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Actively targeting solid tumours with thermoresponsive drug delivery systems that respond to mild hyperthermia.

Publication ,  Journal Article
McDaniel, JR; Dewhirst, MW; Chilkoti, A
Published in: Int J Hyperthermia
September 2013

A diverse range of drug delivery vehicles have been developed to specifically target chemotherapeutics to solid tumours while avoiding systemic dose-limiting toxicity. Many of these active targeting strategies display limited efficacy because they rely on subtle differences in expression patterns between pathogenic tissue and healthy tissue. In contrast, drug delivery systems that exploit thermoresponsive behaviour allow a clinician to spatially and temporally control the accumulation and/or release of the toxic agents within tumour tissue by simply applying mild hyperthermia (defined as 39-43 °C) to the desired site. Although thermally sensitive materials comprise a significant portion of the literature on novel drug delivery systems, only a few systems have been methodically tuned to respond within this narrowly defined physiological temperature range in an in vivo environment. This review discusses the materials and strategies developed to control the primary tumour through the combined application of hyperthermia and chemotherapy.

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Published In

Int J Hyperthermia

DOI

EISSN

1464-5157

Publication Date

September 2013

Volume

29

Issue

6

Start / End Page

501 / 510

Location

England

Related Subject Headings

  • Pharmaceutical Preparations
  • Peptides
  • Oncology & Carcinogenesis
  • Neoplasms
  • Micelles
  • Hyperthermia, Induced
  • Hydrogels
  • Humans
  • Drug Delivery Systems
  • Animals
 

Citation

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Chicago
ICMJE
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McDaniel, J. R., Dewhirst, M. W., & Chilkoti, A. (2013). Actively targeting solid tumours with thermoresponsive drug delivery systems that respond to mild hyperthermia. Int J Hyperthermia, 29(6), 501–510. https://doi.org/10.3109/02656736.2013.819999
McDaniel, Jonathan R., Mark W. Dewhirst, and Ashutosh Chilkoti. “Actively targeting solid tumours with thermoresponsive drug delivery systems that respond to mild hyperthermia.Int J Hyperthermia 29, no. 6 (September 2013): 501–10. https://doi.org/10.3109/02656736.2013.819999.
McDaniel JR, Dewhirst MW, Chilkoti A. Actively targeting solid tumours with thermoresponsive drug delivery systems that respond to mild hyperthermia. Int J Hyperthermia. 2013 Sep;29(6):501–10.
McDaniel, Jonathan R., et al. “Actively targeting solid tumours with thermoresponsive drug delivery systems that respond to mild hyperthermia.Int J Hyperthermia, vol. 29, no. 6, Sept. 2013, pp. 501–10. Pubmed, doi:10.3109/02656736.2013.819999.
McDaniel JR, Dewhirst MW, Chilkoti A. Actively targeting solid tumours with thermoresponsive drug delivery systems that respond to mild hyperthermia. Int J Hyperthermia. 2013 Sep;29(6):501–510.

Published In

Int J Hyperthermia

DOI

EISSN

1464-5157

Publication Date

September 2013

Volume

29

Issue

6

Start / End Page

501 / 510

Location

England

Related Subject Headings

  • Pharmaceutical Preparations
  • Peptides
  • Oncology & Carcinogenesis
  • Neoplasms
  • Micelles
  • Hyperthermia, Induced
  • Hydrogels
  • Humans
  • Drug Delivery Systems
  • Animals