Journal ArticleOptics letters · February 2025
We demonstrate the feasibility of swept-source visible-light optical coherence tomography (SS-vis-OCT). We used a fanout periodically poled lithium niobate (PPLN) crystal for second-harmonic generation (SHG) to convert a commercial near-infrared swept-sour ...
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Journal ArticleBiomedical optics express · February 2025
Low-cost optical coherence tomography (OCT) has shown promise in increasing access to noninvasive retinal imaging at the point of care, especially in low-resource environments. A next-generation low-cost OCT system is presented which improves performance o ...
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Journal ArticleOptica · January 20, 2025
The scattering and absorption of light within biological tissue severely limits the penetration depth of optical imaging techniques. Recently, it has been found that water-soluble, strongly absorbing dye molecules, such as tartrazine, can achieve in vivo t ...
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Journal ArticleIEEE transactions on medical imaging · August 2024
We seek to develop techniques for high-resolution imaging of the tree shrew retina for visualizing and parameterizing retinal ganglion cell (RGC) axon bundles in vivo. We applied visible-light optical coherence tomography fibergraphy (vis-OCTF) and tempora ...
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Journal ArticleOptics letters · August 2024
We demonstrate the use of a novel, to the best of our knowledge, localization algorithm for digitally refocusing fluorescence images from a three-dimensional cell culture. Simultaneous phase and fluorescence intensity images are collected through a multimo ...
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Journal ArticleOptics express · June 2024
Endoscopic angle-resolved light scattering methods have been developed for early cancer detection but they typically require multi-element coherent fiber optic bundles to recover scattering distributions from tissues. Recent work has focused on using a sin ...
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Journal ArticleBiomedical optics express · October 2023
Balanced detection optical coherence tomography (BD-OCT) enables near-shot noise-limited imaging by suppressing wavelength-dependent relative intensity noise (RIN) originating from the light source. In spectral-domain BD-OCT (SD-BD-OCT), the level of RIN s ...
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Journal ArticleJournal of visualized experiments : JoVE · June 2023
In recent years, in vivo retinal imaging, which provides non-invasive, real-time, and longitudinal information about biological systems and processes, has been increasingly applied to obtain an objective assessment of neural damage in eye diseases. Ex vivo ...
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Journal ArticleTranslational vision science & technology · May 2023
PurposeWe developed a new analytic tool based on visible-light optical coherence tomography fibergraphy (vis-OCTF) to longitudinally track individual axon bundle transformation as a new in vivo biomarker for retinal ganglion cell (RGC) damage. ...
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Journal ArticleCommunications medicine · April 2023
BackgroundRetinal oxygen saturation (sO2) provides essential information about the eye's response to pathological changes that can result in vision loss. Visible-light optical coherence tomography (vis-OCT) is a noninvasive tool that ha ...
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Journal ArticleProceedings of the National Academy of Sciences of the United States of America · November 2022
Retinal ganglion cells (RGCs) are heterogeneous projection neurons that convey distinct visual features from the retina to brain. Here, we present a high-throughput in vivo RGC activity assay in response to light stimulation using noninvasive Ca2+
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Journal ArticleIEEE transactions on medical imaging · July 2022
Increases in speed and sensitivity enabled rapid clinical adoption of optical coherence tomography (OCT) in ophthalmology. Recently, visible-light OCT (vis-OCT) achieved ultrahigh axial resolution, improved tissue contrast, and provided new functional imag ...
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Journal ArticleExperimental eye research · May 2022
Aniridia is a panocular condition characterized by impaired eye development and vision, which is mainly due to the haploinsufficiency of the paired-box-6 (PAX6) gene. Like what is seen in aniridia patients, Pax6-deficient mice Pax6Sey-Neu/+ ...
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Journal ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience · December 2021
Retinal ganglion cells (RGCs) exhibit compartmentalized organization, receiving synaptic inputs through their dendrites and transmitting visual information from the retina to the brain through the optic nerve. Little is known about the structure of RGC axo ...
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Journal ArticleExperimental eye research · October 2021
The growth of the mouse eye and retina after birth is a dynamic, highly regulated process. In this study, we applied visible-light optical coherence tomography (vis-OCT), a non-invasive imaging technique, to examine developing retinal layer structures afte ...
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Journal ArticleTranslational vision science & technology · October 2020
PurposeTo develop a practical technique for visualizing and quantifying retinal ganglion cell (RGC) axon bundles in vivo.MethodsWe applied visible-light optical coherence tomography (vis-OCT) to image the RGC axon bundles, referred ...
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Journal ArticleOptics letters · May 2020
Recent development of visible-light optical coherence tomography (vis-OCT) has introduced new applications for noninvasive spectroscopic imaging. However, the measured spectra may be altered by spectrally dependent roll-off (SDR). We formulated a mathemati ...
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