Scholars@Duke
Mark Wesley Dewhirst

Mark Wesley Dewhirst

Gustavo S. Montana Distinguished Professor Emeritus of Radiation Oncology
Radiation Oncology
mark.dewhirst@duke.edu
Box 3455 Med Ctr, Durham, NC 27710
201 Med Sci Res Bldg, Research Drive, Durham, NC 27710

Selected Grants

Proteomic Signatures of Space Radiation Induced Cardiovascular Degeneration

ResearchCo Investigator · Awarded by National Aeronautics and Space Administration · 2016 - 2022

Preclinical Oxygen Imager to Model Efficient Cancer Treatment

ResearchCollaborator · Awarded by O2M Technologies, LLC · 2019 - 2021

Role of RBC Reactive Oxygen Species and Their Vicious Cycle in Sickle Vasculopathy

ResearchAdvisor · Awarded by National Institutes of Health · 2017 - 2021

Systemically administrered EGRFvIII-targeted bispecific antibody as an immunotherapeutic for glioblastoma.

FellowshipCollaborator · Awarded by National Institutes of Health · 2015 - 2019

Dissecting mechanism(s) by which ionizing radiation promotes clonal expansion of premalignant cells in the thymus

ResearchCollaborator · Awarded by National Institutes of Health · 2016 - 2018

Duke CTSA (UL1)

ResearchProgram Director · Awarded by National Institutes of Health · 2013 - 2018

Optimization of radiofrequency ablation with electrically conductive particles

ResearchCollaborator · Awarded by National Institutes of Health · 2015 - 2018

The role of ERRalpha/PGC-1 in disease pathogenesis

ResearchCo Investigator · Awarded by National Institutes of Health · 2006 - 2018

Luminescent Oxygen Nanosensors for Tumor Hypoxia Imaging

ResearchPrincipal Investigator · Awarded by University of Virginia - Charlottesville · 2012 - 2017

Effects of Exercise Training on Tumor Growth in Triple Negative Breast Cancer

ResearchPrincipal Investigator · Awarded by Memorial Sloan-Kettering Cancer Center · 2014 - 2017

A Quantitative Optical Sensor to Monitor Tumor Vascular Physiology

ResearchPrincipal Investigator · Awarded by Zenalux Biomedical, Inc. · 2015 - 2016

Janssen Research AGreement

ResearchPrincipal Investigator · Awarded by Janssen Research & Development, LLC · 2014 - 2016

HIF-1 driven therapeutic resistance mechanisms in chest wall recurrences of inflammatory breast cancer (IBC)

ResearchPrincipal Investigator · Awarded by Inflammatory Breast Cancer Research Foundation · 2013 - 2016

Targeting nuclear FGF receptor to improve chemotherapy response in triple-negative breast cancer

ResearchInvestigator · Awarded by Department of Defense · 2013 - 2016

Research Training In Neuro-Oncology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1998 - 2016

Thermally Triggered Multivalent Targeting of Tumors

ResearchCo Investigator · Awarded by National Institutes of Health · 2007 - 2016

BMX-001 as a Radio-Protector in Head and Neck Cancer Therapy

ResearchPrincipal Investigator · Awarded by BioMimetix Pharmaceutical, Inc. · 2015 - 2016

Thermally Targeted Drug Delivery by Elastin Biopolymers

ResearchCo Investigator · Awarded by National Institutes of Health · 2002 - 2016

Cancer Biology Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Cancer Institute · 1993 - 2016

Radiation Therapy: Dissecting the Role of Stromal Cells in Tumor Control

ResearchCollaborator · Awarded by National Institutes of Health · 2013 - 2016

Detection of Novel Alternative Splicing Biomarkers of Hypoxia in Breast and Lung Tumors

ResearchPrincipal Investigator · Awarded by Rsna Research & Education Fund · 2014 - 2015

Heat and Radiation Effects on Tumor Microcirculation

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1985 - 2015

Harnessing the power of light to see and treat breast cancer

ResearchInvestigator · Awarded by United States Army Medical Research and Materiel Command · 2009 - 2015

