Skip to main content

A method to convert MRI images of temperature change into images of absolute temperature in solid tumours.

Publication ,  Journal Article
Davis, RM; Viglianti, BL; Yarmolenko, P; Park, J-Y; Stauffer, P; Needham, D; Dewhirst, MW
Published in: Int J Hyperthermia
September 2013

PURPOSE: During hyperthermia (HT), the therapeutic response of tumours varies substantially within the target temperature range (39-43 °C). Current thermometry methods are either invasive or measure only temperature change, which limits the ability to study tissue responses to HT. This study combines manganese-containing low temperature sensitive liposomes (Mn-LTSL) with proton resonance frequency shift (PRFS) thermometry to measure absolute temperature in tumours with high spatial and temporal resolution using MRI. METHODS: Liposomes were loaded with 300 mM MnSO(4). The phase transition temperature (T(m)) of Mn-LTSL samples was measured by differential scanning calorimetry (DSC). The release of manganese from Mn-LTSL in saline was characterised with inductively coupled plasma atomic emission spectroscopy. A 2T GE small animal scanner was used to acquire dynamic T1-weighted images and temperature change images of Mn-LTSL in saline phantoms and fibrosarcoma-bearing Fisher-344 rats receiving hyperthermia after Mn-LTSL injection. RESULTS: The T(m) of Mn-LTSL in rat blood was 42.9 ± 0.2 °C (DSC). For Mn-LTSL samples (0.06 mM-0.5 mM Mn(2+) in saline) heated monotonically from 30 °C to 50 °C, a peak in the rate of MRI signal enhancement occurred at 43.1° ± 0.3 °C. The same peak in signal enhancement rate was observed during heating of fibrosarcoma tumours (N = 3) after injection of Mn-LTSL, and the peak was used to convert temperature change images into absolute temperature. Accuracies of calibrated temperature measurements were in the range 0.9-1.8 °C. CONCLUSION: The release of Mn(2+) from Mn-LTSL affects the rate of MR signal enhancement which enables conversion of MRI-based temperature change images to absolute temperature.

Duke Scholars

Published In

Int J Hyperthermia

DOI

EISSN

1464-5157

Publication Date

September 2013

Volume

29

Issue

6

Start / End Page

569 / 581

Location

England

Related Subject Headings

  • Thermography
  • Rats, Inbred F344
  • Rats
  • Oncology & Carcinogenesis
  • Neoplasms
  • Manganese
  • Magnetic Resonance Imaging
  • Liposomes
  • Hyperthermia, Induced
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Davis, R. M., Viglianti, B. L., Yarmolenko, P., Park, J.-Y., Stauffer, P., Needham, D., & Dewhirst, M. W. (2013). A method to convert MRI images of temperature change into images of absolute temperature in solid tumours. Int J Hyperthermia, 29(6), 569–581. https://doi.org/10.3109/02656736.2013.790091
Davis, Ryan M., Benjamin L. Viglianti, Pavel Yarmolenko, Ji-Young Park, Paul Stauffer, David Needham, and Mark W. Dewhirst. “A method to convert MRI images of temperature change into images of absolute temperature in solid tumours.Int J Hyperthermia 29, no. 6 (September 2013): 569–81. https://doi.org/10.3109/02656736.2013.790091.
Davis RM, Viglianti BL, Yarmolenko P, Park J-Y, Stauffer P, Needham D, et al. A method to convert MRI images of temperature change into images of absolute temperature in solid tumours. Int J Hyperthermia. 2013 Sep;29(6):569–81.
Davis, Ryan M., et al. “A method to convert MRI images of temperature change into images of absolute temperature in solid tumours.Int J Hyperthermia, vol. 29, no. 6, Sept. 2013, pp. 569–81. Pubmed, doi:10.3109/02656736.2013.790091.
Davis RM, Viglianti BL, Yarmolenko P, Park J-Y, Stauffer P, Needham D, Dewhirst MW. A method to convert MRI images of temperature change into images of absolute temperature in solid tumours. Int J Hyperthermia. 2013 Sep;29(6):569–581.

Published In

Int J Hyperthermia

DOI

EISSN

1464-5157

Publication Date

September 2013

Volume

29

Issue

6

Start / End Page

569 / 581

Location

England

Related Subject Headings

  • Thermography
  • Rats, Inbred F344
  • Rats
  • Oncology & Carcinogenesis
  • Neoplasms
  • Manganese
  • Magnetic Resonance Imaging
  • Liposomes
  • Hyperthermia, Induced
  • Female