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David Gooden

Research Scientist
Chemistry
Box 90317, Durham, NC 27708-0348
A02 Levine Science Research Center, Durham, NC 27708

Selected Publications


Characterizing azobenzene disperse dyes in commercial mixtures and children's polyester clothing.

Journal Article Environ Pollut · October 15, 2021 Azobenzene disperse dyes are the fastest-growing class of dyestuffs, yet little is known about dye occurrences, sources, and transformations; azo dyes are also underrepresented in chemical standard catalogs, molecular databases, and mass spectral libraries ... Full text Open Access Link to item Cite

Potential Utility of Synthetic D-Lactate Polymers in Skin Cancer.

Journal Article JID innovations : skin science from molecules to population health · September 2021 Increased breakdown of glucose through glycolysis in both aerobic and anaerobic conditions is a hallmark feature of mammalian cancer and leads to increased production of L-lactate. The high-level lactate present within the tumor microenvironment is reused ... Full text Cite

Psoralen Derivatives with Enhanced Potency.

Journal Article Photochem Photobiol · September 2020 Psoralen is a furocoumarin natural product that intercalates within DNA and forms covalent adducts when activated by ultraviolet radiation. It is well known that this property contributes to psoralen's clinical efficacy in several disease contexts, which i ... Full text Link to item Cite

SYNTHESIS AND IN VITRO ACTIVITY OF D-LACTIC ACID OLIGOMERS

Internet Publication · September 27, 2018 This invention describes the synthesis and pharmacologic activity of n = 2 , n = 3 , n = 4 , n = 5 , and n = 6 D - lactic acid oligomers . D - lactic acid dimer has pharmacologic activity and sequesters L - lactate , and the other D - lactic acid oligom er ... Open Access Link to item Cite

Synthesis and evaluation of radiolabeled AGI-5198 analogues as candidate radiotracers for imaging mutant IDH1 expression in tumors.

Journal Article Bioorg Med Chem Lett · February 15, 2018 Mutations in the metabolic enzyme isocitrate dehydrogenase 1 (IDH1) are commonly found in gliomas. AGI-5198, a potent and selective inhibitor of the mutant IDH1 enzyme, was radiolabeled with radioiodine and fluorine-18. These radiotracers were evaluated as ... Full text Link to item Cite

A genetically engineered thermally responsive sustained release curcumin depot to treat neuroinflammation.

Journal Article Journal of controlled release : official journal of the Controlled Release Society · October 2013 Radiculopathy, a painful neuroinflammation that can accompany intervertebral disc herniation, is associated with locally increased levels of the pro-inflammatory cytokine tumor necrosis factor alpha (TNF╬▒). Systemic administration of TNF antagonists for ra ... Full text Open Access Cite

Investigating a novel flame retardant known as V6: measurements in baby products, house dust, and car dust.

Journal Article Environmental science & technology · May 2013 With the phase-out of polybrominated diphenyl ether (PBDE) flame retardants, the use of new and alternate flame retardants has been increasing. 2,2-bis(chloromethyl)propane-1,3-diyltetrakis(2-chloroethyl) bisphosphate, known as V6, is a flame retardant app ... Full text Cite

Studies on the biosynthesis of the lipodepsipeptide antibiotic Ramoplanin A2.

Journal Article Bioorganic & medicinal chemistry · January 2012 Ramoplanin, a non-ribosomally synthesized peptide antibiotic, is highly effective against several drug-resistant Gram-positive bacteria, including vancomycin-resistant Enterococcus faecium (VRE) and methicillin-resistant Staphylococcus aureus (MRSA), two i ... Full text Cite

Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B.

Journal Article Bioorganic & medicinal chemistry letters · May 2008 A facile synthetic route to substituted trans-2-arylcyclopropylamines was developed to provide access to mechanism-based inhibitors of the human flavoenzyme oxidase lysine-specific histone demethylase LSD1 and related enzyme family members such as monoamin ... Full text Cite

Quantification of naturally occurring pyrrole acids in melanosomes.

Journal Article Photochemistry and photobiology · May 2008 Three naturally occurring pyrrole acids were found in Sepia, human black hair, and bovine choroid and iris melanosomes using high-performance liquid chromatography and mass spectrometry--pyrrole-2,3-dicarboxylic acid (PDCA), pyrrole-2,3,5-tricarboxylic aci ... Full text Cite

A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells.

Journal Article Proc Natl Acad Sci U S A · March 22, 2005 Many key regulatory proteins, including members of the Ras family of GTPases, are modified at their C terminus by a process termed prenylation. This processing is initiated by the addition of an isoprenoid lipid, and the proteins are further modified by a ... Full text Link to item Cite

C-nitroso compounds: synthesis, physicochemical properties and biological activities.

Journal Article Current topics in medicinal chemistry · January 2005 Because of the chemical and physical properties of nitric oxide, its effective use and delivery for therapeutic application represents a significant challenge. Accordingly, current understanding of nitric oxide biology largely stems from the use of nitric ... Full text Cite

Additivity and the physical basis of multivalency effects: a thermodynamic investigation of the calcium EDTA interaction.

Journal Article Journal of the American Chemical Society · June 2003 To better understand the origin of multivalency effects in ligand binding, the binding of a series of mono-, bi-, tri- and tetravalent carboxylate ligands to Ca(II) was examined by isothermal titration calorimetry (ITC). The data are inconsistent with an e ... Full text Cite