Skip to main content

Mark Wesley Dewhirst

Gustavo S. Montana Distinguished Professor Emeritus of Radiation Oncology
Radiation Oncology
Box 3455 Med Ctr, Durham, NC 27710
201 Med Sci Res Bldg, Research Drive, Durham, NC 27710

Selected Publications


Announcement of leadership transition

Journal Article International Journal of Hyperthermia · January 1, 2024 Full text Cite

Supplementary Table S1 from Long-term Consequences of Pelvic Irradiation: Toxicities, Challenges, and Therapeutic Opportunities with Pharmacologic Mitigators

Other · March 31, 2023 <p>Summary of Patient Related Factors Associated with Pelvic Radiation Disease</p> ... Full text Cite

Data from Long-term Consequences of Pelvic Irradiation: Toxicities, Challenges, and Therapeutic Opportunities with Pharmacologic Mitigators

Other · March 31, 2023 <div>Abstract<p>A percentage of long-term cancer survivors who receive pelvic irradiation will develop treatment-related late effects, collectively termed pelvic radiation disease. Thus, there is a need to prevent or ameliorate treatmen ... Full text Cite

Supplementary Table S1 from Long-term Consequences of Pelvic Irradiation: Toxicities, Challenges, and Therapeutic Opportunities with Pharmacologic Mitigators

Other · March 31, 2023 <p>Summary of Patient Related Factors Associated with Pelvic Radiation Disease</p> ... Full text Cite

Data from Long-term Consequences of Pelvic Irradiation: Toxicities, Challenges, and Therapeutic Opportunities with Pharmacologic Mitigators

Other · March 31, 2023 <div>Abstract<p>A percentage of long-term cancer survivors who receive pelvic irradiation will develop treatment-related late effects, collectively termed pelvic radiation disease. Thus, there is a need to prevent or ameliorate treatmen ... Full text Cite

Translating energy balance research from the bench to the clinic to the community: Parallel animal-human studies in cancer.

Journal Article CA Cancer J Clin · 2023 Advances in energy balance and cancer research to date have largely occurred in siloed work in rodents or patients. However, substantial benefit can be derived from parallel studies in which animal models inform the design of clinical and population studie ... Full text Link to item Cite

Editors' awardees for 2023.

Journal Article Int J Hyperthermia · 2023 Full text Link to item Cite

Quantifying the effects of anesthesia on intracellular oxygen via low-cost portable microscopy using dual-emissive nanoparticles.

Journal Article Biomed Opt Express · July 1, 2022 Intracellular oxygenation is an important parameter for numerous biological studies. While there are a variety of methods available for acquiring in vivo measurements of oxygenation in animal models, most are dependent on indirect oxygen measurements, rest ... Full text Link to item Cite

Late onset cardiovascular dysfunction in adult mice resulting from galactic cosmic ray exposure.

Journal Article iScience · April 15, 2022 The complex and inaccessible space radiation environment poses an unresolved risk to astronaut cardiovascular health during long-term space exploration missions. To model this risk, healthy male c57BL/6 mice aged six months (corresponding to an astronaut o ... Full text Link to item Cite

Accurate Three-Dimensional Thermal Dosimetry and Assessment of Physiologic Response Are Essential for Optimizing Thermoradiotherapy.

Journal Article Cancers (Basel) · March 27, 2022 Numerous randomized trials have revealed that hyperthermia (HT) + radiotherapy or chemotherapy improves local tumor control, progression free and overall survival vs. radiotherapy or chemotherapy alone. Despite these successes, however, some individuals fa ... Full text Link to item Cite

Immunologic Effects of Stereotactic Body Radiotherapy in Dogs with Spontaneous Tumors and the Impact of Intratumoral OX40/TLR Agonist Immunotherapy.

Journal Article Int J Mol Sci · January 13, 2022 Stereotactic body radiotherapy (SBRT) is known to induce important immunologic changes within the tumor microenvironment (TME). However, little is known regarding the early immune responses within the TME in the first few weeks following SBRT. Therefore, w ... Full text Link to item Cite

Characterization and initial demonstration of in vivo efficacy of a novel heat-activated metalloenediyne anti-cancer agent.

Journal Article Int J Hyperthermia · 2022 BACKGROUND: Enediynes are anti-cancer agents that are highly cytotoxic due to their propensity for low thermal activation of radical generation. The diradical intermediate produced from Bergman cyclization of the enediyne moiety may induce DNA damage and c ... Full text Link to item Cite

Editors' awardees for 2022.

Journal Article Int J Hyperthermia · 2022 Full text Link to item Cite

Drug development of lyso-thermosensitive liposomal doxorubicin: Combining hyperthermia and thermosensitive drug delivery.

Journal Article Adv Drug Deliv Rev · November 2021 We review the drug development of lyso-thermosensitive liposomal doxorubicin (LTLD) which is the first heat-activated formulation of a liposomal drug carrier to be utilized in human clinical trials. This class of compounds is designed to carry a payload of ... Full text Link to item Cite

Manganese Porphyrin and Radiotherapy Improves Local Tumor Response and Overall Survival in Orthotopic Murine Mammary Carcinoma Models.

Journal Article Radiat Res · February 1, 2021 Novel synthetic compounds, known as manganese porphyrins (MnPs), have been designed to shift the redox status of both normal cells and cancer cells. When MnPs are coupled with cancer therapies, such as radiation, they have been shown to sensitize tumor cel ... Full text Link to item Cite

Polymer-assisted intratumoral delivery of ethanol: Preclinical investigation of safety and efficacy in a murine breast cancer model.

Journal Article PLoS One · 2021 Focal tumor ablation with ethanol could provide benefits in low-resource settings because of its low overall cost, minimal imaging technology requirements, and acceptable clinical outcomes. Unfortunately, ethanol ablation is not commonly utilized because o ... Full text Link to item Cite

Editors' awardees for 2021.

Journal Article Int J Hyperthermia · 2021 Full text Link to item Cite

Imaging Hypoxia

Chapter · January 1, 2021 Hypoxia is a well-established pathophysiologic feature of solid tumors that has demonstrated links to poor prognosis. It is a direct cause of radioresistance and also contributes to chemoresistance. In addition, it is immunosuppressive. Given these pleiotr ... Full text Cite

Cyclic Hypoxia: An Update on Its Characteristics, Methods to Measure It and Biological Implications in Cancer.

Journal Article Cancers (Basel) · December 23, 2020 Regions of hypoxia occur in most if not all solid cancers. Although the presence of tumor hypoxia is a common occurrence, the levels of hypoxia and proportion of the tumor that are hypoxic vary significantly. Importantly, even within tumors, oxygen levels ... Full text Link to item Cite

Announcement of leadership transition

Journal Article International Journal of Hyperthermia · January 1, 2024 Full text Cite

Supplementary Table S1 from Long-term Consequences of Pelvic Irradiation: Toxicities, Challenges, and Therapeutic Opportunities with Pharmacologic Mitigators

Other · March 31, 2023 <p>Summary of Patient Related Factors Associated with Pelvic Radiation Disease</p> ... Full text Cite

Data from Long-term Consequences of Pelvic Irradiation: Toxicities, Challenges, and Therapeutic Opportunities with Pharmacologic Mitigators

Other · March 31, 2023 <div>Abstract<p>A percentage of long-term cancer survivors who receive pelvic irradiation will develop treatment-related late effects, collectively termed pelvic radiation disease. Thus, there is a need to prevent or ameliorate treatmen ... Full text Cite

Supplementary Table S1 from Long-term Consequences of Pelvic Irradiation: Toxicities, Challenges, and Therapeutic Opportunities with Pharmacologic Mitigators

Other · March 31, 2023 <p>Summary of Patient Related Factors Associated with Pelvic Radiation Disease</p> ... Full text Cite

Data from Long-term Consequences of Pelvic Irradiation: Toxicities, Challenges, and Therapeutic Opportunities with Pharmacologic Mitigators

Other · March 31, 2023 <div>Abstract<p>A percentage of long-term cancer survivors who receive pelvic irradiation will develop treatment-related late effects, collectively termed pelvic radiation disease. Thus, there is a need to prevent or ameliorate treatmen ... Full text Cite

Translating energy balance research from the bench to the clinic to the community: Parallel animal-human studies in cancer.

Journal Article CA Cancer J Clin · 2023 Advances in energy balance and cancer research to date have largely occurred in siloed work in rodents or patients. However, substantial benefit can be derived from parallel studies in which animal models inform the design of clinical and population studie ... Full text Link to item Cite

Editors' awardees for 2023.

Journal Article Int J Hyperthermia · 2023 Full text Link to item Cite

Quantifying the effects of anesthesia on intracellular oxygen via low-cost portable microscopy using dual-emissive nanoparticles.

Journal Article Biomed Opt Express · July 1, 2022 Intracellular oxygenation is an important parameter for numerous biological studies. While there are a variety of methods available for acquiring in vivo measurements of oxygenation in animal models, most are dependent on indirect oxygen measurements, rest ... Full text Link to item Cite

Late onset cardiovascular dysfunction in adult mice resulting from galactic cosmic ray exposure.

Journal Article iScience · April 15, 2022 The complex and inaccessible space radiation environment poses an unresolved risk to astronaut cardiovascular health during long-term space exploration missions. To model this risk, healthy male c57BL/6 mice aged six months (corresponding to an astronaut o ... Full text Link to item Cite

Accurate Three-Dimensional Thermal Dosimetry and Assessment of Physiologic Response Are Essential for Optimizing Thermoradiotherapy.

Journal Article Cancers (Basel) · March 27, 2022 Numerous randomized trials have revealed that hyperthermia (HT) + radiotherapy or chemotherapy improves local tumor control, progression free and overall survival vs. radiotherapy or chemotherapy alone. Despite these successes, however, some individuals fa ... Full text Link to item Cite

Immunologic Effects of Stereotactic Body Radiotherapy in Dogs with Spontaneous Tumors and the Impact of Intratumoral OX40/TLR Agonist Immunotherapy.

Journal Article Int J Mol Sci · January 13, 2022 Stereotactic body radiotherapy (SBRT) is known to induce important immunologic changes within the tumor microenvironment (TME). However, little is known regarding the early immune responses within the TME in the first few weeks following SBRT. Therefore, w ... Full text Link to item Cite

Characterization and initial demonstration of in vivo efficacy of a novel heat-activated metalloenediyne anti-cancer agent.

Journal Article Int J Hyperthermia · 2022 BACKGROUND: Enediynes are anti-cancer agents that are highly cytotoxic due to their propensity for low thermal activation of radical generation. The diradical intermediate produced from Bergman cyclization of the enediyne moiety may induce DNA damage and c ... Full text Link to item Cite

Editors' awardees for 2022.

Journal Article Int J Hyperthermia · 2022 Full text Link to item Cite

Drug development of lyso-thermosensitive liposomal doxorubicin: Combining hyperthermia and thermosensitive drug delivery.

Journal Article Adv Drug Deliv Rev · November 2021 We review the drug development of lyso-thermosensitive liposomal doxorubicin (LTLD) which is the first heat-activated formulation of a liposomal drug carrier to be utilized in human clinical trials. This class of compounds is designed to carry a payload of ... Full text Link to item Cite

Manganese Porphyrin and Radiotherapy Improves Local Tumor Response and Overall Survival in Orthotopic Murine Mammary Carcinoma Models.

Journal Article Radiat Res · February 1, 2021 Novel synthetic compounds, known as manganese porphyrins (MnPs), have been designed to shift the redox status of both normal cells and cancer cells. When MnPs are coupled with cancer therapies, such as radiation, they have been shown to sensitize tumor cel ... Full text Link to item Cite

Polymer-assisted intratumoral delivery of ethanol: Preclinical investigation of safety and efficacy in a murine breast cancer model.

Journal Article PLoS One · 2021 Focal tumor ablation with ethanol could provide benefits in low-resource settings because of its low overall cost, minimal imaging technology requirements, and acceptable clinical outcomes. Unfortunately, ethanol ablation is not commonly utilized because o ... Full text Link to item Cite

Editors' awardees for 2021.

Journal Article Int J Hyperthermia · 2021 Full text Link to item Cite

Imaging Hypoxia

Chapter · January 1, 2021 Hypoxia is a well-established pathophysiologic feature of solid tumors that has demonstrated links to poor prognosis. It is a direct cause of radioresistance and also contributes to chemoresistance. In addition, it is immunosuppressive. Given these pleiotr ... Full text Cite

Cyclic Hypoxia: An Update on Its Characteristics, Methods to Measure It and Biological Implications in Cancer.

Journal Article Cancers (Basel) · December 23, 2020 Regions of hypoxia occur in most if not all solid cancers. Although the presence of tumor hypoxia is a common occurrence, the levels of hypoxia and proportion of the tumor that are hypoxic vary significantly. Importantly, even within tumors, oxygen levels ... Full text Link to item Cite

Dual-emissive, oxygen-sensing boron nanoparticles quantify oxygen consumption rate in breast cancer cells.

Journal Article J Biomed Opt · November 2020 SIGNIFICANCE: Decreasing the oxygen consumption rate (OCR) of tumor cells is a powerful method for ameliorating tumor hypoxia. However, quantifying the change in OCR is challenging in complex experimental systems. AIM: We present a method for quantifying t ... Full text Open Access Link to item Cite

Psoralen Derivatives with Enhanced Potency.

Journal Article Photochem Photobiol · September 2020 Psoralen is a furocoumarin natural product that intercalates within DNA and forms covalent adducts when activated by ultraviolet radiation. It is well known that this property contributes to psoralen's clinical efficacy in several disease contexts, which i ... Full text Link to item Cite

Long-term Consequences of Pelvic Irradiation: Toxicities, Challenges, and Therapeutic Opportunities with Pharmacologic Mitigators.

Journal Article Clin Cancer Res · July 1, 2020 A percentage of long-term cancer survivors who receive pelvic irradiation will develop treatment-related late effects, collectively termed pelvic radiation disease. Thus, there is a need to prevent or ameliorate treatment-related late effects in these pati ... Full text Link to item Cite

Transitioning from Gamma Rays to X Rays for Comparable Biomedical Research Irradiations: Energy Matters.

Journal Article Radiat Res · June 1, 2020 Many studies in biomedical research and various allied fields, in which cells or laboratory animals are exposed to radiation, rely on adequate radiation dose standardization for reproducibility and comparability of biological data. Due to increasing concer ... Full text Link to item Cite

A New Assay to Measure Intestinal Crypt Survival after Irradiation: Challenges and Opportunities.

Journal Article Cancer Res · March 1, 2020 Radiotherapy is a critical component of many current, curative cancer treatments, yet it is accompanied by unavoidable irradiation of normal tissues. Abdominal and pelvic radiation almost always results in some dose delivered to the bowel with deleterious ... Full text Link to item Cite

Editors' awardees for 2020.

Journal Article Int J Hyperthermia · 2020 Full text Link to item Cite

Cherenkov emissions for studying tumor changes during radiation therapy: An exploratory study in domesticated dogs with naturally-occurring cancer.

Journal Article PLoS One · 2020 PURPOSE: Real-time monitoring of physiological changes of tumor tissue during radiation therapy (RT) could improve therapeutic efficacy and predict therapeutic outcomes. Cherenkov radiation is a normal byproduct of radiation deposited in tissue. Previous s ... Full text Open Access Link to item Cite

Radiofrequency Ablation Duration per Tumor Volume May Correlate with Overall Survival in Solitary Hepatocellular Carcinoma Patients Treated with Radiofrequency Ablation Plus Lyso-Thermosensitive Liposomal Doxorubicin.

Journal Article J Vasc Interv Radiol · December 2019 PURPOSE: To determine whether burn time per tumor volume (BPV) (min/mL), where burn time is the total time during which radiofrequency (RF) energy is being applied, is correlated with hepatocellular carcinoma (HCC) treatment outcomes using RF ablation and ... Full text Link to item Cite

Mechanism-Specific Pharmacodynamics of a Novel Complex-I Inhibitor Quantified by Imaging Reversal of Consumptive Hypoxia with [18F]FAZA PET In Vivo.

Journal Article Cells · November 21, 2019 Tumors lack a well-regulated vascular supply of O2 and often fail to balance O2 supply and demand. Net O2 tension within many tumors may not only depend on O2 delivery but also depend strongly on O2 demand. Thus, tumor O2 consumption rates may influence tu ... Full text Link to item Cite

Comparative Approach to the Temporo-Spatial Organization of the Tumor Microenvironment

Journal Article Frontiers in Oncology · November 7, 2019 The complex ecosystem in which tumor cells reside and interact, termed the tumor microenvironment (TME), encompasses all cells and components associated with a neoplasm that are not transformed cells. Interactions between tumor cells and the TME are comple ... Full text Open Access Cite

E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms.

Journal Article Mol Cancer Res · June 2019 CDH1 (also known as E-cadherin), an epithelial-specific cell-cell adhesion molecule, plays multiple roles in maintaining adherens junctions, regulating migration and invasion, and mediating intracellular signaling. Downregulation of E-cadherin is a hallmar ... Full text Link to item Cite

Can Exercise-Induced Modulation of the Tumor Physiologic Microenvironment Improve Antitumor Immunity?

Journal Article Cancer Res · May 15, 2019 The immune system plays an important role in controlling cancer growth. However, cancers evolve to evade immune detection. Immune tolerance and active immune suppression results in unchecked cancer growth and progression. A major contributor to immune tole ... Full text Link to item Cite

Clarifying the Relative Impacts of Vascular and Nerve Injury That Culminate in Erectile Dysfunction in a Pilot Study Using a Rat Model of Prostate Irradiation and a Thrombopoietin Mimetic.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2019 PURPOSE: Radiation therapy (RT) offers an important and curative approach to treating prostate cancer, but it is associated with a high incidence of erectile dysfunction (ED). It is not clear whether the etiology of radiation-induced ED (RI-ED) is driven b ... Full text Link to item Cite

Simultaneous in vivo optical quantification of key metabolic and vascular endpoints reveals tumor metabolic diversity in murine breast tumor models.

Journal Article J Biophotonics · April 2019 Therapeutically exploiting vascular and metabolic endpoints becomes critical to translational cancer studies because altered vascularity and deregulated metabolism are two important cancer hallmarks. The metabolic and vascular phenotypes of three sibling b ... Full text Link to item Cite

A new photogrammetric system for high-precision monitoring of tunnel deformations

Journal Article Proceedings of the Institution of Civil Engineers - Transport · April 2019 A new photogrammetric system has been developed to monitor tunnel deformations with high precision. The system fundamentally applies digital image correlation techniques to process images. It is digital in nature and is compatible with the industr ... Full text Cite

Exercise as Adjunct Therapy in Cancer.

Journal Article Semin Radiat Oncol · January 2019 Data from observational studies indicate that both physical activity as well as exercise (ie, structured physical activity) is associated with reductions in the risk of recurrence and cancer mortality after a diagnosis of certain forms of cancer. Emerging ... Full text Link to item Cite

Clinical and Pre-clinical Methods for Quantifying Tumor Hypoxia.

Journal Article Adv Exp Med Biol · 2019 Hypoxia, a prevalent characteristic of most solid malignant tumors, contributes to diminished therapeutic responses and more aggressive phenotypes. The term hypoxia has two definitions. One definition would be a physiologic state where the oxygen partial p ... Full text Link to item Cite

Development and Preliminary Evaluation of a Murine Model of Chronic Radiation-Induced Proctitis.

Journal Article Int J Radiat Oncol Biol Phys · August 1, 2018 PURPOSE: Radiotherapy (RT) is commonly used to treat most pelvic malignancies. While treatment is often effective, curative radiation doses to the rectum can result in chronic radiation-induced proctitis, which is characterized by diarrhea, tenesmus, and/o ... Full text Link to item Cite

Application of a Novel Murine Ear Vein Model to Evaluate the Effects of a Vascular Radioprotectant on Radiation-Induced Vascular Permeability and Leukocyte Adhesion.

Journal Article Radiat Res · July 2018 Vascular injury after radiation exposure contributes to multiple types of tissue injury through a cascade of events. Some of the earliest consequences of radiation damage include increased vascular permeability and promotion of inflammation, which is parti ... Full text Link to item Cite

Near-simultaneous quantification of glucose uptake, mitochondrial membrane potential, and vascular parameters in murine flank tumors using quantitative diffuse reflectance and fluorescence spectroscopy.

Journal Article Biomed Opt Express · July 1, 2018 The shifting metabolic landscape of aggressive tumors, with fluctuating oxygenation conditions and temporal changes in glycolysis and mitochondrial metabolism, is a critical phenomenon to study in order to understand negative treatment outcomes. Recently, ... Full text Link to item Cite

In Reply to Pratx and Kapp.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2018 Full text Link to item Cite

Assessing effects of pressure on tumor and normal tissue physiology using an automated self-calibrated, pressure-sensing probe for diffuse reflectance spectroscopy.

Journal Article J Biomed Opt · May 2018 Diffuse reflectance spectroscopy (DRS) represents a quantitative, noninvasive, nondestructive means of assessing vascular oxygenation, vascularity, and structural properties. However, it is known that such measurements can be influenced by the effects of p ... Full text Link to item Cite

Metaboloptics: Visualization of the tumor functional landscape via metabolic and vascular imaging.

Journal Article Sci Rep · March 8, 2018 Many cancers adeptly modulate metabolism to thrive in fluctuating oxygen conditions; however, current tools fail to image metabolic and vascular endpoints at spatial resolutions needed to visualize these adaptations in vivo. We demonstrate a high-resolutio ... Full text Link to item Cite

Enhancing Radiation Therapy Through Cherenkov Light-Activated Phototherapy.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2018 PURPOSE: This work investigates a new approach to enhance radiotherapy through a photo therapeutic agent activated by Cherenkov light produced from the megavoltage photon beam. The process is termed Radiotherapy Enhanced with Cherenkov photo-Activation (RE ... Full text Open Access Link to item Cite

Concurrent tracking of anatomy and metabolism.

Journal Article Nat Biomed Eng · February 2018 Full text Link to item Cite

Nanoparticle formulation improves doxorubicin efficacy by enhancing host antitumor immunity.

Journal Article J Control Release · January 10, 2018 Strategies that enhance the host antitumor immune response promise to revolutionize cancer therapy. Optimally mobilizing the immune system will likely require a multi-pronged approach to overcome the resistance developed by tumors to therapy. Recently, it ... Full text Link to item Cite

Non-invasive, simultaneous quantification of vascular oxygenation, glucose uptake and mitochondria membrane potential in a flank tumor model

Conference Optics InfoBase Conference Papers · January 1, 2018 For the first time, we performed simultaneous in vivo spectroscopy of tissue hemoglobin, 2-NBDG, and TMRE in a preclinical model, to successfully capture vascular and metabolic parameters in vivo in solid tumors. ... Full text Cite

Exercise inhibits tumor growth and central carbon metabolism in patient-derived xenograft models of colorectal cancer.

Journal Article Cancer & metabolism · January 2018 BackgroundWhile self-reported exercise is associated with a reduction in the risk of recurrence in colorectal cancer, the molecular mechanisms underpinning this relationship are unknown. Furthermore, the effect of exercise on intratumoral metaboli ... Full text Cite

Distinct Angiogenic Changes during Carcinogenesis Defined by Novel Label-Free Dark-Field Imaging in a Hamster Cheek Pouch Model.

Journal Article Cancer Res · December 15, 2017 There remain gaps in knowledge concerning how vascular morphology evolves during carcinogenesis. In this study, we imaged neovascularization by label-free dark-field microscopy of a 7,12-Dimethylbenz[a]anthracene (DMBA)-induced hamster cheek pouch model of ... Full text Link to item Cite

Transport of drugs from blood vessels to tumour tissue.

Journal Article Nat Rev Cancer · December 2017 The effectiveness of anticancer drugs in treating a solid tumour is dependent on delivery of the drug to virtually all cancer cells in the tumour. The distribution of drug in tumour tissue depends on the plasma pharmacokinetics, the structure and function ... Full text Link to item Cite

Differential response to exercise in claudin-low breast cancer.

Journal Article Oncotarget · November 24, 2017 Exposure to exercise following a breast cancer diagnosis is associated with reductions in the risk of recurrence. However, it is not known whether breast cancers within the same molecular-intrinsic subtype respond differently to exercise. Syngeneic mouse m ... Full text Open Access Link to item Cite

Endothelial cell-surface tissue transglutaminase inhibits neutrophil adhesion by binding and releasing nitric oxide.

Journal Article Sci Rep · November 23, 2017 Nitric oxide (NO) produced by endothelial cells in response to cytokines displays anti-inflammatory activity by preventing the adherence, migration and activation of neutrophils. The molecular mechanism by which NO operates at the blood-endothelium interfa ... Full text Link to item Cite

Multidisciplinary Mentoring Programs to Enhance Junior Faculty Research Grant Success.

Journal Article Acad Med · October 2017 PROBLEM: Junior faculty face challenges in establishing independent research careers. Declining funding combined with a shift to multidisciplinary, collaborative science necessitates new mentorship models and enhanced institutional support. APPROACH: Two m ... Full text Link to item Cite

Enhancing Radiation Therapy Through Cherenkov Light-Activated Phototherapy from Clinical Megavoltage Treatment Beams

Conference International Journal of Radiation Oncology*Biology*Physics · October 2017 Full text Cite

NIR-emissive PEG-b-TCL micelles for breast tumor imaging and minimally invasive pharmacokinetic analysis.

Journal Article Nanoscale · September 21, 2017 Motivated by the goal of developing a fully biodegradable optical contrast agent with translational clinical potential, a nanoparticle delivery vehicle was generated from the self-assembly of poly(ethylene-glycol)-block-poly(trimethylene carbonate-co-capro ... Full text Link to item Cite

GBM radiosensitizers: dead in the water…or just the beginning?

Journal Article J Neurooncol · September 2017 The finding that most GBMs recur either near or within the primary site after radiotherapy has fueled great interest in the development of radiosensitizers to enhance local control. Unfortunately, decades of clinical trials testing a wide range of novel th ... Full text Link to item Cite

Luminescent boron polymers for biomedical imaging

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · August 20, 2017 Link to item Cite

Development of enhanced ethanol ablation as an alternative to surgery in treatment of superficial solid tumors.

Journal Article Sci Rep · August 18, 2017 While surgery is at the foundation of cancer treatment, its access is limited in low-income countries. Here, we describe development of a low-cost alternative therapy based on intratumoral ethanol injection suitable for resource-limited settings. Although ... Full text Link to item Cite

Noninvasive measurement of tissue blood oxygenation with Cerenkov imaging during therapeutic radiation delivery.

Journal Article Opt Lett · August 15, 2017 Tumor tissue oxygenation significantly affects the outcome of radiotherapy. Real-time monitoring of tumor hypoxia is highly desirable for effective radiotherapy, and is the basis for improved treatment because hypoxic tumor cells are more resistant to radi ... Full text Open Access Link to item Cite

Subtype-Specific Radiation Response and Therapeutic Effect of FAS Death Receptor Modulation in Human Breast Cancer.

Journal Article Radiat Res · August 2017 Breast cancer is the most common malignancy diagnosed among women and represents a heterogeneous group of subtypes. Radiation therapy is a critical component of treatment for breast cancer patients. However, little is known about radiation response among t ... Full text Link to item Cite

Potential for a novel manganese porphyrin compound as adjuvant canine lymphoma therapy.

Journal Article Cancer Chemother Pharmacol · August 2017 PURPOSE: Manganese porphyrins are redox-active drugs and superoxide dismutase mimics, which have been shown to chemosensitize lymphoma, a cancer which frequently occurs in dogs. This study aimed to identify critical information regarding the pharmacokineti ... Full text Link to item Cite

Inhibition of the Continuum of Radiation-Induced Normal Tissue Injury by a Redox-Active Mn Porphyrin.

Journal Article Radiat Res · July 2017 Normal tissue damage after head and neck radiotherapy involves a continuum of pathologic events to the mucosa, tongue and salivary glands. We examined the radioprotective effects of MnBuOE, a redox-active manganese porphyrin, at three stages of normal tiss ... Full text Link to item Cite

Inflammatory breast cancer tumor emboli express high levels of anti-apoptotic proteins: use of a quantitative high content and high-throughput 3D IBC spheroid assay to identify targeting strategies.

Journal Article Oncotarget · April 18, 2017 Inflammatory breast cancer (IBC) is one of the most lethal breast cancer variants; with existing therapy, 5-yr survival rate is only 35%. Current barriers to successful treatment of IBC include frequent infiltration and the presence of tumor cell clusters, ... Full text Link to item Cite

Evidence for Feedback Regulation Following Cholesterol Lowering Therapy in a Prostate Cancer Xenograft Model.

Journal Article Prostate · April 2017 BACKGROUND: Epidemiologic data suggest cholesterol-lowering drugs may prevent the progression of prostate cancer, but not the incidence of the disease. However, the association of combination therapy in cholesterol reduction on prostate or any cancer is un ... Full text Link to item Cite

Encapsulating a Hydrophilic Chemotherapeutic into Rod-like Nanoparticles of a Genetically Encoded Asymmetric Triblock Polypeptide Improves its Efficacy.

Journal Article Adv Funct Mater · March 24, 2017 Encapsulating hydrophilic chemotherapeutics into the core of polymeric nanoparticles can improve their therapeutic efficacy by increasing their plasma half-life, tumor accumulation and intracellular uptake, and by protecting them from premature degradation ... Full text Link to item Cite

Oxygen and Perfusion Kinetics in Response to Fractionated Radiation Therapy in FaDu Head and Neck Cancer Xenografts Are Related to Treatment Outcome.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2016 PURPOSE: To test whether oxygenation kinetics correlate with the likelihood for local tumor control after fractionated radiation therapy. METHODS AND MATERIALS: We used diffuse reflectance spectroscopy to noninvasively measure tumor vascular oxygenation an ... Full text Link to item Cite

Etiology of Radiation-Induced Erectile Dysfunction: Vessel or Nerve?

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2016 Full text Link to item Cite

Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements.

Journal Article J Proteome Res · August 5, 2016 Manassantin A is a natural product that has been shown to have anticancer activity in cell-based assays, but has a largely unknown mode-of-action. Described here is the use of two different energetics-based approaches to identify protein targets of manassa ... Full text Link to item Cite

Efficacy and Mechanisms of Aerobic Exercise on Cancer Initiation, Progression, and Metastasis: A Critical Systematic Review of In Vivo Preclinical Data.

Journal Article Cancer Res · July 15, 2016 A major objective of the emerging field of exercise-oncology research is to determine the efficacy of, and biological mechanisms by which, aerobic exercise affects cancer incidence, progression, and/or metastasis. There is a strong inverse association betw ... Full text Link to item Cite

Abstract SY22-02: Exercise and cancer progression: Preclinical evidence

Conference Cancer Research · July 15, 2016 AbstractA major objective of the emerging field of exercise-oncology research is to determine the efficacy of, and biological mechanisms by which, aerobic exercise affects cancer incidence, progression and/o ... Full text Cite

Abstract 1647: Radiation response genome-wide analysis using paired pre and post-radiation FFPE human breast tumor samples

Conference Cancer Research · July 15, 2016 AbstractBackground: Breast cancer is the most common female malignancy in the US, and radiotherapy is a routine part of multi-disciplinary breast cancer care. Radiation treatment (RT) tailored to target radi ... Full text Cite

Abstract 1656: Subtype-specific radiation response in human breast cancer and potential therapeutic effect of FAS death receptor modulation

Conference Cancer Research · July 15, 2016 AbstractBreast cancer is the most common malignancy diagnosed among women worldwide and represents a heterogeneous group of subtypes. Radiation therapy is an important component of multimodal treatment for w ... Full text Cite

Improving the Predictive Value of Preclinical Studies in Support of Radiotherapy Clinical Trials.

Journal Article Clin Cancer Res · July 1, 2016 There is an urgent need to improve reproducibility and translatability of preclinical data to fully exploit opportunities for molecular therapeutics involving radiation and radiochemotherapy. For in vitro research, the clonogenic assay remains the current ... Full text Link to item Cite

Effects of hyperthermia in neutralising mechanisms of drug resistance in non-muscle-invasive bladder cancer.

Journal Article Int J Hyperthermia · June 2016 Non-muscle-invasive bladder cancer is a challenging disease, even given its superficial nature. It is prone to multiple recurrences and progression to muscle-invasive cancer. These features of this disease contribute significantly to reduced quality of lif ... Full text Link to item Cite

Implications of Increase in Vascular Permeability in Tumors by VEGF: A Commentary on the Pioneering Work of Harold Dvorak.

Journal Article Cancer Res · June 1, 2016 See related article by Senger et al., Cancer Res 1986;46:5629-32Visit the Cancer Research 75(th) Anniversary timeline. ... Full text Link to item Cite

Neurobehavioral radiation mitigation to standard brain cancer therapy regimens by Mn(III) n-butoxyethylpyridylporphyrin-based redox modifier.

Journal Article Environ Mol Mutagen · June 2016 Combinations of radiotherapy (RT) and chemotherapy have shown efficacy toward brain tumors. However, therapy-induced oxidative stress can damage normal brain tissue, resulting in both progressive neurocognitive loss and diminished quality of life. We have ... Full text Link to item Cite

WE-FG-BRA-01: Cancer Treatment Utilizing Photo-Activation of Psoralen with KV X-Rays.

Journal Article Med Phys · June 2016 PURPOSE: This work investigates X-PACT (X-ray Psoralen Activated Cancer Therapy): a new approach for the treatment of cancer. X-PACT utilizes psoralen, a potent anti-cancer therapeutic with immunogenic anti-cancer potential. Psoralen therapies have been li ... Full text Link to item Cite

TH-EF-207A-06: High-Resolution Optical-CT/ECT Imaging of Unstained Mice Femur, Brain, Spleen, and Tumor.

Journal Article Med Phys · June 2016 PURPOSE: Optical transmission and emission computed tomography (optical-CT/ECT) provides high-resolution 3D attenuation and emission maps in unsectioned large (∼1cm(3) ) ex vivo tissue samples at a resolution of 12.9µm(3) per voxel. Here we apply optical-C ... Full text Link to item Cite

SU-G-IeP4-08: Initial Investigations of Up-Converting Nanoparticles (UCNP) for 3D Tissue Imaging in Optical-ECT.

Journal Article Med Phys · June 2016 PURPOSE: Near-IR absorptive up-converting nanoparticles (UCNPs) is a novel contrast for optical-ECT that allows auto-fluorescence-free 3D imaging of labeled cells in a matrix of large (∼1cm(3) ) unsectioned normal tissue. This has the potential to image sm ... Full text Link to item Cite

ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer.

Journal Article Cell Rep · April 12, 2016 Imaging studies in animals and in humans have indicated that the oxygenation and nutritional status of solid tumors is dynamic. Furthermore, the extremely low level of glucose within tumors, while reflecting its rapid uptake and metabolism, also suggests t ... Full text Link to item Cite

Perspectives from man's best friend: National Academy of Medicine's Workshop on Comparative Oncology.

