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A dual-emissive-materials design concept enables tumour hypoxia imaging.

Publication ,  Journal Article
Zhang, G; Palmer, GM; Dewhirst, MW; Fraser, CL
Published in: Nat Mater
September 2009

Luminescent materials are widely used for imaging and sensing owing to their high sensitivity, rapid response and facile detection by many optical technologies. Typically materials must be chemically tailored to achieve intense, photostable fluorescence, oxygen-sensitive phosphorescence or dual emission for ratiometric sensing, often by blending two dyes in a matrix. Dual-emissive materials combining all of these features in one easily tunable molecular platform are desirable, but when fluorescence and phosphorescence originate from the same dye, it can be challenging to vary relative fluorescence/phosphorescence intensities for practical sensing applications. Heavy-atom substitution alone increases phosphorescence by a given, not variable amount. Here, we report a strategy for modulating fluorescence/phosphorescence for a single-component, dual-emissive, iodide-substituted difluoroboron dibenzoylmethane-poly(lactic acid) (BF(2)dbm(I)PLA) solid-state sensor material. This is accomplished through systematic variation of the PLA chain length in controlled solvent-free lactide polymerization combined with heavy-atom substitution. We demonstrate the versatility of this approach by showing that films made from low-molecular-weight BF(2)dbm(I)PLA with weak fluorescence and strong phosphorescence are promising as 'turn on' sensors for aerodynamics applications, and that nanoparticles fabricated from a higher-molecular-weight polymer with balanced fluorescence and phosphorescence intensities serve as ratiometric tumour hypoxia imaging agents.

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Published In

Nat Mater

DOI

EISSN

1476-4660

Publication Date

September 2009

Volume

8

Issue

9

Start / End Page

747 / 751

Location

England

Related Subject Headings

  • Temperature
  • Spectrometry, Fluorescence
  • Polymers
  • Polyesters
  • Neoplasms
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Mice
  • Lactic Acid
  • Hypoxia
 

Citation

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Zhang, G., Palmer, G. M., Dewhirst, M. W., & Fraser, C. L. (2009). A dual-emissive-materials design concept enables tumour hypoxia imaging. Nat Mater, 8(9), 747–751. https://doi.org/10.1038/nmat2509
Zhang, Guoqing, Gregory M. Palmer, Mark W. Dewhirst, and Cassandra L. Fraser. “A dual-emissive-materials design concept enables tumour hypoxia imaging.Nat Mater 8, no. 9 (September 2009): 747–51. https://doi.org/10.1038/nmat2509.
Zhang G, Palmer GM, Dewhirst MW, Fraser CL. A dual-emissive-materials design concept enables tumour hypoxia imaging. Nat Mater. 2009 Sep;8(9):747–51.
Zhang, Guoqing, et al. “A dual-emissive-materials design concept enables tumour hypoxia imaging.Nat Mater, vol. 8, no. 9, Sept. 2009, pp. 747–51. Pubmed, doi:10.1038/nmat2509.
Zhang G, Palmer GM, Dewhirst MW, Fraser CL. A dual-emissive-materials design concept enables tumour hypoxia imaging. Nat Mater. 2009 Sep;8(9):747–751.

Published In

Nat Mater

DOI

EISSN

1476-4660

Publication Date

September 2009

Volume

8

Issue

9

Start / End Page

747 / 751

Location

England

Related Subject Headings

  • Temperature
  • Spectrometry, Fluorescence
  • Polymers
  • Polyesters
  • Neoplasms
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Mice
  • Lactic Acid
  • Hypoxia