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Individual responses to chemotherapy-induced oxidative stress.

Publication ,  Journal Article
Il'yasova, D; Kennedy, K; Spasojevic, I; Wang, F; Tolun, AA; Base, K; Young, SP; Kelly Marcom, P; Marks, J; Millington, DS; Dewhirst, MW
Published in: Breast Cancer Res Treat
January 2011

Differences in redox homeostatic control between cancer patients may underlie predisposition to drug resistance and toxicities. To evaluate interindividual differences in redox response among newly diagnosed breast cancer patients undergoing standard chemotherapy, urine samples were collected before (T0), and at 1 (T1) and 24 h (T24) after chemotherapy administration. Oxidative status was assessed by urinary levels of allantoin and four F2-isoprostanes, quantified by LC-MS/MS. In all subjects, biomarker levels increased at T1 and returned to baseline at T24. Analyzing individual responses, two patterns were revealed: 10 subjects showed uniform increases of biomarker levels at T1 ("increase" pattern) and 8 subjects showed mixed (increase/unchanged/decrease) responses for different biomarkers ("mixed" pattern). The increase-pattern group had lower pre-treatment (T0) levels of the biomarkers and showed a sharp increase at T1 (64-141%) with a subsequent decrease at T24. The mixed-pattern group had higher pre-treatment biomarker levels and showed no change in biomarkers either at T1 or at T24. These findings indicate that there may be at least two distinct redox phenotypes with different homeostatic mechanisms balancing oxidative stress in humans. Recognizing redox phenotypes in human populations may lead to more precise assessment of health risks and benefits associated with individual redox make-up, and may also help to identify cancer patients who are especially susceptible to drug resistance and/or drug toxicity.

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Published In

Breast Cancer Res Treat

DOI

EISSN

1573-7217

Publication Date

January 2011

Volume

125

Issue

2

Start / End Page

583 / 589

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Tandem Mass Spectrometry
  • Reactive Oxygen Species
  • Oxidative Stress
  • Oncology & Carcinogenesis
  • Humans
  • Female
  • Drug Resistance, Neoplasm
  • Doxorubicin
 

Citation

APA
Chicago
ICMJE
MLA
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Il’yasova, D., Kennedy, K., Spasojevic, I., Wang, F., Tolun, A. A., Base, K., … Dewhirst, M. W. (2011). Individual responses to chemotherapy-induced oxidative stress. Breast Cancer Res Treat, 125(2), 583–589. https://doi.org/10.1007/s10549-010-1158-7
Il’yasova, Dora, Kelly Kennedy, Ivan Spasojevic, Frances Wang, Adviye A. Tolun, Karel Base, Sarah P. Young, et al. “Individual responses to chemotherapy-induced oxidative stress.Breast Cancer Res Treat 125, no. 2 (January 2011): 583–89. https://doi.org/10.1007/s10549-010-1158-7.
Il’yasova D, Kennedy K, Spasojevic I, Wang F, Tolun AA, Base K, et al. Individual responses to chemotherapy-induced oxidative stress. Breast Cancer Res Treat. 2011 Jan;125(2):583–9.
Il’yasova, Dora, et al. “Individual responses to chemotherapy-induced oxidative stress.Breast Cancer Res Treat, vol. 125, no. 2, Jan. 2011, pp. 583–89. Pubmed, doi:10.1007/s10549-010-1158-7.
Il’yasova D, Kennedy K, Spasojevic I, Wang F, Tolun AA, Base K, Young SP, Kelly Marcom P, Marks J, Millington DS, Dewhirst MW. Individual responses to chemotherapy-induced oxidative stress. Breast Cancer Res Treat. 2011 Jan;125(2):583–589.
Journal cover image

Published In

Breast Cancer Res Treat

DOI

EISSN

1573-7217

Publication Date

January 2011

Volume

125

Issue

2

Start / End Page

583 / 589

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Tandem Mass Spectrometry
  • Reactive Oxygen Species
  • Oxidative Stress
  • Oncology & Carcinogenesis
  • Humans
  • Female
  • Drug Resistance, Neoplasm
  • Doxorubicin