Journal Article Sci Transl Med · February 3, 2016 Scientists gather to survey comparative oncology research and pinpoint potential contributions to human therapeutics. ... Full text Link to item Cite

The future of biology in driving the field of hyperthermia.

Journal Article Int J Hyperthermia · 2016 In 2011 Hanahan and Weinberg updated their well-established paper 'The hallmarks of cancer'. The rationale for that review and its predecessor was to produce a conceptual framework for future research in cancer. The original Hallmarks included: cell signal ... Full text Link to item Cite

X-Ray Psoralen Activated Cancer Therapy (X-PACT).

Journal Article PLoS One · 2016 This work investigates X-PACT (X-ray Psoralen Activated Cancer Therapy): a new approach for the treatment of solid cancer. X-PACT utilizes psoralen, a potent anti-cancer therapeutic with current application to proliferative disease and extracorporeal photo ... Full text Open Access Link to item Cite

Hyperspectral imaging of glucose uptake, mitochondrial membrane potential, and vascular oxygenation differentiates breast cancers with distinct metastatic potential in vivo

Conference Optics InfoBase Conference Papers · January 1, 2016 We performed in vivo hyperspectral imaging in a preclinical cancer model to capture key metabolic endpoints (glucose uptake, mitochondrial membrane potential, and vascular oxygenation) to successfully distinguish metastatic and non-metastatic tumors. ... Full text Cite

Using Hyperthermia to Augment Drug Delivery

Chapter · January 1, 2016 We will focus on the eects of hyperthermia treatment in the temperature range of 39-42°C, because it is in this temperature range that profound physiologic eects occur in tumors that can mediate improvements in drug delivery (Song et al. 2001) (Figure 16.1 ... Full text Cite

Anticancer therapeutic potential of Mn porphyrin/ascorbate system.

Journal Article Free Radic Biol Med · December 2015 Ascorbate (Asc) as a single agent suppressed growth of several tumor cell lines in a mouse model. It has been tested in a Phase I Clinical Trial on pancreatic cancer patients where it exhibited no toxicity to normal tissue yet was of only marginal efficacy ... Full text Link to item Cite

Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2015 PURPOSE: To test the effects of a novel Mn porphyrin oxidative stress modifier, Mn(III) meso-tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin (MnBuOE), for its radioprotective and radiosensitizing properties in normal tissue versus tumor, respectively. ME ... Full text Open Access Link to item Cite

FAS Death Receptor: A Breast Cancer Subtype-Specific Radiation Response Biomarker and Potential Therapeutic Target.

Journal Article Radiat Res · November 2015 Although a standardized approach to radiotherapy has been used to treat breast cancer, regardless of subtype (e.g., luminal, basal), recent clinical data suggest that radiation response may vary significantly among subtypes. We hypothesized that this clini ... Full text Link to item Cite

Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition.

Journal Article J Med Chem · October 8, 2015 To cope with hypoxia, tumor cells have developed a number of adaptive mechanisms mediated by hypoxia-inducible factor 1 (HIF-1) to promote angiogenesis and cell survival. Due to significant roles of HIF-1 in the initiation, progression, metastasis, and res ... Full text Link to item Cite

Prognostic significance of differential expression of angiogenic genes in women with high-grade serous ovarian carcinoma.

Journal Article Gynecol Oncol · October 2015 OBJECTIVES: To identify angiogenic biomarkers associated with tumor angiogenesis and clinical outcome in high-grade serous ovarian cancer (HGSC). METHODS: 51 HGSC samples were analyzed using Affymetrix HG-U133A microarray. Microvessel density (MVD) counts ... Full text Link to item Cite

Microdosimetric and Biological Effects of Photon Irradiation at Different Energies in Bone Marrow.

Journal Article Radiat Res · October 2015 To ensure reliability and reproducibility of radiobiological data, it is necessary to standardize dosimetry practices across all research institutions. The photoelectric effect predominates over other interactions at low energy and in high atomic number ma ... Full text Link to item Cite

Abstract 3302: Subtype-specific radiation response in a mouse model of human breast cancer

Conference Cancer Research · August 1, 2015 AbstractRadiation therapy is an important component of multimodal treatment for women with breast cancer. However, breast radiotherapy is currently delivered uniformly, regardless of breast cancer subtype. R ... Full text Cite

Preoperative Single-Fraction Partial Breast Radiation Therapy: A Novel Phase 1, Dose-Escalation Protocol With Radiation Response Biomarkers.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2015 PURPOSE: Women with biologically favorable early-stage breast cancer are increasingly treated with accelerated partial breast radiation (PBI). However, treatment-related morbidities have been linked to the large postoperative treatment volumes required for ... Full text Link to item Cite

Doxorubicin-conjugated polypeptide nanoparticles inhibit metastasis in two murine models of carcinoma.

Journal Article J Control Release · June 28, 2015 Drug delivery vehicles are often assessed for their ability to control primary tumor growth, but the outcome of cancer treatment depends on controlling or inhibiting metastasis. Therefore, we studied the efficacy of our genetically encoded polypeptide nano ... Full text Link to item Cite

Dynamic treatment effect (DTE) curves reveal the mode of action for standard and experimental cancer therapies.

Journal Article Oncotarget · June 10, 2015 We present a method for estimating the empirical dynamic treatment effect (DTE) curves from tumor growth delay (TGD) studies. This improves on current common methods of TGD analysis, such as T/C ratio and doubling times, by providing a more detailed treatm ... Full text Link to item Cite

Genomic profiling in locally advanced and inflammatory breast cancer and its link to DCE-MRI and overall survival.

Journal Article Int J Hyperthermia · June 2015 PURPOSE: We have previously reported that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) perfusion patterns obtained from locally advanced breast cancer (LABC) patients prior to neoadjuvant therapy predicted pathologic clinical response. Ge ... Full text Link to item Cite

HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism.

Journal Article Radiat Res · June 2015 Hypoxia is a major cause of radiation resistance, which may predispose to local recurrence after radiation therapy. While hypoxia increases tumor cell survival after radiation exposure because there is less oxygen to oxidize damaged DNA, it remains unclear ... Full text Link to item Cite

WE-EF-BRA-11: Precision Partial-Tumor Irradiation of Dorsal Rodent Mammary Tumors.

Journal Article Med Phys · June 2015 PURPOSE: To introduce a pre-clinical treatment technique on a micro-irradiator to treat specific volumes of dorsal mammary tumors in BALB/c mice while sparing lungs and spine. This technique facilitates pre-clinical investigation of tumor response to sub-o ... Full text Link to item Cite

Modulation of murine breast tumor vascularity, hypoxia and chemotherapeutic response by exercise.

Journal Article J Natl Cancer Inst · May 2015 Exercise has been shown to improve postischemia perfusion of normal tissues; we investigated whether these effects extend to solid tumors. Estrogen receptor-negative (ER-, 4T1) and ER+ (E0771) tumor cells were implanted orthotopically into syngeneic mice ( ... Full text Open Access Link to item Cite

A tribute to Philip Marcus and the development of the clonogenic assay.

Journal Article Radiat Res · May 2015 Philip Marcus (1927-2013), a prominent and celebrated virus and interferon researcher, was also influential to the field of radiobiology. His work as a graduate student led to the development of the first mammalian cell clonogenic assay. This tribute to Ph ... Full text Link to item Cite

Exercise Affects Tumor Growth and Drug Response in a Mouse Model of Breast Cancer

Journal Article Journal of the National Cancer Institute · May 1, 2015 Full text Cite

Luminescent difluoroboron β-diketonate PEG-PLA oxygen nanosensors for tumor imaging.

Journal Article Macromol Rapid Commun · April 2015 Surface modification of nanoparticles and biosensors is a dynamic, expanding area of research for targeted delivery in vivo. For more efficient delivery, surfaces are PEGylated to impart stealth properties, long circulation, and enable enhanced permeabilit ... Full text Link to item Cite

Design, synthesis, and biological evaluation of manassantin analogues for HIF-1 alpha inhibition

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · March 22, 2015 Link to item Cite

Targeting N-cadherin increases vascular permeability and differentially activates AKT in melanoma.

Journal Article Ann Surg · February 2015 OBJECTIVE: We investigate the mechanism through which N-cadherin disruption alters the effectiveness of regional chemotherapy for locally advanced melanoma. BACKGROUND: N-cadherin antagonism during regional chemotherapy has demonstrated variable treatment ... Full text Link to item Cite

Effects of high-dose microbeam irradiation on tumor microvascular function and angiogenesis.

Journal Article Radiat Res · February 2015 Microbeam radiation therapy (MRT) is a form of cancer treatment in which a single large dose of radiation is spatially fractionated in-line or grid-like patterns. Preclinical studies have demonstrated that MRT is capable of eliciting high levels of tumor r ... Full text Link to item Cite

Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells.

Journal Article Oncogene · January 29, 2015 Epithelial-mesenchymal transition (EMT) is an essential step for tumor progression, although the mechanisms driving EMT are still not fully understood. In an effort to investigate these mechanisms, we observed that heregulin (HRG)-mediated activation of HE ... Full text Link to item Cite

Radioprotection of the brain white matter by Mn(III) n-Butoxyethylpyridylporphyrin-based superoxide dismutase mimic MnTnBuOE-2-PyP5+.

Journal Article Mol Cancer Ther · January 2015 Cranial irradiation is a standard therapy for primary and metastatic brain tumors. A major drawback of radiotherapy (RT), however, is long-term cognitive loss that affects quality of life. Radiation-induced oxidative stress in normal brain tissue is though ... Full text Link to item Cite

Common responses of tumors and wounds to hypoxia.

Journal Article Cancer J · 2015 Hypoxia is a characteristic of tumors and wounds. Hypoxic cells develop 2 common strategies to face hypoxia: the glycolytic switch and the angiogenic switch. At the onset of hypoxia, alleviation of the Pasteur effect ensures short-term cell survival. Long- ... Full text Link to item Cite

Evolution of Thermal Dosimetry for Application of Hyperthermia to Treat Cancer

Chapter · January 1, 2015 The use of heat to treat cancer has been extensively studied in preclinical models and in human clinical trials. When combined with radiotherapy and chemotherapy, hyperthermia can yield synergistic interactions that increase likelihood that tumors will be ... Full text Cite

Hyperthermia

Chapter · January 1, 2015 Full text Cite

Automated measurement of microcirculatory blood flow velocity in pulmonary metastases of rats.

Journal Article J Vis Exp · November 30, 2014 Because the lung is a major target organ of metastatic disease, animal models to study the physiology of pulmonary metastases are of great importance. However, very few methods exist to date to investigate lung metastases in a dynamic fashion at the microc ... Full text Link to item Cite

The Role of Ascorbate in Therapeutic Actions of Cationic Mn Porphyrin-Based SOD Mimics

Journal Article Free Radical Biology and Medicine · November 2014 Full text Cite

Abstract 3774: Hyperthermia treatment overcomes temozolomide resistance in glioma cells by downregulating MGMT expression and increasing temozolomide uptake

Conference Cancer Research · October 1, 2014 AbstractGlioblastoma multiforme (GBM) is the most common and malignant brain tumor. Current standard treatment for GBM following maximum safe resection includes temozolomide (TMZ) with concurrent radiotherap ... Full text Cite

The additive damage model: a mathematical model for cellular responses to drug combinations.

Journal Article J Theor Biol · September 21, 2014 Mathematical models to describe dose-dependent cellular responses to drug combinations are an essential component of computational simulations for predicting therapeutic responses. Here, a new model, the additive damage model, is introduced and tested in c ... Full text Link to item Cite

Systemic anti-tumour effects of local thermally sensitive liposome therapy.

Journal Article Int J Hyperthermia · September 2014 PURPOSE: There were two primary objectives of this study: (1) to determine whether treatment of a tumour site with systemically administered thermally sensitive liposomes and local hyperthermia (HT) for triggered release would have dual anti-tumour effect ... Full text Link to item Cite

HIF-1α Regulates Radiation Resistance in Primary Sarcomas in a Tumor-Cell Autonomous Mechanism

Conference International Journal of Radiation Oncology*Biology*Physics · September 2014 Full text Cite

Hypoxia Induces mRNA 3’UTR Truncation in Multiple Cell Types In Vitro

Conference International Journal of Radiation Oncology*Biology*Physics · September 2014 Full text Cite

Tuning optical properties of difluoroboron beta-diketonate biomaterials for oxygen sensing

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · August 10, 2014 Link to item Cite

Boron nanoparticles for oxygen sensing: Material design, optical properties, and bioimaging

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · August 10, 2014 Link to item Cite

Rationalization of thermal injury quantification methods: application to skin burns.

Journal Article Burns · August 2014 Classification of thermal injury is typically accomplished either through the use of an equivalent dosimetry method (equivalent minutes at 43 °C, CEM43 °C) or through a thermal-injury-damage metric (the Arrhenius method). For lower-temperature levels, the ... Full text Link to item Cite

Verification of a novel method for tube voltage constancy measurement of orthovoltage x-ray irradiators.

Journal Article Med Phys · August 2014 PURPOSE: For orthovoltage x-ray irradiators, the tube voltage is one of the most fundamental system parameters as this directly relates to the dosimetry in radiation biology studies; however, to the best of our knowledge, there is no commercial portable qu ... Full text Link to item Cite

Two phase I dose-escalation/pharmacokinetics studies of low temperature liposomal doxorubicin (LTLD) and mild local hyperthermia in heavily pretreated patients with local regionally recurrent breast cancer.

Journal Article Int J Hyperthermia · August 2014 PURPOSE: Unresectable chest wall recurrences of breast cancer (CWR) in heavily pretreated patients are especially difficult to treat. We hypothesised that thermally enhanced drug delivery using low temperature liposomal doxorubicin (LTLD), given with mild ... Full text Link to item Cite

Imaging tumor hypoxia to advance radiation oncology.

Journal Article Antioxid Redox Signal · July 10, 2014 SIGNIFICANCE: Most solid tumors contain regions of low oxygenation or hypoxia. Tumor hypoxia has been associated with a poor clinical outcome and plays a critical role in tumor radioresistance. RECENT ADVANCES: Two main types of hypoxia exist in the tumor ... Full text Link to item Cite

Comparison of the Hypoxia PET Tracer (18)F-EF5 to Immunohistochemical Marker EF5 in 3 Different Human Tumor Xenograft Models.

Journal Article J Nucl Med · July 2014 UNLABELLED: The availability of (18)F-labeled and unlabeled 2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)-acetamide (EF5) allows for a comparative assessment of tumor hypoxia by PET and immunohistochemistry; however, the combined use of thes ... Full text Link to item Cite

Measuring tumor cycling hypoxia and angiogenesis using a side-firing fiber optic probe.

Journal Article J Biophotonics · July 2014 Hypoxia and angiogenesis can significantly influence the efficacy of cancer therapy and the behavior of surviving tumor cells. There is a growing demand for technologies to measure tumor hypoxia and angiogenesis temporally in vivo to enable advances in dru ... Full text Link to item Cite

Linking the history of radiation biology to the hallmarks of cancer.

Journal Article Radiat Res · June 2014 Hanahan and Weinberg recently updated their conceptual framework of the "Hallmarks of Cancer". The original article, published in 2000, is among the most highly cited reviews in the field of oncology. The goal of this review is to highlight important disco ... Full text Link to item Cite

WE-E-BRE-06: High-Dose Microbeam Radiation Induces Different Responses in Tumor Microenvironment Compared to Conventional Seamless Radiation in Window Chamber Tumor Models.

Journal Article Med Phys · June 2014 PURPOSE: Microbeam radiation therapy and GRID therapy are different forms of Spatially-Fractioned Radiation Therapy (SFRT) that is fundamentally different from the conventional seamless and temporally fractionated radiation therapy. SFRT is characterized b ... Full text Link to item Cite

Rational design of "heat seeking" drug loaded polypeptide nanoparticles that thermally target solid tumors.

Journal Article Nano Lett · May 14, 2014 This paper demonstrates the first example of targeting a solid tumor that is externally heated to 42 °C by "heat seeking" drug-loaded polypeptide nanoparticles. These nanoparticles consist of a thermally responsive elastin-like polypeptide (ELP) conjugated ... Full text Link to item Cite

A pilot clinical trial of intravesical mitomycin-C and external deep pelvic hyperthermia for non-muscle-invasive bladder cancer.

Journal Article Int J Hyperthermia · May 2014 PURPOSE: This paper aims to evaluate the safety and heating efficiency of external deep pelvic hyperthermia combined with intravesical mitomycin C (MMC) as a novel therapy for non-muscle-invasive bladder cancer (NMIBC). MATERIALS AND METHODS: We enrolled s ... Full text Link to item Cite

Thermal dosimetry characteristics of deep regional heating of non-muscle invasive bladder cancer.

Journal Article Int J Hyperthermia · May 2014 PURPOSE: The aim of this paper is to report thermal dosimetry characteristics of external deep regional pelvic hyperthermia combined with intravesical mitomycin C (MMC) for treating bladder cancer following transurethral resection of bladder tumour, and to ... Full text Link to item Cite

Hypoxia in melanoma: using optical spectroscopy and EF5 to assess tumor oxygenation before and during regional chemotherapy for melanoma.

Journal Article Ann Surg Oncol · May 2014 BACKGROUND: There is increasing evidence that tumor hypoxia plays a significant role in the chemoresistance of melanoma, but to our knowledge, real-time tumor oxygenation during isolated limb infusion (ILI) has not been studied. We sought to demonstrate th ... Full text Link to item Cite

Toward an organ based dose prescription method for the improved accuracy of murine dose in orthovoltage x-ray irradiators.

Journal Article Med Phys · March 2014 PURPOSE: Accurate dosimetry is essential when irradiating mice to ensure that functional and molecular endpoints are well understood for the radiation dose delivered. Conventional methods of prescribing dose in mice involve the use of a single dose rate me ... Full text Link to item Cite

Corrigendum

Journal Article Microcirculation · February 2014 Full text Cite

Optical monitoring of glucose demand and vascular delivery in a preclinical murine model

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2014 Targeted therapies such as PI3K inhibition can affect tumor vasculature, and hence delivery of imaging agents like FDG, while independently modifying intrinsic glucose demand. Therefore, it is important to identify whether perceived changes in glucose upta ... Full text Cite

Anti-hypotensive treatment and endothelin blockade synergistically antagonize exercise fatigue in rats under simulated high altitude.

Journal Article PLoS One · 2014 Rapid ascent to high altitude causes illness and fatigue, and there is a demand for effective acute treatments to alleviate such effects. We hypothesized that increased oxygen delivery to the tissue using a combination of a hypertensive agent and an endoth ... Full text Open Access Link to item Cite

Delivery-corrected imaging of fluorescently-labeled glucose reveals distinct metabolic phenotypes in murine breast cancer.

Journal Article PLoS One · 2014 When monitoring response to cancer therapy, it is important to differentiate changes in glucose tracer uptake caused by altered delivery versus a true metabolic shift. Here, we propose an optical imaging method to quantify glucose uptake and correct for in ... Full text Link to item Cite

Abstract P4-15-05: Novel targeted therapy for breast cancer chest wall recurrence: Low temperature liposomal doxorubicin and mild local hyperthermia

Journal Article Cancer Research · December 15, 2013 AbstractBackground: Unresectable breast cancer chest wall recurrence (CWR) following radiation is very difficult to treat and often responds poorly to standard chemotherapy. Symptoms include pain, reduced ra ... Full text Cite

Magnetic fluid hyperthermia for bladder cancer: a preclinical dosimetry study.

Journal Article Int J Hyperthermia · December 2013 PURPOSE: This paper describes a preclinical investigation of the feasibility of thermotherapy treatment of bladder cancer with magnetic fluid hyperthermia (MFH), performed by analysing the thermal dosimetry of nanoparticle heating in a rat bladder model. M ... Full text Link to item Cite

Abstract B151: Monitoring tumor microenvironment (Hb saturation and oxygenation) in response to plasmonics-assisted photothermal cancer therapy.

Journal Article Molecular Cancer Therapeutics · November 1, 2013 AbstractIntroduction: Advanced biophotonic technology provides a novel strategy to not only achieve target-specific cancer therapy, but also monitor physiological response during treatment. To date, photoact ... Full text Cite

Quantitative mapping of hemodynamics in the lung, brain, and dorsal window chamber-grown tumors using a novel, automated algorithm.

Journal Article Microcirculation · November 2013 OBJECTIVE: Hemodynamic properties of vascular beds are of great interest in a variety of clinical and laboratory settings. However, there presently exists no automated, accurate, technically simple method for generating blood velocity maps of complex micro ... Full text Link to item Cite

PET with 62Cu-ATSM and 62Cu-PTSM is a useful imaging tool for hypoxia and perfusion in pulmonary lesions.

Journal Article AJR Am J Roentgenol · November 2013 OBJECTIVE: Hypoxia is a characteristic of many tumors and portends a worse prognosis in lung, cervical, prostate, and rectal cancers. Unlike the others, lung cancers present a unique challenge in measuring hypoxia, with invasive biopsies and higher rates o ... Full text Link to item Cite

Tumor cells upregulate normoxic HIF-1α in response to doxorubicin.

Journal Article Cancer Res · October 15, 2013 Hypoxia-inducible factor 1 (HIF-1) is a master transcription factor that controls cellular homeostasis. Although its activation benefits normal tissue, HIF-1 activation in tumors is a major risk factor for angiogenesis, therapeutic resistance, and poor pro ... Full text Link to item Cite

Temperature matters! And why it should matter to tumor immunologists.

Journal Article Cancer Immunol Res · October 2013 A major goal of cancer immunology is to stimulate the generation of long-lasting, tumor antigen-specific immune responses that recognize and destroy tumor cells. This article discusses advances in thermal medicine with the potential to improve cancer immun ... Full text Link to item Cite

Radiation Induces Epithelial-Mesenchymal Transition in an In Vitro Mammary Carcinoma Tumor Model

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Understanding the tumor microenvironment and radioresistance by combining functional imaging with global gene expression.

Journal Article Semin Radiat Oncol · October 2013 The objective of this review is to present an argument for performing joint analyses between functional imaging with global gene expression studies. The reason for making this link is that tumor microenvironmental influences on functional imaging can be un ... Full text Link to item Cite

Introduction: tumor as an organ.

Journal Article Semin Radiat Oncol · October 2013 Full text Link to item Cite

Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy.

Journal Article Cancer Prev Res (Phila) · September 2013 Aerobic exercise training (AET) is an effective adjunct therapy to attenuate the adverse side-effects of adjuvant chemotherapy in women with early breast cancer. Whether AET interacts with the antitumor efficacy of chemotherapy has received scant attention ... Full text Link to item Cite

A role for the copper transporter Ctr1 in the synergistic interaction between hyperthermia and cisplatin treatment.

Journal Article Int J Hyperthermia · September 2013 PURPOSE: Hyperthermia enhances cytotoxic effects of chemotherapeutic agents such as cisplatin. However, the underlying molecular mechanisms remain unclear. We hypothesised that hyperthermia increases cisplatin accumulation and efficacy by modulating functi ... Full text Link to item Cite

Actively targeting solid tumours with thermoresponsive drug delivery systems that respond to mild hyperthermia.

Journal Article Int J Hyperthermia · September 2013 A diverse range of drug delivery vehicles have been developed to specifically target chemotherapeutics to solid tumours while avoiding systemic dose-limiting toxicity. Many of these active targeting strategies display limited efficacy because they rely on ... Full text Link to item Cite

A method to convert MRI images of temperature change into images of absolute temperature in solid tumours.

Journal Article Int J Hyperthermia · September 2013 PURPOSE: During hyperthermia (HT), the therapeutic response of tumours varies substantially within the target temperature range (39-43 °C). Current thermometry methods are either invasive or measure only temperature change, which limits the ability to stud ... Full text Link to item Cite

CEM43°C thermal dose thresholds: a potential guide for magnetic resonance radiofrequency exposure levels?

Journal Article Eur Radiol · August 2013 OBJECTIVE: To define thresholds of safe local temperature increases for MR equipment that exposes patients to radiofrequency fields of high intensities for long duration. These MR systems induce heterogeneous energy absorption patterns inside the body and ... Full text Link to item Cite

18F-EF5 PET imaging as an early response biomarker for the hypoxia-activated prodrug SN30000 combined with radiation treatment in a non-small cell lung cancer xenograft model.

Journal Article J Nucl Med · August 2013 UNLABELLED: Hypoxia is a significant therapeutic problem for solid tumors because hypoxic cells are treatment-resistant and more aggressive. Hypoxia-activated prodrugs such as SN30000 use a mechanism of activation in hypoxic cells similar to that of 2-nitr ... Full text Link to item Cite

Novel approaches to treatment of hepatocellular carcinoma and hepatic metastases using thermal ablation and thermosensitive liposomes.

Journal Article Surg Oncol Clin N Am · July 2013 Because of the limitations of surgical resection, thermal ablation is commonly used for the treatment of hepatocellular carcinoma and liver metastases. Current methods of ablation can result in marginal recurrences of larger lesions and in tumors located n ... Full text Link to item Cite

WE-E-108-09: An Investigation of the Feasibility of Rodentmorphic 3D Dosimeters for Verification of Precision Micro-Irradiator Treatment.

Journal Article Med Phys · June 2013 PURPOSE: To evaluate the feasibility of novel rodentmorphic 3D dosimeters for comprehensive high-resolution verification of the treatment accuracy of a state-of-the-art micro-irradiator equipped with on-line cone-beam-CT guidance. METHODS: Anatomically acc ... Full text Link to item Cite

MO-D-141-09: An Investigation of the Feasibility of Volumetric Imaging of Fluorescent Bio-Markers Using Optical-ECT.

Journal Article Med Phys · June 2013 PURPOSE: Toptical-ECT is a technique with potential for high resolution 3D imaging of the distribution of fluoresent biomarkers (including reporter proteins like GFP) in un-sectioned tissue samples. Accurate optical-ECT data is only feasible if the biomark ... Full text Link to item Cite

Endothelial colony forming cells (ECFCs) as a model for studying effects of low-dose ionizing radiation: growth inhibition by a single dose.

Journal Article Cancer Invest · June 2013 Identification of measurable nontransient responses to low-dose radiation in human primary cell cultures remains a problem. To this end, circulating endothelial colony-forming (progenitor) cells (ECFCs) were examined as an experimental model. ECFCs were is ... Full text Link to item Cite

Monitoring of cycling hypoxia and angiogenesis in FaDu head and neck tumors using a side-firing sensor

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · May 27, 2013 Many studies have found that hypoxia, particularly cycling hypoxia (CH), can lead to enhanced tumor metastasis and resistance to radiation and chemotherapy. It was also reported that tumor total hemoglobin content (THb), which is directly related to tumor ... Full text Cite

A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53.

Journal Article Sci Signal · May 7, 2013 In the intrinsic pathway of apoptosis, cell-damaging signals promote the release of cytochrome c from mitochondria, triggering activation of the Apaf-1 and caspase-9 apoptosome. The ubiquitin E3 ligase MDM2 decreases the stability of the proapoptotic facto ... Full text Open Access Link to item Cite

Resveratrol worsens survival in SCID mice with prostate cancer xenografts in a cell-line specific manner, through paradoxical effects on oncogenic pathways.

Journal Article Prostate · May 2013 BACKGROUND: Resveratrol increases lifespan and decreases the risk of many cancers. We hypothesized resveratrol will slow the growth of human prostate cancer xenografts. METHODS: SCID mice were fed Western diet (40% fat, 44% carbohydrate, 16% protein by kca ... Full text Link to item Cite

The impact of temperature and urinary constituents on urine viscosity and its relevance to bladder hyperthermia treatment.

Journal Article Int J Hyperthermia · May 2013 PURPOSE: The aim of this study was to determine the kinematic viscosity of human urine and factors associated with its variability. This value is necessary for accurate modelling of fluid mechanics and heat transfer during hyperthermia treatments of bladde ... Full text Link to item Cite

Abstract 364: Exercise slows tumor progression and normalizes tumor vasculature in murine models of breast cancer.

Conference Cancer Research · April 15, 2013 AbstractThe effect of endurance exercise to improve post-ischemia perfusion of normal tissues is established but whether such effects extend to hypoxic solid tumors is largely uninvestigated. Thus, we evalua ... Full text Cite

The effect of carbohydrate restriction on prostate cancer tumor growth in a castrate mouse xenograft model.

Journal Article Prostate · April 2013 BACKGROUND: No- and low-carbohydrate diets delay tumor growth compared to western diet (WD) in prostate cancer (PCa) xenograft studies. The effect of these diets in concert with androgen deprivation is unknown. METHODS: A total of 160 male SCID mice were i ... Full text Link to item Cite

Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer.

Journal Article J Med Food · April 2013 Enterolactone and enterodiol, mammalian lignans derived from dietary sources such as flaxseed, sesame seeds, kale, broccoli, and apricots, may impede tumor proliferation by inhibiting activation of nuclear factor kappa B (NFκB) and vascular endothelial gro ... Full text Link to item Cite

Effects and potential mechanisms of exercise training on cancer progression: a translational perspective.

Journal Article Brain Behav Immun · March 2013 Over the past decade there has been increasing research and clinical interest in the role of exercise therapy/rehabilitation as an adjunct therapy to improve symptom control and management following a cancer diagnosis. More recently, the field of 'exercise ... Full text Link to item Cite

Radiation induces aerobic glycolysis through reactive oxygen species.

Journal Article Radiother Oncol · March 2013 Featured Publication BACKGROUND AND PURPOSE: Although radiation induced reoxygenation has been thought to increase radiosensitivity, we have shown that its associated oxidative stress can have radioprotective effects, including stabilization of the transcription factor hypoxia ... Full text Link to item Cite

Preclinical Dosimetry of Magnetic Fluid Hyperthermia for Bladder Cancer.

Other Proc SPIE Int Soc Opt Eng · February 26, 2013 BACKGROUND: Despite positive efficacy, thermotherapy is not widely used in clinical oncology. Difficulties associated with field penetration and controlling power deposition patterns in heterogeneous tissue have limited its use for heating deep in the body ... Full text Link to item Cite

Automated measurement of blood flow velocity and direction and hemoglobin oxygen saturation in the rat lung using intravital microscopy.

Journal Article Am J Physiol Lung Cell Mol Physiol · January 15, 2013 Featured Publication Intravital microscopy of the pulmonary microcirculation in research animals is of great scientific interest for its utility in identifying regional changes in pulmonary microcirculatory blood flow. Although feasibility studies have been reported, the pulmo ... Full text Link to item Cite

Sickle erythrocytes target cytotoxics to hypoxic tumor microvessels and potentiate a tumoricidal response.

Journal Article PLoS One · 2013 Resistance of hypoxic solid tumor niches to chemotherapy and radiotherapy remains a major scientific challenge that calls for conceptually new approaches. Here we exploit a hitherto unrecognized ability of sickled erythrocytes (SSRBCs) but not normal RBCs ... Full text Open Access Link to item Cite

Angiogenesis: an adaptive dynamic biological patterning problem.

Journal Article PLoS Comput Biol · 2013 Formation of functionally adequate vascular networks by angiogenesis presents a problem in biological patterning. Generated without predetermined spatial patterns, networks must develop hierarchical tree-like structures for efficient convective transport o ... Full text Link to item Cite

Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer.

Journal Article PLoS One · 2013 Lactate accumulation in tumors has been associated with metastases and poor overall survival in cancer patients. Lactate promotes angiogenesis and metastasis, providing rationale for understanding how it is processed by cells. The concentration of lactate ... Full text Link to item Cite

Delivery rate affects uptake of a fluorescent glucose analog in murine metastatic breast cancer.

Journal Article PLoS One · 2013 We demonstrate an optical strategy using intravital microscopy of dorsal skin flap window chamber models to image glucose uptake and vascular oxygenation in vivo. Glucose uptake was imaged using a fluorescent glucose analog, 2-[N-(7-nitrobenz-2-oxa-1,3-dia ... Full text Link to item Cite

A multi-institution experience comparing the clinical and physiologic differences between upper extremity and lower extremity melphalan-based isolated limb infusion.

Journal Article Cancer · December 15, 2012 BACKGROUND: Although studies of melphalan-based isolated limb infusion (ILI) combine data from upper extremity (UE) treatments with those from lower extremity (LE) treatments, differences between the 2 may be clinically important. METHODS: Candidates for U ... Full text Link to item Cite

Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to improve drug penetration into tumors.

Journal Article Cancer Res · November 1, 2012 Traditionally, the goal of nanoparticle-based chemotherapy has been to decrease normal tissue toxicity by improving drug specificity to tumors. The enhanced permeability and retention effect can permit passive accumulation into tumor interstitium. However, ... Full text Link to item Cite

Gene Expression Response to Ionizing Radiation in Luminal and Basal Breast Cancer Cell Lines

Conference International Journal of Radiation Oncology*Biology*Physics · November 2012 Full text Cite

Heat induces gene amplification in cancer cells.

Journal Article Biochem Biophys Res Commun · October 26, 2012 BACKGROUND: Hyperthermia plays an important role in cancer therapy. However, as with radiation, it can cause DNA damage and therefore genetic instability. We studied whether hyperthermia can induce gene amplification in cancer cells and explored potential ... Full text Link to item Cite

Carbohydrate restriction and lactate transporter inhibition in a mouse xenograft model of human prostate cancer.

Journal Article BJU Int · October 2012 UNLABELLED: What's known on the subject? and What does the study add? It is known that both lactate inhibition and carbohydrate restriction inhibit tumour growth. What is unknown is whether the two work synergistically together. This study adds that though ... Full text Link to item Cite

A simplified synthesis of the hypoxia imaging agent 2-(2-Nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-[(18)F]pentafluoropropyl)-acetamide ([18F]EF5).

Journal Article Nucl Med Biol · October 2012 INTRODUCTION: [(18)F]EF5 is a validated marker for PET imaging of tumor hypoxia. It is prepared by reacting a trifluoroallyl precursor with carrier-added [(18)F]F(2) gas in trifluoroacetic acid (TFA) solvent. We report here an improved radiosynthesis and p ... Full text Link to item Cite

Exercise modulation of the host-tumor interaction in an orthotopic model of murine prostate cancer.

Journal Article J Appl Physiol (1985) · July 2012 The purpose of this study is to investigate the effects of exercise on cancer progression, metastasis, and underlying mechanisms in an orthotopic model of murine prostate cancer. C57BL/6 male mice (6-8 wk of age) were orthotopically injected with transgeni ... Full text Link to item Cite

Bevacizumab-induced alterations in vascular permeability and drug delivery: a novel approach to augment regional chemotherapy for in-transit melanoma.

