Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations.
Publication
, Journal Article
Kasper, AC; Moon, EJ; Hu, X; Park, Y; Wooten, CM; Kim, H; Yang, W; Dewhirst, MW; Hong, J
Published in: Bioorg Med Chem Lett
July 15, 2009
We have shown that manassantin A downregulated the HIF-1alpha expression and inhibited the secretion of VEGF. We have also demonstrated that the 2,3-cis-3,4-trans-4,5-cis-configuration of the tetrahydrofuran is critical to the HIF-1 inhibition of manassantin A.
Duke Scholars
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Published In
Bioorg Med Chem Lett
DOI
EISSN
1464-3405
Publication Date
July 15, 2009
Volume
19
Issue
14
Start / End Page
3783 / 3786
Location
England
Related Subject Headings
- Vascular Endothelial Growth Factor A
- Mice
- Medicinal & Biomolecular Chemistry
- Lignans
- Hypoxia-Inducible Factor 1
- Furans
- Cell Line
- Animals
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry
Citation
APA
Chicago
ICMJE
MLA
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Kasper, A. C., Moon, E. J., Hu, X., Park, Y., Wooten, C. M., Kim, H., … Hong, J. (2009). Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations. Bioorg Med Chem Lett, 19(14), 3783–3786. https://doi.org/10.1016/j.bmcl.2009.04.071
Kasper, Amanda C., Eui Jung Moon, Xiangqian Hu, Yongho Park, Ceshea M. Wooten, Hyoungsu Kim, Weitao Yang, Mark W. Dewhirst, and Jiyong Hong. “Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations.” Bioorg Med Chem Lett 19, no. 14 (July 15, 2009): 3783–86. https://doi.org/10.1016/j.bmcl.2009.04.071.
Kasper AC, Moon EJ, Hu X, Park Y, Wooten CM, Kim H, et al. Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations. Bioorg Med Chem Lett. 2009 Jul 15;19(14):3783–6.
Kasper, Amanda C., et al. “Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations.” Bioorg Med Chem Lett, vol. 19, no. 14, July 2009, pp. 3783–86. Pubmed, doi:10.1016/j.bmcl.2009.04.071.
Kasper AC, Moon EJ, Hu X, Park Y, Wooten CM, Kim H, Yang W, Dewhirst MW, Hong J. Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations. Bioorg Med Chem Lett. 2009 Jul 15;19(14):3783–3786.
Published In
Bioorg Med Chem Lett
DOI
EISSN
1464-3405
Publication Date
July 15, 2009
Volume
19
Issue
14
Start / End Page
3783 / 3786
Location
England
Related Subject Headings
- Vascular Endothelial Growth Factor A
- Mice
- Medicinal & Biomolecular Chemistry
- Lignans
- Hypoxia-Inducible Factor 1
- Furans
- Cell Line
- Animals
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry