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Mark Wesley Dewhirst

Gustavo S. Montana Distinguished Professor Emeritus of Radiation Oncology
Radiation Oncology
Box 3455 Med Ctr, Durham, NC 27710
201 Med Sci Res Bldg, Research Drive, Durham, NC 27710

Selected Grants


Proteomic Signatures of Space Radiation Induced Cardiovascular Degeneration

ResearchCo Investigator · Awarded by National Aeronautics and Space Administration · 2016 - 2022

Preclinical Oxygen Imager to Model Efficient Cancer Treatment

ResearchCollaborator · Awarded by O2M Technologies, LLC · 2019 - 2021

Role of RBC Reactive Oxygen Species and Their Vicious Cycle in Sickle Vasculopathy

ResearchAdvisor · Awarded by National Institutes of Health · 2017 - 2021

Systemically administrered EGRFvIII-targeted bispecific antibody as an immunotherapeutic for glioblastoma.

FellowshipCollaborator · Awarded by National Institutes of Health · 2015 - 2019

Proteomic Signatures of Space Radiation Induced Cardiovascular Degeneration

ResearchCo Investigator · Awarded by National Aeronautics and Space Administration · 2016 - 2022

Preclinical Oxygen Imager to Model Efficient Cancer Treatment

ResearchCollaborator · Awarded by O2M Technologies, LLC · 2019 - 2021

Role of RBC Reactive Oxygen Species and Their Vicious Cycle in Sickle Vasculopathy

ResearchAdvisor · Awarded by National Institutes of Health · 2017 - 2021

Systemically administrered EGRFvIII-targeted bispecific antibody as an immunotherapeutic for glioblastoma.

FellowshipCollaborator · Awarded by National Institutes of Health · 2015 - 2019

Dissecting mechanism(s) by which ionizing radiation promotes clonal expansion of premalignant cells in the thymus

ResearchCollaborator · Awarded by National Institutes of Health · 2016 - 2018

Duke CTSA (UL1)

ResearchProgram Director · Awarded by National Institutes of Health · 2013 - 2018

Optimization of radiofrequency ablation with electrically conductive particles

ResearchCollaborator · Awarded by National Institutes of Health · 2015 - 2018

The role of ERRalpha/PGC-1 in disease pathogenesis

ResearchCo Investigator · Awarded by National Institutes of Health · 2006 - 2018

Luminescent Oxygen Nanosensors for Tumor Hypoxia Imaging

ResearchPrincipal Investigator · Awarded by University of Virginia - Charlottesville · 2012 - 2017

Effects of Exercise Training on Tumor Growth in Triple Negative Breast Cancer

ResearchPrincipal Investigator · Awarded by Memorial Sloan-Kettering Cancer Center · 2014 - 2017

A Quantitative Optical Sensor to Monitor Tumor Vascular Physiology

ResearchPrincipal Investigator · Awarded by Zenalux Biomedical, Inc. · 2015 - 2016

Janssen Research AGreement

ResearchPrincipal Investigator · Awarded by Janssen Research & Development, LLC · 2014 - 2016

HIF-1 driven therapeutic resistance mechanisms in chest wall recurrences of inflammatory breast cancer (IBC)

ResearchPrincipal Investigator · Awarded by Inflammatory Breast Cancer Research Foundation · 2013 - 2016

Targeting nuclear FGF receptor to improve chemotherapy response in triple-negative breast cancer

ResearchInvestigator · Awarded by Department of Defense · 2013 - 2016

Research Training In Neuro-Oncology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1998 - 2016

Thermally Triggered Multivalent Targeting of Tumors

ResearchCo Investigator · Awarded by National Institutes of Health · 2007 - 2016

BMX-001 as a Radio-Protector in Head and Neck Cancer Therapy

ResearchPrincipal Investigator · Awarded by BioMimetix Pharmaceutical, Inc. · 2015 - 2016

Thermally Targeted Drug Delivery by Elastin Biopolymers

ResearchCo Investigator · Awarded by National Institutes of Health · 2002 - 2016

Cancer Biology Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Cancer Institute · 1993 - 2016

Radiation Therapy: Dissecting the Role of Stromal Cells in Tumor Control

ResearchCollaborator · Awarded by National Institutes of Health · 2013 - 2016

Detection of Novel Alternative Splicing Biomarkers of Hypoxia in Breast and Lung Tumors