Journal Article Clin Cancer Res · June 15, 2012 PURPOSE: To investigate whether the systemically administered anti-VEGF monoclonal antibody bevacizumab could improve regional chemotherapy treatment of advanced extremity melanoma by enhancing delivery and tumor uptake of regionally infused melphalan (LPA ... Full text Link to item Cite

SU-E-I-07: Proposal for a Novel Algorithm of Effective Dose Evaluation for Medical Radiation Exposure.

Journal Article Med Phys · June 2012 PURPOSE: The validity of effective dose (ED) in medical applications, which mostly involving partial-organ irradiation, has long been argued. We now propose a new algorithm of effective dose evaluation for medical radiation exposure. The new algorithm will ... Full text Link to item Cite

TH‐A‐BRB‐04: Vascular Response to Microbeam Radiation Therapy in Vivo Using a Murine Window Chamber Tumor Model

Conference Medical Physics · June 2012 Microbeam Radiation Therapy (MRT) has shown a marked tumor‐specific effect. The tissue‐sparing property of this unique treatment is possibly facilitated by efficient normal‐vessel repair mechanisms, contrary to the catastrophic disruption of poorly ... Full text Cite

Cellular responses to lactate in breast cancer

Conference JOURNAL OF CLINICAL ONCOLOGY · May 20, 2012 Link to item Cite

Doxorubicin-conjugated chimeric polypeptide nanoparticles that respond to mild hyperthermia.

Journal Article J Control Release · May 10, 2012 This paper reports the design, physicochemical characterization and in vitro cytotoxicity of a thermally responsive chimeric polypeptide (CP), derived from an elastin-like polypeptide (ELP). The CP self-assembles into ~40 nm diameter nanoparticles upon con ... Full text Link to item Cite

Abstract 3220: The effects of cholesterol treatment drugs alone and in combination on prostate tumor xenograft growth

Journal Article Cancer Research · April 15, 2012 AbstractBackground: Epidemiologic data suggest cholesterol-lowering drugs may prevent the progression of prostate cancer (PC), but not the incidence of the disease. This may occur by lowering levels of low-d ... Full text Cite

A heterogeneous human tissue mimicking phantom for RF heating and MRI thermal monitoring verification.

Journal Article Phys Med Biol · April 7, 2012 This paper describes a heterogeneous phantom that mimics a human thigh with a deep-seated tumor, for the purpose of studying the performance of radiofrequency (RF) heating equipment and non-invasive temperature monitoring with magnetic resonance imaging (M ... Full text Link to item Cite

Introduction to the special issue on molecular imaging in radiation biology.

Journal Article Radiat Res · April 2012 Molecular imaging is an evolving science that is concerned with the development of novel imaging probes and biomarkers that can be used to non-invasively image molecular and cellular processes. This special issue approaches molecular imaging in the context ... Full text Link to item Cite

Application of optical imaging and spectroscopy to radiation biology.

Journal Article Radiat Res · April 2012 Optical imaging and spectroscopy is a diverse field that has been of critical importance in a wide range of areas in radiation research. It is capable of spanning a wide range of spatial and temporal scales, and has the sensitivity and specificity needed f ... Full text Link to item Cite

A novel angiopoietin-derived peptide displays anti-angiogenic activity and inhibits tumour-induced and retinal neovascularization.

Journal Article Br J Pharmacol · March 2012 BACKGROUND AND PURPOSE: Pathological angiogenesis is associated with various human diseases, such as cancer, autoimmune diseases and retinopathy. The angiopoietin (Ang)-Tie2 system plays critical roles in several steps of angiogenic remodelling. Here, we h ... Full text Link to item Cite

Utility of treatment planning for thermochemotherapy treatment of nonmuscle invasive bladder carcinoma.

Journal Article Med Phys · March 2012 PURPOSE: A recently completed Phase I clinical trial combined concurrent Mitomycin-C chemotherapy with deep regional heating using BSD-2000 Sigma-Ellipse applicator (BSD Corporation, Salt Lake City, UT, U.S.A.) for the treatment of nonmuscle invasive bladd ... Full text Link to item Cite

Carbonic anhydrase IX is a predictive marker of doxorubicin resistance in early-stage breast cancer independent of HER2 and TOP2A amplification.

Journal Article Br J Cancer · February 28, 2012 BACKGROUND: In early-stage breast cancer, adjuvant chemotherapy is associated with significant systemic toxicity with only a modest survival benefit. Therefore, there is considerable interest in identifying predictive markers of response to therapy. Doxoru ... Full text Link to item Cite

ErbB1/2 tyrosine kinase inhibitor mediates oxidative stress-induced apoptosis in inflammatory breast cancer cells.

Journal Article Breast Cancer Res Treat · February 2012 Overexpression of epidermal growth factor receptors (ErbB) is frequently seen in inflammatory breast cancer (IBC). Treatment with ErbB1/2-targeting agents (lapatinib) mediates tumor apoptosis by downregulating ErbB1/2 phosphorylation and downstream surviva ... Full text Link to item Cite

β-arrestin1 mediates metastatic growth of breast cancer cells by facilitating HIF-1-dependent VEGF expression.

Journal Article Oncogene · January 19, 2012 β-Arrestins 1 and 2 are multifunctional adaptor proteins originally discovered for their role in desensitizing seven-transmembrane receptor signaling via the heterotrimeric guanine nucleotide-binding proteins. Recently identified roles of β-arrestins inclu ... Full text Link to item Cite

Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells.

Journal Article Oncogene · January 5, 2012 The Hedgehog signaling pathway is one of the most dysregulated pathways in human cancers. The glioma-associated oncogene homolog 1 (GLI1) transcription factor is the terminal effector of the Hedgehog pathway, frequently activated in human breast cancer and ... Full text Link to item Cite

Hyperthermia

Chapter · January 1, 2012 Full text Cite

Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities.

Journal Article Amino Acids · January 2012 The most efficacious Mn(III) porphyrinic (MnPs) scavengers of reactive species have positive charges close to the Mn site, whereby they afford thermodynamic and electrostatic facilitation for the reaction with negatively charged species such as O (2) (•-) ... Full text Link to item Cite

Structural adaptation of normal and tumour vascular networks.

Journal Article Basic Clin Pharmacol Toxicol · January 2012 Vascular networks are dynamic structures, adapting to changing conditions by structural remodelling of vessel diameters and by growth of new vessels and regression of existing vessels. The vast number of blood vessels in the circulatory system, more than 1 ... Full text Link to item Cite

Thermal dose fractionation affects tumour physiological response.

Journal Article Int J Hyperthermia · 2012 PURPOSE: It is unknown whether a thermal dose should be administered using a few large fractions with higher temperatures or a larger number of fractions with lower temperatures. To evaluate this we assessed the effect of administering the same total therm ... Full text Link to item Cite

Miniature microwave applicator for murine bladder hyperthermia studies.

Journal Article Int J Hyperthermia · 2012 PURPOSE: Novel combinations of heat with chemotherapeutic agents are often studied in murine tumour models. Currently, no device exists to selectively heat small tumours at depth in mice. In this project we modelled, built and tested a miniature microwave ... Full text Link to item Cite

Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.

Journal Article PLoS One · 2012 Switching to a glycolytic metabolism is a rapid adaptation of tumor cells to hypoxia. Although this metabolic conversion may primarily represent a rescue pathway to meet the bioenergetic and biosynthetic demands of proliferating tumor cells, it also create ... Full text Link to item Cite

High-resolution in vivo imaging of fluorescent proteins using window chamber models.

Journal Article Methods Mol Biol · 2012 Fluorescent proteins enable in vivo characterization of a wide and growing array of morphological and functional biomarkers. To fully capitalize on the spatial and temporal information afforded by these reporter proteins, a method for imaging these protein ... Full text Link to item Cite

Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate.

Journal Article Free Radic Res · November 2011 Due to the ability to easily accept and donate electrons Mn(III)N-alkylpyridylporphyrins (MnPs) can dismute O(2)(·-), reduce peroxynitrite, but also generate reactive species and behave as pro-oxidants if conditions favour such action. Herein two ortho iso ... Full text Link to item Cite

In vivo tumor targeting by a NGR-decorated micelle of a recombinant diblock copolypeptide.

Journal Article J Control Release · October 30, 2011 Antivascular targeting is a promising strategy for tumor therapy. This strategy has the potential to overcome many of the transport barriers associated with targeting tumor cells in solid tumors, because the tumor vasculature is directly accessible to targ ... Full text Link to item Cite

Effect of low-fat diets on plasma levels of NF-κB-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer.

Journal Article Cancer Prev Res (Phila) · October 2011 Diet, nutritional status, and certain dietary supplements are postulated to influence the development and progression of prostate cancer. Angiogenesis and inflammation are central to tumor growth and progression, but the effect of diet on these processes r ... Full text Link to item Cite

IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells.

Journal Article J Clin Invest · October 2011 Immune cells are key regulators of neoplastic progression, which is often mediated through their release of cytokines. Inflammatory cytokines such as IL-6 exert tumor-promoting activities by driving growth and survival of neoplastic cells. However, whether ... Full text Link to item Cite

Protein Pathway Activation after Ionizing Radiation in Luminal and Basal Breast Cancer Cell Lines

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

42 and 44°C Hyperthermia Induces Gene Amplification in Colorectal Cancer HCT116 Cells

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics.

Journal Article Free Radic Biol Med · September 1, 2011 Oxidative stress, a redox imbalance between the endogenous reactive species and antioxidant systems, is common to numerous pathological conditions such as cancer, central nervous system injuries, radiation injury, diabetes etc. Therefore, compounds able to ... Full text Link to item Cite

Luminescent boron b-diketonate biomaterials: Synthesis, properties and applications

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · August 28, 2011 Link to item Cite

In vivo optical molecular imaging and analysis in mice using dorsal window chamber models applied to hypoxia, vasculature and fluorescent reporters.

Journal Article Nat Protoc · August 18, 2011 Optical techniques for functional imaging in mice have a number of key advantages over other common imaging modalities such as magnetic resonance imaging, positron emission tomography or computed tomography, including high resolution, low cost and an exten ... Full text Link to item Cite

Analysis of tumor environmental response and oncogenic pathway activation identifies distinct basal and luminal features in HER2-related breast tumor subtypes.

Journal Article Breast Cancer Res · June 7, 2011 INTRODUCTION: Breast cancer heterogeneity occurs as a consequence of the dysregulation of numerous oncogenic pathways as well as many non-genetic factors, including tumor microenvironmental stresses such as hypoxia, lactic acidosis, and glucose deprivation ... Full text Link to item Cite

Abstract 5306: 18F-EF5 microPET imaging of treatment response from a novel, hypoxia-selective cytotoxin SN30000 in a human lung cancer xenograft model

Journal Article Cancer Research · April 15, 2011 AbstractIntroduction: SN30000 (CEN-209) is a structural analogue of the clinically tested hypoxic cell cytotoxin tirapazamine, with improved tumor penetration and increased hypoxic cell kill activity in vitr ... Full text Cite

Abstract 2337: Defining significance of the novel tGLI1 transcription factor in cancer growth and progression

Journal Article Cancer Research · April 15, 2011 AbstractThe goal of this study is to gain a greater understanding of the molecular pathways that drive breast cancer progression and metastasis, the leading cause of breast cancer mortality. In achieving thi ... Full text Cite

Abstract 5377: A role for Ctr1 in the synergistic interaction between mild hyperthermia and cisplatin treatment

Conference Cancer Research · April 15, 2011 AbstractThe ability of mild hyperthermia to synergistically enhance the chemotherapeutic effects of cisplatin has long been recognized, but the mechanism underlying this process remains unclear. It is known ... Full text Cite

Comparison of genomics and functional imaging from canine sarcomas treated with thermoradiotherapy predicts therapeutic response and identifies combination therapeutics.

Journal Article Clin Cancer Res · April 15, 2011 PURPOSE: While hyperthermia is an effective adjuvant treatment to radiotherapy, we do not completely understand the nature of the response heterogeneity. EXPERIMENTAL DESIGN: We performed gene expression analysis of 22 spontaneous canine sarcomas before an ... Full text Link to item Cite

Cellular redox modulator, ortho Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) in the treatment of brain tumors.

Journal Article Anticancer Agents Med Chem · February 2011 Despite intensive efforts to improve multimodal treatment of brain tumor, survival remains limited. Current therapy consists of a combination of surgery, irradiation and chemotherapy with predisposition to long-term complications. Identifying novel targete ... Full text Link to item Cite

Molecular imaging of hypoxia.

Journal Article J Nucl Med · February 2011 A wide variety of imaging approaches have been developed in the past few decades for monitoring tumor oxygenation and hypoxia in vivo. In particular, nuclear medicine has seen the development of several radiolabeled hypoxia markers and is the preferred met ... Full text Link to item Cite

Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site.

Journal Article Free Radic Res · February 2011 In the cell Mn porphyrins (MnPs) likely couple with cellular reductants which results in a drop of total charge from 5+ to 4+ and dramatically increases their lipophilicity by up to three orders of magnitude depending upon the length of alkylpyridyl chains ... Full text Link to item Cite

Hyperthermia

Chapter · January 1, 2011 Full text Cite

Formulation and characterisation of magnetic resonance imageable thermally sensitive liposomes for use with magnetic resonance-guided high intensity focused ultrasound.

Journal Article Int J Hyperthermia · 2011 PURPOSE: Objectives of this study were to: 1) develop iLTSL, a low temperature sensitive liposome co-loaded with an MRI contrast agent (ProHance® Gd-HP-DO3A) and doxorubicin, 2) characterise doxorubicin and Gd-HP-DO3A release from iLTSL and 3) investigate ... Full text Link to item Cite

Thresholds for thermal damage to normal tissues: an update.

Journal Article Int J Hyperthermia · 2011 The purpose of this review is to summarise a literature survey on thermal thresholds for tissue damage. This review covers published literature for the consecutive years from 2002-2009. The first review on this subject was published in 2003. It included an ... Full text Link to item Cite

Individual responses to chemotherapy-induced oxidative stress.

Journal Article Breast Cancer Res Treat · January 2011 Differences in redox homeostatic control between cancer patients may underlie predisposition to drug resistance and toxicities. To evaluate interindividual differences in redox response among newly diagnosed breast cancer patients undergoing standard chemo ... Full text Link to item Cite

Nanoscale Drug Delivery and Hyperthermia: The Materials Design and Preclinical and Clinical Testing of Low Temperature-Sensitive Liposomes Used in Combination with Mild Hyperthermia in the Treatment of Local Cancer.

Journal Article Open Nanomed J · January 1, 2011 The overall objective of liposomal drug delivery is to selectively target drug delivery to diseased tissue, while minimizing drug delivery to critical normal tissues. The purpose of this review is to provide an overview of temperature-sensitive liposomes i ... Full text Link to item Cite

Durable palliation of breast cancer chest wall recurrence with radiation therapy, hyperthermia, and chemotherapy.

Journal Article Radiother Oncol · December 2010 BACKGROUND AND PURPOSE: Chest wall recurrences of breast cancer are a therapeutic challenge and durable local control is difficult to achieve. Our objective was to determine the local progression free survival (LPFS) and toxicity of thermochemoradiotherapy ... Full text Link to item Cite

NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment.

Journal Article Proc Natl Acad Sci U S A · November 23, 2010 Hyperthermia (HT) is a strong adjuvant treatment with radiotherapy and chemotherapy because it causes tumor reoxygenation. However, the detailed molecular mechanisms of how HT enhances tumor oxygenation have not been elucidated. Here we report that 1 h of ... Full text Link to item Cite

Longitudinal Monitoring of Functional Changes in Irradiated Head and Neck Tumors using Optical Spectroscopy

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Variation in Microenvironmental Effects and Drug Delivery between Different Classes of Antiangiogenic Drugs

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Stereocomplexed poly(lactic acid)-poly(ethylene glycol) nanoparticles with dual-emissive boron dyes for tumor accumulation.

Journal Article ACS Nano · September 28, 2010 Responsive biomaterials play important roles in imaging, diagnostics, and therapeutics. Polymeric nanoparticles (NPs) containing hydrophobic and hydrophilic segments are one class of biomaterial utilized for these purposes. The incorporation of luminescent ... Full text Open Access Link to item Cite

A feasibility study using radiochromic films for fast neutron 2D passive dosimetry.

Journal Article Phys Med Biol · September 7, 2010 The objective of this paper is threefold: (1) to establish sensitivity of XRQA and EBT radiochromic films to fast neutron exposure; (2) to develop a film response to radiation dose calibration curve and (3) to investigate a two-dimensional (2D) film dosime ... Full text Link to item Cite

Low-carbohydrate diets and prostate cancer: how low is "low enough"?

Journal Article Cancer Prev Res (Phila) · September 2010 Previous studies indicate that carbohydrate intake influences prostate cancer biology, as mice fed a no-carbohydrate ketogenic diet (NCKD) had significantly smaller xenograft tumors and longer survival than mice fed a Western diet. As it is nearly impossib ... Full text Link to item Cite

Establishing the Tumor Microenvironment

Journal Article · August 31, 2010 Full text Cite

The shunt problem: control of functional shunting in normal and tumour vasculature.

Journal Article Nat Rev Cancer · August 2010 Networks of blood vessels in normal and tumour tissues have heterogeneous structures, with widely varying blood flow pathway lengths. To achieve efficient blood flow distribution, mechanisms for the structural adaptation of vessel diameters must be able to ... Full text Link to item Cite

A comprehensive method for optical-emission computed tomography.

Journal Article Phys Med Biol · July 21, 2010 Optical-computed tomography (CT) and optical-emission computed tomography (ECT) are recent techniques with potential for high-resolution multi-faceted 3D imaging of the structure and function in unsectioned tissue samples up to 1-4 cc. Quantitative imaging ... Full text Link to item Cite

Application of mixed spin iMQCs for temperature and chemical-selective imaging.

Journal Article J Magn Reson · June 2010 The development of accurate and non-invasive temperature imaging techniques has a wide variety of applications in fields such as medicine, chemistry and materials science. Accurate detection of temperature both in phantoms and in vivo can be obtained using ... Full text Link to item Cite

Effect of pazopanib on tumor microenvironment and liposome delivery.

Journal Article Mol Cancer Ther · June 2010 Pathologic angiogenesis creates an abnormal microenvironment in solid tumors, characterized by elevated interstitial fluid pressure (IFP) and hypoxia. Emerging theories suggest that judicious downregulation of proangiogenic signaling pathways may transient ... Full text Link to item Cite

Non-invasive monitoring of intra-tumor drug concentration and therapeutic response using optical spectroscopy.

Journal Article J Control Release · March 19, 2010 Featured Publication Optical spectroscopy was used to monitor changes in tumor physiology with therapy, and its influence on drug delivery and treatment efficacy for hyperthermia treatment combined with free doxorubicin or a low-temperature sensitive liposomal formulation. Mon ... Full text Link to item Cite

Phosphorylated epidermal growth factor receptor and cyclooxygenase-2 expression in localized non-small cell lung cancer.

Journal Article Med Oncol · March 2010 PURPOSE: The prognostic significance of epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) expression remains unestablished, although EGFR and COX-2 are frequently overexpressed in non-small cell lung cancer (NSCLC). Considering the impor ... Full text Link to item Cite

Mathematical formulation and analysis of the nonlinear system reconstruction of the online image-guided adaptive control of hyperthermia.

Journal Article Med Phys · March 2010 PURPOSE: A nonlinear system reconstruction can theoretically provide timely system reconstruction when designing a real-time image-guided adaptive control for multisource heating for hyperthermia. This clinical need motivates an analysis of the essential m ... Full text Link to item Cite

Effective learning strategies for real-time image-guided adaptive control of multiple-source hyperthermia applicators.

Journal Article Med Phys · March 2010 PURPOSE: This paper investigates overall theoretical requirements for reducing the times required for the iterative learning of a real-time image-guided adaptive control routine for multiple-source heat applicators, as used in hyperthermia and thermal abla ... Full text Link to item Cite

SplicerAV: a tool for mining microarray expression data for changes in RNA processing.

Journal Article BMC Bioinformatics · February 25, 2010 BACKGROUND: Over the past two decades more than fifty thousand unique clinical and biological samples have been assayed using the Affymetrix HG-U133 and HG-U95 GeneChip microarray platforms. This substantial repository has been used extensively to characte ... Full text Open Access Link to item Cite

Effect of aerobic exercise on tumor physiology in an animal model of human breast cancer.

Journal Article J Appl Physiol (1985) · February 2010 Featured Publication Recent epidemiologic studies report that regular exercise may be associated with substantial reductions in cancer-specific and all-cause mortality following a breast cancer diagnosis. The mechanisms underlying this relationship have not been identified. We ... Full text Link to item Cite

Why Would Hyperthermia Work?

Journal Article JOURNAL OF THE NATIONAL CANCER INSTITUTE · January 20, 2010 Link to item Cite

TU‐E‐201C‐06: Imaging the Biological Structure and Characteristics of Model Tumors Using Optical Computed Transmission and Emission Tomography

Conference Medical Physics · January 1, 2010 Purpose: To obtain the first co‐registered high resolution 3D images of an intact xenograft tumor showing (i) the vasculature network labeled with an absorbing vasculature contrast agent, and imaged with optical‐CT (ii) the distribution of red‐fluorescent‐ ... Full text Cite

Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation.

Journal Article Future Oncol · January 2010 Featured Publication Tumor metabolism consists of complex interactions between oxygenation states, metabolites, ions, the vascular network and signaling cascades. Accumulation of lactate within tumors has been correlated with poor clinical outcomes. While its production has ne ... Full text Link to item Cite

Novel MRI and fluorescent probes responsive to the Factor XIII transglutaminase activity.

Journal Article Contrast Media Mol Imaging · 2010 Transglutaminases, including factor XIII and tissue transglutaminase, participate in multiple extracellular processes associated with remodeling of the extracellular matrix during wound repair, blood clotting, tumor progression and fibrosis of ischemic inj ... Full text Link to item Cite

Utility of functional imaging in prediction or assessment of treatment response and prognosis following thermotherapy.

Journal Article Int J Hyperthermia · 2010 The purpose of this review is to examine the roles that functional imaging may play in prediction of treatment response and determination of overall prognosis in patients who are enrolled in thermotherapy trials, either in combination with radiotherapy, ch ... Full text Link to item Cite

Hyperthermia for locally advanced breast cancer.

Journal Article Int J Hyperthermia · 2010 Hyperthermia (HT) has a proven benefit for treating superficial malignancies, particularly chest wall recurrences of breast cancer. There has been less research utilising HT in patients with locally advanced breast cancer (LABC), but available data are pro ... Full text Link to item Cite

Comparative effects of thermosensitive doxorubicin-containing liposomes and hyperthermia in human and murine tumours.

Journal Article Int J Hyperthermia · 2010 PURPOSE: In previous reports, laboratory-made lysolecithin-containing thermosensitive liposome encapsulating doxorubicin (LTSL-DOX) showed potent anticancer effects in FaDu human squamous cell carcinoma. To further study the spectrum of LTSL-DOX activity, ... Full text Link to item Cite

Longitudinal optical imaging of tumor metabolism and hemodynamics.

Journal Article J Biomed Opt · 2010 An important feature of tumor hypoxia is its temporal instability, or "cycling hypoxia." The primary consequence of cycling hypoxia is increased tumor aggressiveness and treatment resistance beyond that of chronic hypoxia. Longitudinal imaging of tumor met ... Full text Link to item Cite

A phase I/II study of neoadjuvant liposomal doxorubicin, paclitaxel, and hyperthermia in locally advanced breast cancer.

Journal Article Int J Hyperthermia · 2010 PURPOSE: The prognosis for locally advanced breast cancer (LABC) patients continues to be poor, with an estimated five-year survival of only 50-60%. Preclinical data demonstrates enhanced therapeutic efficacy with liposomal encapsulation of doxorubicin com ... Full text Link to item Cite

Hyperthermia combined with radiation therapy for superficial breast cancer and chest wall recurrence: a review of the randomised data.

Journal Article Int J Hyperthermia · 2010 Hyperthermia has long been used in combination with radiation for the treatment of superficial malignancies, in part due to its radiosensitising capabilities. Patients who suffer superficial recurrences of breast cancer, be it in their chest wall following ... Full text Link to item Cite

Optical imaging of tumor hypoxia dynamics.

Journal Article J Biomed Opt · 2010 The influence of the tumor microenvironment and hypoxia plays a significant role in determining cancer progression, treatment response, and treatment resistance. That the tumor microenvironment is highly heterogeneous with significant intratumor and intert ... Full text Link to item Cite

Magnetic resonance imaging: a potential tool in assessing the addition of hyperthermia to neoadjuvant therapy in patients with locally advanced breast cancer.

Journal Article Int J Hyperthermia · 2010 The poor overall survival for patients with locally advanced breast cancers has led over the past decade to the introduction of numerous neoadjuvant combined therapy regimens to down-stage the disease before surgery. At the same time, more evidence suggest ... Full text Link to item Cite

Growth and Structural Adaptation of Blood Vessels in Normal and Tumor Tissues

Conference NEW PERSPECTIVES IN MATHEMATICAL BIOLOGY · January 1, 2010 Link to item Cite

Abstract A7: Targeting the tumor microenvironment via inhibition of VEGF and PDGF to improve liposomal drug delivery in human non-small cell lung cancer xenografts

Conference Molecular Cancer Therapeutics · December 10, 2009 AbstractBackground: Pathological angiogenesis creates an abnormal microenvironment in tumors, characterized by elevated interstitial fluid pressure (IFP) and hypoxia. Judicious attenuation of angiogenic sign ... Full text Cite

Abstract A10: Antiangiogenic therapy (VEGF-R1–3 and PDGFR inhibitor) increases tumor hemoglobin saturation and decreases interstitial pressure, and microvessel density

Conference Molecular Cancer Therapeutics · December 10, 2009 AbstractMethods: We evaluate the effects of pazopanib, a novel multi-targeted tyrosine kinase inhibitor, by examining its effects on tumor oxygenation, interstitial pressure (IFP), and vascularity as compare ... Full text Cite

Combined hyperspectral and optical coherence tomography microscope for non-invasive hemodynamic imaging

Journal Article Optics InfoBase Conference Papers · December 1, 2009 Hyperspectral microscopy of hemoglobin oxygenation and optical coherence microscopy of three-dimensional microvessel morphology and blood velocity was demonstrated in growing tumors in the mouse skin fold window chamber. © 2007 Optical Society of America. ... Cite

Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress.

Journal Article Radiat Res · December 2009 Featured Publication This Failla Lecture focused on the inter-relationships between tumor angiogenesis, HIF-1 expression and radiotherapy responses. A common thread that bonds all of these factors together is microenvironmental stress caused by reactive oxygen and nitrogen spe ... Full text Link to item Cite

Accuracy of real time noninvasive temperature measurements using magnetic resonance thermal imaging in patients treated for high grade extremity soft tissue sarcomas.

Journal Article Med Phys · November 2009 Featured Publication PURPOSE: To establish accuracy of real time noninvasive temperature measurements using magnetic resonance thermal imaging in patients treated for high grade extremity soft tissue sarcomas. METHODS: Protocol patients with advanced extremity sarcomas were tr ... Full text Link to item Cite

Synchronous Chemoradiation and Multiple Targeted Drugs for Advanced Head and Neck Cancer

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Long-term Palliation of Breast Cancer Chestwall Recurrence with Radiation Therapy, Hyperthermia, and Chemotherapy

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Increased skin carcinogenesis in caspase-activated DNase knockout mice.

Journal Article Carcinogenesis · October 2009 Caspase-activated DNase (CAD), also called DNA fragmentation factor (DFF), is the enzyme responsible for DNA fragmentation during apoptosis, a hallmark of programmed cell death. CAD/DFF has been shown to suppress radiation-induced carcinogenesis by prevent ... Full text Link to item Cite

Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor.

Journal Article Free Radic Biol Med · October 1, 2009 MnTE-2-PyP(5+) is a potent catalytic scavenger of reactive oxygen and nitrogen species, primarily superoxide and peroxynitrite. It therefore not only attenuates primary oxidative damage, but was found to modulate redox-based signaling pathways (HIF-1alpha, ... Full text Link to item Cite

Using optical spectroscopy to longitudinally monitor physiological changes within solid tumors.

Journal Article Neoplasia · September 2009 The feasibility of using quantitative diffuse reflectance spectroscopy to longitudinally monitor physiological response to cancer therapy was evaluated in a preclinical model. This study included two groups of nude mice bearing 4T1 flank tumors (N = 50), h ... Full text Link to item Cite

A dual-emissive-materials design concept enables tumour hypoxia imaging.

Journal Article Nat Mater · September 2009 Featured Publication Luminescent materials are widely used for imaging and sensing owing to their high sensitivity, rapid response and facile detection by many optical technologies. Typically materials must be chemically tailored to achieve intense, photostable fluorescence, o ... Full text Link to item Cite

Characterization of a 137Cs irradiator from a new perspective with modern dosimetric tools.

Journal Article Health Phys · September 2009 To provide for accurate dosimetry in a 137Cs irradiator, the following were investigated: (1) correct mapping of the irradiator cavity's dose distribution, (2) rotated versus stationary dose rate measurements, (3) exposure-to-dose calibration selection for ... Full text Link to item Cite

POLY 216-Boron biomaterials for imaging and oxygen sensing

Journal Article ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · August 16, 2009 Link to item Cite

Dynamic contrast-enhanced magnetic resonance imaging as a predictor of clinical outcome in canine spontaneous soft tissue sarcomas treated with thermoradiotherapy.

Journal Article Clin Cancer Res · August 1, 2009 Featured Publication PURPOSE: This study tests whether dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters obtained from canine patients with soft tissue sarcomas, treated with hyperthermia and radiotherapy, are predictive of therapeutic outcome. EXPERIME ... Full text Link to item Cite

Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations.

Journal Article Bioorg Med Chem Lett · July 15, 2009 We have shown that manassantin A downregulated the HIF-1alpha expression and inhibited the secretion of VEGF. We have also demonstrated that the 2,3-cis-3,4-trans-4,5-cis-configuration of the tetrahydrofuran is critical to the HIF-1 inhibition of manassant ... Full text Link to item Cite

Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins.

Journal Article Free Radic Biol Med · July 1, 2009 Mn(III) N-alkylpyridylporphyrins are among the most potent known SOD mimics and catalytic peroxynitrite scavengers and modulators of redox-based cellular transcriptional activity. In addition to their intrinsic antioxidant capacity, bioavailability plays a ... Full text Link to item Cite

Novel imaging provides new insights into mechanisms of oxygen transport in tumors.

Journal Article Curr Mol Med · May 2009 Featured Publication Hypoxia is a common feature of solid tumors, and abnormal tumor oxygen transport is a key factor in the imbalance between tumor oxygen supply and demand. Novel advanced imaging techniques can enable new insights into the complexities of tumor oxygen transp ... Full text Link to item Cite

Structural adaptation and heterogeneity of normal and tumor microvascular networks.

Journal Article PLoS Comput Biol · May 2009 Featured Publication Relative to normal tissues, tumor microcirculation exhibits high structural and functional heterogeneity leading to hypoxic regions and impairing treatment efficacy. Here, computational simulations of blood vessel structural adaptation are used to explore ... Full text Link to item Cite

The performance of a reduced-order adaptive controller when used in multi-antenna hyperthermia treatments with nonlinear temperature-dependent perfusion.

Journal Article Phys Med Biol · April 7, 2009 In large multi-antenna systems, adaptive controllers can aid in steering the heat focus toward the tumor. However, the large number of sources can greatly increase the steering time. Additionally, controller performance can be degraded due to changes in ti ... Full text Link to item Cite

Real-time MRI-guided hyperthermia treatment using a fast adaptive algorithm.

Journal Article Phys Med Biol · April 7, 2009 Magnetic resonance (MR) imaging is promising for monitoring and guiding hyperthermia treatments. The goal of this work is to investigate the stability of an algorithm for online MR thermal image guided steering and focusing of heat into the target volume. ... Full text Link to item Cite

Light emitting boron biomaterials for imaging and oxygen sensing

Journal Article ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · March 22, 2009 Link to item Cite

The International Journal of Hyperthermia - The first 25 years

Journal Article International Journal of Hyperthermia · February 27, 2009 Full text Cite

Clinical Utility of Magnetic Resonance Thermal Imaging (MRTI) For Realtime Guidance of Deep Hyperthermia.

Journal Article Proc SPIE Int Soc Opt Eng · February 25, 2009 A critical need has emerged for volumetric thermometry to visualize 3D temperature distributions in real time during deep hyperthermia treatments used as an adjuvant to radiation or chemotherapy for cancer. For the current effort, magnetic resonance therma ... Full text Link to item Cite

Control time reduction using virtual source projection for treating a leg sarcoma with nonlinear perfusion.

Journal Article Proc SPIE Int Soc Opt Eng · February 12, 2009 PURPOSE: Blood perfusion is a well-known factor that complicates accurate control of heating during hyperthermia treatments of cancer. Since blood perfusion varies as a function of time, temperature and location, determination of appropriate power depositi ... Full text Link to item Cite

Combined hyperspectral and spectral domain optical coherence tomography microscope for noninvasive hemodynamic imaging.

Journal Article Opt Lett · February 1, 2009 Featured Publication We have combined hyperspectral imaging with spectral domain optical coherence tomography (SDOCT) to noninvasively image changes in hemoglobin saturation, blood flow, microvessel morphology, and sheer rate on the vessel wall with tumor growth. Changes in th ... Full text Link to item Cite

WE‐C‐BRC‐02: Combined Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE‐MRI) and Magnetic Resonance Thermal Imaging (MRTI) for Optimal Hyperthermia Treatment of Advanced Extremity Sarcomas: Fifteen Patients Update

Conference Medical Physics · January 1, 2009 Purpose: To deliver optimal hyperthermia (HT) treatments for patients with advanced extremity sarcomas using DCE‐MRI and MRTI Method and Materials: Patients were treated on a protocol using radiotherapy consisting of 45 Gy and once a week HT for 5 weeks in ... Full text Cite

Combined hyperspectral and optical coherence tomography microscope for non-invasive hemodynamic imaging

Conference Optics InfoBase Conference Papers · January 1, 2009 Hyperspectral microscopy of hemoglobin oxygenation and optical coherence microscopy of three-dimensional microvessel morphology and blood velocity was demonstrated in growing tumors in the mouse skin fold window chamber. © 2007 Optical Society of America. ... Full text Cite

Nucleophilic addition of organozinc reagents to 2-sulfonyl cyclic ethers: stereoselective synthesis of manassantins A and B.

Journal Article Org Lett · January 1, 2009 A convergent route to the synthesis of manassantins A and B, potent inhibitors of HIF-1, is described. Central to the synthesis is a stereoselective addition of an organozinc reagent to a 2-benzenesulfonyl cyclic ether to achieve the 2,3-cis-3,4-trans-4,5- ... Full text Link to item Cite

Quantitative optical spectroscopy can identify long-term local tumor control in irradiated murine head and neck xenografts.

