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Doxorubicin-conjugated chimeric polypeptide nanoparticles that respond to mild hyperthermia.

Publication ,  Journal Article
McDaniel, JR; Macewan, SR; Dewhirst, M; Chilkoti, A
Published in: J Control Release
May 10, 2012

This paper reports the design, physicochemical characterization and in vitro cytotoxicity of a thermally responsive chimeric polypeptide (CP), derived from an elastin-like polypeptide (ELP). The CP self-assembles into ~40 nm diameter nanoparticles upon conjugation of multiple copies of doxorubicin (Dox), and displays a nanoparticle-to-aggregate phase transition between 39 and 42 °C in media, a temperature range suitable for mild hyperthermia of solid tumors. The CP-Dox nanoparticle is stable upon dilution to low micromolar concentrations, and is cytotoxic at both 37 and 42 °C. A thermally responsive nanoparticle formulation of Dox may prove to be broadly useful in hyperthermia targeted chemotherapy of a variety of solid tumors.

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Published In

J Control Release

DOI

EISSN

1873-4995

Publication Date

May 10, 2012

Volume

159

Issue

3

Start / End Page

362 / 367

Location

Netherlands

Related Subject Headings

  • Transition Temperature
  • Surface Properties
  • Phase Transition
  • Pharmacology & Pharmacy
  • Peptide Library
  • Oligopeptides
  • Nanoparticles
  • Microscopy, Fluorescence
  • Mice
  • Hot Temperature
 

Citation

APA
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ICMJE
MLA
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McDaniel, J. R., Macewan, S. R., Dewhirst, M., & Chilkoti, A. (2012). Doxorubicin-conjugated chimeric polypeptide nanoparticles that respond to mild hyperthermia. J Control Release, 159(3), 362–367. https://doi.org/10.1016/j.jconrel.2012.02.030
McDaniel, Jonathan R., Sarah R. Macewan, Mark Dewhirst, and Ashutosh Chilkoti. “Doxorubicin-conjugated chimeric polypeptide nanoparticles that respond to mild hyperthermia.J Control Release 159, no. 3 (May 10, 2012): 362–67. https://doi.org/10.1016/j.jconrel.2012.02.030.
McDaniel JR, Macewan SR, Dewhirst M, Chilkoti A. Doxorubicin-conjugated chimeric polypeptide nanoparticles that respond to mild hyperthermia. J Control Release. 2012 May 10;159(3):362–7.
McDaniel, Jonathan R., et al. “Doxorubicin-conjugated chimeric polypeptide nanoparticles that respond to mild hyperthermia.J Control Release, vol. 159, no. 3, May 2012, pp. 362–67. Pubmed, doi:10.1016/j.jconrel.2012.02.030.
McDaniel JR, Macewan SR, Dewhirst M, Chilkoti A. Doxorubicin-conjugated chimeric polypeptide nanoparticles that respond to mild hyperthermia. J Control Release. 2012 May 10;159(3):362–367.
Journal cover image

Published In

J Control Release

DOI

EISSN

1873-4995

Publication Date

May 10, 2012

Volume

159

Issue

3

Start / End Page

362 / 367

Location

Netherlands

Related Subject Headings

  • Transition Temperature
  • Surface Properties
  • Phase Transition
  • Pharmacology & Pharmacy
  • Peptide Library
  • Oligopeptides
  • Nanoparticles
  • Microscopy, Fluorescence
  • Mice
  • Hot Temperature