ResearchPrincipal Investigator · Awarded by Rsna Research & Education Fund · 2014 - 2015

Heat and Radiation Effects on Tumor Microcirculation

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1985 - 2015

Harnessing the power of light to see and treat breast cancer

ResearchInvestigator · Awarded by United States Army Medical Research and Materiel Command · 2009 - 2015

Clinical Oncology Research Career Development Program

ResearchMentor · Awarded by National Institutes of Health · 2009 - 2015

27-hydroxycholesterol as a link between obesity and breast cancer pathogenesis

ResearchCo-Mentor · Awarded by National Institutes of Health · 2013 - 2014

Resveratrol, Carbohydrate Restriction and Prostate Cancer Progression

ResearchInvestigator · Awarded by National Institutes of Health · 2008 - 2014

Truncated GLI1 In Glioblastoma

ResearchCo Investigator · Awarded by National Institutes of Health · 2014 - 2014

Modulation of the blood-tumor barrier through targeted suppression of claudin 5

ResearchMentor · Awarded by National Institutes of Health · 2011 - 2013

Cross-disciplinary Training in Medical Physics

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2007 - 2013

The Use of Hyperthermia and Copper Chelation to Overcome Cisplatin Resistance

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2011 - 2013

Inhibition of metastasis-initiating cells by chimeric polypeptide nanoparticles

ResearchCo-Mentor · Awarded by National Institutes of Health · 2010 - 2012

Can Optical Spectroscopy Predict Early Treatment Response in Solid Tumors

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2010 - 2012

Nuclear EGFR Signaling Network in Human Cancer

ResearchConsultant · Awarded by National Institutes of Health · 2006 - 2012

Molecular mechanisms of chemoresistance in breast cancer

ResearchCollaborator · Awarded by National Institutes of Health · 2010 - 2012

Small Animal PET / CT Molecular Imaging

EquipmentMajor User · Awarded by National Institutes of Health · 2011 - 2012

Investigation of Anti-Angiogenic Mechanisms Using Novel Imaging Techniques

FellowshipMentor · Awarded by US Army Medical Research and Materiel Command · 2009 - 2012

The Role of PTEN in Endothelial Biology

ResearchConsultant · Awarded by National Institutes of Health · 2008 - 2012

Image-Guided Radiation Therapy and Radiosurgery for Small Animals

EquipmentMajor User · Awarded by National Institutes of Health · 2009 - 2011

Hyperthermia and Perfusion Effects in Cancer Therapy

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2005 - 2011

Intravital point-scanning confocal microscope

ResearchMajor User · Awarded by National Institutes of Health · 2010 - 2011

Accurate Models for Predicting Radiation-Induced Injury

ResearchInvestigator · Awarded by National Institutes of Health · 2006 - 2011

Role of XIAP in Therapeutic Resistance in Inflammatory Breast Cancer

FellowshipCo-Mentor · Awarded by Dept. of the Army -- USAMRAA · 2008 - 2010

Research Training In Neuro-Oncology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2005 - 2010

Functional Optical Coherence Tomography for Monitoring Drug Resistance in Cancer

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2009 - 2010

Hyperthermia and Perfusion Effects in Cancer Therapy

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1987 - 2010

Erythropoietin Receptors in Breast Cancer

ResearchCo Investigator · Awarded by National Institutes of Health · 2004 - 2010

Training in Biomolecular and Tissue Engineering

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2003 - 2009

Stem Cell-Like Glioma Cells in Angiogenesis

ResearchConsultant · Awarded by National Institutes of Health · 2008 - 2009

TGFbeta-PTEN Interactions in Glioma Biology & Therapy

ResearchConsultant · Awarded by National Institutes of Health · 2006 - 2008

13th International Congress of Radiation Research

ConferencePrincipal Investigator · Awarded by Department of Energy · 2007 - 2008

13th International Congress of Radiation Research

ConferencePrincipal Investigator · Awarded by National Institutes of Health · 2007 - 2008

Biomarker Studies for Novel Anti-Cancer Agents

ResearchConsultant · Awarded by National Institutes of Health · 2003 - 2008

Noninvasive Monitoring Glutathione Metabolism in Tumors

ResearchConsultant · Awarded by National Institutes of Health · 2006 - 2007

Mechanism of hypoxia mediated radiation lung injury

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2003 - 2007

Activation of Sickle Red Cell Adhesion

ResearchConsultant · Awarded by National Institutes of Health · 2003 - 2007

Imaging Alternative Splicing During Tumor Progression

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2002 - 2007

The Duke University Molecular Imaging Center

ResearchSenior Investigator · Awarded by National Institutes of Health · 2001 - 2006