Journal Article J Biomed Opt · 2009 Featured Publication Noninvasive and longitudinal monitoring of tumor oxygenation status using quantitative diffuse reflectance spectroscopy is used to test whether a final treatment outcome could be estimated from early optical signatures in a murine model of head and neck ca ... Full text Link to item Cite

DCE-MRI parameters have potential to predict response of locally advanced breast cancer patients to neoadjuvant chemotherapy and hyperthermia: a pilot study.

Journal Article Int J Hyperthermia · 2009 Featured Publication UNLABELLED: Combined therapies represent a staple of modern medicine. For women treated with neoadjuvant chemotherapy (NA ChT) for locally advanced breast cancer (LABC), early determination of whether the patient will fail to respond can enable the use of ... Full text Link to item Cite

Quantitative diffuse reflectance and fluorescence spectroscopy: tool to monitor tumor physiology in vivo.

Journal Article J Biomed Opt · 2009 Featured Publication This study demonstrates the use of optical spectroscopy for monitoring tumor oxygenation and metabolism in response to hyperoxic gas breathing. Hemoglobin saturation and redox ratio were quantified for a set of 14 and 9 mice, respectively, measured at base ... Full text Link to item Cite

Her2/neu signaling blockade improves tumor oxygenation in a multifactorial fashion in Her2/neu+ tumors.

Journal Article Cancer Chemother Pharmacol · January 2009 PURPOSE: Tumor hypoxia reduces the efficacy of radiation and chemotherapy as well as altering gene expression that promotes cell survival and metastasis. The growth factor receptor, Her2/neu, is overexpressed in 25-30% of breast tumors. Tumors that are Her ... Full text Link to item Cite

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.

Journal Article J Clin Invest · December 2008 Featured Publication Tumors contain oxygenated and hypoxic regions, so the tumor cell population is heterogeneous. Hypoxic tumor cells primarily use glucose for glycolytic energy production and release lactic acid, creating a lactate gradient that mirrors the oxygen gradient i ... Full text Link to item Cite

The role of hypoxia in canine cancer.

Journal Article Vet Comp Oncol · December 2008 Human oncology has clearly demonstrated the existence of hypoxic tumours and the problematic nature of those tumours. Hypoxia is a significant problem in the treatment of all types of solid tumours and a common reason for treatment failure. Hypoxia is a ne ... Full text Link to item Cite

In vivo bioluminescence imaging monitoring of hypoxia-inducible factor 1alpha, a promoter that protects cells, in response to chemotherapy.

Journal Article AJR Am J Roentgenol · December 2008 Featured Publication OBJECTIVE: Bioluminescence imaging is a powerful technique that has shown that hypoxia-inducible factor 1 (HIF-1), a transcription factor that protects tumor cells from hypoxia, is up-regulated in tumors after radiation therapy. We tested the hypothesis th ... Full text Link to item Cite

The genomic analysis of lactic acidosis and acidosis response in human cancers.

Journal Article PLoS Genet · December 2008 The tumor microenvironment has a significant impact on tumor development. Two important determinants in this environment are hypoxia and lactic acidosis. Although lactic acidosis has long been recognized as an important factor in cancer, relatively little ... Full text Link to item Cite

Radiofrequency ablation: the effect of distance and baseline temperature on thermal dose required for coagulation.

Journal Article Int J Hyperthermia · November 2008 PURPOSE: To determine the effects of applied current, distance from an RF electrode and baseline tissue temperature upon thermal dosimetry requirements to induce coagulation in ex vivo bovine liver and in vivo porcine muscle models. MATERIALS AND METHODS: ... Full text Link to item Cite

Estrogen-related receptor alpha is critical for the growth of estrogen receptor-negative breast cancer.

Journal Article Cancer Res · November 1, 2008 Expression of estrogen-related receptor alpha (ERRalpha) has recently been shown to carry negative prognostic significance in breast and ovarian cancers. The specific role of this orphan nuclear receptor in tumor growth and progression, however, is yet to ... Full text Link to item Cite

Improving the quantitative accuracy of optical-emission computed tomography by incorporating an attenuation correction: application to HIF1 imaging.

Journal Article Phys Med Biol · October 7, 2008 Optical computed tomography (optical-CT) and optical-emission computed tomography (optical-ECT) are new techniques for imaging the 3D structure and function (including gene expression) of whole unsectioned tissue samples. This work presents a method of imp ... Full text Link to item Cite

Tumor microvascular permeability is a key determinant for antivascular effects of doxorubicin encapsulated in a temperature sensitive liposome.

Journal Article Int J Hyperthermia · September 2008 Previous data have demonstrated that doxorubicin (DOX) released from a lysolecithin-containing thermosensitive liposome (LTSL) can shut down blood flow in a human tumor xenograft (FaDu) in mice when the treatment is combined with hyperthermia (HT), suggest ... Full text Link to item Cite

The pervasive presence of fluctuating oxygenation in tumors.

Journal Article Cancer Res · July 15, 2008 Featured Publication Tumor hypoxia is a persistent obstacle for traditional therapies in solid tumors. Strategies for mitigating the effects of hypoxic tumor cells have been developed under the assumption that chronically hypoxic tumor cells were the central cause of treatment ... Full text Link to item Cite

Induction of the human heat shock promoter HSP70B by nutritional stress: implications for cancer gene therapy.

Journal Article Cancer Invest · July 2008 BACKGROUND: We designed and tested, in vitro, an adenoviral construct containing the feline interleukin-12 (IL-12) gene under control of the heat-inducible promoter HSP70B. This construct, AdhspfIL12, was used in a phase I trial in feline soft tissue sarco ... Full text Link to item Cite

Bromelain treatment decreases neutrophil migration to sites of inflammation.

Journal Article Clin Immunol · July 2008 Bromelain, a mixture of proteases derived from pineapple stem, has been reported to have therapeutic benefits in a variety of inflammatory diseases, including murine inflammatory bowel disease. The purpose of this work was to understand potential mechanism ... Full text Link to item Cite

Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response.

Journal Article Nat Rev Cancer · June 2008 Featured Publication Hypoxia and free radicals, such as reactive oxygen and nitrogen species, can alter the function and/or activity of the transcription factor hypoxia-inducible factor 1 (HIF1). Interplay between free radicals, hypoxia and HIF1 activity is complex and can inf ... Full text Link to item Cite

Comparison of three physiologically-based pharmacokinetic models for the prediction of contrast agent distribution measured by dynamic MR imaging.

Journal Article J Magn Reson Imaging · June 2008 PURPOSE: To compare the performance of three physiologically-based pharmacokinetic (PBPK) models for predicting gadolinium contrast agent concentration-time curves (Gd-CTCs) obtained in superior sagittal sinus (SSS), cerebral cortex, and psoas muscle. MATE ... Full text Link to item Cite

One-stop-shop tumor imaging: buy hypoxia, get lactate free.

Journal Article J Clin Invest · May 2008 Featured Publication The ability to noninvasively assess physiological changes in solid tumors is desired for its diagnostic and therapeutic potential. In this issue of JCI, Matsumoto and colleagues reveal their development and use of a novel imaging approach, combining pulsed ... Full text Link to item Cite

Inhibition of in vivo tumor angiogenesis and growth via systemic delivery of an angiopoietin 2-specific RNA aptamer.

Journal Article J Surg Res · May 1, 2008 BACKGROUND: Cellular events mediated by the Tie2 receptor are important to tumor neovascularization. Despite the complex interplay of the best-characterized Tie2 ligands, angiopoietins 1 and 2, Ang2 is purportedly "proangiogenic" in the presence of vascula ... Full text Link to item Cite

Use of bioluminescence imaging to detect enhanced hepatic and systemic tumor growth following partial hepatectomy in mice.

Journal Article Eur J Surg Oncol · April 2008 BACKGROUND: The impact of partial hepatectomy on intra-hepatic and distant tumor growth is a matter of controversy. Utilizing a highly sensitive tumor imaging strategy, we sought to demonstrate whether this growth-acceleration occurs, and to develop an ani ... Full text Link to item Cite

Fast temperature optimization of multi-source hyperthermia applicators with reduced-order modeling of 'virtual sources'.

Journal Article Phys Med Biol · March 21, 2008 The goal of this work is to build the foundation for facilitating real-time magnetic resonance image guided patient treatment for heating systems with a large number of physical sources (e.g. antennas). Achieving this goal requires knowledge of how the tem ... Full text Link to item Cite

Analytic solution to steady-state radial diffusion of a substrate with first-order reaction kinetics in the tissue of a Krogh's cylinder.

Journal Article Radiat Res · March 2008 It is often useful to calculate the concentration profile for a substrate undergoing reaction in the tissue surrounding a capillary. In this paper, we consider a model geometry consisting of a long straight cylinder of tissue surrounding a capillary. Subst ... Full text Link to item Cite

Rationale for and measurement of liposomal drug delivery with hyperthermia using non-invasive imaging techniques.

Journal Article Int J Hyperthermia · February 2008 The purpose of this review is to present an overview of the state-of-the-art imaging modalities used to track drug delivery from liposomal formulations into tumors during or after hyperthermia treatment. Liposomes are a drug delivery system comprised of a ... Full text Link to item Cite

Elevated CAIX Expression is Associated with an Increased Risk of Distant Failure in Early-Stage Cervical Cancer.

Journal Article Biomark Insights · February 1, 2008 Tumor hypoxia is associated with adverse outcome in many malignancies. The goal of this study was to determine if elevated expression of carbonic anhydrase IX (CAIX), a biomarker of hypoxia, predicts for recurrence in early-stage cervical cancer. The chart ... Full text Link to item Cite

PET of hypoxia and perfusion with 62Cu-ATSM and 62Cu-PTSM using a 62Zn/62Cu generator.

Journal Article AJR Am J Roentgenol · February 2008 OBJECTIVE: Copper-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM) and copper-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (Cu-PTSM) are being studied as potential markers of hypoxia and perfusion, respectively. The use of short-lived radionuclides (e.g ... Full text Link to item Cite

Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan.

Journal Article J Clin Oncol · January 10, 2008 PURPOSE: The combination of a vascular endothelial growth factor (VEGF) -neutralizing antibody, bevacizumab, and irinotecan is associated with high radiographic response rates and improved survival outcomes in patients with recurrent malignant gliomas. The ... Full text Link to item Cite

RNA Aptamer-targeted Inhibition of NF-κB Suppresses Non-small Cell Lung Cancer Resistance to Doxorubicin.

Journal Article Mol Ther · January 2008 Due to the prevalence of tumor chemoresistance, the clinical response of advanced non-small cell lung cancer (NSCLC) to chemotherapy is poor. We suppressed tumor resistance to doxorubicin (Dox) in A549 cells, a human NSCLC cell line, both in vitro and in v ... Full text Link to item Cite

TU‐FF‐A4‐03: Improving the Accuracy of Optical‐Emission‐CT Imaging Through Application of a Non‐Uniform Attenuation Correction

Conference Medical Physics · January 1, 2008 Purpose: Optical computed tomography (optical‐CT) and emission tomography (optical‐ECT) are new techniques with demonstrated potential for imaging structure and function (including gene expression) in unsectioned tissue samples. This work presents the firs ... Full text Cite

SU‐GG‐T‐367: Fast Hyperthermia Temperature Optimization for Pelvic Carcinoma Patient Treated in Sigma‐Eye Applicator

Conference Medical Physics · January 1, 2008 Purpose: Though hyperthermia shows promising features being used with radiation and chemotherapy, it requires accurate spatial power focusing, which leads a workload proportional to square of number of antennas in an applicator. This motivates this investi ... Full text Cite

SU‐GG‐T‐366: Hyperthermia Treatment for a Patient with Two Shank Sarcomas Treated by a Fast Pre‐Treatment Optimization Method

Conference Medical Physics · January 1, 2008 Purpose: Cancerous cells are infiltrative and can invade neighborhood and/or distant body. While hyperthermia shows promising synergistic effects being used with radiation and/or chemotherapy, current microwave/radiofrequency power focusing techniques only ... Full text Cite

Optical clearing of unsectioned specimens for three-dimensional imaging via optical transmission and emission tomography.

Journal Article J Biomed Opt · 2008 Optical computed tomography (optical-CT) and optical emission computed tomography (optical-ECT) are new techniques that enable unprecedented high-resolution 3-D multimodal imaging of tissue structure and function. Applications include imaging macroscopic g ... Full text Link to item Cite

Spectral imaging facilitates visualization and measurements of unstable and abnormal microvascular oxygen transport in tumors.

Journal Article J Biomed Opt · 2008 Featured Publication Abnormal microvasculature contributes to the pathophysiologic microenvironment of tumors. Understanding microvascular tumor oxygen transport is necessary to comprehend the factors that influence tumor biology, physiology, and therapy. Previously, we descri ... Full text Link to item Cite

In vivo monitoring of a fluorescently labeled antibody in mice with breast cancer xenografts

Journal Article IEEE Sensors Journal · January 1, 2008 Following the uptake kinetics of a monoclonal antibody cancer therapy in vivo is addressed in this study via the use of a surface probe to assay a fluorescent label attached to the antibody. Female NCr-nu athymic mice were implanted with cells from a human ... Full text Cite

Response to comments by Dr. Luijik and Dr. Schippers

Journal Article Medical Physics · January 1, 2008 Full text Cite

Longitudinal monitoring of 4t1-tumor physiology in vivo with doxorubicin treatment via diffuse optical spectroscopy

Journal Article Biomedical Optics, BIOMED 2008 · January 1, 2008 A diffuse optical spectrometer was used to monitor 4T1 breast carcinoma tumors implanted in mice. Animals treated with doxorubicin showed relative increased oxygen saturation and decreased blood volume vs. Controls, over a 10 day period. © 2008 Optical Soc ... Full text Cite

State of the journal, 2007

Journal Article International Journal of Hyperthermia · December 1, 2007 Full text Cite

Low molecular weight catalytic metalloporphyrin antioxidant AEOL 10150 protects lungs from fractionated radiation.

Journal Article Free Radic Res · November 2007 The objective of this study was to determine whether administration of a catalytic antioxidant, Mn(III) tetrakis(N,N'-diethylimidazolium-2-yl) porphyrin, AEOL10150, reduces the severity of long-term lung injury induced by fractionated radiation (RT). Fishe ... Full text Link to item Cite

Online feedback focusing algorithm for hyperthermia cancer treatment.

Journal Article Int J Hyperthermia · November 2007 PURPOSE: Magnetic resonance (MR) imaging is increasingly being utilized to visualize the 3D temperature distribution in patients during treatment with hyperthermia or thermal ablation therapy. The goal of this work is to lay the foundation for improving th ... Full text Link to item Cite

A 400 MHz hyperthermia system using rotating spiral antennas for uniform treatment of large superficial and sub-surface tumors

Journal Article IEEE MTT-S International Microwave Symposium Digest · October 2, 2007 Numerous studies have shown that hyperthermia can significantly increase the tumor-killing effects of radiation therapy and/or chemotherapy. Superficial tumors are usually treated with waveguide-based systems operating at 915 MHz which do not heat evenly o ... Full text Cite

Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo.

Journal Article Blood · October 1, 2007 Sickle red cell (SS RBC) adhesion is believed to contribute to the process of vaso-occlusion in sickle cell disease (SCD). We previously found that the LW RBC adhesion receptor can be activated by epinephrine to mediate SS RBC adhesion to endothelial alpha ... Full text Link to item Cite

Monitoring changes in the microenvironment during targeted therapies

Journal Article ONCOLOGY · October 1, 2007 Both antiangiogenic and vascular-targeted therapies hold great promise. The approval of some antiangiogenic agents in combination with other therapies bode well for the future clinical use of these agents. Similarly, the increased interest in vascular-targ ... Cite

Corneal Angiogenesis Assay

Journal Article · September 27, 2007 New vessel growth in the avascular and transparent cornea occurs under a variety of pathological conditions and is readily distinguishable. Therefore, the corneal neovascularization (CNV) assay has become a widely used in vivo model for angiogenesis resear ... Full text Cite

Treatment with imatinib improves drug delivery and efficacy in NSCLC xenografts.

Journal Article Br J Cancer · September 17, 2007 Featured Publication Imatinib, an inhibitor of PDGF-Rbeta and other tyrosine kinase receptors, has been shown to decrease microvessel density and interstitial fluid pressure in solid tumours, thereby improving subsequent delivery of small molecules. The purpose of this study w ... Full text Link to item Cite

Radiation and a metalloporphyrin radioprotectant in a mouse prostate tumor model

Journal Article Anticancer Research · September 1, 2007 Background: Antioxidants have the potential to protect normal tissues against radiation-induced damage, but must not protect tumor cells during radiotherapy. The major objectives were to determine whether a metalloporphyrin antioxidant affects prostate tum ... Cite

The potential role of intrinsic hypoxia markers as prognostic variables in cancer.

Journal Article Antioxid Redox Signal · August 2007 Tumor hypoxia is related to tumor progression and therapy resistance, which leads to poor patient outcome. It has been suggested that measuring the hypoxic status of a tumor helps to predict patient outcome and to select more targeted treatment. However, c ... Full text Link to item Cite

An in vitro system to evaluate the effects of ischemia on survival of cells used for cell therapy.

Journal Article Ann Biomed Eng · August 2007 Maintaining cell viability is a major challenge associated with transplanting cells into ischemic myocardium to restore function. A likely contributor to significant cell death during cardiac cell therapy is hypoxia/anoxia. We developed a system that enabl ... Full text Link to item Cite

Predicting lung radiotherapy-induced pneumonitis using a model combining parametric Lyman probit with nonparametric decision trees.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2007 PURPOSE: To develop and test a model to predict for lung radiation-induced Grade 2+ pneumonitis. METHODS AND MATERIALS: The model was built from a database of 234 lung cancer patients treated with radiotherapy (RT), of whom 43 were diagnosed with pneumonit ... Full text Link to item Cite

Self-consistent tumor control probability and normal tissue complication probability models based on generalized EUDa).

Journal Article Med Phys · July 2007 Traditional methods to compute the tumor control probability (TCP) or normal tissue complication probability (NTCP) typically require a heterogeneous radiation dose distribution to be converted into a simple uniform dose distribution with an equivalent bio ... Full text Link to item Cite

A note from the Editor-in-Chief

Journal Article International Journal of Hyperthermia · June 27, 2007 Full text Cite

Erythropoietin blockade inhibits the induction of tumor angiogenesis and progression.

Journal Article PLoS One · June 20, 2007 Featured Publication BACKGROUND: The induction of tumor angiogenesis, a pathologic process critical for tumor progression, is mediated by multiple regulatory factors released by tumor and host cells. We investigated the role of the hematopoietic cytokine erythropoietin as an a ... Full text Link to item Cite

Requirements for T lymphocyte migration in explanted lymph nodes.

Journal Article J Immunol · June 15, 2007 Although the requirements for T lymphocyte homing to lymph nodes (LNs) are well studied, much less is known about the requirements for T lymphocyte locomotion within LNs. Imaging of murine T lymphocyte migration in explanted LNs using two-photon laser-scan ... Full text Link to item Cite

Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment.

Journal Article Cancer Metastasis Rev · June 2007 A large body of clinical evidence exists to suggest that tumor hypoxia negatively impacts radiotherapy. As a result, there has been longstanding active research into novel methods of improving tumor oxygenation, targeting hypoxic tumor cells, and otherwise ... Full text Link to item Cite

Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy.

Journal Article Radiother Oncol · June 2007 The objective of this review is to examine the role that HIF-1 plays in the initiation of angiogenesis and in radiotherapy response. Although these two phenomena may at first seem unrelated, there are parallelisms to be drawn associated with the importance ... Full text Link to item Cite

Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1F0 ATP synthase.

Journal Article Cancer Res · May 15, 2007 The antiangiogenic protein angiostatin inhibits ATP synthase on the endothelial cell surface, blocking cellular proliferation. To examine the specificity of this interaction, we generated monoclonal antibodies (mAb) directed against ATP synthase. mAb direc ... Full text Link to item Cite

Thermal cycling enhances the accumulation of a temperature-sensitive biopolymer in solid tumors.

Journal Article Cancer Res · May 1, 2007 Featured Publication The delivery of anticancer therapeutics to solid tumors remains a critical problem in the treatment of cancer. This study reports a new methodology to target a temperature-responsive macromolecular drug carrier, an elastin-like polypeptide (ELP) to solid t ... Full text Link to item Cite

Targeting the molecular effects of a hypoxic tumor microenvironment.

Journal Article Front Biosci · May 1, 2007 Tumor hypoxia is a serious and enduring problem for traditional solid tumor therapies. Many scientists continue to explore methods to improve or exploit tumor oxygenation; more recently, scientists have also focused on altering the molecular effects of hyp ... Full text Link to item Cite

Functional imaging in bulk tissue specimens using optical emission tomography: fluorescence preservation during optical clearing.

Journal Article Phys Med Biol · April 21, 2007 Optical emission computed tomography (optical-ECT) is a technique for imaging the three-dimensional (3D) distribution of fluorescent probes in biological tissue specimens with high contrast and spatial resolution. In optical-ECT, functional information can ... Full text Link to item Cite

Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth.

Journal Article Cancer Res · April 15, 2007 Featured Publication Angiopoietin-2 (Ang-2) is a conditional antagonist and agonist for the endothelium-specific Tie-2 receptor. Although endogenous Ang-2 cooperates with vascular endothelial growth factor (VEGF) to protect tumor endothelial cells, the effect on tumor vasculat ... Full text Link to item Cite

Regulation of HIF-1alpha stability through S-nitrosylation.

Journal Article Mol Cell · April 13, 2007 Featured Publication Hypoxia-inducible factor 1 (HIF-1) is a master transcriptional factor. Under normal oxygen tension, HIF-1 activity is usually suppressed due to the rapid, oxygen-dependent degradation of one of its two subunits, HIF-1alpha. Here we report that normoxic HIF ... Full text Link to item Cite

Effects of fluctuating oxygenation on tirapazamine efficacy: Theoretical predictions.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2007 PURPOSE: To examine the effects of fluctuating oxygen levels on the hypoxic cytotoxin tirapazamine (TPZ) using theoretical predictions. METHODS AND MATERIALS: Tirapazamine's pharmacokinetic and pharmacodynamic oxygen dependence has previously been characte ... Full text Link to item Cite

Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting.

Journal Article Cancer Res · February 1, 2007 Featured Publication Hypoxia-inducible factor-1 (HIF-1) stabilization is a pivotal event in the response to hypoxic stress. A study in the December 15, 2006 issue of Cancer Research shows that HIF-1 stabilization occurs more robustly as a result of intermittent hypoxia compare ... Full text Link to item Cite

Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2007 PURPOSE: To determine whether administration of a catalytic antioxidant, Mn(III) tetrakis(N,N'-diethylimidazolium-2-yl) porphyrin, AEOL 10150, with superoxide dismutase (SOD) mimetic properties, reduces the severity of radiation-induced injury to the lung ... Full text Link to item Cite

Multiple etiologies of tumor hypoxia require multifaceted solutions.

Journal Article Clin Cancer Res · January 15, 2007 Featured Publication Full text Link to item Cite

Magnetic resonance imaging of temperature-sensitive liposome release: drug dose painting and antitumor effects.

Journal Article J Natl Cancer Inst · January 3, 2007 Featured Publication BACKGROUND: In preclinical studies, lysolipid-based temperature-sensitive liposomes (LTSLs) containing chemotherapy drugs administered in combination with local hyperthermia have been found to increase tumor drug concentrations and improve antitumor effica ... Full text Link to item Cite

Radiation and a metalloporphyrin radioprotectant in a mouse prostate tumor model.

Journal Article Anticancer Res · 2007 BACKGROUND: Antioxidants have the potential to protect normal tissues against radiation-induced damage, but must not protect tumor cells during radiotherapy. The major objectives were to determine whether a metalloporphyrin antioxidant affects prostate tum ... Link to item Cite

A phase I trial of hyperthermia-induced interleukin-12 gene therapy in spontaneously arising feline soft tissue sarcomas.

Journal Article Mol Cancer Ther · January 2007 Interleukin-12 (IL-12), a proinflammatory cytokine, shows anticancer properties. Systemically administered IL-12 causes dose-dependent toxicity. To achieve localized intratumoral gene expression, an adenoviral gene therapy vector with IL-12 controlled by a ... Full text Link to item Cite

Three-dimensional imaging of whole rodent organs using optical computed and emission tomography.

Journal Article J Biomed Opt · 2007 We explore the potential of optical computed tomography (optical-CT) and optical emission computed tomography (optical-ECT) in a new area-whole organ imaging. The techniques are implemented on an in-house prototype benchtop system with improved image quali ... Full text Link to item Cite

A 400 MHz hyperthermia system using rotating spiral antennas for uniform treatment of large superficial and sub-surface tumors

Conference 2007 IEEE/MTT-S INTERNATIONAL MICROWAVE SYMPOSIUM DIGEST, VOLS 1-6 · January 1, 2007 Link to item Cite

TH‐E‐M100E‐03: Optimizing the Methodology for Incorporating SPECT‐Guidance to Reduce Intensity Modulated Radiation Therapy (IMRT) Dose to Functioning Lung

Conference Medical Physics · January 1, 2007 Purpose: Single photon emission computed tomography (SPECT) provides a spatial distribution map of lung perfusion. Previously, an algorithmic methodology was developed using IMRT and SPECT guidance to deliberately divert dose away from higher functioning ( ... Full text Cite

Tumor necrosis factor-alpha is a potent endogenous mutagen that promotes cellular transformation.

Journal Article Cancer Res · December 15, 2006 Tumor necrosis factor-alpha (TNF-alpha) is an important inflammation cytokine without known direct effect on DNA. In this study, we found that TNF-alpha can cause DNA damages through reactive oxygen species. The mutagenic effect of TNF-alpha is comparable ... Full text Link to item Cite

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.

Journal Article Nature · December 7, 2006 Ionizing radiation represents the most effective therapy for glioblastoma (World Health Organization grade IV glioma), one of the most lethal human malignancies, but radiotherapy remains only palliative because of radioresistance. The mechanisms underlying ... Full text Link to item Cite

A methodology for using SPECT to reduce intensity-modulated radiation therapy (IMRT) dose to functioning lung.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2006 PURPOSE: Single photon emission computed tomography (SPECT) provides a map of the spatial distribution of lung perfusion. Thus, SPECT guidance can be used to divert dose away from higher-functioning lung, potentially reducing lung toxicity. We present a me ... Full text Link to item Cite

A tracer dose of technetium-99m-labeled liposomes can estimate the effect of hyperthermia on intratumoral doxil extravasation.

Journal Article Clin Cancer Res · November 15, 2006 PURPOSE: A noninvasive method to monitor intratumoral Doxil delivery in individual patients during targeted tumor therapy is important to predict treatment response. The purpose of this study was to determine if a small tracer dose of technetium-99m (99mTc ... Full text Link to item Cite

Anti-angiogenic effects of interleukin-12 delivered by a novel hyperthermia induced gene construct.

Journal Article Int J Hyperthermia · November 2006 PURPOSE: Interleukin-12 (IL-12) is a pro-inflammatory cytokine possessing anti-cancer and anti-angiogenic properties. This study quantitatively assessed the anti-angiogenic effect of IL-12 delivered using an adenoviral vector with murine IL-12 placed under ... Full text Link to item Cite

Chemodosimetry of in vivo tumor liposomal drug concentration using MRI.

Journal Article Magn Reson Med · November 2006 Effective cancer chemotherapy depends on the delivery of therapeutic drugs to cancer cells at cytotoxic concentrations. However, physiologic barriers, such as variable vessel permeability, high interstitial fluid pressure, and heterogeneous perfusion, make ... Full text Link to item Cite

2026

Conference International Journal of Radiation Oncology*Biology*Physics · November 2006 Full text Cite

2808

Conference International Journal of Radiation Oncology*Biology*Physics · November 2006 Full text Cite

32

Conference International Journal of Radiation Oncology*Biology*Physics · November 2006 Full text Cite

Treatment with Imatinib in NSCLC is associated with decrease of phosphorylated PDGFR-beta and VEGF expression, decrease in interstitial fluid pressure and improvement of oxygenation.

Journal Article Br J Cancer · October 23, 2006 Elevated intratumoral interstitial fluid pressure (IFP) and tumour hypoxia are independent predictive factors for poor survival and poor treatment response in cancer patients. However, the relationship between IFP and tumour hypoxia has not yet been clearl ... Full text Open Access Link to item Cite

Assessing the ability of the antiangiogenic and anticytokine agent thalidomide to modulate radiation-induced lung injury.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2006 PURPOSE: Thalidomide has broad anticytokine properties, which might protect normal tissues in patients undergoing chemoradiotherapy. The purpose of this study was to determine the maximal tolerated dose of thalidomide when used in combination with vinorelb ... Full text Link to item Cite

Extracellular pH and P-31 magnetic resonance spectroscopic variables are related to outcome in canine soft tissue sarcomas treated with thermoradiotherapy.

Journal Article Clin Cancer Res · October 1, 2006 Featured Publication PURPOSE: The objective was to test whether tumor pH and (31)P magnetic resonance spectroscopic end points were related to treatment outcome in pet canine patients with spontaneous soft tissue sarcomas treated with thermoradiotherapy. EXPERIMENTAL DESIGN: F ... Full text Link to item Cite

Alternative inclusion of fibroblast growth factor receptor 2 exon IIIc in Dunning prostate tumors reveals unexpected epithelial mesenchymal plasticity.

Journal Article Proc Natl Acad Sci U S A · September 19, 2006 In epithelial cells, alternative splicing of fibroblast growth factor receptor 2 (FGFR2) transcripts leads to the expression of the FGFR2(IIIb) isoform, whereas in mesenchymal cells, the same process results in the synthesis of FGFR2(IIIc). Expression of t ... Full text Link to item Cite

Three-dimensional imaging of xenograft tumors using optical computed and emission tomography.

Journal Article Med Phys · September 2006 The physical basis and preliminary applications of optical computed tomography (optical-CT) and optical emission computed tomography (optical-ECT) are introduced, as new techniques with potential to provide unique 3D information on a variety of aspects of ... Full text Link to item Cite

Apoptotic DNA fragmentation factor maintains chromosome stability in a P53-independent manner.

Journal Article Oncogene · August 31, 2006 DNA fragmentation factor (DFF)/caspase-activated DNase (CAD) is responsible for DNA fragmentation, a hallmark event during apoptosis. Although DNA fragmentation is an evolutionarily conserved process across species, its biological function is not clearly u ... Full text Link to item Cite

Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxia-targeted anticancer drugs.

Journal Article J Natl Cancer Inst · August 16, 2006 Featured Publication BACKGROUND: Because of the inefficient vasculature of solid tumors, anticancer drugs must penetrate relatively long distances through the extravascular compartment. The requirement for such diffusion may limit their activity, especially that of hypoxia-tar ... Full text Link to item Cite

Changes in tumour oxygenation during fractionated hyperthermia and radiation therapy in spontaneous canine sarcomas.

Journal Article Int J Hyperthermia · August 2006 Featured Publication Tumour oxygenation was measured in seven canine soft tissue sarcomas being treated with a fractionated course of radiation and hyperthermia. Measurements obtained during treatment were compared to pre-treatment measurements. The most important finding was ... Full text Link to item Cite

Preferential extravasation and accumulation of liposomal vincristine in tumor comparing to normal tissue enhances antitumor activity.

Journal Article Cancer Chemother Pharmacol · August 2006 To quantitatively evaluate the extravasation, accumulation and selectivity to tumor tissues of liposomal vincristine (LV), dorsal skin-fold window chambers on athymic mice with or without LX-1, a human small cell lung cancer, xenograft implants and fluores ... Full text Link to item Cite

In Reply to van der Zee et al. [2]

Journal Article International Journal of Hyperthermia · August 1, 2006 Full text Cite

Untitled - Reply

Journal Article INTERNATIONAL JOURNAL OF HYPERTHERMIA · August 1, 2006 Link to item Cite

HIF-1 and tumour radiosensitivity.

Journal Article Br J Cancer · July 3, 2006 Hypoxia-inducible factor-1 (HIF-1) plays important roles in regulating radiosensitivity, making it a potentially promising target for tumour radiosensitisation. Here, we discuss the rationale for, and the potential pitfalls of, combining HIF-1 blockade wit ... Full text Link to item Cite

Phase I trial of doxorubicin-containing low temperature sensitive liposomes in spontaneous canine tumors.

Journal Article Clin Cancer Res · July 1, 2006 Featured Publication PURPOSE: To determine the maximum tolerated dose, dose-limiting toxicities, and pharmacokinetic characteristics of doxorubicin encapsulated in a low temperature sensitive liposome (LTSL) when given concurrently with local hyperthermia to canine solid tumor ... Full text Link to item Cite

ROS production and angiogenic regulation by macrophages in response to heat therapy.

Journal Article Int J Hyperthermia · June 2006 PURPOSE: It has been well established that inadequate blood supply combined with high metabolic rates of oxygen consumption results in areas of low oxygen tension (<1%) within malignant tumours and that elevating tumour temperatures above 39 degrees Celsiu ... Full text Link to item Cite

Intertumoral differences in hypoxia selectivity of the PET imaging agent 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone).

Journal Article J Nucl Med · June 2006 Featured Publication UNLABELLED: Cu-Diacetyl-bis(N(4)-methylthiosemicarbazone) (Cu-ATSM) is a recently developed PET imaging agent for tumor hypoxia. However, its accuracy and reliability for measuring hypoxia have not been fully characterized in vivo. The aim of this study wa ... Link to item Cite

The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis.

Journal Article Proc Natl Acad Sci U S A · May 23, 2006 Although the prognosis for patients with early-stage breast cancer has improved, the therapeutic options for patients with locally advanced and metastatic disease are limited. To improve the treatment of these patients, the molecular mechanisms underlying ... Full text Link to item Cite

Optical imaging measurements of oxygen transport fluctuations and gradients in tumor microvascular networks

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · May 8, 2006 It is well established that hypoxia can influence tumor biology and physiology, gene expression, metastatic potential, treatment efficacy, and patient survival. Most human solid tumors have been shown to have some hypoxic regions, thus there is a strong mo ... Full text Cite

Hyperthermia mediated liposomal drug delivery.

Journal Article Int J Hyperthermia · May 2006 Drug delivery systems have been developed for cancer therapy in an attempt to increase the tumour drug concentration while limiting systemic exposure. Liposomes have achieved passive targeting of solid tumours through enhanced vascular permeability, which ... Full text Link to item Cite

Prospective thermal dosimetry: the key to hyperthermia's future.

