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Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry.

Publication ,  Journal Article
Dreher, MR; Elas, M; Ichikawa, K; Barth, ED; Chilkoti, A; Rosen, GM; Halpern, HJ; Dewhirst, M
Published in: Med Phys
October 2004

Hyperthermia, as an adjuvant with radiation and chemotherapy, has shown promise in the treatment of cancer. The relevant biological effects of a hyperthermia treatment are both time and temperature-dependent, creating a need for accurate thermometry. We present a novel noninvasive thermometry modality that combines a temperature responsive biopolymer, the elastin-like polypeptide (ELP), and nitroxide to produce an ELP-nitroxide conjugate. When examined with electron paramagnetic resonance (EPR) spectroscopy, the ELP-nitroxide conjugate has temperature-dependent spectral line widths whose predictive accuracy is approximately 0.3 degrees C (80 microM). We believe that the temperature-dependent changes observed in the EPR spectrum are due to the combined effect of temperature, viscosity and effective radius on the rotational correlation time of the ELP-nitroxide conjugate.

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Published In

Med Phys

DOI

ISSN

0094-2405

Publication Date

October 2004

Volume

31

Issue

10

Start / End Page

2755 / 2762

Location

United States

Related Subject Headings

  • Thermometers
  • Thermography
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Peptides
  • Nuclear Medicine & Medical Imaging
  • Nitrogen Oxides
  • Materials Testing
  • Hot Temperature
  • Equipment Failure Analysis
 

Citation

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Dreher, M. R., Elas, M., Ichikawa, K., Barth, E. D., Chilkoti, A., Rosen, G. M., … Dewhirst, M. (2004). Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry. Med Phys, 31(10), 2755–2762. https://doi.org/10.1118/1.1782677
Dreher, Matthew R., Martyna Elas, Kazuhiro Ichikawa, Eugene D. Barth, Ashutosh Chilkoti, Gerald M. Rosen, Howard J. Halpern, and Mark Dewhirst. “Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry.Med Phys 31, no. 10 (October 2004): 2755–62. https://doi.org/10.1118/1.1782677.
Dreher MR, Elas M, Ichikawa K, Barth ED, Chilkoti A, Rosen GM, et al. Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry. Med Phys. 2004 Oct;31(10):2755–62.
Dreher, Matthew R., et al. “Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry.Med Phys, vol. 31, no. 10, Oct. 2004, pp. 2755–62. Pubmed, doi:10.1118/1.1782677.
Dreher MR, Elas M, Ichikawa K, Barth ED, Chilkoti A, Rosen GM, Halpern HJ, Dewhirst M. Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry. Med Phys. 2004 Oct;31(10):2755–2762.

Published In

Med Phys

DOI

ISSN

0094-2405

Publication Date

October 2004

Volume

31

Issue

10

Start / End Page

2755 / 2762

Location

United States

Related Subject Headings

  • Thermometers
  • Thermography
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Peptides
  • Nuclear Medicine & Medical Imaging
  • Nitrogen Oxides
  • Materials Testing
  • Hot Temperature
  • Equipment Failure Analysis