Rationale for and measurement of liposomal drug delivery with hyperthermia using non-invasive imaging techniques.
The purpose of this review is to present an overview of the state-of-the-art imaging modalities used to track drug delivery from liposomal formulations into tumors during or after hyperthermia treatment. Liposomes are a drug delivery system comprised of a phospholipid bilayer surrounding an aqueous core and have been shown to accumulate following hyperthermia therapy. Use of contrast-containing liposomes in conjunction with hyperthermia therapy holds great promise to be able to directly measure drug dose concentrations as well as to non-invasively describe patterns of drug distribution with MR and PET/SPECT imaging modalities. We will review the rationale for using this approach and the potential advantages of having such information available during and after treatment.
Duke Scholars
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Related Subject Headings
- Tomography, Emission-Computed, Single-Photon
- Tissue Distribution
- Rats
- Oncology & Carcinogenesis
- Neoplasms
- Nanoparticles
- Magnetic Resonance Imaging
- Liposomes
- Hyperthermia, Induced
- Humans
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Tomography, Emission-Computed, Single-Photon
- Tissue Distribution
- Rats
- Oncology & Carcinogenesis
- Neoplasms
- Nanoparticles
- Magnetic Resonance Imaging
- Liposomes
- Hyperthermia, Induced
- Humans