Journal Article Int J Hyperthermia · May 2006 PURPOSE: This review summarizes recent results from two randomized trials testing the complete response rate and local control benefits for the addition of hyperthermia to external beam radiation. METHODS: In both series, there was a statistically signific ... Full text Link to item Cite

Radiation sensitive liposomes

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · March 26, 2006 Link to item Cite

A clinically proven, prospective, thermal dose descriptor exists [4]

Journal Article Clinical Cancer Research · March 15, 2006 Full text Cite

Characterization of a recombinant adenovirus vector encoding heat-inducible feline interleukin-12 for use in hyperthermia-induced gene-therapy.

Journal Article Int J Hyperthermia · March 2006 Interleukin-12 (IL-12) is a pro-inflammatory cytokine that has shown great promise as a therapeutic agent in experimental models of infectious disease and cancer. However, it is also a highly toxic molecule and for that reason has not been accepted readily ... Full text Link to item Cite

Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers.

Journal Article J Natl Cancer Inst · March 1, 2006 Featured Publication BACKGROUND: Delivery of anticancer therapeutic agents to solid tumors is problematic. Macromolecular drug carriers are an attractive alternative drug delivery method because they appear to target tumors and have limited toxicity in normal tissues. We inves ... Full text Link to item Cite

Intra-peritoneal cisplatin and whole abdomen hyperthermia for relapsed ovarian carcinoma.

Journal Article Int J Hyperthermia · March 2006 The study was designed to determine the maximum tolerated dose (MTD) of IP cisplatin [CDDP] combined with intravenous thiosulphate and concurrent whole abdomen hyperthermia for advanced, recurrent or progressive ovarian carcinoma. Between September 1991 an ... Full text Link to item Cite

A comparison of antiangiogenic therapies for the prevention of liver metastases.

Journal Article J Surg Res · March 2006 Angiogenesis is essential for solid tumor growth. Although successful antiangiogenic therapies have been demonstrated in animal models, a systematic comparison of the efficacy of different antiangiogenic factors has not been described in the hepatic enviro ... Full text Link to item Cite

Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor.

Journal Article Cancer Res · February 15, 2006 Featured Publication To test the hypothesis that temporal variations in microvessel red cell flux cause unstable oxygen levels in tumor interstitium, extravascular oxygenation of R3230Ac mammary tumors grown in skin-fold window chambers was measured using recessed tip polarogr ... Full text Link to item Cite

Erythropoietin inhibits apoptosis in breast cancer cells via an Akt-dependent pathway without modulating in vivo chemosensitivity.

Journal Article Mol Cancer Ther · February 2006 Evidence for erythropoietin signaling has been shown in several nonhematopoietic tissues, including many tumor types. Clinically, recombinant erythropoietin treatment of malignancy-related anemia has yet to be definitively associated with any modulation of ... Full text Link to item Cite

Gene expression profiles of multiple breast cancer phenotypes and response to neoadjuvant chemotherapy.

Journal Article Clin Cancer Res · February 1, 2006 Featured Publication PURPOSE: Breast cancer is a heterogeneous disease, and markers for disease subtypes and therapy response remain poorly defined. For that reason, we employed a prospective neoadjuvant study in locally advanced breast cancer to identify molecular signatures ... Full text Link to item Cite

The effect of darbepoetin alfa on growth, oxygenation and radioresponsiveness of a breast adenocarcinoma.

Journal Article Radiat Res · February 2006 Tumor hypoxia is associated with poor clinical outcome in a variety of tumors, including cervical, head/neck and breast cancer. Administration of erythropoietic factors has been suggested as a means of improving tumor oxygenation (pO2). This study randomiz ... Full text Link to item Cite

A unique role of the DNA fragmentation factor in maintaining genomic stability.

Journal Article Proc Natl Acad Sci U S A · January 31, 2006 DNA fragmentation is a hallmark of apoptosis (programmed cell death). However, the biological function of apoptotic DNA fragmentation remains unclear. Here, we show that DNA fragmentation factor plays an important role for maintaining genomic stability. In ... Full text Link to item Cite

New PEG-ylated Mn(III) porphyrins approaching catalytic activity of SOD enzyme.

Journal Article Dalton Trans · January 28, 2006 Two new tri(ethyleneglycol)-derivatized Mn(III) porphyrins were synthesized with the aim of increasing their bioavailability, and blood-circulating half-life. These are Mn(III) tetrakis(N-(1-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)pyridinium-2-yl)porphyrin, Mn ... Full text Link to item Cite

Erythropoietin biology in cancer.

Journal Article Clin Cancer Res · January 15, 2006 Erythropoietin (Epo) has long been known to be the principal hematopoietic growth factor that regulates cellular proliferation and differentiation along the erythroid lineage. Recent studies have shown that Epo is a pleiotropic cytokine that is proangiogen ... Full text Link to item Cite

Optimizing a novel regional chemotherapeutic agent against melanoma: hyperthermia-induced enhancement of temozolomide cytotoxicity.

Journal Article Clin Cancer Res · January 1, 2006 PURPOSE: Previous preclinical studies have shown that regional temozolomide therapy via isolated limb infusion is more effective than melphalan, the current drug of choice for regional chemotherapy for advanced extremity melanoma. The aim of this study was ... Full text Link to item Cite

Quantitative comparison of the inhibitory effects of GW5638 and tamoxifen on angiogenesis in the cornea pocket assay.

Journal Article Angiogenesis · 2006 GW5638 is a novel tissue-selective estrogen receptor (ER) modulator. Structurally, it is a derivative of tamoxifen that is known for its inhibitory effects on angiogenesis in an ER-independent manner. Therefore, it is possible that GW5638 has the same effe ... Full text Link to item Cite

Camptothecin analogs with enhanced activity against human breast cancer cells. II. Impact of the tumor pH gradient.

Journal Article Cancer Chemother Pharmacol · January 2006 Human breast tumors often exist in an acidic and hypoxic microenvironment, which can promote resistance to radiation and chemotherapies. A tumor-selective pH gradient arises in these tumors which favors uptake and retention of drugs like camptothecin that ... Full text Link to item Cite

Tissue transglutaminase expression in early-stage cervical cancer

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · 2006 Full text Cite

SU‐FF‐J‐125: Therapy Assessment Using a Full Time Point (fTP) Pharmacokinetic Analysis of Dynamic Contrast‐Enhanced Magnetic Resonance Imaging (DCE‐MRI): Role of Region of Interest (ROI) Selection in Three Tumor Sites

Conference Medical Physics · January 1, 2006 Background: DCE‐MRI has great potential to provide routine assessment of cancer treatment response. The contrast agent preferentially accumulates in tumors due to increased tumor vascular permeability. The MR based parameters that can be used for treatment ... Full text Cite

WE‐D‐330A‐02: Optical‐Computed‐and Emmission Tomography: Applications in Cancer Research

Conference Medical Physics · January 1, 2006 Purpose: This work explores the potential of optical‐computed and emission‐tomography (OCT/OET), when coupled with optical clearing techniques, for imaging aspects of biological structure and function for cancer research. OCT/OET are the optical analogues ... Full text Cite

WE‐D‐330A‐01: 3D Optical Imaging of Tumor Microvasculature and Viable Cell Distribution

Conference Medical Physics · January 1, 2006 Purpose: The ability to image 3D global structure (e.g. microvasculature) and function (e.g. gene expression) in whole unsectioned tumors, in high‐resolution and with high‐contrast, is of significant present interest in cancer research. We have developed n ... Full text Cite

TH‐C‐224C‐09: Using SPECT‐Guidance to Reduce Intensity Modulated Radiation Therapy (IMRT) Dose to Functioning Lung

Conference Medical Physics · January 1, 2006 Purpose: Single photon emission computed tomography (SPECT) provides a map of the spatial distribution of lung perfusion. Thus, SPECT guidance can be used to deliberately divert dose away from higher functioning lung, thereby potentially reducing lung toxi ... Full text Cite

Human recombinant erythropoietin (rEpo) has no effect on tumour growth or angiogenesis.

Journal Article Br J Cancer · December 12, 2005 Tumour hypoxia has been shown to increase mutation rate, angiogenesis, and metastatic potential, and decrease response to conventional therapeutics. Improved tumour oxygenation should translate into increased treatment response. Exogenous recombinant eryth ... Full text Link to item Cite

Thermal medicine, heat shock proteins and cancer.

Journal Article Int J Hyperthermia · December 2005 Full text Link to item Cite

Re-setting the biologic rationale for thermal therapy.

Journal Article Int J Hyperthermia · December 2005 This review takes a retrospective look at how hyperthermia biology, as defined from studies emerging from the late 1970s and into the 1980s, mis-directed the clinical field of hyperthermia, by placing too much emphasis on the necessity of killing cells wit ... Full text Link to item Cite

Cytokine profiling for prediction of symptomatic radiation-induced lung injury.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2005 PURPOSE: To analyze plasma cytokine profiles before the initiation of radiation therapy to define a cytokine phenotype that correlates with risk of developing symptomatic radiation-induced lung injury (SRILI). METHODS AND MATERIALS: Symptomatic radiation-i ... Full text Link to item Cite

In regard to Arvold et al. (Int J Radiat Oncol Biol Phys 2005;62:207-212).

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2005 Full text Link to item Cite

Improved magnetic resonance thermal imaging by combining proton resonance frequency shift (PRFS) and apparent diffusion coefficient (ADC) data.

Journal Article Int J Hyperthermia · November 2005 Featured Publication Effective thermal therapy for cancer is dependent on adequate tumor heating. Adequate heating, in turn, is dependent on reliable volumetric measurement of temperature to guide heating. Proton resonance frequency shift (PRFS) magnetic resonance imaging is f ... Full text Link to item Cite

In regard to Arvold et al. (Int J Radiat Oncol Biol Phys 2005;62:207-212).

Journal Article International journal of radiation oncology, biology, physics · November 2005 Cite

A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2005 PURPOSE: To determine the effect of the superoxide dismutase mimetic Mn(III) tetrakis(N-ethylpyridinium-2-yl)porphyrin (MnTE-2-PyP(5+)) on tumor radioresponsiveness. METHODS AND MATERIALS: Various rodent tumor (4T1, R3230, B16) and endothelial (SVEC) cell ... Full text Link to item Cite

A Randomized Trial of Hyperthermia and Radiation for Superficial Tumors

Conference International Journal of Radiation Oncology*Biology*Physics · October 2005 Full text Cite

Hyperpolarized 129Xe MRI for Functional Assessment of Radiation-Induced Lung Injury

Conference International Journal of Radiation Oncology*Biology*Physics · October 2005 Full text Cite

A Novel Method of Imaging Unperturbed Tumor Vasculature in 3D

Conference International Journal of Radiation Oncology*Biology*Physics · October 2005 Full text Cite

The role of blood-brain barrier permeability in brain tumor imaging and therapeutics.

Journal Article AJR Am J Roentgenol · September 2005 OBJECTIVE: Our purpose is to describe methods of assessing leakiness of the blood-brain barrier and explain mechanisms for exploiting the blood-brain barrier for therapeutic purposes. CONCLUSION: Knowledge of the workings of the blood-brain barrier is impo ... Full text Link to item Cite

Expression of HIF-1alpha, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer.

Journal Article Lung Cancer · September 2005 Endogenous hypoxia markers have been studied as prognostic indicators because they appear to be associated with tumor aggressiveness. This study was undertaken to compare the expression of two endogenous hypoxia markers, Hypoxia-inducible factor-1alpha (HI ... Full text Link to item Cite

Measurement of hemoglobin saturation in tumor microvasculature in preclinical models using hyperspectral imaging

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · August 16, 2005 Tumor hypoxia has been shown to be of prognostic value in several clinical trials involving radiation, chemotherapy, and surgery. Studies of tumor oxygenation at the microvascular and microregional levels can provide understanding of tumor oxygen transport ... Full text Cite

Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity.

Journal Article Cancer Cell · August 2005 Featured Publication We have previously shown that radiation increases HIF-1 activity in tumors, causing significant radioprotection of the tumor vasculature. The impact that HIF-1 activation has on overall tumor radiosensitivity, however, is unknown. We reveal here that HIF-1 ... Full text Link to item Cite

Thermal dose is related to duration of local control in canine sarcomas treated with thermoradiotherapy.

Journal Article Clin Cancer Res · July 15, 2005 Featured Publication PURPOSE: To test that prospective delivery of higher thermal dose is associated with longer tumor control duration. EXPERIMENTAL DESIGN: 122 dogs with a heatable soft tissue sarcoma were randomized to receive a low (2-5 CEM43 degrees CT90) or high (20-50 C ... Full text Link to item Cite

Lev Aleksandrovish Zil'ber (1894-1966). Life in science

Journal Article EUROPE-ASIA STUDIES · July 1, 2005 Link to item Cite

Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation.

Journal Article Cancer Res · July 1, 2005 Featured Publication It is well established that hypoxia potently stimulates tumor angiogenesis by activating hypoxia inducible factor-1 (HIF-1)-induced proangiogenic factors, such as vascular endothelial growth factor. However, very little is known about the role of hypoxia i ... Full text Link to item Cite

Spatial heterogeneity and oxygen dependence of glucose consumption in R3230Ac and fibrosarcomas of the Fischer 344 rat.

Journal Article Cancer Res · June 15, 2005 To examine the oxygen-dependence of glucose consumption in solid tumors, we monitored gradients of glucose, lactate, and hypoxia in R3230Ac and FSA tumors growing in Fischer 344 rats. Bioluminescence imaging, detection of Hoechst 33342, and immunostaining ... Full text Link to item Cite

Overexpression of extracellular superoxide dismutase reduces acute radiation induced lung toxicity.

Journal Article BMC Cancer · June 10, 2005 BACKGROUND: Acute RT-induced damage to the lung is characterized by inflammatory changes, which proceed to the development of fibrotic lesions in the late phase of injury. Ultimately, complete structural ablation will ensue, if the source of inflammatory/f ... Full text Link to item Cite

Expression of phosphorylated epidermal growth factor receptor (p-EGFR) in early stage non-small cell lung cancer: its relationship with overexpression of EGFR and cyclooxygenase-2 (COX-2), and survival.

Journal Article J Clin Oncol · June 2005 9614 Background: Epidermal growth factor receptor (EGFR) is widely overexpressed in various cancers, and reported to relate with growth and invasion of cancer cells. However, clinical significance of EGFR overexpression is still controversial because its c ... Link to item Cite

Phase I/II trial of intravenous Doxil and whole abdomen hyperthermia in patients with refractory ovarian cancer.

Journal Article Int J Hyperthermia · June 2005 OBJECTIVE: A phase I/II study of Doxil combined with whole abdomen hyperthermia was conducted in patients with refractory ovarian cancer. Liposomal doxorubicin combined with hyperthermia has been shown to increase both liposomal delivery and drug extravasa ... Full text Link to item Cite

Prospective assessment of quality of life in ovarian cancer patients receiving whole abdomen hyperthermia and liposomal doxorubicin.

Journal Article Int J Hyperthermia · June 2005 PURPOSE: Prospective assessment of quality of life (QoL) in patients with refractory, residual or recurrent ovarian cancer receiving whole abdomen hyperthermia and intravenous liposomal doxorubicin chemotherapy. METHODS: Treatment consisted of six cycles o ... Full text Link to item Cite

Oxygen regulation of tumor perfusion by S-nitrosohemoglobin reveals a pressor activity of nitric oxide.

Journal Article Circ Res · May 27, 2005 In erythrocytes, S-nitrosohemoglobin (SNO-Hb) arises from S-nitrosylation of oxygenated hemoglobin (Hb). It has been shown that SNO-Hb behaves as a nitric oxide (NO) donor at low oxygen tensions. This property, in combination with oxygen transport capacity ... Full text Link to item Cite

Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2005 The ability to optimize treatments for cancer on the basis of relative risks for normal tissue injury has important implications in oncology, because higher doses of radiation might, in some diseases, improve both local control and survival. To achieve thi ... Full text Link to item Cite

Randomized trial of hyperthermia and radiation for superficial tumors.

Journal Article J Clin Oncol · May 1, 2005 Featured Publication PURPOSE: Randomized clinical trials have demonstrated hyperthermia (HT) enhances radiation response. These trials, however, generally lacked rigorous thermal dose prescription and administration. We report the final results of a prospective randomized tria ... Full text Link to item Cite

Development of magnetic resonance imaging contrast material for in vivo mapping of tissue transglutaminase activity.

Journal Article Cancer Res · February 15, 2005 Transglutaminases are a family of enzymes that play an important role in tissue remodeling by catalyzing covalent cross-links between proteins of the extracellular matrix. Elevated activity of transglutaminase was shown at the boundaries of invading tumors ... Full text Link to item Cite

Relation between pO2, 31P magnetic resonance spectroscopy parameters and treatment outcome in patients with high-grade soft tissue sarcomas treated with thermoradiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2005 Featured Publication PURPOSE: In a prior study, the combination of (31)P magnetic resonance spectroscopy (MRS)-based intracellular pH (pHi) and T2 relaxation time was highly predictive of the pathologic complete response (pCR) rate in a small series of patients with soft tissu ... Full text Link to item Cite

Characterizing tumor changes during neoadjuvant treatment of locally advanced breast cancer patients (LABC) using dynamic-enhanced magnetic resonance imaging (DE-MRI)

Journal Article Proc. SPIE - Int. Soc. Opt. Eng. (USA) · 2005 At Duke University Medical Center, selective LABC patients were treated on a protocol using neoadjuvant Myocet/Paclitaxel (ChT) and HT. With the purpose of generating perfusion/permeability parametric maps and to use gadolinium (Gd) enhancement curves to s ... Full text Link to item Cite

Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development.

Journal Article J Biomed Opt · 2005 Featured Publication Tumor hypoxia has been shown to have prognostic value in clinical trials involving radiation, chemotherapy, and surgery. Tumor oxygenation studies at microvascular levels can provide understanding of oxygen transport on scales at which oxygen transfer to t ... Full text Link to item Cite

Monitoring metabolite gradients in the blood, liver, and tumor after induced hyperglycemia in rats with R3230 flank tumors using microdialysis and bioluminescence imaging.

Journal Article Adv Exp Med Biol · 2005 Hypoxia is a common cause of reduced tumor response to treatment such as irradiation. The purpose of this study was to establish a method in a rat model that is clinically applicable to monitor the efficiency of glucose transport to both tumor and normal t ... Full text Link to item Cite

Method for improved accuracy in endogenous urea recovery marker calibrations for microdialysis in tumors.

Journal Article J Pharmacol Toxicol Methods · 2005 INTRODUCTION: Urea has been proposed as an endogenous recovery marker for microdialysis for absolute concentration calculations of analytes in microdialysis samples. Previously we demonstrated a linear relationship between urea concentrations in a rat mamm ... Full text Link to item Cite

Predicting radiotherapy-induced cardiac perfusion defects.

Journal Article Med Phys · January 2005 The purpose of this work is to compare the efficacy of mathematical models in predicting the occurrence of radiotherapy-induced left ventricular perfusion defects assessed using single-photon emission computed tomography (SPECT). The basis of this study is ... Full text Link to item Cite

Factors controlling oxygen utilization.

Journal Article Adv Exp Med Biol · 2005 We demonstrate, theoretically, that oxygen diffusion distance is related to the metabolic rate of tumors (QO2) as well as the oxygen tension. The difference in QO2 rate between tumors can vary by as much as 80-fold. Inhibition of oxygen utilization by gluc ... Full text Link to item Cite

New Mn(III) porphyrins with high superoxide disproportionating ability

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2005 Link to item Cite

SU‐EE‐A2‐06: Non‐Contact, Non‐Invasive Breast Thermography Has Potential to Evaluate Treatment Response in Breast Cancer Patients

Conference Medical Physics · January 1, 2005 Purpose: The purpose of the study is to determine the feasibility of using Breast Thermography (BT) to improve the evaluation of treatment response in breast cancer patients. Method and Materials: A protocol is underway at our institution that enlisted 17/ ... Full text Cite

WE‐D‐I‐609‐05: Optical Imaging of Tumor Microvasculature in 3D

Conference Medical Physics · January 1, 2005 Purpose: Great interest exists at present in determining methods to image and understand tumor micro‐vasculature structure and how it can be perturbed by a variety of agents, including radiation and anti‐angiogenic drug therapies. Present methods including ... Full text Cite

SU‐EE‐A4‐04: Compartment Modeling Analysis of Cu‐ATSM Dynamic PET Images

Conference Medical Physics · January 1, 2005 Purpose: Copper labeled diacetyl‐bis(N4‐methylthiosemicarbazone) (Cu‐ATSM) has been reported to selectively bind to hypoxic tumor cells. This makes Cu‐ATSM PET a promising modality to image tumor hypoxia. However, intravascular Cu‐ATSM that is not related ... Full text Cite

Carbonic anhydrase IX in early-stage non-small cell lung cancer.

Journal Article Clin Cancer Res · December 1, 2004 PURPOSE: Tumor hypoxia is associated with poor prognosis and increased tumor aggressiveness. Carbonic anhydrase (CA) IX, an endogenous marker for tumor hypoxia, catalyzes the hydration of carbon dioxide into carbonic acid and contributes to the pH regulati ... Full text Link to item Cite

Utilizing MRI information to estimate F18-FDG distributions in rat flank tumors

Conference IEEE Nuclear Science Symposium Conference Record · December 1, 2004 This paper investigates the potential of magnetic resonance imaging (MRI) to improve the estimation of within-tumor variations in F18-FDG concentration. An image model is described for incorporating MRI images into positron emission tomography (PET) and si ... Cite

Epinephrine-Induced Sickle Red Cell Adhesion and Vaso-Occlusion In Vivo Is Inhibited by the β-Adrenoceptor Blocker Propranolol.

Conference Blood · November 16, 2004 AbstractPainful vaso-occlusive episodes in SCD are commonly associated with infection and other less definable stressors. Since epinephrine activates sickle red cell (SS RBC) adhesion in vitro, we studied th ... Full text Cite

Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha.

Journal Article Cancer Res · November 15, 2004 Hypoxia-inducible factor-1alpha (HIF-1alpha) is an important transcriptional factor that is activated when mammalian cells experience hypoxia, a tumor microenvironmental condition that plays pivotal roles in tumor progression and treatment. In this study, ... Full text Link to item Cite

Green's function methods for analysis of oxygen delivery to tissue by microvascular networks.

Journal Article Ann Biomed Eng · November 2004 Delivery of oxygen to tissue is an essential function of the circulatory system. The distance that oxygen can diffuse into oxygen-consuming tissue is small, and so tissue oxygenation is critically dependent on the spatial arrangement of microvessels in tis ... Full text Link to item Cite

Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry.

Journal Article Med Phys · October 2004 Hyperthermia, as an adjuvant with radiation and chemotherapy, has shown promise in the treatment of cancer. The relevant biological effects of a hyperthermia treatment are both time and temperature-dependent, creating a need for accurate thermometry. We pr ... Full text Link to item Cite

Targeting tumor microvessels using doxorubicin encapsulated in a novel thermosensitive liposome.

Journal Article Mol Cancer Ther · October 2004 Liposomal drugs accumulate only in perivascular regions in tumors after i.v. injection. Thus, they cannot kill tumor cells in deeper tissue layers. To circumvent this problem, we investigated effects of doxorubicin (DOX) encapsulated in a lysolecithin-cont ... Link to item Cite

The relationship between the tumor physiologic microenvironment and angiogenesis.

Journal Article Hematol Oncol Clin North Am · October 2004 This article examines the pathophysiology of tumors, with an emphasis on how these features influence angiogenesis in tumors. ... Full text Link to item Cite

The role of hyperthermia in regional alkylating agent chemotherapy.

Journal Article Clin Cancer Res · September 1, 2004 The role of hyperthermia during regional alkylating agent chemotherapy is controversial. The aim of this study was to determine the exact contribution of hyperthermia to tumor response during isolated limb infusion with l-phenylalanine mustard. Rats bearin ... Full text Link to item Cite

Raising the bar: how HIF-1 helps determine tumor radiosensitivity.

Journal Article Cell Cycle · September 2004 Through a poorly understood mechanism, tumors respond to radiation by secreting cytokines which inhibit endothelial cell apoptosis, thereby limiting treatment response by minimizing vessel damage. We have recently discovered that this pathway is governed b ... Link to item Cite

Tumor-dependent kinetics of partial pressure of oxygen fluctuations during air and oxygen breathing.

Journal Article Cancer Res · September 1, 2004 The primary purpose of this study was to examine the kinetics of partial pressure of oxygen (pO2) fluctuations in fibrosarcoma (FSA) and 9L tumors under air and O2 breathing conditions. The overall hypothesis was that key factors relating to oxygen tension ... Full text Link to item Cite

Thermochemoradiotherapy improves oxygenation in locally advanced breast cancer

Journal Article Women's Oncology Review · September 1, 2004 Full text Cite

Chemodosimetry of in-vivo tumor liposome/drug concentration using MRI

Conference International Journal of Radiation OncologyBiologyPhysics · September 2004 Full text Cite

Effect of calcitonin gene related peptide vs sodium nitroprusside to increase temperature in spontaneous canine tumours during local hyperthermia.

Journal Article Int J Hyperthermia · August 2004 The objectives of this study were to compare the effects of two vasodilators, sodium nitroprusside (SNP) and calcitonin gene-related peptide (CGRP) on mean arterial pressure (MAP), heart rate (HR) and temperatures in tumour and surrounding normal tissue du ... Full text Link to item Cite

Use of in vivo bioluminescence imaging to predict hepatic tumor burden in mice.

Journal Article J Surg Res · August 2004 BACKGROUND: We used bioluminescence imaging (BLI) to validate serial assessment of neoplastic growth within the murine liver. We hypothesized that, in mice bearing luciferase-expressing liver metastases, bioluminescence would reflect neoplastic burden esti ... Full text Link to item Cite

Phase I/II trial of intravenous liposomal doxorubicin and whole abdomen hyperthermia in patients with refractory ovarian cancer.

Journal Article J Clin Oncol · July 15, 2004 5089 Background: A phase I/II study of liposomal doxorubicin combined with whole abdominal hyperthermia was conducted in patients with refractory ovarian cancer. Liposomal doxorubicin combined with hyperthermia has been shown to increase liposomal extravas ... Link to item Cite

Erythropoietin (EPO) has no direct effect on tumor growth or angiogenesis in animal models.

Journal Article J Clin Oncol · July 15, 2004 9530 Background: Erythropoietin (EPO) increases tumor oxygenation in several pre-clinical models. This improvement in oxygenation should lead to enhanced treatment responses. However, EPO has failed to show improved treatment outcomes in 2 recent, randomiz ... Link to item Cite

Intraperitoneal cisplatin and whole abdomen hyperthermia for relapsed ovarian carcinoma.

Journal Article J Clin Oncol · July 15, 2004 5038 Background:The study was designed to determine the maximum tolerated dose (MTD) of intraperitoneal cisplatin [CDDP] combined with intravenous thiosulfate and concurrent whole abdomen hyperthermia for advanced, recurrent or progressive ovarian carcinom ... Link to item Cite

The relationship between hypoxia and angiogenesis.

Journal Article Semin Radiat Oncol · July 2004 Recent studies have generated a large amount of data supporting the hypothesis that hypoxia drives tumor angiogenesis. The relationship between the two is often considered a matter of supply and demand: ineffectively-vascularized tumor tissue becomes hypox ... Full text Link to item Cite

Thermochemoradiotherapy improves oxygenation in locally advanced breast cancer.

Journal Article Clin Cancer Res · July 1, 2004 PURPOSE: The purpose of this research was to evaluate toxicity, response, and changes in oxygenation (pO(2)) in patients with locally advanced breast cancer (LABC) treated with concurrent taxol, hyperthermia (HT), and radiation therapy (RT) followed by mas ... Full text Link to item Cite

Predicting the effect of temporal variations in PO2 on tumor radiosensitivity.

Journal Article Int J Radiat Oncol Biol Phys · July 1, 2004 PURPOSE: Tumor hypoxia is associated with less effective radiation-mediated cell killing, increased metastatic potential, and poorer prognosis. Transient variations in hypoxia, with characteristic periodicity on the order of 1 to 10 min, have been observed ... Full text Link to item Cite

Circulating D-dimer levels are better predictors of overall survival and disease progression than carcinoembryonic antigen levels in patients with metastatic colorectal carcinoma.

Journal Article Cancer · July 1, 2004 BACKGROUND: Fibrin formation is required for tumor angiogenesis, metastasis, and invasion. D-dimer, a fibrin degradation product, is produced when crosslinked fibrin is degraded by plasmin. The current study prospectively examined D-dimer levels in patient ... Full text Link to item Cite

HER-2 gene amplification correlates with higher levels of angiogenesis and lower levels of hypoxia in primary breast tumors.

Journal Article Clin Cancer Res · June 15, 2004 PURPOSE: This study investigated the connection among HER-2 gene amplification, HER-2 protein expression, and markers of tumor angiogenesis and oxygenation in patients with operable, invasive breast tumors. EXPERIMENTAL DESIGN: From 1988 to 1995, 425 patie ... Full text Link to item Cite

Feasibility of optimizing the dose distribution in lung tumors using fluorine-18-fluorodeoxyglucose positron emission tomography and single photon emission computed tomography guided dose prescriptions.

Journal Article Med Phys · June 2004 The information provided by functional images may be used to guide radiotherapy planning by identifying regions that require higher radiation dose. In this work we investigate the dosimetric feasibility of delivering dose to lung tumors in proportion to th ... Full text Link to item Cite

Synergistic effects of hyperoxic gas breathing and reduced oxygen consumption on tumor oxygenation: a theoretical model.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2004 PURPOSE: To simulate effects of reduced oxygen consumption combined with hyperoxic gas breathing on tumor oxygenation, and to test for synergistic effects. METHODS AND MATERIALS: Diffusive oxygen transport was simulated for a small region of tumor containi ... Full text Link to item Cite

In vivo monitoring of tissue pharmacokinetics of liposome/drug using MRI: illustration of targeted delivery.

Journal Article Magn Reson Med · June 2004 The purpose of this study was to determine if MnSO(4)/doxorubicin (DOX) loaded liposomes could be used for in vivo monitoring of liposome concentration distribution and drug release using MRI. In vitro results show that T(1) shortening correlates with MnSO ... Full text Link to item Cite

Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules.

Journal Article Cancer Cell · May 2004 Through a poorly understood mechanism, tumors respond to radiation by secreting cytokines capable of inhibiting apoptosis in endothelial cells, thereby diminishing treatment response by minimizing vascular damage. We reveal here that this pathway is govern ... Full text Link to item Cite

Proton and hyperpolarized helium magnetic resonance imaging of radiation-induced lung injury in rats.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2004 PURPOSE: To assess the usefulness of hyperpolarized helium (3He) MRI, including apparent diffusion coefficient measurements, in the detection and evaluation of radiation-induced lung injury in rats. METHODS AND MATERIALS: Female Fischer-344 rats were treat ... Full text Link to item Cite

Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival.

Journal Article The FASEB journal : official publication of the Federation of American Societies for Experimental Biology · February 2004 Neoplastic cells overexpress several angiogenic cytokines, which stimulate neovascularization. Whether the responses of the host endothelial cells to these signaling molecules affect tumor cells during early tumorigenesis has not been investigated. We inve ... Cite

Role of hyperthermia in regional alkylating agent chemotherapy

Conference Annals of Surgical Oncology · February 2004 Full text Cite

Functional significance of Tie2 signaling in the adult vasculature.

Journal Article Recent Prog Horm Res · 2004 Abundant data now demonstrate that the growth of new blood vessels, termed angiogenesis, plays both pathological and beneficial roles in human disease. Based on these data, a tremendous effort has been undertaken to understand the molecular mechanisms that ... Full text Link to item Cite

MNTE-2-PYP5+ enhances tumor radiosensitivity by sensitizing tumor vasculature

Conference FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2004 Link to item Cite

3-D reconstruction of tumor vascular networks

Conference JOURNAL OF VASCULAR RESEARCH · January 1, 2004 Link to item Cite

Concerted regulation of skeletal muscle contractility by oxygen tension and endogenous nitric oxide.

Journal Article Proc Natl Acad Sci U S A · December 9, 2003 It is generally accepted that inhibition of nitric oxide synthase (NOS) facilitates, and thus nitric oxide (NO) inhibits, contractility of skeletal muscle. However, standard assessments of contractility are carried out at a nonphysiological oxygen tension ... Full text Link to item Cite

Overexpression of extracellular superoxide dismutase protects mice from radiation-induced lung injury.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2003 PURPOSE: The purpose of this study was to determine if radiation-induced lung injury is associated with prolonged oxidative stress, and whether chronic overexpression of extracellular superoxide dismutase (EC-SOD) in the lung of transgenic mice protects ag ... Full text Link to item Cite

Accuracy of MRI in the detection of residual breast cancer after neoadjuvant chemotherapy.

Journal Article AJR Am J Roentgenol · November 2003 OBJECTIVE: This study was undertaken to evaluate the ability of MRI to accurately show residual primary breast malignancy in women treated with neoadjuvant chemotherapy. MATERIALS AND METHODS: Twenty-one patients with locally advanced primary breast carcin ... Full text Link to item Cite

Human recombinant erythropoietin significantly improves tumor oxygenation independent of its effects on hemoglobin.

Journal Article Cancer Res · October 1, 2003 Tumor oxygenation is known to be an important predictive/prognostic marker in a variety of tumors, including cervix, head/neck, sarcoma, non-small cell of the lung, and breast. Tumor oxygenation is influenced by many interactions, including oxygen delivery ... Link to item Cite

The activity of camptothecin analogues is enhanced in histocultures of human tumors and human tumor xenografts by modulation of extracellular pH.

Journal Article Cancer Chemother Pharmacol · September 2003 BACKGROUND: Most solid human tumors exist in an acidic microenvironment, due in part to inefficient vasculature and a higher intrinsic rate of glycolysis. This leads to a tumor-selective pH gradient, which can be exploited therapeutically with antitumor ag ... Full text Link to item Cite

Endoscopic components separation for abdominal compartment syndrome.

Journal Article Am J Surg · August 2003 BACKGROUND: Sustained intraabdominal pressures of 14 to 20 mm Hg have significant pathophysiological consequences, but there is currently no satisfactory low-morbidity procedure appropriate for intervention early in the disease process of abdominal compart ... Full text Link to item Cite

Synergy between tumor immunotherapy and antiangiogenic therapy.

Journal Article Blood · August 1, 2003 This study tested the hypothesis that combination of antiangiogenic therapy and tumor immunotherapy of cancer is synergistic. To inhibit angiogenesis, mice were immunized with dendritic cells (DCs) transfected with mRNA that encode products that are prefer ... Full text Link to item Cite

Effect of longitudinal oxygen gradients on effectiveness of manipulation of tumor oxygenation.

