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Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor.

Publication ,  Journal Article
Lanzen, J; Braun, RD; Klitzman, B; Brizel, D; Secomb, TW; Dewhirst, MW
Published in: Cancer Res
February 15, 2006

To test the hypothesis that temporal variations in microvessel red cell flux cause unstable oxygen levels in tumor interstitium, extravascular oxygenation of R3230Ac mammary tumors grown in skin-fold window chambers was measured using recessed tip polarographic microelectrodes. Red cell fluxes in microvessels surrounding pO2 measurement locations were measured using fluorescently labeled red cells. Temporal pO2 instability was observed in all experiments. Median pO2 was inversely related to radial distance from microvessels. Transient fluctuations above and below 10 mm Hg were consistently seen, except in one experiment near the oxygen diffusion distance limit (140 microm) where pO2 fluctuations were <2 mm Hg and median pO2 was <5 mm Hg. Vascular stasis was not seen in these experiments. These results show that fluctuations in red cell flux, as opposed to vascular stasis, can cause temporal variations in pO2 that extend from perivascular regions to the maximum oxygen diffusion distance.

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Published In

Cancer Res

DOI

ISSN

0008-5472

Publication Date

February 15, 2006

Volume

66

Issue

4

Start / End Page

2219 / 2223

Location

United States

Related Subject Headings

  • Rats, Inbred F344
  • Rats
  • Partial Pressure
  • Oxygen
  • Oncology & Carcinogenesis
  • Neovascularization, Pathologic
  • Mammary Neoplasms, Experimental
  • Female
  • Cell Hypoxia
  • Animals
 

Citation

APA
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ICMJE
MLA
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Lanzen, J., Braun, R. D., Klitzman, B., Brizel, D., Secomb, T. W., & Dewhirst, M. W. (2006). Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor. Cancer Res, 66(4), 2219–2223. https://doi.org/10.1158/0008-5472.CAN-03-2958
Lanzen, Jennifer, Rod D. Braun, Bruce Klitzman, David Brizel, Timothy W. Secomb, and Mark W. Dewhirst. “Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor.Cancer Res 66, no. 4 (February 15, 2006): 2219–23. https://doi.org/10.1158/0008-5472.CAN-03-2958.
Lanzen J, Braun RD, Klitzman B, Brizel D, Secomb TW, Dewhirst MW. Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor. Cancer Res. 2006 Feb 15;66(4):2219–23.
Lanzen, Jennifer, et al. “Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor.Cancer Res, vol. 66, no. 4, Feb. 2006, pp. 2219–23. Pubmed, doi:10.1158/0008-5472.CAN-03-2958.
Lanzen J, Braun RD, Klitzman B, Brizel D, Secomb TW, Dewhirst MW. Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor. Cancer Res. 2006 Feb 15;66(4):2219–2223.

Published In

Cancer Res

DOI

ISSN

0008-5472

Publication Date

February 15, 2006

Volume

66

Issue

4

Start / End Page

2219 / 2223

Location

United States

Related Subject Headings

  • Rats, Inbred F344
  • Rats
  • Partial Pressure
  • Oxygen
  • Oncology & Carcinogenesis
  • Neovascularization, Pathologic
  • Mammary Neoplasms, Experimental
  • Female
  • Cell Hypoxia
  • Animals