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The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors.

Publication ,  Journal Article
Needham, D; Dewhirst, MW
Published in: Advanced drug delivery reviews
December 2001

Our laboratories have been working together in close collaboration for over 10 years concerning the design and performance of lipid-based drug delivery systems. Over the past 3 years we have conceived of, developed, and tested pre-clinically, a new liposome-based temperature-sensitive drug delivery system for the treatment of solid tumors. This work is reported in a series of four publications: "J. Liposome Res. 9 (1999) 491; Cancer Res. Adv. Brief 60(5) (2000) 1197; Cancer Res. 6(9) (2000) 748; and Cancer Res. 60 (2000) 6950". Following a brief introduction concerning the motivations behind the work, this article will review these studies, including some of our earlier work that led to these ideas, and will present the rational design of the new liposome formulation from a materials engineering perspective.

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Published In

Advanced drug delivery reviews

DOI

EISSN

1872-8294

ISSN

0169-409X

Publication Date

December 2001

Volume

53

Issue

3

Start / End Page

285 / 305

Related Subject Headings

  • Temperature
  • Pharmacology & Pharmacy
  • Liposomes
  • Lipid Bilayers
  • Humans
  • Drug Delivery Systems
  • Antineoplastic Agents
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

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Needham, D., & Dewhirst, M. W. (2001). The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors. Adv Drug Deliv Rev, 53(3), 285–305. https://doi.org/10.1016/s0169-409x(01)00233-2
Needham, D., and M. W. Dewhirst. “The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors.Adv Drug Deliv Rev 53, no. 3 (December 31, 2001): 285–305. https://doi.org/10.1016/s0169-409x(01)00233-2.
Needham, D., and M. W. Dewhirst. “The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors.Adv Drug Deliv Rev, vol. 53, no. 3, Dec. 2001, pp. 285–305. Pubmed, doi:10.1016/s0169-409x(01)00233-2.
Journal cover image

Published In

Advanced drug delivery reviews

DOI

EISSN

1872-8294

ISSN

0169-409X

Publication Date

December 2001

Volume

53

Issue

3

Start / End Page

285 / 305

Related Subject Headings

  • Temperature
  • Pharmacology & Pharmacy
  • Liposomes
  • Lipid Bilayers
  • Humans
  • Drug Delivery Systems
  • Antineoplastic Agents
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences