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A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury.

Publication ,  Journal Article
Vujaskovic, Z; Batinic-Haberle, I; Rabbani, ZN; Feng, Q-F; Kang, SK; Spasojevic, I; Samulski, TV; Fridovich, I; Dewhirst, MW; Anscher, MS
Published in: Free Radic Biol Med
September 15, 2002

Radiation therapy (RT) is an important therapeutic modality in the treatment of thoracic tumors. The maximum doses to these tumors are often limited by the radiation tolerance of lung tissues. Lung injury from ionizing radiation is believed to be a consequence of oxidative stress and a cascade of cytokine activity. Superoxide dismutase (SOD) is a key enzyme in cellular defenses against oxidative damage. The objective of this study was to determine whether the SOD mimetic AEOL 10113 [manganese (III) mesotetrakis (N-ethylpyridinium-2-yl) porphyrin (MnTE-2-PyP(5+))] increases the tolerance of lung to ionizing radiation. AEOL 10113 was able to significantly reduce the severity of RT-induced lung injury. This was strongly supported with histopathology results and measurements of collagen deposition (hydroxyproline content). There was a significant reduction in the plasma level of the profibrogenic cytokine transforming growth factor-beta (TGF-beta) in the group of rats receiving RT + AEOL 10113. In conclusion, the novel SOD mimetic, AEOL 10113, demonstrates a significant protective effect from radiation-induced lung injury.

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Published In

Free Radic Biol Med

DOI

ISSN

0891-5849

Publication Date

September 15, 2002

Volume

33

Issue

6

Start / End Page

857 / 863

Location

United States

Related Subject Headings

  • Transforming Growth Factor beta
  • Time Factors
  • Thoracic Neoplasms
  • Superoxide Dismutase
  • Respiration
  • Rats, Inbred F344
  • Rats
  • Radiation Injuries
  • Metalloporphyrins
  • Lung Injury
 

Citation

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Vujaskovic, Z., Batinic-Haberle, I., Rabbani, Z. N., Feng, Q.-F., Kang, S. K., Spasojevic, I., … Anscher, M. S. (2002). A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury. Free Radic Biol Med, 33(6), 857–863. https://doi.org/10.1016/s0891-5849(02)00980-2
Vujaskovic, Zeljko, Ines Batinic-Haberle, Zahid N. Rabbani, Qin-fu Feng, Song K. Kang, Ivan Spasojevic, Thaddeus V. Samulski, Irwin Fridovich, Mark W. Dewhirst, and Mitchell S. Anscher. “A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury.Free Radic Biol Med 33, no. 6 (September 15, 2002): 857–63. https://doi.org/10.1016/s0891-5849(02)00980-2.
Vujaskovic Z, Batinic-Haberle I, Rabbani ZN, Feng Q-F, Kang SK, Spasojevic I, et al. A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury. Free Radic Biol Med. 2002 Sep 15;33(6):857–63.
Vujaskovic, Zeljko, et al. “A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury.Free Radic Biol Med, vol. 33, no. 6, Sept. 2002, pp. 857–63. Pubmed, doi:10.1016/s0891-5849(02)00980-2.
Vujaskovic Z, Batinic-Haberle I, Rabbani ZN, Feng Q-F, Kang SK, Spasojevic I, Samulski TV, Fridovich I, Dewhirst MW, Anscher MS. A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury. Free Radic Biol Med. 2002 Sep 15;33(6):857–863.
Journal cover image

Published In

Free Radic Biol Med

DOI

ISSN

0891-5849

Publication Date

September 15, 2002

Volume

33

Issue

6

Start / End Page

857 / 863

Location

United States

Related Subject Headings

  • Transforming Growth Factor beta
  • Time Factors
  • Thoracic Neoplasms
  • Superoxide Dismutase
  • Respiration
  • Rats, Inbred F344
  • Rats
  • Radiation Injuries
  • Metalloporphyrins
  • Lung Injury