivocal radionuclide ... Full text Link to item Cite

Ultrasound and gallium for the diagnosis of abdominal and pelvic abscesses.

Journal Article Gastrointest Radiol · August 31, 1978 Two hundred and twenty-two patients presented with clinical suspicion of an abdominal or pelvic abscess. Abscesses tend to locate in the perihepatic spaces or the pelvis, and these areas can easily be examined by ultrasound, using the liver or the urinary ... Full text Link to item Cite

Gray scale ultrasound and isotope scanning: complementary techniques for imaging the liver.

Journal Article AJR Am J Roentgenol · February 1977 Technical advances in gray scale ultrasound have led to better signal-to-noise ratios and improved resolution. A display of the texture of the liver is now possible, making ultrasound an important complementary technique to radioisotope scanning. In the po ... Full text Link to item Cite

Scintigraphy, ultrasound and CT scanning of the liver.

Journal Article Yale J Biol Med · 1977 Isotope examination of the liver depends on the functional activity of the liver phagocytes, while ultrasound and CT scanning display the anatomical structure. Cold areas on an isotope scan may be due to impaired function or space-occupying lesions. The me ... Link to item Cite