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Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures.

Publication ,  Journal Article
Li, CY; Little, JB; Hu, K; Zhang, W; Zhang, L; Dewhirst, MW; Huang, Q
Published in: Cancer Res
January 15, 2001

A hallmark of cancer cells is their pronounced genetic instability, which has been implicated in both tumor development and negative treatment outcomes. Recently, it has been reported that ionizing radiation may induce a persistent state of hypermutability in mammalian cells that lasts for many (>30) cell divisions. In this study, we examined whether other stress signals (both DNA-damaging non-DNA-damaging) can initiate a similar process. We show that persistent genetic instability was induced by nongenotoxic stress exposures such as heat treatment, serum starvation, or the tumor microenvironment, as well as genotoxic stresses such as ionizing radiation and exposure to hydrogen peroxide. Progeny of 10-20% of surviving cells exhibited persistent and pronounced genetic instability at both an artificially transfected gene and a genomic minisatellite locus 23 cell divisions after the initial exposure. Stress-induced persistent genetic instability may be a general response of tumor cells to a wide range of genotoxic or nongenotoxic stress conditions.

Duke Scholars

Published In

Cancer Res

ISSN

0008-5472

Publication Date

January 15, 2001

Volume

61

Issue

2

Start / End Page

428 / 432

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Transfection
  • Oncology & Carcinogenesis
  • Microscopy, Fluorescence
  • Microsatellite Repeats
  • Mice, Inbred BALB C
  • Mice
  • Mammary Neoplasms, Animal
  • Luminescent Proteins
  • Hydrogen Peroxide
 

Citation

APA
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ICMJE
MLA
NLM
Li, C. Y., Little, J. B., Hu, K., Zhang, W., Zhang, L., Dewhirst, M. W., & Huang, Q. (2001). Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures. Cancer Res, 61(2), 428–432.
Li, C. Y., J. B. Little, K. Hu, W. Zhang, L. Zhang, M. W. Dewhirst, and Q. Huang. “Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures.Cancer Res 61, no. 2 (January 15, 2001): 428–32.
Li CY, Little JB, Hu K, Zhang W, Zhang L, Dewhirst MW, et al. Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures. Cancer Res. 2001 Jan 15;61(2):428–32.
Li, C. Y., et al. “Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures.Cancer Res, vol. 61, no. 2, Jan. 2001, pp. 428–32.
Li CY, Little JB, Hu K, Zhang W, Zhang L, Dewhirst MW, Huang Q. Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures. Cancer Res. 2001 Jan 15;61(2):428–432.

Published In

Cancer Res

ISSN

0008-5472

Publication Date

January 15, 2001

Volume

61

Issue

2

Start / End Page

428 / 432

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Transfection
  • Oncology & Carcinogenesis
  • Microscopy, Fluorescence
  • Microsatellite Repeats
  • Mice, Inbred BALB C
  • Mice
  • Mammary Neoplasms, Animal
  • Luminescent Proteins
  • Hydrogen Peroxide