Journal Article Cancer Res · August 1, 2003 The purpose of this study was to test the hypothesis that longitudinal O(2) gradients in tumor affect response to manipulation of oxygenation. Previously we showed that pO(2) is higher on the fascial than the tumor surface of the R3230Ac rat mammary carcin ... Link to item Cite

A pilot Phase II trial of concurrent radiotherapy, chemotherapy, and hyperthermia for locally advanced cervical carcinoma.

Journal Article Cancer · July 15, 2003 BACKGROUND: Five randomized studies have demonstrated a benefit derived from adding cisplatin (CDDP)-based chemotherapy to radiotherapy (RT) for treatment of cervical carcinoma. The Dutch Phase III pelvic tumor trial demonstrated a survival and local contr ... Full text Link to item Cite

THERMAL DOSE REQUIREMENT FOR TISSUE EFFECT: EXPERIMENTAL AND CLINICAL FINDINGS.

Journal Article Proc SPIE Int Soc Opt Eng · June 2, 2003 In this review we have summarized the basic principles that govern the relationships between thermal exposure (Temperature and time of exposure) and thermal damage, with an emphasis on normal tissue effects. We have also attempted to identify specific ther ... Full text Link to item Cite

Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2.

Journal Article Proc Natl Acad Sci U S A · April 29, 2003 Angiopoietin-2 (Ang2) appears to be a naturally occurring antagonist of the endothelial receptor tyrosine kinase Tie2, an important regulator of vascular stability. Destabilization of the endothelium by Ang2 is believed to potentiate the actions of proangi ... Full text Link to item Cite

A novel rodent mammary window of orthotopic breast cancer for intravital microscopy.

Journal Article Microvasc Res · March 2003 Orthotopic and ectopic organ environments differentially influence tumor growth, metastasis, and sensitivity to therapy. In this study we present a novel rodent mammary window of orthotopic breast cancer, which is amenable to study of microvascular functio ... Full text Link to item Cite

Increased resistance of tumor cells to hyperthermia mediated by integrin-linked kinase.

Journal Article Clin Cancer Res · March 2003 PURPOSE: Integrin-linked kinase (ILK) is a serine-threonine kinase associated with anchorage-independent growth and tumorigenic transformation. Previous studies indicate that overexpression of ILK is common among several types of tumors, and it is involved ... Link to item Cite

A mathematical model of tumor oxygen and glucose mass transport and metabolism with complex reaction kinetics.

Journal Article Radiat Res · March 2003 Hypoxia imparts radioresistance to tumors, and various approaches have been developed to enhance oxygenation, thereby improving radiosensitivity. This study explores the influence of kinetic and physical factors on substrate metabolism in a tumor model, ba ... Full text Link to item Cite

Reduction of wound angiogenesis in patients treated with BMS-275291, a broad spectrum matrix metalloproteinase inhibitor.

Journal Article Clin Cancer Res · February 2003 Featured Publication PURPOSE: The purpose of this study was to evaluate the feasibility of incorporating a novel wound angiogenesis assay into a Phase I study of BMS-275291, a broad-spectrum matrix metalloproteinase inhibitor, and to determine whether the wound angiogenesis as ... Link to item Cite

Mechanisms underlying hypoxia development in tumors.

Journal Article Adv Exp Med Biol · 2003 Featured Publication Full text Link to item Cite

The effect of nicotinamide & hyperoxic gases on blood glucose.

Journal Article Adv Exp Med Biol · 2003 Featured Publication Full text Link to item Cite

Basic principles of thermal dosimetry and thermal thresholds for tissue damage from hyperthermia.

Journal Article Int J Hyperthermia · 2003 This paper is one of several in this Special Issue of the International Journal of Hyperthermia that discusses the current state of knowledge about the human health risks of hyperthermia. This special issue emanated from a workshop sponsored by the World H ... Full text Link to item Cite

Effect of mild hyperglycemia +/- meta-iodo-benzylguanidine on the radiation response of R3230 Ac tumors.

Journal Article Adv Exp Med Biol · 2003 The effects of glucose or meta-iodo-benzylguanidine (MIBG) on oxygen utilization (QO2) of several tumor cell lines were studied using a Clark-type electrode chamber. For in vivo studies, rats bearing R3230 Ac rat mammary adenocarcinomas were utilized. To e ... Full text Link to item Cite

Carcinogenic effects of hyperthermia.

Journal Article Int J Hyperthermia · 2003 The purpose of this paper is to assess the evidence for and against the premise that hyperthermia is carcinogenic. The paper is one of several published in this issue of the International Journal of Hyperthermia on the subject of the health risks of hypert ... Full text Link to item Cite

Dietary glycine inhibits angiogenesis during wound healing and tumor growth.

Journal Article Cancer Biol Ther · 2003 In this study we investigated the effects of glycine on angiogenesis during embryogenesis, wound healing and tumor growth. In chorioallantoic membrane (CAM) assay, glycine (100 microM) inhibited angiogenesis by more than 50%. We studied dietary glycine's e ... Full text Link to item Cite

Ultrasound guided pO2 measurement of breast cancer reoxygenation after neoadjuvant chemotherapy and hyperthermia treatment.

Journal Article Int J Hyperthermia · 2003 The objective of this study was to determine whether neoadjuvant chemotherapy in combination with hyperthermia (HT) would improve oxygenation in locally advanced breast tumours. The study describes a new optimized ultrasound guided technique of pO2 measure ... Full text Link to item Cite

Summary, conclusions and recommendations: adverse temperature levels in the human body.

Journal Article Int J Hyperthermia · 2003 In the spring of 2002, The World Health Organization workshop 'Adverse Temperature Levels in the Human Body' brought together scientists with expertise in biological effects of hyperthermia to review the data and determine the evidence that could be used t ... Full text Link to item Cite

Effects of cell damage and glycosaminoglycan degradation on available extravascular space of different dextrans in a rat fibrosarcoma.

Journal Article Int J Hyperthermia · 2003 Drug delivery to solid tumors may be enhanced through increasing the available volume fraction (K(AV)) of drugs. Therefore, two approaches were investigated that may increase K(AV) of dextrans in a rat fibrosarcoma: (a) damaging cells in tumours via ex viv ... Full text Link to item Cite

A clinical model of dermal wound angiogenesis.

Journal Article Wound Repair Regen · 2003 Full-thickness dermal biopsies were performed in healthy volunteers to establish the range of angiogenic responses in wound healing in a normal population. Four-millimeter punch biopsies were made in the forearms of 15 healthy volunteers. Each wound was ev ... Full text Link to item Cite

Glutathione depletion or radiation treatment alters respiration and induces apoptosis in R3230Ac mammary carcinoma.

Journal Article Adv Exp Med Biol · 2003 Glutathione depletion by L-buthionine sulfoximine inhibits the growth of Ehrlich mouse mammary carcinoma, R3230Ac rat mammary carcinoma and the PC3 human prostrate carcinoma cells, in vitro. Inhibition of growth occurs within the first 24 hours after expos ... Full text Link to item Cite

Toward a national consensus: teaching radiobiology to radiation oncology residents.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2002 Featured Publication PURPOSE: The ASTRO Joint Working Group on Radiobiology Teaching, a committee composed of members having affiliations with several national radiation oncology and biology-related societies and organizations, commissioned a survey designed to address issues ... Full text Link to item Cite

A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury.

Journal Article Free Radic Biol Med · September 15, 2002 Featured Publication Radiation therapy (RT) is an important therapeutic modality in the treatment of thoracic tumors. The maximum doses to these tumors are often limited by the radiation tolerance of lung tissues. Lung injury from ionizing radiation is believed to be a consequ ... Full text Link to item Cite

Intravascular location of breast cancer cells after spontaneous metastasis to the lung.

Journal Article Am J Pathol · September 2002 Featured Publication In this study, we examined the hypothesis that early pulmonary metastases form within the vasculature. We introduced primary tumors in immunocompromised mice by subcutaneous injection of murine breast carcinoma cells (4T1) expressing green fluorescent prot ... Full text Link to item Cite

Toward a consensus on radiobiology teaching to radiation oncology residents.

Journal Article Radiat Res · May 2002 Featured Publication There are approximately 82 radiation oncology residency programs in the United States, which provide training opportunities for about 400 residents. All accredited radiation oncology residency programs must have at least one basic scientist on the faculty, ... Full text Link to item Cite

A theoretical model for the effects of reduced hemoglobin-oxygen affinity on tumor oxygenation.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2002 Featured Publication PURPOSE: To develop a theoretical model for oxygen delivery to tumors, and to use the model to simulate the effects of changing the affinity of hemoglobin for oxygen on tumor oxygenation. METHODS AND MATERIALS: Hemoglobin affinity is expressed in terms of ... Full text Link to item Cite

Hypoxia in the thymus: role of oxygen tension in thymocyte survival.

Journal Article Am J Physiol Heart Circ Physiol · April 2002 Featured Publication Our previous studies using oxygen microelectrodes showed that the thymus is grossly hypoxic under normal physiological conditions. We now have investigated how oxygen tension affects the thymus at the cellular and molecular level. Adducts of the hypoxia ma ... Full text Link to item Cite

SU5416 delays wound healing through inhibition of TGF-beta 1 activation.

Journal Article Cancer Biol Ther · 2002 Featured Publication Angiogenesis, development of new blood vessels, is essential for wound healing and tumor growth. A potentially important side effect of anti-angiogenic therapy can be delayed wound healing. In this study we address this issue by using a novel in vivo metho ... Full text Link to item Cite

Intravital fluorescence facilitates measurement of multiple physiologic functions and gene expression in tumors of live animals.

Journal Article Dis Markers · 2002 The purpose of this report is to present an overview of the use of fluorescence imaging in vivo, with particular emphasis on oncology. It is important to note, however, that many of the methods described herein have been applied to the study of non-maligna ... Full text Link to item Cite

Hyperthermia-regulated immunogene therapy.

Journal Article Int J Hyperthermia · 2002 One of the key milestones that must be reached before gene therapy becomes feasible for clinical cancer treatment is to be able to regulate therapeutic gene expression. This is true for most current cancer gene therapy approaches, since the majority of the ... Full text Link to item Cite

Hyperthermia and the Immune System

Journal Article International Journal of Hyperthermia · January 1, 2002 Full text Cite

The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors.

Journal Article Adv Drug Deliv Rev · December 31, 2001 Featured Publication Our laboratories have been working together in close collaboration for over 10 years concerning the design and performance of lipid-based drug delivery systems. Over the past 3 years we have conceived of, developed, and tested pre-clinically, a new liposom ... Full text Link to item Cite

A bayesian model for detecting acute change in nonlinear profiles

Journal Article Journal of the American Statistical Association · December 1, 2001 We propose a model for longitudinal data with random effects that includes model-based smoothing of measurements over time. This research is motivated by experiments evaluating the hemodynamic effects of various agents in tumor-bearing rats. In one set of ... Full text Cite

Analysis of the heterogeneity of pO2 dynamics during photodynamic therapy with verteporfin.

Journal Article Photochem Photobiol · November 2001 Featured Publication Photodynamic therapy (PDT) with verteporfin provides a reliable way to destroy malignant tissues. Changes in the blood flow and oxygen partial pressure (pO2) during verteporfin-PDT were studied here in the tumor tissue of the rat mammary R3230Ac carcinoma ... Full text Link to item Cite

Systemic vector leakage and transgene expression by intratumorally injected recombinant adenovirus vectors.

Journal Article Clin Cancer Res · November 2001 Featured Publication Interleukin 12 is a heterodimeric cytokine that exhibits potent immunostimulatory effects. It has shown some promise in preclinical and clinical studies but was accompanied by serious systemic toxicity such as flu-like syndromes, a rapid transient leukopen ... Link to item Cite

Urea as a recovery marker for quantitative assessment of tumor interstitial solutes with microdialysis.

Journal Article Cancer Res · November 1, 2001 Featured Publication Microdialysis is a technique that enables measurement of extracellular concentrations of unbound analytes. A small probe with a semipermeable membrane is implanted in tissue and constantly perfused. Small analytes in the interstitial fluid diffuse into the ... Link to item Cite

Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2001 Featured Publication PURPOSE: It has been shown that oxygen gradients exist in R3230AC tumors grown in window chambers. The fascial surface is better oxygenated than the tumor surface. The purpose of the present study was to determine whether gradients exist for energy metabol ... Full text Link to item Cite

Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2001 Featured Publication PURPOSE: Hypoxia shifts the balance of cellular energy production toward glycolysis with lactate generation as a by-product. Quantitative bioluminescence imaging allows for the quantitation of lactate concentrations in individual tumors. We assessed the re ... Full text Link to item Cite

Simultaneous administration of glucose and hyperoxic gas achieves greater improvement in tumor oxygenation than hyperoxic gas alone.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2001 Featured Publication PURPOSE: To test the feasibility of hyperglycemic reduction of oxygen consumption combined with oxygen breathing (O(2)), to improve tumor oxygenation. METHODS AND MATERIALS: Fischer-344 rats bearing 1 cm R3230Ac flank tumors were anesthetized with Nembutal ... Full text Link to item Cite

Transcriptional response to hypoxia in human tumors.

Journal Article J Natl Cancer Inst · September 5, 2001 Featured Publication BACKGROUND: The presence of hypoxic regions within solid tumors is associated with a more malignant tumor phenotype and worse prognosis. To obtain a blood supply and protect against cellular damage and death, oxygen-deprived cells in tumors alter gene expr ... Full text Link to item Cite

Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability.

Journal Article Cancer Res · September 1, 2001 Featured Publication The tumor vascular effects of the tubulin destabilizing agent disodium combretastatinA-4 3-O-phosphate (CA-4-P) were investigated in the rat P22 tumor growing in a dorsal skin flap window chamber implanted into BD9 rats. CA-4-P is in clinical trial as a tu ... Link to item Cite

The novel tubulin-binding drug BTO-956 inhibits R3230AC mammary carcinoma growth and angiogenesis in Fischer 344 rats.

Journal Article Clin Cancer Res · August 2001 Featured Publication BTO-956 [methyl-3,5-diiodo-4-(4'-methoxyphenoxy)benzoate], a novel tubulin-binding drug and thyroid hormone analogue, was originally found to inhibit human carcinoma cell proliferation in vitro and to have potent growth delay activity in human breast and o ... Link to item Cite

Radiation-induced hypoxia may perpetuate late normal tissue injury.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2001 Featured Publication PURPOSE: The purpose of this study was to determine whether or not hypoxia develops in rat lung tissue after radiation. METHODS AND MATERIALS: Fisher-344 rats were irradiated to the right hemithorax using a single dose of 28 Gy. Pulmonary function was asse ... Full text Link to item Cite

Drug targeting using thermally responsive polymers and local hyperthermia.

Journal Article J Control Release · July 6, 2001 Featured Publication We report a new thermal targeting method in which a thermally responsive drug carrier selectively accumulates in a solid tumor that is maintained above physiological temperature by externally applied, focused hyperthermia. We synthesized two thermally resp ... Full text Link to item Cite

Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents.

Journal Article Am J Physiol Heart Circ Physiol · June 2001 Featured Publication In this study we compare oxygen tension (PO2) histograms measured with O2 microelectrodes and a new optical PO2 measurement device, the OxyLite, in normal tissues (mouse spleen and thymus) and in tumors (R3230Ac in rats) (n = 5-6). The transient response t ... Full text Link to item Cite

Effects of the interaction between carbogen and nicotinamide on R3230 Ac tumor blood flow in Fischer 344 rats.

Journal Article Radiat Res · May 2001 Featured Publication Braun, R. D., Lanzen, J. L., Turnage, J. A., Rosner, G. and Dewhirst, M. W. Effects of the Interaction between Carbogen and Nicotinamide on R3230 Ac Tumor Blood Flow in Fischer 344 Rats. Radiat. Res. 155, 724-733 (2001). The purpose of this study was to de ... Full text Link to item Cite

In vivo BOLD contrast MRI mapping of subcutaneous vascular function and maturation: validation by intravital microscopy.

Journal Article Magn Reson Med · May 2001 Featured Publication Bold contrast MRI was applied for mapping vascular maturation in tumor- and wound-induced skin angiogenesis using the response of mature vessels to hypercapnia (inhalation of air vs. air 5% CO(2)) and the response of all vessels to hyperoxia (air 5% CO(2) ... Full text Link to item Cite

Effective tumor therapy with plasmid-encoded cytokines combined with in vivo electroporation.

Journal Article Cancer Res · April 15, 2001 Featured Publication Plasmids may have unique advantages as a gene delivery system. However, a major obstacle is the low in vivo transduction efficiency. In this study, an electroporation-based gene transduction approach was taken to study the effect of interleukin (IL)-2 or I ... Link to item Cite

Characterization of the effect of hyperthermia on nanoparticle extravasation from tumor vasculature.

Journal Article Cancer Res · April 1, 2001 Featured Publication The efficacy of novel cancer therapeutics can be hampered by inefficient delivery of agents to the tumor at effective concentrations. Liposomes have been used as a method to overcome some delivery issues and, in combination with hyperthermia, have been sho ... Link to item Cite

Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor.

Journal Article Cancer Res · April 1, 2001 Featured Publication Tamoxifen inhibits estrogen receptor (ER) transcriptional activity by competitively inhibiting estradiol binding and inducing conformational changes in the receptor that may prevent its interaction with coactivators. In bone, the cardiovascular system, and ... Link to item Cite

Targeting a genetically engineered elastin-like polypeptide to solid tumors by local hyperthermia.

Journal Article Cancer Res · February 15, 2001 Featured Publication Elastin-like polypeptides (ELPs) are biopolymers of the pentapeptide repeat Val-Pro-Gly-Xaa-Gly that undergo an inverse temperature phase transition. They are soluble in aqueous solutions below their transition temperature (T1) but hydrophobically collapse ... Link to item Cite

Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures.

Journal Article Cancer Res · January 15, 2001 Featured Publication A hallmark of cancer cells is their pronounced genetic instability, which has been implicated in both tumor development and negative treatment outcomes. Recently, it has been reported that ionizing radiation may induce a persistent state of hypermutability ... Link to item Cite

A phase II trial testing the thermal dose parameter CEM43 degrees T90 as a predictor of response in soft tissue sarcomas treated with pre-operative thermoradiotherapy.

Journal Article Int J Hyperthermia · 2001 Featured Publication We prospectively evaluated whether delivering a thermal dose of > 10 cumulative equivalent minutes at 43 degrees C to >90% of the tumour sites monitored (CEM43 degrees T90) would produce a pathologic complete response (pCR) in > 75% of high-grade soft tiss ... Full text Link to item Cite

Oxygen microelectrode measurements in R3230Ac tumors during photodynamic therapy with verteporfin

Journal Article Proceedings of SPIE-The International Society for Optical Engineering · January 1, 2001 Measurements of tissue oxygen partial pressure (pO2), blood flow and blood pressure were recorded in rat mammary R3230Ac tumors during treatment with verteporfin-based photodynamic therapy. Microelectrodes of 12 micron tip diameter were used in a fixed pos ... Full text Cite

Magnetic resonance imaging applications in the evaluation of tumor angiogenesis.

Journal Article Semin Radiat Oncol · January 2001 Featured Publication Angiogenesis, the growth of new blood vessels, is a critical component in the development of solid tumors. Over the last decade, progress in the study of the biology of angiogenesis has led to identification of a large number of molecules that promote, par ... Full text Link to item Cite

Superoxide dismutase (SOD) mimetics in radiation therapy

Journal Article FREE RADICAL BIOLOGY AND MEDICINE · January 1, 2001 Link to item Cite

Control of gene therapy by the heat shock promoter

Conference PROGRESS IN RADIO-ONCOLOGY VII, PROCEEDINGS · January 1, 2001 Link to item Cite

Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release.

Journal Article Cancer Res · December 15, 2000 The tumor drug concentrations, drug distributions, and therapeutic efficacies achieved by three fundamentally different liposomes, nonthermosensitive liposome (NTSL), traditional thermosensitive liposome (TTSL), and low temperature sensitive liposome (LTSL ... Link to item Cite

Interstitial hydraulic conductivity in a fibrosarcoma.

Journal Article Am J Physiol Heart Circ Physiol · December 2000 Convective transport of therapeutic agents in solid tumors can be improved through intratumoral infusion. To optimize the convection, we investigated the dependence of the hydraulic conductivity on tissue deformation induced by interstitial fluid pressure ... Full text Link to item Cite

Enhancement of radiotherapy by hyperthermia-regulated gene therapy.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2000 PURPOSE: Interleukin 12 (IL-12) has shown strong antitumoral effects in numerous pre-clinical studies and appears to act synergistically with radiation in murine tumors. The major impediment to its clinical use has been its systemic toxicity. While using i ... Full text Link to item Cite

Inhibition of tyrosine kinase activity by sugen 5416 inhibits fibrin dependent angiogenesis

Journal Article Blood · December 1, 2000 Fibrin provides the provisional matrix that aids wound healing and angiogenesis. In this study we used a novel in vivo method (Z-Chambers) to study fibrin dependent angiogenesis and tested whether inhibition of tyrosine kinase would alter tumor angiogenesi ... Cite

Human erythrocyte and endothelial cells contain tbs ce transglutaminase that can regulates inflammation a nd platelet function by binding and releasing nitric oxde

Journal Article Blood · December 1, 2000 Nitric oxide (NO) plays an important role in vascular biology. NO modifies proi eins through nitrosylation of free cysteine residues and such modifications play an impo tant role in signaling and protein function. Tissue transglutaminase (tTG) is an extrac ... Cite

Delivery of plasmid DNA through intratumoral infusion and electroporation

Journal Article American Society of Mechanical Engineers, Bioengineering Division (Publication) BED · December 1, 2000 We investigated DNA transport in the interstitial space and across cell membrane facilitated by intratumoral infusion and in vivo electroporation, respectively. In the study, a rat fibrosarcoma was perfused ex vivo, and apparent hydraulic conductivity (Kap ... Cite

New technique for measurement of distribution volume of color molecules in solid tumors

Journal Article Annals of Biomedical Engineering · December 1, 2000 To optimize intramural infusion of macromolecules, a novel technique was developed to quantify the distribution volume of color molecules in solid tumors. It was shown that infusion pressure and volume significantly affects the distribution volume of drugs ... Cite

Available volume fraction of macromolecules in solid tumors

Journal Article Annals of Biomedical Engineering · December 1, 2000 An ex vivo method was developed to quantify available volume fraction (Kav) in tumor tissues and polymer gels. It was shown that Kav is an important transport parameter that depends on physichochemical properties of drugs and tissue structures. ... Cite

Tamoxifen inhibits angiogenesis in estrogen receptor-negative animal models.

Journal Article Clin Cancer Res · November 2000 Inhibition of tumor angiogenesis is a therapeutic strategy that can inhibit tumor growth and metastases. The aim of this study was to determine whether the estrogen receptor (ER) ligand drug tamoxifen has antiangiogenic effects. We used three different mod ... Link to item Cite

Review of methods used to study oxygen transport at the microcirculatory level.

Journal Article Int J Cancer · October 20, 2000 The existence of hypoxic regions in tumors has long been recognized as a key factor leading to radiation resistance. More recently, it has been found that low oxygen levels also affect drug resistance, angiogenesis, cytokine production, cell cycle control, ... Link to item Cite

Hyperthermia increases accumulation of technetium-99m-labeled liposomes in feline sarcomas.

Journal Article Clin Cancer Res · September 2000 The effect of hyperthermia on the accumulation of technetium-99m-labeled liposomes was studied in feline sarcomas. Each cat received two separate injections of liposomes. The first was used to quantify the amount of technetium-99m-labeled liposomes within ... Link to item Cite

Combination treatment of murine tumors by adenovirus-mediated local B7/IL12 immunotherapy and radiotherapy.

Journal Article Mol Ther · September 2000 Failure of local tumor control still poses a problem for radiotherapy and translates into reduced survival. Combining radiation with chemotherapy or other newer modalities has shown promising results. Immunological approaches to tumor therapy have found re ... Full text Link to item Cite

Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size.

Journal Article Cancer Res · August 15, 2000 The efficacy of novel cancer therapeutics has been hampered by the ability to deliver these agents to the tumor at effective concentrations. Liposomes have been used as a method to overcome some delivery issues and, in combination with hyperthermia, have b ... Link to item Cite

Local 42 degrees C hyperthermia improves vascular conductance of the R3230Ac rat mammary adenocarcinoma during sodium nitroprusside infusion.

Journal Article Radiat Res · August 2000 The effect of sodium nitroprusside-induced hypotension on the perfusion of the R3230 adenocarcinoma during local 42 degrees C hyperthermia was studied using a combination of intravital microscopy and laser Doppler flowmetry. Fischer 344 rats were implanted ... Full text Link to item Cite

Heat-induced gene expression as a novel targeted cancer gene therapy strategy.

Journal Article Cancer Res · July 1, 2000 One of the main advantages of gene therapy over traditional therapy is the potential to target the expression of therapeutic genes in desired cells or tissues. To achieve targeted gene expression, we experimented with a new approach based on the long-estab ... Link to item Cite

The relationship between intracellular and extracellular pH in spontaneous canine tumors.

Journal Article Clin Cancer Res · June 2000 Recently, it has been suggested that the cellular uptake of chemotherapeutic drugs may be dependent on the pH gradient between the intracellular (pHi) and extracellular (pHe) compartments. It has been demonstrated in murine tumor models that the extracellu ... Link to item Cite

A pilot study of preoperative continuous infusion 5-fluorouracil, external microwave hyperthermia, and external beam radiotherapy for treatment of locally advanced, unresectable, or recurrent rectal cancer.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2000 PURPOSE: To determine the feasibility of combining external beam radiotherapy, continuous infusion 5-fluorouracil (5-FU), and external microwave hyperthermia in patients with locally advanced, unresectable, or recurrent adenocarcinoma of the rectum. METHOD ... Full text Link to item Cite

Ascaris haemoglobin is a nitric oxide-activated "deoxygenase"

Journal Article Chemtracts · May 1, 2000 Cite

Genetically engineered biopolymer conjugate for thermal targeting of anticancer therapeutics.

Journal Article ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · March 26, 2000 Link to item Cite

A new temperature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model.

Journal Article Cancer Res · March 1, 2000 The single biggest challenge now facing drug delivery (for liposomes and indeed other carriers) is to initiate and produce release of the encapsulated drug only at the diseased site and at controllable rates. Our efforts have focused on developing a new th ... Link to item Cite

Genetically engineered polypeptide carrier for thermal targeting of anticancer therapeutics

Journal Article American Chemical Society, Polymer Preprints, Division of Polymer Chemistry · March 1, 2000 The thermally-responsive carrier, an elastin-like polypeptide (ELP), is an oligomer of a Val-Pro-Gly-Xaa-Gly pentapeptide repeat. Below a specific, inverse phase transition temperature (Tt), ELPs are highly soluble in aqueous solution. However, upon raisin ... Cite

Plasma D-dimer levels in operable breast cancer patients correlate with clinical stage and axillary lymph node status.

Journal Article J Clin Oncol · February 2000 PURPOSE: To investigate the relationship between preoperative plasma D-dimer levels and extent of tumor involvement in operable breast cancer patients. PATIENTS AND METHODS: A total of 140 preoperative plasma specimens were obtained from women scheduled to ... Full text Link to item Cite

Initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models.

Journal Article J Natl Cancer Inst · January 19, 2000 BACKGROUND: There is a paucity of information about events that follow immediately after tumor cells are triggered to initiate the process of angiogenesis (the formation of new blood vessels). Such information is relevant to the issue of when micrometastas ... Full text Link to item Cite

Delivery of plasmid DNA through intratumoral infusion and electroporation

Conference ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE) · January 1, 2000 We investigated DNA transport in the interstitial spaceand across cell membrane facilitated by intratumoral infusionand in vivo electroporation, respectively. In the study, a ratfibrosarcoma was perfused ex vivo, and apparent hydraulicconductivity (Kaap) w ... Full text Cite

Early wound healing exhibits cytokine surge without evidence of hypoxia.

Journal Article Ann Surg · January 2000 OBJECTIVE: To ascertain the spatial and temporal relation of wound hypoxia to the cell types involved, expression of selected angiogenic cytokines, the proliferative status of cells in the wound site, and angiogenesis. SUMMARY BACKGROUND DATA: Hypoxia is c ... Full text Link to item Cite

Acute pancreatitis associated with administration of a nitric oxide synthase inhibitor in tumor-bearing dogs.

Journal Article In Vivo · 2000 BACKGROUND: Nitric oxide synthase (NOS) inhibitors have been investigated as potential cytotoxic agents to treat tumors lacking p53 function. Furthermore, their ability to reduce tumor blood flow can be combined with drugs that are specifically designed to ... Link to item Cite

Camptothecin analogues with enhanced antitumor activity at acidic pH.

Journal Article Cancer Chemother Pharmacol · 2000 BACKGROUND: Camptothecin (CPT) is a specific inhibitor of the nuclear enzyme topoisomerase I, which is involved in cellular DNA replication and transcription. Topoisomerase I is therefore an attractive target for anticancer drug development, and two analog ... Full text Link to item Cite

Using units of CEM 43 degrees C T90, local hyperthermia thermal dose can be delivered as prescribed.

Journal Article Int J Hyperthermia · 2000 A randomized study was designed in dogs with spontaneous soft tissue sarcomas to gain information about the relationship between hyperthermia dose and outcome. The study compared two levels of thermal dose applied to dogs with heatable tumours, so it was n ... Full text Link to item Cite

Temperature-dependent changes in physiologic parameters of spontaneous canine soft tissue sarcomas after combined radiotherapy and hyperthermia treatment.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2000 PURPOSE: The objectives of this study were to evaluate effects of hyperthermia on tumor oxygenation, extracellular pH (pHe), and blood flow in 13 dogs with spontaneous soft tissue sarcomas prior to and after local hyperthermia. METHODS AND MATERIALS: Tumor ... Full text Link to item Cite

Role of incipient angiogenesis in cancer metastasis.

Journal Article Cancer Metastasis Rev · 2000 Metastasis is the primary cause of mortality in cancer patients. Angiogenesis is intimately involved in metastasis at the site of entry of tumor cells into the vasculature and at the site of eventual metastasis growth. In this commentary, we review current ... Full text Link to item Cite

Modulation of tumour blood flow by nitric oxide

Conference RADIATION RESEARCH, VOL 2, CONGRESS PROCEEDINGS · January 1, 2000 Link to item Cite

Wound-induced angiogenesis: A clinical model

Journal Article ORTHOGONAL POLARIZATION SPECTRAL IMAGING · January 1, 2000 Link to item Cite

Use of hyperthermia to augment liposomal drug delivery to tumours

Conference RADIATION RESEARCH, VOL 2, CONGRESS PROCEEDINGS · January 1, 2000 Link to item Cite

Boris Pasternak: A literary biography, vol 2, 1928-1960.

Journal Article EUROPE-ASIA STUDIES · December 1, 1999 Link to item Cite

Tissue transglutaminase is expressed as a host response to tumor invasion and inhibits tumor growth.

Journal Article Lab Invest · December 1999 A stable extracellular matrix (ECM) constitutes an important part of host response mechanism against tumor growth and invasion. Tissue transglutaminase (TG), a calcium-dependent enzyme, can cross-link all major ECM proteins to form a stable ECM, because th ... Link to item Cite

Analysis of oxygen transport to tumors: causes of heterogeneous tissue oxygenation

Journal Article American Society of Mechanical Engineers, Bioengineering Division (Publication) BED · December 1, 1999 A theoretical model was used to study the factors that contribute to the heterogeneous distribution of tissue pressure of oxygen (PO2) and the occurrence of hypoxic regions in tumors. A Green=s function method was used to predict the distribution of PO2. F ... Cite

Three-dimensional microvascular networks fractal structure: potential for tissue characterization?

Journal Article American Society of Mechanical Engineers, Bioengineering Division (Publication) BED · December 1, 1999 It has been shown that the fractal dimension of 2D microvascular networks can discriminate between normal vs. tumor tissue (Gazit et al., 1995, 1997). We have determined the fractal characteristics of five 3D microvascular networks and conclude on the corr ... Cite

Genetically-engineered polypeptide carrier for thermal targeting of therapeutics

Journal Article Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings · December 1, 1999 We report the synthesis of a environmentally-responsive polypeptide carrier for thermally-targeted delivery of radionuclide therapeutics. We hypothesized that systemically-injected radionuclide-polypeptide conjugates are likely to be cleared from circulati ... Cite

Pressure and temperature-dependence of the hydraulic conductivity in a fibrosarcoma

Conference Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings · December 1, 1999 Intratumor infusion has been used to deliver therapeutic agents to tumor cells. The distribution volume of infused agents depends on the hydraulic conductivity (K) in tumors, which may vary with the infusion pressure. Therefore, we quantified K in a rat fi ... Cite

The treatment of high-grade soft tissue sarcomas with preoperative thermoradiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 1999 PURPOSE: To explore the use of a novel program of preoperative radiation and hyperthermia in the management of high-grade soft tissue sarcomas (STS). METHODS AND MATERIALS: Eligible patients were adults over 18 with Grade 2 or 3 STS, surgically resectable ... Full text Link to item Cite

Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome.

Journal Article Radiother Oncol · November 1999 BACKGROUND AND PURPOSE: To evaluate the long term clinical significance of tumor oxygenation in a population of head and neck cancer patients receiving radiotherapy and to assess changes in tumor oxygenation during the course of treatment. METHODS AND MATE ... Full text Link to item Cite

Tissue transglutaminase is expressed, active, and directly involved in rat dermal wound healing and angiogenesis.

Journal Article FASEB J · October 1999 Tissue transglutaminase (TG) is an enzyme that stabilizes the structure of tissues by covalently ligating extracellular matrix molecules. Expression and localization of TG are not well established during wound healing. We performed punch biopsy wounds on a ... Full text Link to item Cite

Ascaris haemoglobin is a nitric oxide-activated 'deoxygenase'.

Journal Article Nature · September 30, 1999 The parasitic nematode Ascaris lumbricoides infects one billion people worldwide. Its perienteric fluid contains an octameric haemoglobin that binds oxygen nearly 25,000 times more tightly than does human haemoglobin. Despite numerous investigations, the b ... Full text Link to item Cite

Available volume fraction of macromolecules in the extravascular space of a fibrosarcoma: implications for drug delivery.

Journal Article Cancer Res · August 15, 1999 Steric exclusion of molecules in the extravascular space of tissues can be quantified by the available volume fraction (K(AV)). Despite its clinical importance, however, there is a paucity of data in the literature regarding the available volume fraction o ... Link to item Cite

Fourier analysis of fluctuations of oxygen tension and blood flow in R3230Ac tumors and muscle in rats.

