Molecular Imaging: Principles and Practice
Imaging Hypoxia
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, Chapter
Yuan, H; Palmer, GM; Dewhirst, MW
January 1, 2021
Hypoxia is a well-established pathophysiologic feature of solid tumors that has demonstrated links to poor prognosis. It is a direct cause of radioresistance and also contributes to chemoresistance. In addition, it is immunosuppressive. Given these pleiotropic effects, there is strong rationale for developing strategies to image hypoxia. This chapter reviews the characteristics of hypoxia that enable it to be imaged. A critical review of the three major methods for imaging hypoxia (Optics, PET/SPECT, and Magnetic Resonance Imaging) is presented; the strengths and weaknesses of each method for preclinical and clinical uses are described.
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Yuan, H., Palmer, G. M., & Dewhirst, M. W. (2021). Imaging Hypoxia. In Molecular Imaging: Principles and Practice (pp. 869–895). https://doi.org/10.1016/B978-0-12-816386-3.00074-0
Yuan, H., G. M. Palmer, and M. W. Dewhirst. “Imaging Hypoxia.” In Molecular Imaging: Principles and Practice, 869–95, 2021. https://doi.org/10.1016/B978-0-12-816386-3.00074-0.
Yuan H, Palmer GM, Dewhirst MW. Imaging Hypoxia. In: Molecular Imaging: Principles and Practice. 2021. p. 869–95.
Yuan, H., et al. “Imaging Hypoxia.” Molecular Imaging: Principles and Practice, 2021, pp. 869–95. Scopus, doi:10.1016/B978-0-12-816386-3.00074-0.
Yuan H, Palmer GM, Dewhirst MW. Imaging Hypoxia. Molecular Imaging: Principles and Practice. 2021. p. 869–895.