Clinical Oncology Research Career Development Program

ResearchMentor · Awarded by National Institutes of Health · 2009 - 2015

27-hydroxycholesterol as a link between obesity and breast cancer pathogenesis

ResearchCo-Mentor · Awarded by National Institutes of Health · 2013 - 2014

Resveratrol, Carbohydrate Restriction and Prostate Cancer Progression

ResearchInvestigator · Awarded by National Institutes of Health · 2008 - 2014

Truncated GLI1 In Glioblastoma

ResearchCo Investigator · Awarded by National Institutes of Health · 2014 - 2014

Modulation of the blood-tumor barrier through targeted suppression of claudin 5

ResearchMentor · Awarded by National Institutes of Health · 2011 - 2013

Cross-disciplinary Training in Medical Physics

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2007 - 2013

The Use of Hyperthermia and Copper Chelation to Overcome Cisplatin Resistance

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2011 - 2013

Inhibition of metastasis-initiating cells by chimeric polypeptide nanoparticles

ResearchCo-Mentor · Awarded by National Institutes of Health · 2010 - 2012

Can Optical Spectroscopy Predict Early Treatment Response in Solid Tumors

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2010 - 2012

Nuclear EGFR Signaling Network in Human Cancer

ResearchConsultant · Awarded by National Institutes of Health · 2006 - 2012

Molecular mechanisms of chemoresistance in breast cancer

ResearchCollaborator · Awarded by National Institutes of Health · 2010 - 2012

Small Animal PET / CT Molecular Imaging

EquipmentMajor User · Awarded by National Institutes of Health · 2011 - 2012

Investigation of Anti-Angiogenic Mechanisms Using Novel Imaging Techniques

FellowshipMentor · Awarded by US Army Medical Research and Materiel Command · 2009 - 2012

The Role of PTEN in Endothelial Biology

ResearchConsultant · Awarded by National Institutes of Health · 2008 - 2012

Image-Guided Radiation Therapy and Radiosurgery for Small Animals

EquipmentMajor User · Awarded by National Institutes of Health · 2009 - 2011

Hyperthermia and Perfusion Effects in Cancer Therapy

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2005 - 2011

Intravital point-scanning confocal microscope

ResearchMajor User · Awarded by National Institutes of Health · 2010 - 2011

Accurate Models for Predicting Radiation-Induced Injury

ResearchInvestigator · Awarded by National Institutes of Health · 2006 - 2011

Role of XIAP in Therapeutic Resistance in Inflammatory Breast Cancer

FellowshipCo-Mentor · Awarded by Dept. of the Army -- USAMRAA · 2008 - 2010

Research Training In Neuro-Oncology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2005 - 2010

Functional Optical Coherence Tomography for Monitoring Drug Resistance in Cancer

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2009 - 2010

Hyperthermia and Perfusion Effects in Cancer Therapy

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1987 - 2010

Erythropoietin Receptors in Breast Cancer

ResearchCo Investigator · Awarded by National Institutes of Health · 2004 - 2010

Training in Biomolecular and Tissue Engineering

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2003 - 2009

Stem Cell-Like Glioma Cells in Angiogenesis

ResearchConsultant · Awarded by National Institutes of Health · 2008 - 2009

TGFbeta-PTEN Interactions in Glioma Biology & Therapy

ResearchConsultant · Awarded by National Institutes of Health · 2006 - 2008

13th International Congress of Radiation Research

ConferencePrincipal Investigator · Awarded by Department of Energy · 2007 - 2008

13th International Congress of Radiation Research

ConferencePrincipal Investigator · Awarded by National Institutes of Health · 2007 - 2008

Biomarker Studies for Novel Anti-Cancer Agents

ResearchConsultant · Awarded by National Institutes of Health · 2003 - 2008

Noninvasive Monitoring Glutathione Metabolism in Tumors

ResearchConsultant · Awarded by National Institutes of Health · 2006 - 2007

Mechanism of hypoxia mediated radiation lung injury

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2003 - 2007

Activation of Sickle Red Cell Adhesion

ResearchConsultant · Awarded by National Institutes of Health · 2003 - 2007

Imaging Alternative Splicing During Tumor Progression

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2002 - 2007

The Duke University Molecular Imaging Center

ResearchSenior Investigator · Awarded by National Institutes of Health · 2001 - 2006