Mentored Clinical Research Scholar Program

ResearchMentor · Awarded by National Institutes of Health · 2002 - 2006

Hyperthermia-mediated gene therapy approach for cancer

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1999 - 2006

Cancer Immunotherapy Targeting Endothelial Antigens

ResearchInvestigator · Awarded by National Institutes of Health · 2003 - 2006

The Role of Glucose Metabolism on Tumor PO2

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2006

The Role of Glucose and O2 Transport on Tumor PO2

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2000 - 2006

Antiestrogenic Effects on Tumor Angiogenesis

FellowshipSponsor · Awarded by National Institutes of Health · 2001 - 2006

Measurement of Hypoxia in Non-Small Cell Lung Carcinoma

ResearchInvestigator · Awarded by National Institutes of Health · 2002 - 2006

New Clinical Biomarker for Cancer--Wound Angiogenesis

ResearchMentor · Awarded by National Institutes of Health · 2000 - 2006

Cell Viability in Implantable Diffusion Chambers

ResearchCollaborator · Awarded by National Institutes of Health · 2000 - 2005

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ResearchCollaborator · Awarded by National Institutes of Health · 1999 - 2005

TIE2-Associated Molecular Targets in Tumor Vasculature

ResearchCo Investigator · Awarded by National Institutes of Health · 2002 - 2005

Upgrade of a Shared Instrumentation Resource in the PSOE: The Laser Scanning Confocal Microscope

EquipmentCo-Principal Investigator · Awarded by Lord Foundation of North Carolina · 2002 - 2005

Molecular Imaging Center Planning Grant

ResearchCo Investigator · Awarded by National Institutes of Health · 2000 - 2004

Heat and Radiation Effects on Tumor Microcirculation

ResearchPrincipal Investigator · Awarded by National Cancer Institute · 1985 - 2004

Hyperglycemia and Oxygen Breathing in Head & Neck Cancer

ResearchCo Investigator · Awarded by National Institutes of Health · 2000 - 2004

Methods To Improve Camptothecan-Based Chemotherapy

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1998 - 2001

Predicting Human Tumor Response by 31p MRS

ResearchCo Investigator · Awarded by National Institutes of Health · 1995 - 2001

Impaired Leukocyte/Endothelium Interactions In Tumors

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1997 - 2000

Hyperthermia And Perfusion Effects In Cancer Therapy

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1997 - 1999

Hyperthermia And Perfusion Effects In Cancer Therapy

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1995 - 1999

Hyperthermia And Perfusion Effects In Cancer Therapy

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1987 - 1999

Tek Kinase And Breast Tunor Angiogenesis

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1995 - 1999

Heat & Radiation Effects On Tumor Microcirculation

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1997 - 1999

Effects Of Heat And Radiation On Tumor

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1996 - 1999

Astatine And Iodine Radiolabeled Monoclonal Antibodies

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1994 - 1999

Astatine And Iodine Radiolabeled Monoclonal Antibodies

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1993 - 1999

Astatine And Iodine Radiolabeled Monoclonal Antibodies

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1985 - 1999

Comprehensive Cancer Center Core Support Grant

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1976 - 1998

Comprehensive Cancer Center Core Support Grant

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1976 - 1998

Cancer Center Core Support Grant

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1976 - 1998

Spore In Breast Cancer

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1995 - 1998

Spore In Breast Cancer

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1995 - 1998

Spore In Breast Cancer

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1995 - 1998

Tek Kinase And Breast Tumor Angiogenesis

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1995 - 1998

Effects Of Heat And Radiation On Tumor Microcirculation

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1994 - 1996

Effects Of Heat And Radiation On Tumor Microcirculation

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1985 - 1996

Hyperthermia And Perfusion Effects In Cancer Therapy

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1993 - 1995

Hyperthermia & Perfusion Effects In Cancer Therapy

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1990 - 1995

Heat And Radiation Effects In Tumor Microcirculation

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1992 - 1993

Response Of Canine Tumors To Nonstandard Fractionation

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1987 - 1988

Heat And Readiation Effects In Tumor Microcirculation

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1986 - 1987

Heat And Radiaition Effects In Tumor Microcirculation

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1984 - 1985