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Rationale for and measurement of liposomal drug delivery with hyperthermia using non-invasive imaging techniques.

Publication ,  Journal Article
Tashjian, JA; Dewhirst, MW; Needham, D; Viglianti, BL
Published in: Int J Hyperthermia
February 2008

The purpose of this review is to present an overview of the state-of-the-art imaging modalities used to track drug delivery from liposomal formulations into tumors during or after hyperthermia treatment. Liposomes are a drug delivery system comprised of a phospholipid bilayer surrounding an aqueous core and have been shown to accumulate following hyperthermia therapy. Use of contrast-containing liposomes in conjunction with hyperthermia therapy holds great promise to be able to directly measure drug dose concentrations as well as to non-invasively describe patterns of drug distribution with MR and PET/SPECT imaging modalities. We will review the rationale for using this approach and the potential advantages of having such information available during and after treatment.

Duke Scholars

Published In

Int J Hyperthermia

DOI

ISSN

0265-6736

Publication Date

February 2008

Volume

24

Issue

1

Start / End Page

79 / 90

Location

England

Related Subject Headings

  • Tomography, Emission-Computed, Single-Photon
  • Tissue Distribution
  • Rats
  • Oncology & Carcinogenesis
  • Neoplasms
  • Nanoparticles
  • Magnetic Resonance Imaging
  • Liposomes
  • Hyperthermia, Induced
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Tashjian, J. A., Dewhirst, M. W., Needham, D., & Viglianti, B. L. (2008). Rationale for and measurement of liposomal drug delivery with hyperthermia using non-invasive imaging techniques. Int J Hyperthermia, 24(1), 79–90. https://doi.org/10.1080/02656730701840147
Tashjian, Jessica A., Mark W. Dewhirst, David Needham, and Benjamin L. Viglianti. “Rationale for and measurement of liposomal drug delivery with hyperthermia using non-invasive imaging techniques.Int J Hyperthermia 24, no. 1 (February 2008): 79–90. https://doi.org/10.1080/02656730701840147.
Tashjian JA, Dewhirst MW, Needham D, Viglianti BL. Rationale for and measurement of liposomal drug delivery with hyperthermia using non-invasive imaging techniques. Int J Hyperthermia. 2008 Feb;24(1):79–90.
Tashjian, Jessica A., et al. “Rationale for and measurement of liposomal drug delivery with hyperthermia using non-invasive imaging techniques.Int J Hyperthermia, vol. 24, no. 1, Feb. 2008, pp. 79–90. Pubmed, doi:10.1080/02656730701840147.
Tashjian JA, Dewhirst MW, Needham D, Viglianti BL. Rationale for and measurement of liposomal drug delivery with hyperthermia using non-invasive imaging techniques. Int J Hyperthermia. 2008 Feb;24(1):79–90.
Journal cover image

Published In

Int J Hyperthermia

DOI

ISSN

0265-6736

Publication Date

February 2008

Volume

24

Issue

1

Start / End Page

79 / 90

Location

England

Related Subject Headings

  • Tomography, Emission-Computed, Single-Photon
  • Tissue Distribution
  • Rats
  • Oncology & Carcinogenesis
  • Neoplasms
  • Nanoparticles
  • Magnetic Resonance Imaging
  • Liposomes
  • Hyperthermia, Induced
  • Humans