Mentored Clinical Research Scholar Program

ResearchMentor · Awarded by National Institutes of Health · 2002 - 2006

Hyperthermia-mediated gene therapy approach for cancer

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1999 - 2006

Cancer Immunotherapy Targeting Endothelial Antigens

ResearchInvestigator · Awarded by National Institutes of Health · 2003 - 2006

The Role of Glucose Metabolism on Tumor PO2

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2006

The Role of Glucose and O2 Transport on Tumor PO2

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2000 - 2006

Antiestrogenic Effects on Tumor Angiogenesis

FellowshipSponsor · Awarded by National Institutes of Health · 2001 - 2006

Measurement of Hypoxia in Non-Small Cell Lung Carcinoma

ResearchInvestigator · Awarded by National Institutes of Health · 2002 - 2006

New Clinical Biomarker for Cancer--Wound Angiogenesis

ResearchMentor · Awarded by National Institutes of Health · 2000 - 2006

Cell Viability in Implantable Diffusion Chambers

ResearchCollaborator · Awarded by National Institutes of Health · 2000 - 2005

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ResearchCollaborator · Awarded by National Institutes of Health · 1999 - 2005

TIE2-Associated Molecular Targets in Tumor Vasculature

ResearchCo Investigator · Awarded by National Institutes of Health · 2002 - 2005

Upgrade of a Shared Instrumentation Resource in the PSOE: The Laser Scanning Confocal Microscope

EquipmentCo-Principal Investigator · Awarded by Lord Foundation of North Carolina · 2002 - 2005

Molecular Imaging Center Planning Grant

ResearchCo Investigator · Awarded by National Institutes of Health · 2000 - 2004

Heat and Radiation Effects on Tumor Microcirculation

ResearchPrincipal Investigator · Awarded by National Cancer Institute · 1985 - 2004

Hyperglycemia and Oxygen Breathing in Head & Neck Cancer

ResearchCo Investigator · Awarded by National Institutes of Health · 2000 - 2004

Methods To Improve Camptothecan-Based Chemotherapy

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1998 - 2001

Predicting Human Tumor Response by 31p MRS

ResearchCo Investigator · Awarded by National Institutes of Health · 1995 - 2001

Impaired Leukocyte/Endothelium Interactions In Tumors

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1997 - 2000

Hyperthermia And Perfusion Effects In Cancer Therapy

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1997 - 1999

Hyperthermia And Perfusion Effects In Cancer Therapy

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1995 - 1999

Hyperthermia And Perfusion Effects In Cancer Therapy

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1987 - 1999

Tek Kinase And Breast Tunor Angiogenesis

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1995 - 1999

Heat & Radiation Effects On Tumor Microcirculation

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1997 - 1999

Effects Of Heat And Radiation On Tumor

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1996 - 1999

Astatine And Iodine Radiolabeled Monoclonal Antibodies

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1994 - 1999

Astatine And Iodine Radiolabeled Monoclonal Antibodies

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1993 - 1999

Astatine And Iodine Radiolabeled Monoclonal Antibodies

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1985 - 1999

Cancer Center Core Support Grant

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1976 - 1998

Comprehensive Cancer Center Core Support Grant

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1976 - 1998

Comprehensive Cancer Center Core Support Grant

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1976 - 1998

Spore In Breast Cancer

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1995 - 1998

Spore In Breast Cancer

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1995 - 1998

Spore In Breast Cancer

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1995 - 1998

Tek Kinase And Breast Tumor Angiogenesis

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1995 - 1998

Effects Of Heat And Radiation On Tumor Microcirculation

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1994 - 1996

Effects Of Heat And Radiation On Tumor Microcirculation

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1985 - 1996

Hyperthermia And Perfusion Effects In Cancer Therapy

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1993 - 1995

Hyperthermia & Perfusion Effects In Cancer Therapy

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1990 - 1995

Heat And Radiation Effects In Tumor Microcirculation

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1992 - 1993

Response Of Canine Tumors To Nonstandard Fractionation

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1987 - 1988

Heat And Readiation Effects In Tumor Microcirculation

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1986 - 1987

Heat And Radiaition Effects In Tumor Microcirculation

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1984 - 1985