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Interstitial hydraulic conductivity in a fibrosarcoma.

Publication ,  Journal Article
Zhang, XY; Luck, J; Dewhirst, MW; Yuan, F
Published in: Am J Physiol Heart Circ Physiol
December 2000

Convective transport of therapeutic agents in solid tumors can be improved through intratumoral infusion. To optimize the convection, we investigated the dependence of the hydraulic conductivity on tissue deformation induced by interstitial fluid pressure gradient during the infusion. Two experimental systems were used in the investigation: 1) one-dimensional perfusion through tumor slices and 2) intratumoral infusion using a needle. With these systems, we found that the apparent hydraulic conductivity (K(app)) could be altered by several orders of magnitude in fibrosarcomas through changes in perfusion conditions. When the perfusion pressure was less than a threshold level, fluid flow in tissues could not be detected. When the perfusion pressure was increased above the threshold level, K(app) depended on perfusion system and pressure. The maximum variation in K(app) in fibrosarcomas reached 80,260-fold in our experiments. The large variation in K(app) could be explained by perfusion pressure-induced tissue deformation. These experimental data suggest that the hydraulic conductivity is very sensitive to tissue deformation and imply that it is possible to improve intratumoral infusion of therapeutic agents through optimization of infusion conditions.

Duke Scholars

Published In

Am J Physiol Heart Circ Physiol

DOI

ISSN

0363-6135

Publication Date

December 2000

Volume

279

Issue

6

Start / End Page

H2726 / H2734

Location

United States

Related Subject Headings

  • Soft Tissue Neoplasms
  • Rats, Inbred F344
  • Rats
  • Perfusion
  • Neoplasm Transplantation
  • Models, Biological
  • Hydrostatic Pressure
  • Fibrosarcoma
  • Female
  • Extracellular Space
 

Citation

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Zhang, X. Y., Luck, J., Dewhirst, M. W., & Yuan, F. (2000). Interstitial hydraulic conductivity in a fibrosarcoma. Am J Physiol Heart Circ Physiol, 279(6), H2726–H2734. https://doi.org/10.1152/ajpheart.2000.279.6.H2726
Zhang, X. Y., J. Luck, M. W. Dewhirst, and F. Yuan. “Interstitial hydraulic conductivity in a fibrosarcoma.Am J Physiol Heart Circ Physiol 279, no. 6 (December 2000): H2726–34. https://doi.org/10.1152/ajpheart.2000.279.6.H2726.
Zhang XY, Luck J, Dewhirst MW, Yuan F. Interstitial hydraulic conductivity in a fibrosarcoma. Am J Physiol Heart Circ Physiol. 2000 Dec;279(6):H2726–34.
Zhang, X. Y., et al. “Interstitial hydraulic conductivity in a fibrosarcoma.Am J Physiol Heart Circ Physiol, vol. 279, no. 6, Dec. 2000, pp. H2726–34. Pubmed, doi:10.1152/ajpheart.2000.279.6.H2726.
Zhang XY, Luck J, Dewhirst MW, Yuan F. Interstitial hydraulic conductivity in a fibrosarcoma. Am J Physiol Heart Circ Physiol. 2000 Dec;279(6):H2726–H2734.

Published In

Am J Physiol Heart Circ Physiol

DOI

ISSN

0363-6135

Publication Date

December 2000

Volume

279

Issue

6

Start / End Page

H2726 / H2734

Location

United States

Related Subject Headings

  • Soft Tissue Neoplasms
  • Rats, Inbred F344
  • Rats
  • Perfusion
  • Neoplasm Transplantation
  • Models, Biological
  • Hydrostatic Pressure
  • Fibrosarcoma
  • Female
  • Extracellular Space