Journal Article Am J Physiol · August 1999 Tumor hypoxia is a major barrier to tumor radiation therapy. Typically tumor hypoxia occurs in two forms: chronic and acute. Although the existence of acute hypoxia has long been acknowledged, its temporal characteristics have never been directly measured ... Full text Link to item Cite

Fourier analysis of fluctuations of oxygen tension and blood flow in R3230Ac tumors and muscle in rats

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY · August 1, 1999 Link to item Cite

The effects of hyperoxic and hypercarbic gases on tumour blood flow.

Journal Article Br J Cancer · April 1999 Carbogen (95% O2 and 5% CO2) has been used in preference to 100% oxygen (O2) as a radiosensitizer, because it is believed that CO2 blocks O2-induced vasoconstriction. However, recent work suggests that both normal and tumour arterioles of dorsal flap windo ... Full text Link to item Cite

Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia.

Journal Article Br J Cancer · April 1999 We previously reported that the arteriolar input in window chamber tumours is limited in number and is constrained to enter the tumour from one surface, and that the pO2 of tumour arterioles is lower than in comparable arterioles of normal tissues. On aver ... Full text Link to item Cite

THREE-DIMENSIONAL MICROVASCULAR NETWORKS FRACTAL STRUCTURE: POTENTIAL FOR TISSUE CHARACTERIZATION?

Conference ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE) · January 1, 1999 It has been shown that the fractal dimension of 2D microvascular networks can discriminate between normal vs. tumor tissue (Gazit et al., 1995, 1997). We have determined the fractal characteristics of five 3D microvascular networks and conclude on the corr ... Full text Cite

Tumour cell kinetics as predictors of response in canine lymphoma treated with chemotherapy alone or combined with whole body hyperthermia.

Journal Article Int J Hyperthermia · 1999 Kinetic parameters including potential doubling time (Tpot), duration of S phase (Ts), labelling index (LI), and DNA index (DI) were obtained from 42 dogs with previously untreated lymphoma. Standard flow cytometric techniques using BrdUrd were employed. A ... Full text Link to item Cite

Hyperthermia and liposomes.

Journal Article Int J Hyperthermia · 1999 Hyperthermia and liposomal drug delivery are treatment modalities that have been used to treat cancer over the last two decades. More recently, the two therapies have been used together in an attempt to exploit their mutual interactions against cancer. The ... Full text Link to item Cite

Use of whole body hyperthermia as a method to heat inaccessible tumours uniformly: a phase III trial in canine brain masses.

Journal Article Int J Hyperthermia · 1999 In this study, whole body hyperthermia (WBH) was assessed as a means of heating intracranial tumours uniformly. Twenty-five dogs received radiation therapy and 20 the combination of radiation and WBH. Total radiation dose was randomly assigned and was eith ... Full text Link to item Cite

Variability in blood flow and pO2 in tumors in response to carbogen breathing.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 1998 PURPOSE: There is speculation that the CO2 in carbogen (95% O2, 5% CO2) can block the vasoconstrictive effects of oxygen. However, it has recently been shown that blood flow in human tumors is variable while patients breathe carbogen. Furthermore, we have ... Full text Link to item Cite

MIBG inhibits respiration: potential for radio- and hyperthermic sensitization.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 1998 INTRODUCTION: Meta-iodobenzylguanidine (MIBG) in its 131I-labeled form is clinically used as a tumor-targeted radiopharmaceutical in the diagnosis and treatment of adrenergic tumors. This well established drug may have additional clinical applications as a ... Full text Link to item Cite

Temporal changes in PO2 of R3230AC tumors in Fischer-344 rats.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 1998 PURPOSE: The purpose of this study was to characterize the kinetics of hypoxia-reoxygenation in a murine tumor. Information on the prevalence and kinetics of this process are lacking in solid tumors, although there are data on blood flow fluctuation. MATER ... Full text Link to item Cite

Role of Tie2 in pathologic angiogenesis

Journal Article JOURNAL OF VASCULAR RESEARCH · September 1, 1998 Link to item Cite

Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2.

Journal Article Proc Natl Acad Sci U S A · July 21, 1998 Angiogenesis is required for tumor growth and metastasis, and inhibition of angiogenesis is a promising approach for anticancer therapy. Tie2 (a.k.a Tek) is an endothelium-specific receptor tyrosine kinase known to play a role in tumor angiogenesis. To exp ... Full text Link to item Cite

Concepts of oxygen transport at the microcirculatory level.

Journal Article Semin Radiat Oncol · July 1998 This article compares and contrasts the classic paradigms underlying the development of chronic and acute hypoxia in tumors. The classic theory of Thomlinson and Gray suggested that chronic hypoxia is the result of large intravascular distances. Newer evid ... Full text Link to item Cite

Introduction.

Journal Article Semin Radiat Oncol · July 1998 Copyright ... Full text Link to item Cite

The multifaceted roles of nitric oxide in cancer.

Journal Article Carcinogenesis · May 1998 The roles of nitric oxide (NO) in numerous disease states have generated considerable discussion over the past several years. NO has been labeled as the causative agent in different pathophysiological mechanisms, yet appears to protect against various chem ... Full text Link to item Cite

Artificial neural network model of survival in patients treated with irradiation with and without concurrent chemotherapy for advanced carcinoma of the head and neck.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 1998 PURPOSE: This study was performed to investigate the feasibility of predicting survival in squamous cell carcinoma of the head and neck (SCCHN) with an artificial neural network (ANN), and to compare ANN performance with conventional models. METHODS AND MA ... Full text Link to item Cite

Serial in vivo observations of cerebral vasculature after treatment with a large single fraction of radiation.

Journal Article Radiat Res · April 1998 To test whether single high doses of radiation, similar to those used with radiosurgery, given to normal cerebral vasculature can cause changes in leukocyte-vessel wall interactions and tissue perfusion, a rat pial window model was used to view the cerebra ... Link to item Cite

Should interstitial thermometry be used for deep hyperthermia?

Journal Article Int J Radiat Oncol Biol Phys · March 15, 1998 Full text Link to item Cite

Oxygen distributions within R3230Ac tumors growing in dorsal flap window chambers in rats.

Journal Article Adv Exp Med Biol · 1998 R3230Ac mammary tumors were grown in transparent window chambers implanted into the dorsal skin flap of 250 g Fischer 344 rats (see Dewhirst et al, 1992). The oxygen pressure distributions in the tumor and host tissue were measured by the oxygen dependent ... Full text Link to item Cite

Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor.

Journal Article Cell Growth Differ · January 1998 Vascular endothelial growth factor (VEGF) is a leading candidate for an endogenous mediator of tumor angiogenesis. Recently, two endothelial cell surface receptors, flk-1 and flt-1, have been shown to mediate the angiogenic activities of VEGF. In this stud ... Link to item Cite

Combretastatin A-4 P as a tumour vascular targeting agent

Journal Article BRITISH JOURNAL OF CANCER · January 1, 1998 Link to item Cite

Tissue oxygen pressure and oxygen sensing by the carotid body

Conference OXYGEN HOMEOSTASIS AND ITS DYNAMICS · January 1, 1998 Link to item Cite

Hyperthermic treatment of malignant diseases: current status and a view toward the future.

Journal Article Semin Oncol · December 1997 New studies in hyperthermia at the basic science, engineering, and clinical level have stimulated renewed enthusiasm for re-investigating its potential as an anticancer therapy. This article reviews the salient features of these recent results and points o ... Link to item Cite

L-selectin-dependent leukocyte rolling on endothelial monolayers under flow

Journal Article FASEB Journal · December 1, 1997 Lcukocyte-endothelial (L/E) interactions during inflammation are regulated by the synchronized binding of endothelial adhesion molecules with corresponding leukocyte counter-receptors, including L-selectin. The dynamic interactions of rat basophilic leukem ... Cite

Response to the Letter of Drs. Hartmann et al.

Journal Article Radiation Research · November 1997 Full text Cite

Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth.

Journal Article J Clin Invest · October 15, 1997 Tie2 is a novel receptor tyrosine kinase that is expressed almost exclusively by vascular endothelium. Disruption of Tie2 function in transgenic mice resulted in embryonic lethality secondary to characteristic vascular defects; similar defects occurred aft ... Full text Link to item Cite

Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues.

Journal Article Circ Res · October 1997 Angiogenesis, the process of new vessels sprouting from the existing vasculature, is a critical process during early development. However, angiogenesis rarely occurs in the adult, except in response to cyclic hormonal stimulation in the ovary and uterus, i ... Full text Link to item Cite

Interlaboratory variation in oxygen tension measurement by Eppendorf "Histograph" and comparison with hypoxic marker.

Journal Article J Surg Oncol · September 1997 BACKGROUND AND OBJECTIVES: The median of pO2 values in tumor measured by Eppendorf "Histograph" with a needle-type electrode has been used as a prognostic indicator in cancer patients. However, it is not established that a pretreatment measured pO2 value c ... Full text Link to item Cite

Hyperbaric oxygen improves tumor radiation response significantly more than carbogen/nicotinamide.

Journal Article Radiat Res · June 1997 This laboratory previously demonstrated that hyperbaric oxygen and hyperbaric carbogen improved oxygenation in the R3230Ac tumor, but normobaric 100% O2 and carbogen did not. The current study assessed tumor growth after exposure to radiation plus either h ... Link to item Cite

Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 1997 PURPOSE: Tumor hypoxia adversely affects short term clinical radiation response of head and neck cancer lymph node metastases and long term disease-free survival (DFS) in cervix carcinoma. This study was performed to evaluate the relationship between tumor ... Full text Link to item Cite

Combined external beam irradiation and external regional hyperthermia for locally advanced adenocarcinoma of the prostate.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 1997 PURPOSE: To determine the safety and efficacy of combined external beam irradiation and external regional hyperthermia in the treatment of adenocarcinoma of the prostate. METHODS AND MATERIALS: From 1987 to 1994, 30 patients received combined external beam ... Full text Link to item Cite

Quantification of erythrocyte flow in the choroid of the albino rat.

Journal Article Am J Physiol · March 1997 Choroidal blood flow is one of the highest in the body on a global volume basis. Little is known, however, about flow through individual vessels, which has important consequences for ocular blood delivery and oxygen transport. The purpose of this study was ... Full text Link to item Cite

Simultaneous measurement of liposome extravasation and content release in tumors.

Journal Article Microcirculation · March 1997 OBJECTIVE: The success of liposome-based drug delivery systems for tumor targeting relies on maximum extravasation of liposomes into tumor interstitium, as well as optimal release of contents from the liposomes once within the tumor Liposome extravasation ... Full text Link to item Cite

Quantification of erythrocyte flow in the choroid of the albino rat

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY · March 1, 1997 Link to item Cite

Stroma-free human hemoglobin A decreases R3230Ac rat mammary adenocarcinoma blood flow and oxygen partial pressure.

Journal Article Radiat Res · February 1997 We examined the effect of a nitric oxide (NO) quencher, stroma-free human hemoglobin A (HbA0; 0.01, 0.05, 0.1, 0.2 g/kg), on the blood flow measured using the Doppler flow technique, tumor oxygen pressure (pO2) and the diameter of the arterioles using R323 ... Link to item Cite

Effects of diethylamine/nitric oxide on blood perfusion and oxygenation in the R3230Ac mammary carcinoma.

Journal Article Br J Cancer · 1997 The effects of intravenous diethylamine/nitric oxide (DEA/NO), a short-acting nitric oxide (NO) donor, on systemic haemodynamics, muscle and tumour blood flow (MBF and TBF) and tumour oxygenation were examined in rats bearing subcutaneous R3230Ac carcinoma ... Full text Link to item Cite

Local hyperthermia improves uptake of a chimeric monoclonal antibody in a subcutaneous xenograft model.

Journal Article Clin Cancer Res · January 1997 This study was undertaken to determine the effect of local hyperthermia on the tissue distribution of a chimeric human/mouse IgG2 monoclonal antibody, 81C6, reactive with the extracellular matrix protein tenascin, which is expressed at high levels in gliom ... Link to item Cite

A local hyperthermia treatment which enhances antibody uptake in a glioma xenograft model does not affect tumour interstitial fluid pressure.

Journal Article Int J Hyperthermia · 1997 Solid tumours have an elevated interstitial fluid pressure (IFP) due to the lack of normal lymphatics, increased permeability of tumour vasculature and an expanding cell population within a potentially limited space. This elevated IFP has been proposed to ... Full text Link to item Cite

2013 The impact of hypoxia and oxygenation modification on the radiation response of an intracranial rat glioma

Journal Article International Journal of Radiation Oncology*Biology*Physics · January 1997 Full text Cite

152 Identification of longitudinal tissue pO2 gradients as one cause for vascular hypoxia in window chamber tumors

Journal Article International Journal of Radiation Oncology*Biology*Physics · January 1997 Full text Cite

Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma.

Journal Article Cancer Res · December 1, 1996 Hypoxia occurs in two forms in tumors. Chronic or diffusion-limited hypoxia is relatively well characterized. In contrast, intermittent or perfusion-limited hypoxia is not well characterized, and it is not known how common it is in tumors. The purpose of t ... Link to item Cite

Thermosensitive liposomes: extravasation and release of contents in tumor microvascular networks.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 1996 PURPOSE: The purpose of this study was to determine whether hyperthermic exposure would accelerate drug release from thermosensitive sterically stabilized liposomes and enhance their extravasation in tumor tissues. MATERIALS AND METHODS: In vivo fluorescen ... Full text Link to item Cite

Radiation therapy and hyperthermia improve the oxygenation of human soft tissue sarcomas.

Journal Article Cancer Res · December 1, 1996 The adverse prognostic impact of tumor hypoxia has been demonstrated in human malignancy. We report the effects of radiotherapy and hyperthermia (HT) on soft tissue sarcoma oxygenation and the relationship between treatment-induced changes in oxygenation a ... Link to item Cite

Tissue transglutaminase is associated with the neovasculature and extracellular matrix of human breast cancer

Conference FASEB Journal · December 1, 1996 Tissue transglutaminase (tTG) is a calcium-dependent enzyme that catalyzes intermolecular covalent bonds. This protein cross-linking activity of tTG stabilizes the extracellular matrix (ECM) by making it resistant proteolytic degradation. Since angiogenesi ... Cite

Recombinant human tissue transglutaminase modifies angiogenesis and delays mammary tumor growth in vivo

Journal Article FASEB Journal · December 1, 1996 Tissue transglutaminase (tTG) is a calcium-dependent enzyme that stabilizes tissues by covalently crosslinking extracellular matrix (ECM) molecules. The tTG expressed by the tumor vasculature and ECM could modify angiogenesis and tumor growth. We investiga ... Cite

Ca2+-dependent nitric oxide release in endothelial but not R3230Ac rat mammary adenocarcinoma cells

Journal Article American Journal of Physiology · December 1, 1996 We have character-ized the ability of several cell types associated with the microvasculature of solid tumors to release nitric oxide (NO·) in response to increases in cytosolic Ca2+ concentration ([Ca2+]c). EA.hy926 immortalized human umbilical vein endot ... Cite

Re: Kapp editorial IJROBP 35:189-194; 1996.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 1996 Full text Link to item Cite

Tissue transglutaminase expression in human breast cancer.

Journal Article Lab Invest · November 1996 Tissue transglutaminase (tTG) is postulated to play a role in apoptosis, cell adhesion, metastasis, and extracellular matrix (ECM) assembly. In this study, the distribution and expression of tissue transglutaminase was investigated in normal human mammary ... Link to item Cite

Monitoring of neoadjuvant therapy response of soft-tissue and musculoskeletal sarcoma using fluorine-18-FDG PET.

Journal Article J Nucl Med · September 1996 UNLABELLED: The purpose of this study was to investigate the potential role of FDG-PET in the monitoring of neoadjuvant therapy of soft-tissue and musculoskeletal sarcomas. METHODS: Nine patients were studied. Neoadjuvant therapy consisted of either chemot ... Link to item Cite

Modern tsars and princes: the struggle for hegemony in Russia

Journal Article International Affairs · July 1996 Full text Cite

Microvascular studies on the origins of perfusion-limited hypoxia.

Journal Article Br J Cancer Suppl · July 1996 Featured Publication Two forms of hypoxia are thought to exist in tumours: (1) hypoxia caused by limitations of its diffusion (chronic hypoxia); and (2) hypoxia caused by changes in perfusion (acute hypoxia). Indirect information suggests the existence of perfusion-limited hyp ... Link to item Cite

Ca(2+)-dependent nitric oxide release in endothelial but not R3230Ac rat mammary adenocarcinoma cells.

Journal Article Am J Physiol · July 1996 We have characterized the ability of several cell types associated with the microvasculature of solid tumors to release nitric oxide (NO.) in response to increases in cytosolic Ca2+ concentration ([Ca2+]c). EA.hy926 immortalized human umbilical vein endoth ... Full text Link to item Cite

Arteriolar oxygenation in tumour and subcutaneous arterioles: effects of inspired air oxygen content.

Journal Article Br J Cancer Suppl · July 1996 Carbogen is thought to be more effective than normobaric oxygen in reducing tumour hypoxia because it may reduce hyperoxic vasoconstriction. In this study, tumour and normal arteriolar diameters were measured simultaneously with perivascular pO2 during air ... Link to item Cite

Ca2+-dependent nitric oxide release in endothelial but not R3230Ac rat mammary adenocarcinoma cells

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY · July 1, 1996 Link to item Cite

The effects of clinically relevant hyperthermic temperatures on the kinetic binding parameters of a monoclonal antibody.

Journal Article Nucl Med Biol · May 1996 Hyperthermia is a therapeutic modality under investigation for its ability to increase absolute levels of tumor uptake of radiolabeled monoclonal antibodies (MAbs). We have investigated whether hyperthermia may affect the binding parameters of MAbs. The ef ... Full text Link to item Cite

Radiation plus local hyperthermia versus radiation plus the combination of local and whole-body hyperthermia in canine sarcomas.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 1996 PURPOSE: The purpose of this study was to assess the effect of increasing intratumoral temperatures by the combination of local hyperthermia (LH) and whole body hyperthermia (WBH) on the radiation response of canine sarcomas. METHODS AND MATERIALS: Dogs wi ... Full text Link to item Cite

Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.

Journal Article Cancer Res · March 1, 1996 Featured Publication This study was performed to explore the relationship between tumor oxygenation and treatment outcome in human soft tissue sarcoma. Twenty-two patients with nonmestastatic, high-grade, soft tissue sarcomas underwent preoperative irradiation and hyperthermia ... Link to item Cite

Observation and quantification of erythrocyte flow in the choroid of the albino rat

Journal Article Investigative Ophthalmology and Visual Science · February 15, 1996 Purpose. Choroidal blood flow is one of the highest in the body on a global volume basis. Little is known, however, about flow through individual vessels, which has important consequences for blood delivery and oxygen transport. The purpose of this study w ... Cite

Observation and quantification of erythrocyte flow in the choroid of the albino rat

Journal Article INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · February 15, 1996 Link to item Cite

Concepts in tumor oxygen transport

Conference 6TH WORLD CONGRESS FOR MICROCIRCULATION · January 1, 1996 Link to item Cite

Clinical implications and techniques for modification of tumor oxygenation

Conference 6TH WORLD CONGRESS FOR MICROCIRCULATION · January 1, 1996 Link to item Cite

Tumor oxygenation: a matter of supply and demand.

Journal Article Anticancer Res · 1996 Development of new approaches to ameliorate tumor hypoxia may require understanding of the relative importance of supply vs. demand. On the demand side, abnormalities in energy metabolism are known to be related to defects in regulation of respiratory enzy ... Link to item Cite

Phase I evaluation of mitoxantrone alone and combined with whole body hyperthermia in dogs with lymphoma.

Journal Article Int J Hyperthermia · 1996 The maximum tolerated dose of mitoxantrone (MX) administered alone or combined with whole body hyperthermia (WBH) was determined in this nonrandomized, prospective study in dogs with lymphoma. MX was administered to 53 dogs every three weeks for a total of ... Full text Link to item Cite

Measuring Tumor Hypoxia.

Journal Article Semin Radiat Oncol · January 1996 A variety of techniques for measuring oxygen in normal and tumor tissue has been developed over the years in response to the realization that hypoxia is important in a number of pathophysiological conditions in normal tissues and in the response of tumors ... Full text Link to item Cite

Estimation of cell survival in tumours heated to nonuniform temperature distributions.

Journal Article Int J Hyperthermia · 1996 UNLABELLED: A stochastic model describing the probability of cell survival as a function of thermal exposure was developed and fit to data arising from studies of CHO cell survival under hyperthermic conditions. This model characterizes the separate risks ... Full text Link to item Cite

Arteriolar oxygenation in tumour and subcutaneous arterioles: Effects of inspired air oxygen content

Journal Article British Journal of Cancer · January 1, 1996 Carbogen is thought to be more effective than normobaric oxygen in reducing tumour hypoxia because it may reduce hyperoxic vasoconstriction. In this study, tumour and normal arteriolar diameters were measured simultaneously with perivascular pO2 during air ... Cite

Microvascular studies on the origins of perfusion-limited hypoxia

Journal Article British Journal of Cancer · January 1, 1996 Two forms of hypoxia are thought to exist in tumours: (1) hypoxia caused by limitations of its diffusion (chronic hypoxia); and (2) hypoxia caused by changes in perfusion (acute hypoxia). Indirect information suggests the existence of perfusion-limited hyp ... Cite

Ca2+-dependent nitric oxide release in endothelial but not R3230Ac rat mammary adenocarcinoma cells

Journal Article American Journal of Physiology - Cell Physiology · 1996 We have characterized the ability of several cell types associated with the microvasculature of solid tumors to release nitric oxide (NO·) in response to increases in cytosolic Ca2+ concentration ([Ca2+](c)). EA.hy926 immortalized human umbilical vein endo ... Cite

Ca2+-dependent nitric oxide release in endothelial but not R3230Ac rat mammary adenocarcinoma cells

Journal Article American Journal of Physiology · 1996 We have character-ized the ability of several cell types associated with the microvasculature of solid tumors to release nitric oxide (NO·) in response to increases in cytosolic Ca2+ concentration ([Ca2+]c). EA.hy926 immortalized human umbilical vein endot ... Cite

Editorial

Journal Article International Journal of Hyperthermia · January 1996 Full text Cite

Editorial Comment

Journal Article International Journal of Hyperthermia · January 1996 Full text Cite

Radiosurgery in rat brain

Conference RADIOSURGERY 1995 · January 1, 1996 Link to item Cite

The mechanisms by which hyperbaric oxygen and carbogen improve tumour oxygenation.

Journal Article Br J Cancer · November 1995 Hyperbaric oxygen (HBO) has been proposed to reduce tumour hypoxia by increasing the amount of dissolved oxygen in the plasma. That this actually occurs has not been verified experimentally. This study was performed to explore changes in tumour oxygenation ... Full text Link to item Cite

Progress toward a thermal dosimetry system.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 1995 Full text Link to item Cite

Inhibition of radiation-induced up-regulation of leukocyte adhesion to endothelial cells with the platelet-activating factor inhibitor, BN52021.

Journal Article Int J Radiat Oncol Biol Phys · October 15, 1995 Featured Publication PURPOSE: The inflammatory process is likely involved in normal tissue damage after radiation exposure, yet few studies have directly evaluated the factors that might be involved in the regulation of inflammation after irradiation in vivo. We tested the hyp ... Full text Link to item Cite

The legacy of history in Russia and the new states of Eurasia

Journal Article International Affairs · October 1995 Full text Cite

Tumor physiology and cell kinetics.

Journal Article Semin Vet Med Surg Small Anim · August 1995 The abnormal physiological state of tumors has traditionally been thought to be a source of treatment resistance and altered metastatic phenotype. However, the recent recognition that this altered physiological state is unique to solid cancers gives some h ... Link to item Cite

Absence of whole body hyperthermia effect on cisplatin distribution in spontaneous canine tumors.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 1995 PURPOSE: This study was conducted to evaluate the effect of whole body hyperthermia (WBH) on cisplatin (CDDP)-derived platinum (Pt) disposition in tumor and normal tissue in dogs with spontaneously arising neoplasia undergoing conventional pretreatment diu ... Full text Link to item Cite

Patterns and variability of tumor oxygenation in human soft tissue sarcomas, cervical carcinomas, and lymph node metastases.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 1995 PURPOSE: The validity of tumor pO2 measurement as a predictive outcome assay depends upon demonstrating that intrapatient pO2 variation is less than interpatient variation. No consensus exists regarding the appropriate distance between individual measureme ... Full text Link to item Cite

Flunarizine enhancement of melphalan activity against drug-sensitive/resistant rhabdomyosarcoma.

Journal Article Br J Cancer · June 1995 Flunarizine, a diphenylpiperazine calcium channel blocker, is known to increase tumor blood flow. It also interferes with calmodulin function, repair of DNA damage and drug resistance associated with P-glycoprotein. Flunarizine was tested for its ability t ... Full text Link to item Cite

Nitric oxide synthase inhibition irreversibly decreases perfusion in the R3230Ac rat mammary adenocarcinoma.

Journal Article Br J Cancer · June 1995 We examined the microvascular effects of competitive nitric oxide synthase (NOS) inhibition with NG-monomethyl-L-arginine (MeArg), followed by L-arginine, on R3230Ac mammary adenocarcinoma perfusion. In window preparations containing tumours, superfusion o ... Full text Link to item Cite

A pial window model for the intracranial study of human glioma microvascular function.

Journal Article Neurosurgery · May 1995 A new model for human brain tumor uses the intracranial placement of tumor xenografts under transparent glass cranial windows in nude rats, which require no immunosuppression for tumor engraftment. Adult male nude rats underwent implantation of human anapl ... Full text Link to item Cite

Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors.

Journal Article Acta Oncol · 1995 The extent of hypoxic regions in a tumor tissue depends on the arrangement, blood flow rate and blood oxygen content of microvessels, and on the tissue's oxygen consumption rate. Here, the effects of blood flow rate, blood oxygen content and oxygen consump ... Full text Link to item Cite

Hyperthermic modulation of radiolabelled antibody uptake in a human glioma xenograft and normal tissues.

Journal Article Int J Hyperthermia · 1995 These experiments investigate the biodistribution of radiolabelled MAb in a human glioma xenograft model after 4 h of local hyperthermia (HT) with a twofold purpose: to maximize the ratio of cumulative isotope activity in tumour relative to normal tissues, ... Full text Link to item Cite

Nitric oxide synthase inhibition irreversibly decreases perfusion in the R3230Ac rat mammary adenocarcinoma

Journal Article British Journal of Cancer · January 1, 1995 We examined the microvascular effects of competitive nitric oxide synthase (NOS) inhibition with NG-monomethyl-L-arginine (MeArg), followed by L-arginine, on R3230Ac mammary adenocarcinoma perfusion. In window preparations containing tumours, superfusion o ... Full text Cite

The effect of the perflubron emulsion Oxygent on the calibration characteristics of polarographic oxygen electrodes.

Journal Article Radiother Oncol · December 1994 The perfluorocarbon emulsion Oxygent improves normal tissue oxygenation. A clinical trial is planned to evaluate this effect in tumors. Polarographic oxygen electrodes were calibrated in solutions of saline +/- perflubron to assess whether Oxygent influenc ... Full text Link to item Cite

Pretreatment oxygenation profiles of human soft tissue sarcomas.

Journal Article Int J Radiat Oncol Biol Phys · October 15, 1994 PURPOSE: Tumor oxygenation is thought to influence the radiocurability of many malignancies. Advances in polarographic electrode technology have facilitated the in situ measurement of human tumor pO2. The optimal method of defining a "hypoxic" tumor is not ... Full text Link to item Cite

Determination of local oxygen consumption rates in tumors.

Journal Article Cancer Res · July 1, 1994 At any location in a respiring tissue, partial pressure of oxygen (PO2) is influenced by the local oxygen consumption rate. Consumption rates in vascular tumor tissues have previously been estimated for macroscopic regions. Using oxygen electrodes, we meas ... Link to item Cite

Differences in leucocyte-endothelium interactions between normal and adenocarcinoma bearing tissues in response to radiation.

Journal Article Br J Cancer · May 1994 Previously, we demonstrated that the interaction between leucocytes and endothelial cells in tumour tissues is greatly diminished compared with normal tissues under several induced inflammatory conditions. Radiation has been reported to cause release of in ... Full text Link to item Cite

Inverse techniques in hyperthermia: a sensitivity study.

Journal Article IEEE Trans Biomed Eng · April 1994 Numerical modeling methods and hyperthermia treatment temperature measurements have been used together to reconstruct steady-state tumor temperature distributions. However, model errors will exist which may in turn produce errors in the reconstructed tempe ... Full text Link to item Cite

Therapy monitoring in human and canine soft tissue sarcomas using magnetic resonance imaging and spectroscopy.

Journal Article Int J Radiat Oncol Biol Phys · January 15, 1994 PURPOSE: The goals of this study were to determine whether magnetic resonance parameters (a) can identify early during therapy those patients most likely to respond to hyperthermia and radiotherapy, (b) can provide prior to or early during therapy informat ... Full text Link to item Cite

MR imaging and spectroscopy for prognostic evaluation in soft-tissue sarcomas.

Journal Article Radiology · January 1994 Featured Publication PURPOSE: To enable prediction of tumor response to a particular treatment. MATERIALS AND METHODS: The authors studied the value of hydrogen-1 T2 and phosphorus-31 magnetic resonance (MR) spectroscopic metabolic determinations as indicators of prognosis in ... Full text Link to item Cite

Hyperthermic sensitization by the radical initiator 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH). I. In vitro studies.

Journal Article Int J Hyperthermia · 1994 AAPH (2,2'-azobis-(2-amidinopropane dihydrochloride)) is a water-soluble, heat-labile azo compound which undergoes thermal decomposition to produce carbon-centred free radicals. These carbon-centred radicals might be directly cytotoxic or may react with ox ... Full text Link to item Cite

Future directions in hyperthermia biology.

Journal Article Int J Hyperthermia · 1994 Eric Hall pointed out many years ago that in hyperthermia the biology is with us, but the physics is against us. Over the years the basic truth in that statement has not wavered. Our best evidence suggests that temperature distributions are 1-1.5 degrees C ... Full text Link to item Cite

Effect of whole body hyperthermia on carboplatin disposition and toxicity in dogs.

Journal Article Int J Hyperthermia · 1994 Fifty dogs with refractory or disseminated spontaneous tumours were evaluated in two independent phase I studies using either carboplatin (CBDCA) alone or CBDCA plus whole body hyperthermia (WBH). CBDCA was administered as a 30 min infusion at the onset of ... Full text Link to item Cite

Intraperitoneal cisplatin and regional hyperthermia for ovarian carcinoma.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 1993 PURPOSE: To review the theoretical basis and results of a Phase I study of concurrent intraperitoneal cisplatin and hyperthermia in the treatment of ovarian carcinoma. METHODS AND MATERIALS: Previously treated patients with epithelial ovarian carcinoma rec ... Full text Link to item Cite

Mechanisms of hyperthermic cytotoxicity and effects at the tissue level

Journal Article American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD · December 1, 1993 The purpose of this paper is to briefly review current thinking about the mechanisms of thermocytotoxicity at the cellular level and to discuss the variations in normal tissue sensitivity to heat. Extensive reviews are available on these subjects that cove ... Cite

The lack of impact of treatment time on the outcome of definitive radiotherapy for carcinoma of the prostate.

Journal Article Int J Oncol · October 1993 The records of 180 patients definitively irradiated for newly diagnosed adenocarcinoma of the prostate between 1970 and 1988 at Duke University Medical Center (107 patients from 1970-1983) and Moore Regional Hospital (73 patients from 1981-1988) were revie ... Full text Link to item Cite

Measurement of material extravasation in microvascular networks using fluorescence video-microscopy.

Journal Article Microvasc Res · September 1993 We have developed a new method using fluorescence videomicroscopy to quantitate the extravasation of intravenously injected materials. This method can measure the relative plasma concentration of, and the vascular permeability to, these materials in microc ... Full text Link to item Cite

Increased microvascular permeability contributes to preferential accumulation of Stealth liposomes in tumor tissue.

Journal Article Cancer Res · August 15, 1993 Stealth liposomes have recently emerged as a promising antitumor drug delivery system, yet no studies have been reported to examine their dynamic behavior at the microcirculatory level. In this investigation, we have used in vivo fluorescence videomicrosco ... Link to item Cite

Therapeutic effect of infused Fluosol-DA/carbogen with ephedrine, flunarizine, or nitroprusside.

Journal Article Int J Radiat Oncol Biol Phys · April 30, 1993 UNLABELLED: The perfluorochemical emulsion Fluosol-DA plus carbogen breathing has been shown to increase the effectiveness of radiation therapy in preclinical solid tumors when the emulsion was administered by i.v. bolus injection. Much of the enhancement ... Full text Link to item Cite

Cumulative minutes with T90 greater than Tempindex is predictive of response of superficial malignancies to hyperthermia and radiation.

Journal Article Int J Radiat Oncol Biol Phys · April 2, 1993 PURPOSE: To better define thermal parameters related to tumor response in superficial malignancies treated with combined hyperthermia and radiation therapy. METHODS AND MATERIALS: Patients were randomized to receive one or two hyperthermia treatments per w ... Full text Link to item Cite

The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH, and lactate treatment.

Journal Article Br J Cancer · April 1993 Flunarizine is a class IV calcium channel blocker which increases oxygen delivery to hypoxic regions in solid tumours, exerting a radiosensitising effect in vivo in animal tumour models. Precisely how the drug improves oxygenation is not well understood. W ... Full text Link to item Cite

Factors influencing hyperthermic enhancement of drug cytotoxicity.

Journal Article Int J Radiat Oncol Biol Phys · February 15, 1993 Full text Link to item Cite

Analysis of oxygen transport to tumor tissue by microvascular networks.

Journal Article Int J Radiat Oncol Biol Phys · February 15, 1993 We present theoretical simulations of oxygen delivery to tumor tissues by networks of microvessels, based on in vivo observations of vascular geometry and blood flow in the tumor microcirculation. The aim of these studies is to investigate the impact of va ... Full text Link to item Cite

Sensitivity of hyperthermia trial outcomes to temperature and time: implications for thermal goals of treatment.

Journal Article Int J Radiat Oncol Biol Phys · January 15, 1993 PURPOSE: In previous work we have found that the cumulative minutes of treatment for which 90% of measured intratumoral temperatures (T90) exceeded 39.5 degrees C was highly associated with complete response of superficial tumors. Similarly, the cumulative ... Full text Link to item Cite

A comparison of tumor and normal tissue microvascular hematocrits and red cell fluxes in a rat window chamber model.

Journal Article Int J Radiat Oncol Biol Phys · January 15, 1993 This laboratory has previously used a window chamber model to measure red blood cell velocity in mammary tumors and normal granulation tissues of the F-344 rat. Because red cell flux and hematocrit more accurately reflect the oxygen carrying potential of b ... Full text Link to item Cite

Reduction in tumor blood flow in skin flap tumor after hydralazine is not due to a vascular steal phenomenon

Journal Article Radiation Oncology Investigations · January 1, 1993 The purpose of this study was to evaluate whether a “vascular steal” mechanism (preferential arteriolar vasodilation in normal vs. tumor tissue concomitant with a reduction in blood pressure) is responsible for tumor blood flow reduction after hydralazine ... Full text Cite

Development of a model of melphalan-induced gastrointestinal toxicity in mice.

Journal Article Cancer Chemother Pharmacol · 1993 The tolerated dose of melphalan is limited by bone marrow suppression; when this complication is ameliorated by bone marrow transplantation, the dose-limiting toxicity becomes gastrointestinal mucositis. No intervention to date has been successful in modul ... Full text Link to item Cite

Pharmacokinetic and phase I evaluation of carboplatin in dogs.

Journal Article J Vet Intern Med · 1993 Thirty dogs with spontaneously occurring malignant neoplasms were treated monthly with carboplatin (CBDCA) given as a 30-minute intravenous infusion in a dose escalation study. Twenty-eight dogs were considered evaluable for toxicity. The maximally tolerat ... Full text Link to item Cite

Manipulation of intra- and extracellular pH in spontaneous canine tumours by use of hyperglycaemia.

Journal Article Int J Hyperthermia · 1993 We evaluated the use of hyperglycaemia to reduce tumour pH in dog with spontaneous tumours. Dogs were randomized to two groups: control and glucose. Intravenous administration of 20% glucose was used to induce and maintain hyperglycaemia. Extra- and intrac ... Full text Link to item Cite

Serial in vivo observations of cerebral vasculature after a single fraction of radiation using a rat brain window

Journal Article International Journal of Radiation Oncology*Biology*Physics · 1993 Full text Cite

Models for oxygen exchange between microvascular networks and surrounding tissue

Journal Article American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD · December 1, 1992 The Krogh cylinder model for oxygen diffusion from capillaries is the starting point for many theoretical models of oxygen delivery to tissue. It assumes an idealized geometry, in which the capillaries are identical, parallel, and evenly spaced. We present ... Cite

Effects of the calcium channel blocker flunarizine on the hemodynamics and oxygenation of tumor microvasculature.

Journal Article Radiat Res · October 1992 Flunarizine is a diphenylpiperazine calcium entry blocker that has been shown previously to increase tumor blood flow and sensitivity to radiotherapy via reduction in the radiobiologically significant hypoxic fraction. Two mechanisms of action have been pr ... Link to item Cite

Diminished leukocyte-endothelium interaction in tumor microvessels.

Journal Article Cancer Res · August 1, 1992 Leukocyte-endothelium interaction in vivo consists of the rolling of leukocytes along the vascular wall and, under certain conditions, their adherence to endothelial cells. In a rat tumor microcirculation model (mammary adenocarcinoma implanted in rat skin ... Link to item Cite

Effects of bradykinin on the hemodynamics of tumor and granulating normal tissue microvasculature.

Journal Article Radiat Res · June 1992 Bradykinin (BK) is an important endogenous mediator of microvascular flow modulation. Since the structure of the microcirculation is very different in tumor tissues than in normal tissues, bradykinin may elicit different responses in tumors. This study was ... Link to item Cite

Perivascular oxygen tensions in a transplantable mammary tumor growing in a dorsal flap window chamber.

Journal Article Radiat Res · May 1992 Fischer 344 rats with R3230 Ac mammary carcinomas implanted in dorsal flap window chambers served as a model to obtain measurements of perivascular and stromal oxygen tension in normal and tumor tissues using Whalen recessed-tip microelectrodes (3- to 6-mi ... Link to item Cite

Hyperthermia-induced enhancement of melphalan activity against a melphalan-resistant human rhabdomyosarcoma xenograft.

Journal Article Radiat Res · February 1992 The effects of regional hyperthermia (42 degrees C for 70 min) on the antitumor activity of melphalan were examined in athymic mice bearing melphalan-resistant human rhabdomyosarcoma (TE-671 MR) xenografts growing in the right hind limb, and results were c ... Link to item Cite

Phase III evaluation of doxorubicin and whole-body hyperthermia in dogs with lymphoma.

Journal Article Int J Hyperthermia · 1992 Sixty-one dogs with histologically confirmed, untreated, high-grade lymphoma were evaluated and treated with doxorubicin (DOX, 30 mg/m2) alone. Forty-seven dogs (77%) achieved a complete response. Forty-six of the 47 dogs were randomized to receive five ad ... Full text Link to item Cite

Phase I evaluation of doxorubicin and whole-body hyperthermia in dogs with lymphoma.

Journal Article J Vet Intern Med · 1992 Fifteen previously untreated dogs with histologically confirmed, high-grade multicentric lymphoma were entered into a phase I study to evaluate combined doxorubicin and whole-body hyperthermia (DOX/WBH). Groups of three, four, and eight dogs were treated w ... Full text Link to item Cite

Use of nitroprusside to increase tissue temperature during local hyperthermia in normal and tumor-bearing dogs.

Journal Article Int J Radiat Oncol Biol Phys · 1992 The present study investigates the effects of nitroprusside, a potent vasodilating agent, on tissue temperature during local hyperthermia in five normal and five tumor-bearing dogs. Caudal thigh muscles were heated in normal dogs and muscle temperatures we ... Full text Link to item Cite

Response of canine soft tissue sarcomas to radiation or radiation plus hyperthermia: a randomized phase II study.

Journal Article Int J Hyperthermia · 1992 Sixty-four dogs with spontaneous soft tissue sarcomas without evidence of metastases were stratified by tumour volume and randomized to receive graded doses of radiotherapy (XRT) alone or radiotherapy plus hyperthermia (HT). An improvement in duration of l ... Full text Link to item Cite

Serious toxicity associated with annular microwave array induction of whole-body hyperthermia in normal dogs.

Journal Article Int J Hyperthermia · 1992 Using a regional annular microwave array it was possible to produce a systemic temperature of 42 degrees C in approximately 80 min with applied net power levels of approximately 150 W. Resulting temperature distributions were non-uniform. Sites within the ... Full text Link to item Cite

Feasibility of estimating the temperature distribution in a tumor heated by a waveguide applicator.

Journal Article Int J Radiat Oncol Biol Phys · 1992 The feasibility of using a 2-dimensional (2D) modeling approach for retrospectively describing complete temperature distributions in the midplane of a tumor during a clinical hyperthermia treatment was tested. An experimental treatment, using a 915-MHz wav ... Full text Link to item Cite

Relationships among tumor temperature, treatment time, and histopathological outcome using preoperative hyperthermia with radiation in soft tissue sarcomas.

Journal Article Int J Radiat Oncol Biol Phys · 1992 The lack of an unambiguous thermal dosimetry continues to impede progress in clinical hyperthermia. In an attempt to define better this dosimetry, a model based on the cumulative minutes during which arbitrary percentages of measured tumor temperature poin ... Full text Link to item Cite

Quantitative estimation of the thermal dose-modifying factor for cis-diamminedichloroplatinum (CDDP) in tumour-bearing dogs.

Journal Article Int J Hyperthermia · 1992 A statistical method for estimating clinical toxicity was used to determine a theoretical isoeffect dose-modifying factor for dogs with disseminated or refractory neoplasia treated with cis-diammine dichloroplatinum (II) plus whole-body hyperthermia or CDD ... Full text Link to item Cite

Effects of glutathione or polyamine depletion on in vivo thermosensitization.

Journal Article Int J Hyperthermia · 1992 Investigations with the melphalan-sensitive and -resistant human rhabdomyosarcoma xenografts TE-671 and TE-671 MR were performed to examine the effect of glutathione and polyamine modulation on thermosensitivity. Regimens of intraperitoneally injected and ... Full text Link to item Cite

Enhancement of melphalan-induced gastrointestinal toxicity in mice treated with regional hyperthermia and BSO-mediated glutathione depletion.

Journal Article Int J Hyperthermia · 1992 Both hyperthermia and glutathione depletion have been shown to increase the antineoplastic activity of melphalan. Investigations were carried out to define the toxicity and activity of melphalan given in conjunction with local (right hind limb) hyperthermi ... Full text Link to item Cite

Polymer-grafted liposomes: Physical basis for the "stealth" property

Journal Article Journal of Liposome Research · January 1, 1992 Polymer-bearing lipids have recently been incorporated into liposomes that are used in in vivo drug delivery. This strategy has improved the liposome's ability to avoid the reticuloendothelial system and has thereby increased its circulation time in the bl ... Full text Cite

Accelerated repopulation: friend or foe? Exploiting changes in tumor growth characteristics to improve the "efficiency" of radiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · October 1991 Accelerated repopulation (rapid multiplication of surviving clonogens) during a course of radiation therapy may contribute to local failure. This possibility has prompted accelerated treatment programs in an attempt to reduce overall treatment time, thereb ... Full text Link to item Cite

Therapeutic analysis of melphalan-resistant human rhabdomyosarcoma xenograft TE-671 MR.

Journal Article Cancer Res · August 1, 1991 Investigations with the melphalan-resistant human rhabdomyosarcoma xenograft TE-671 MR were carried out to identify patterns of cross-resistance and collateral sensitivity and to define the mechanism(s) mediating melphalan resistance. TE-671 MR was cross-r ... Link to item Cite

RTOG quality assurance guidelines for clinical trials using hyperthermia for deep-seated malignancy.

Journal Article Int J Radiat Oncol Biol Phys · May 1991 Quality assurance has been vague or lacking in many previous hyperthermia trials. Recent publications by the Hyperthermia Physics Center, the Center for Devices and Regulatory Health, and the Radiation Therapy Oncology Group have described general guidelin ... Full text Link to item Cite

RTOG quality assurance guidelines for interstitial hyperthermia.

Journal Article Int J Radiat Oncol Biol Phys · May 1991 This document specifies the current recommendations for quality assurance for hyperthermia administration with interstitial techniques as specified by the Radiation Therapy Oncology Group (RTOG). The document begins by providing a brief description of the ... Full text Link to item Cite

RTOG quality assurance guidelines for clinical trials using hyperthermia administered by ultrasound.

Journal Article Int J Radiat Oncol Biol Phys · May 1991 Clinical quality assurance guidelines are established for RTOG hyperthermia protocols in which unfocused planar ultrasound may be used to administer hyperthermia. Measurement of temperature at a few fixed points is no longer considered to be adequate. Ther ... Full text Link to item Cite

Phase I study of melphalan alone and melphalan plus whole body hyperthermia in dogs with malignant melanoma.

Journal Article Int J Hyperthermia · 1991 The maximum tolerated dose of melphalan combined with whole body hyperthermia (WBH) in dogs with spontaneous malignant melanoma was lower than in dogs not receiving WBH by a factor of 1.9 +/- 0.71. Thirty-three dogs were treated monthly with escalating dos ... Full text Link to item Cite

MICROVASCULAR CHANGES INDUCED BY RADIATION EXPOSURE - IMPLICATIONS FOR THERAPY

Conference TUMOR BLOOD SUPPLY AND METABOLIC MICROENVIRONMENT · January 1, 1991 Link to item Cite

Soft-tissue sarcomas: detection of metabolic heterogeneity with P-31 MR spectroscopy.

Journal Article Radiology · September 1990 Regional variations in metabolic parameters derived with multivoxel, localized phosphorus-31 magnetic resonance (MR) spectroscopy in spontaneous human-soft-tissue sarcomas were compared with variations in the same parameters in normal human legs. In additi ... Full text Link to item Cite

Nonuniform alteration of cis-diamminedichloroplatinum(II) tissue distribution in dogs with whole body hyperthermia.

Journal Article Cancer Res · April 1, 1990 The purpose of this study was to investigate the pharmacokinetics and tissue disposition of cisplatin (CDDP) in euthermic and hyperthermic dogs to determine if hyperthermic alteration of tissue CDDP concentration is uniform. Eighteen female beagle dogs rec ... Link to item Cite

Enhanced delivery of a monoclonal antibody F(ab')2 fragment to subcutaneous human glioma xenografts using local hyperthermia.

Journal Article Cancer Res · March 15, 1990 The purpose of this study was to investigate the effects of tumor-localized hyperthermia at 42 degrees C on the tissue distribution of radioiodinated monoclonal antibody F(ab')2 fragments. Paired-label biodistribution measurements were performed in athymic ... Link to item Cite

Heterogeneity in tumor microvascular response to radiation.

Journal Article Int J Radiat Oncol Biol Phys · March 1990 Viable hypoxic cells have reduced radiosensitivity and could be a potential cause for treatment failure with radiotherapy. The process of reoxygenation, which may occur after radiation exposure, could increase the probability for control. However, incomple ... Full text Link to item Cite

Soft-tissue sarcomas: MR imaging and MR spectroscopy for prognosis and therapy monitoring. Work in progress.

Journal Article Radiology · March 1990 The authors studied the usefulness of hydrogen-1 T2 measurements and phosphorus-31 magnetic resonance (MR) spectroscopy as indicators of prognosis and monitors of response to therapy in a group of patients with soft-tissue sarcomas. All eight patients were ... Full text Link to item Cite

The use of hydralazine to manipulate tumour temperatures during hyperthermia.

Journal Article Int J Hyperthermia · 1990 Hydralazine is an antihypertensive drug which theoretically could increase tumour temperatures during hyperthermia via reduction in tumour blood flow from a vascular 'steal' phenomenon. Doses that are therapeutically effective in reducing blood pressure in ... Full text Link to item Cite

A comparison of temperatures in canine solid tumours during local and whole-body hyperthermia administered alone and simultaneously.

Journal Article Int J Hyperthermia · 1990 Temperature measurements were made in canine solid tumours during whole-body hyperthermia (WBH) alone, local hyperthermia alone and local hyperthermia given simultaneously with WBH. During the plateau phase of WBH alone, mean intratumoral temperature range ... Full text Link to item Cite

Clinical experience with a multi-element ultrasonic hyperthermia system: analysis of treatment temperatures.

Journal Article Int J Hyperthermia · 1990 A summary of tumour temperature data obtained from 31 patients who underwent 147 hyperthermia treatments with the Sonotherm 1000 ultrasonic system is presented. The treatment goal was to achieve a minimum of 42.0 degrees C in tumour for 60 min duration wit ... Full text Link to item Cite

Blood perfusion measurements in human tumours: evaluation of laser Doppler methods.

Journal Article Int J Hyperthermia · 1990 Laser Doppler flowmetry is a simple method of determining, directly and continuously, tissue blood flow. However, its applicability to monitoring tumour blood flow interstitially during hyperthermia treatments is still being evaluated. The purposes of this ... Full text Link to item Cite

Morphologic and hemodynamic comparison of tumor and healing normal tissue microvasculature.

Journal Article Int J Radiat Oncol Biol Phys · July 1989 The purpose of this study was to compare microvascular morphometric and hemodynamic characteristics of a tumor and granulating normal tissue to develop quantitative data that could be used to predict microvascular characteristics which would be most likely ... Full text Link to item Cite

Animal modeling and thermal dose.

Journal Article Radiol Clin North Am · May 1989 This article reviews historical clinical data wherein correlations were observed between simple descriptors of temperature distributions and prognosis from thermoradiotherapy. Methods for obtaining more accurate descriptor that could be tested in the futur ... Link to item Cite

Tumor temperature distributions predict hyperthermia effect.

Journal Article Int J Radiat Oncol Biol Phys · March 1989 Review of clinical hyperthermia (HT) trial results shows that there previously has not been a robust model relating efficacy of HT treatments to characteristics of the temperature distribution. Lack of a model has been an impediment in Phase II trials; the ... Full text Link to item Cite

Hyperthermia quality assurance guidelines.

Journal Article Int J Radiat Oncol Biol Phys · March 1989 These Hyperthermia Quality Assurance guidelines are a result of a joint workshop of the Hyperthermia Committee of the American College of Radiology and the Hyperthermia Physics Center, which is the national quality assurance program under Contract No. N01- ... Full text Link to item Cite

Preoperative hyperthermia and radiation for soft tissue sarcomas: advantage of two vs one hyperthermia treatments per week.

Journal Article Int J Radiat Oncol Biol Phys · January 1989 As part of an ongoing Phase II trial at Duke University Medical Center (DUMC), patients with Stage IIB-IVA soft tissue sarcomas (STS) potentially amenable to wide local excision were treated with preoperative hyperthermia (HT) plus radiation therapy (RT), ... Full text Link to item Cite

Radiotherapy of soft tissue sarcomas in dogs.

Journal Article J Am Vet Med Assoc · January 1, 1989 Megavoltage radiotherapy was administered to 42 dogs with soft tissue sarcoma. Acceptable local control of these aggressive tumors was achieved after one year of treatment. Control rates of 48 and 67% were obtained at doses of 45 and 50 gray (Gy), respecti ... Link to item Cite

Whole body hyperthermia in dogs using a radiant heating device: effect of surface cooling on temperature uniformity.

Journal Article Int J Hyperthermia · 1989 Rectal and subcutaneous temperatures were measured during a total of 10 whole body hyperthermia treatments conducted in six dogs. During five of the treatments skin cooling, by means of initiating air flow through the radiant heating device, was necessary ... Full text Link to item Cite

Characterization of tumour temperature distributions in hyperthermia based on assumed mathematical forms.

Journal Article Int J Hyperthermia · 1989 Assessing the efficacy of hyperthermia treatments involves three distinct problems: (1) adequately sampling the spatial temperature distribution in a region; (2) defining (a set of) 'descriptors', numerical values which could be used in comparing distinct ... Full text Link to item Cite

Stability of temperatures during hyperthermia treatments.

Journal Article Int J Hyperthermia · 1989 Attempts to develop a dosimetry for hyperthermia treatments have been limited by problems such as the inability of hyperthermia delivery systems to produce desired temperature distributions and the complexity of modelling complete temperature distributions ... Full text Link to item Cite

A REVIEW OF TREATMENT PLANNING AND DOSE CALCULATION IN VETERINARY RADIATION ONCOLOGY

Journal Article Veterinary Radiology · January 1, 1989 Because radiation cell killing follows Poisson statistics, radiation dose response curves for tumors and normal tissue response are sigmoidal in shape. This shape implies that small errors in delivery of radiation dose can result in large changes in the pr ... Full text Cite

Unexpected toxicity associated with use of body surface area for dosing melphalan in the dog.

Journal Article Cancer Res · January 15, 1988 A multiinstitutional Phase I study using i.v. melphalan was conducted in dogs with spontaneously occurring neoplasia. Melphalan was administered at 7.5, 10, 11.25, 12.5, and 20 mg/m2 of body surface area. Disproportionately greater toxicity was observed in ... Link to item Cite

Response of canine oral carcinomas to heat and radiation.

Journal Article Int J Radiat Oncol Biol Phys · December 1987 Thermal enhancement of radiation response improved the probability for local tumor control without increasing the risk for late complications in this study of relatively advanced stage tumors. Thirty-eight dogs with naturally occurring oral carcinomas were ... Full text Link to item Cite

Temporal effects of 5.0 Gy radiation in healing subcutaneous microvasculature of a dorsal flap window chamber.

Journal Article Radiat Res · December 1987 The temporal effects of 5.0 Gy of radiation on healing subcutaneous microvasculature were studied using a window chamber in the dorsal flap of the Fischer-344 rat. Microvascular function was assessed by morphometric and dynamic flow measurements which were ... Link to item Cite

MODELING OF SAR VALUES IN TISSUE DUE TO SLAB LOADED WAVEGUIDE APPLICATORS.

Journal Article IEEE/Engineering in Medicine and Biology Society Annual Conference · December 1, 1987 The equivalence principle and the Galerkin finite-element method have been used for modeling the incident and scattered electric fields within tissue for hyperthermia. The goal is to approximate the specific absorption rate (SAR) distribution due to slab-l ... Cite

WHOLE-BODY HYPERTHERMIA AND CHEMOTHERAPY FOR CANINE LYMPHOMAS

Journal Article INTERNATIONAL JOURNAL OF HYPERTHERMIA · November 1, 1987 Link to item Cite

THERMORADIOTHERAPY OF CANINE TUMORS

Journal Article INTERNATIONAL JOURNAL OF HYPERTHERMIA · November 1, 1987 Link to item Cite

Pharmacokinetics and toxicity of intraperitoneal cisplatin combined with regional hyperthermia.

Journal Article J Clin Oncol · October 1987 Hyperthermia (HT) potentiates in vitro cytotoxicity of cisplatin, providing a rationale for HT enhancement of cisplatin effect in vivo. In this study, regional abdominal HT was combined with intraperitoneal (IP) cisplatin in canines to characterize tempera ... Full text Link to item Cite

Automated temperature scanning for hyperthermia treatment monitoring.

Journal Article Int J Radiat Oncol Biol Phys · September 1987 Ideal descriptors of hyperthermia treatments will most likely depend on complete target temperature distributions. Although these distributions can be modeled numerically, the accuracy of models is limited by the sparseness of temperatures measured in vivo ... Full text Link to item Cite

Whole-body hyperthermia. Rationale and potential use for cancer treatment.

Journal Article J Vet Intern Med · 1987 Whole-body hyperthermia is the controlled elevation of systemic temperature for therapeutic purposes. Historically, this treatment has been used for symptomatic control of many diseases. Recently, the potential therapeutic benefit of whole-body hyperthermi ... Full text Link to item Cite

Cardiovascular and metabolic response of tumour-bearing dogs to whole body hyperthermia.

Journal Article Int J Hyperthermia · 1987 Whole body hyperthermia was induced in older, tumour-bearing dogs using a radiant heat device. Dogs were anaesthetized (thiopental), paralysed (atracurium), and mechanically ventilated (100 per cent O2) during the heating procedure. Heart rate, systolic/di ... Full text Link to item Cite

Clinical application of thermal isoeffect dose.

Journal Article Int J Hyperthermia · 1987 Clinically, there is strong rationale for developing a method which will provide a scientific basis for comparing the efficacy of one hyperthermia treatment with another. In order to accomplish this goal, methods must first be developed which will allow th ... Full text Link to item Cite

Whole body hyperthermia and heat-sensitizing drugs: a pilot study in canine lymphoproliferative disease.

Journal Article Int J Hyperthermia · 1987 Thirteen dogs were entered into a pilot study to assess the toxicities associated with polyamine biosynthetic enzyme inhibitors as heat sensitizing drugs and whole body hyperthermia either alone or in combination. Disease-free and tumour-bearing animals we ... Full text Link to item Cite

Temperature measurements in normal and tumor tissue of dogs undergoing whole body hyperthermia.

Journal Article Cancer Res · December 1986 Temperature was measured in the left ventricle, aorta, liver, brain, lung, bone marrow, kidney, and spontaneous solid tumors in dogs undergoing whole body hyperthermia in a radiant heat device. Rectal temperature was found to be a satisfactory indicator of ... Link to item Cite

EFFECTS OF HEATING RATE ON NORMAL AND TUMOR MICROCIRCULATORY FUNCTION.

Journal Article American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD · December 1, 1986 Single vessel responses to hyperthermia were studied in tumor and healing subcutaneous tissues using a transparent access window chamber. Arterioles and venules, with diameters ranging from 15 to 150 mu were studied in both tissues. Rates of heating less t ... Cite

USE OF LIMITED TEMPERATURE OBSERVATIONS TO PREDICT COMPLETE TEMPERATURE FIELDS.

Journal Article IEEE/Engineering in Medicine and Biology Society Annual Conference · December 1, 1986 State and parameter estimation techniques to improve the accuracy of thermal models used to support clinical evaluation of hyperthermia treatments are considered. An implementation using a constrained optimization algorithm combined with a two-dimensional ... Cite

Influence of WR 2721 on radiation response of canine soft tissue sarcomas.

Journal Article Int J Radiat Oncol Biol Phys · November 1986 Seventy-three dogs with soft tissue sarcomas were randomized to 2 dose response assays to receive irradiation alone or with the radioprotector WR-2721. Nausea and vomiting were the major side effects of WR-2721 administration although one death occurred be ... Full text Link to item Cite

Determination of continuous atracurium infusion rate in dogs undergoing whole-body hyperthermia.

Journal Article Cancer Res · November 1986 Infusion rates for atracurium were calculated from multiple bolus injection data for normothermic (38 degrees C; n = 4) and hyperthermic (42 degrees C; n = 14) dogs anesthetized with thiopental and oxymorphone while undergoing whole-body hyperthermia treat ... Link to item Cite

Effect of hyperthermia on cisplatin pharmacokinetics in normal dogs.

Journal Article Int J Hyperthermia · 1986 In vitro and in vivo cisplatin pharmacokinetic studies were conducted at 37 degrees C and 42-43 degrees C in dogs. Cisplatin at 1, 2, 3, 4 and 5 micrograms/ml was incubated with canine serum at 37 degrees and 43 degrees C. Aliquots were processed immediate ... Full text Link to item Cite

Estimation of therapeutic gain in clinical trials involving hyperthermia and radiotherapy.

Journal Article Int J Hyperthermia · 1986 It is clear from discussions in this paper that phase III testing of hyperthermia in human patients must proceed in a cautious and stepwise fashion. Because of the risks of increasing late effects, either due to direct thermal damage or thermo-radiosensiti ... Full text Link to item Cite

Temperature Measurements in Normal and Tumor Tissue of Dogs Undergoing Whole Body Hyperthermia

Journal Article Cancer Research · January 1, 1986 Temperature was measured in the left ventricle, aorta, liver, brain, lung, bone marrow, kidney, and spontaneous solid tumors in dogs undergoing whole body hyperthermia in a radiant heat device. Rectal temperature was found to be a satisfactory indicator of ... Cite

BIOLOGICAL RATIONALE AND CLINICAL OVERVIEW OF HYPERTHERMIA.

Journal Article Advances in Bioengineering · December 1, 1985 This paper provides a brief review of the biologic rationale for the use of hyperthermia in cancer treatment. This is followed by a discussion of the currently available literature on the clinical applications and problems of the technology, as it exists t ... Cite

CONSIDERATIONS IN THE CORRELATION BETWEEN THERMAL DOSE AND TUMOR AND NORMAL TISSUE RESPONSE.

Journal Article IEEE/Engineering in Medicine and Biology Society Annual Conference · December 1, 1985 In a randomized study of 236 pet animals, strong correlations between measured temperature minima and maxima and tumor and normal tissue effects were observed. These results reflect the importance of temperature gradient documentation. The author focuses o ... Cite

TEMPERATURE GRADIENTS: PROGNOSTIC AND DOSIMETRIC IMPLICATIONS.

Journal Article IEEE/Engineering in Medicine and Biology Society Annual Conference · December 1, 1985 The authors review the evidence relating minimum measured intratumoral temperature and percentage of measured sites exceeding 42. 5 degree C (ETV) to response of tumors treated with radiation and hyperthermia. Sources of intertreatment and intratreatment v ... Cite

Use of radiation and/or hyperthermia for treatment of mast cell tumors and lymphosarcoma in dogs.

Journal Article Vet Clin North Am Small Anim Pract · July 1985 Radiation alone can be used to treat mast cell tumors that are not likely to metastasize (that is, differentiated or localized lymphorecticular tumors). In patients with mast cell tumors that are likely to metastasize (that is, undifferentiated, metastatic ... Full text Link to item Cite

Local control and distant metastases in primary canine malignant melanomas treated with hyperthermia and/or radiotherapy.

Journal Article Int J Hyperthermia · 1985 Forty-three dogs with primary malignant melanoma were randomized to receive radiotherapy alone (XRT) or hyperthermia plus radiotherapy (delta + XRT). Tumour responses were analysed in terms of complete response rates, rate of one year disease free survival ... Full text Link to item Cite

TEMPERATURE-GRADIENTS - PROGNOSTIC AND DOSIMETRIC IMPLICATIONS

Journal Article IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING · January 1, 1985 Link to item Cite

COMPUTER-SIMULATION OF CANCER THERMOTHERAPY

Journal Article MEDICAL PHYSICS · January 1, 1985 Link to item Cite

CONSIDERATIONS IN THE CORRELATION BETWEEN THERMAL DOSE AND TUMOR OR NORMAL TISSUE-RESPONSE

Journal Article IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING · January 1, 1985 Link to item Cite

The utility of thermal dose as a predictor of tumor and normal tissue responses to combined radiation and hyperthermia.

Journal Article Cancer Res · October 1984 A total of 236 dogs and cats with a variety of cancers were randomized to receive radiation (XRT) or heat plus XRT. In those tumors which were heated, thermal gradients developed which varied in temperature minima and maxima. The influence of the thermal g ... Link to item Cite

Regional hyperthermia by magnetic induction in a beagle dog model: analysis of thermal dosimetry.

Journal Article Radiat Res · June 1984 We have investigated magnetic induction heating techniques for achieving normal tissue hyperthermia in a beagle dog model to clarify the physics and physiology of "regional heating," to develop an animal model of regional heating in humans, and to develop ... Link to item Cite

Importance of minimum tumor temperature in determining early and long-term responses of spontaneous canine and feline tumors to heat and radiation.

Journal Article Cancer Res · January 1984 A total of 130 dogs and cats with squamous cell carcinomas, melanomas, fibrosarcomas, mammary adenocarcinomas, or mast cell sarcomas were randomized to receive radiation (XRT) or heat plus XRT. Time-temperature data for each monitored tumor location were c ... Link to item Cite

OBSERVATIONS ON THE USE OF FERROMAGNETIC IMPLANTS FOR INDUCTING HYPERTHERMIA.

Journal Article IEEE Transactions on Biomedical Engineering · 1984 The authors discuss the physical parameters which characterize this method and give illustrations from initial clinical investigations in animals. The physical parameters studied include magnetic field strength, frequency, load size, field uniformity, coil ... Cite

The utility of thermal dose as a predictor of tumor and normal tissue responses to combined radiation and hyperthermia

Journal Article Cancer Research · January 1, 1984 A total of 236 dogs and cats with a variety of cancers were randomized to receive radiation (XRT) or heat plus XRT. In those tumors which were heated, thermal gradients developed which varied in temperature minima and maxima. The influence of the thermal g ... Cite

The effect of rate of heating or cooling prior to heating on tumor and normal tissue microcirculatory blood flow.

Journal Article Biorheology · 1984 Single vessel responses to hyperthermia were studied in tumor and normal tissues using a transparent access window chamber. Rates of heating less than or equal to .68 degrees C/minute preserved relatively better vascular function in normal than tumor tissu ... Full text Link to item Cite

Correlation between initial and long-term responses of spontaneous pet animal tumors to heat and radiation or radiation alone.

Journal Article Cancer Res · December 1983 Most early-phase testing of new therapeutic modalities involves analysis of initial tumor response as opposed to estimation of long-term response. In this study, the validity of initial response rates to predict long-term responses was examined for tumors ... Link to item Cite

Correlation between Initial and Long-Term Responses of Spontaneous Pet Animal Tumors to Heat and Radiation or Radiation Alone

Journal Article Cancer Research · December 1, 1983 Most early-phase testing of new therapeutic modalities involves analysis of initial tumor response as opposed to estimation of long-term response. In this study, the validity of initial response rates to predict long-term responses was examined for tumors ... Cite

Preliminary results of a phase III trial of spontaneous animal tumors to heat and/or radiation: early normal tissue response and tumor volume influence on initial response.

Journal Article Int J Radiat Oncol Biol Phys · November 1982 A Phase III randomized trial was initiated to test the relative efficacies of heat alone, radiation alone and heat plus radiation using spontaneous malignancies in pet animals. Heat alone was inferior to the other two treatment arms as demonstrated by a si ... Full text Link to item Cite

A uniform thermal field in a hyperthermia chamber for microvascular studies

Journal Article International Journal of Heat and Mass Transfer · January 1, 1982 Hyperthermia has been the subject of much research recently as a cancer treatment. Its greatest potential lies in its combination with radiotherapy and/or chemotherapy. Elevated temperatures have been shown to alter both tumor and normal tissue microcircul ... Full text Cite

SPEED OF SOUND AS A THERMAL IMAGE CT SCAN PARAMETER.

Journal Article Acoustical Imaging: Proceedings of the International Symposium · January 1, 1982 Full text Cite

THE SPEED OF SOUND AS A FUNCTION OF TEMPERATURE IN MAMMALIAN TISSUE

Conference IEEE TRANSACTIONS ON SONICS AND ULTRASONICS · January 1, 1981 Link to item Cite

Will hyperthermia conquer the elusive hypoxic cell? Implications of heat effects on tumor and normal-tissue microcirculation.

Journal Article Radiology · December 1980 In tumor radiobiology, the hypoxic cell has become especially important because of recent evidence of acute hypoxic regions within experimental tumors. The impact of hyperthermia on the development of acute hypoxia is discussed. Two experiments for studyin ... Full text Link to item Cite

SOVIET BOOK PUBLISHING POLICY - WALKER,G

Journal Article SOVIET STUDIES · January 1, 1979 Link to item Cite

Electrophoretic evaluation of sera from dogs with cancer.

Journal Article Am J Vet Res · September 1978 A quantitative electrophoretic method was developed for evaluating sera from dogs with naturally occurring malignant tumors. Electrophoretic migration ratios (EMR) were devised to standardize characteristic protein components and to analyze alterations in ... Link to item Cite

DISSENT IN USSR - POLITICS, IDEOLOGY, AND PEOPLE - TOKES,RL

Journal Article SOVIET STUDIES · January 1, 1978 Link to item Cite

DETENTE AND DEMOCRATIC MOVEMENT IN USSR - BARGHOORN,FC

Journal Article SOVIET STUDIES · January 1, 1978 Link to item Cite

Idiopathic monoclonal (IgA) gammopathy in a dog.

Journal Article J Am Vet Med Assoc · June 1, 1977 Idiopathic monoclonal (IgA) gammopathy in a dog was differentiated from multiple myeloma, based on the lack of Bence Jones proteinuria, no osteolysis, and no plasma cell infiltration into bone marrow, as well as on the stability of the gammopathy for over ... Link to item Cite

LITSA - ZAMYATIN,E

Journal Article SOVIET STUDIES · January 1, 1970 Link to item Cite

RUSSIAN WRITERS AND SOCIETY, 1825-1904 - HINGLEY,R

Journal Article SOVIET STUDIES · January 1, 1968 Link to item Cite

Manipulation of intra- and extracellular pH in spontaneous canine tumours by use of hyperglycaemia [hyperthermia efficacy improvement]

Journal Article Int. J. Hyperth. (UK) The authors evaluated the use of hyperglycaemia to reduce tumour pH in dogs with spontaneous tumours. Dogs were randomized to two groups: control and glucose. Intravenous administration of 20% glucose was used to induce and maintain hyperglycaemia. Extra a ... Cite