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Gene expression profiles of multiple breast cancer phenotypes and response to neoadjuvant chemotherapy.

Publication ,  Journal Article
Dressman, HK; Hans, C; Bild, A; Olson, JA; Rosen, E; Marcom, PK; Liotcheva, VB; Jones, EL; Vujaskovic, Z; Marks, J; Dewhirst, MW; West, M ...
Published in: Clin Cancer Res
February 1, 2006

PURPOSE: Breast cancer is a heterogeneous disease, and markers for disease subtypes and therapy response remain poorly defined. For that reason, we employed a prospective neoadjuvant study in locally advanced breast cancer to identify molecular signatures of gene expression correlating with known prognostic clinical phenotypes, such as inflammatory breast cancer or the presence of hypoxia. In addition, we defined molecular signatures that correlate with response to neoadjuvant chemotherapy. EXPERIMENTAL DESIGN: Tissue was collected under ultrasound guidance from patients with stage IIB/III breast cancer before four cycles of neoadjuvant liposomal doxorubicin paclitaxel chemotherapy combined with local whole breast hyperthermia. Gene expression analysis was done using Affymetrix U133 Plus 2.0 GeneChip arrays. RESULTS: Gene expression patterns were identified that defined the phenotypes of inflammatory breast cancer as well as tumor hypoxia. In addition, molecular signatures were identified that predicted the persistence of malignancy in the axillary lymph nodes after neoadjuvant chemotherapy. This persistent lymph node signature significantly correlated with disease-free survival in two separate large populations of breast cancer patients. CONCLUSIONS: Gene expression signatures have the capacity to identify clinically significant features of breast cancer and can predict which individual patients are likely to be resistant to neoadjuvant therapy, thus providing the opportunity to guide treatment decisions.

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Published In

Clin Cancer Res

DOI

ISSN

1078-0432

Publication Date

February 1, 2006

Volume

12

Issue

3 Pt 1

Start / End Page

819 / 826

Location

United States

Related Subject Headings

  • Survival Rate
  • Retrospective Studies
  • Prognosis
  • Phenotype
  • Oncology & Carcinogenesis
  • Oligonucleotide Array Sequence Analysis
  • Neoplasm Staging
  • Neoadjuvant Therapy
  • Humans
  • Gene Expression Profiling
 

Citation

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Dressman, H. K., Hans, C., Bild, A., Olson, J. A., Rosen, E., Marcom, P. K., … Blackwell, K. (2006). Gene expression profiles of multiple breast cancer phenotypes and response to neoadjuvant chemotherapy. Clin Cancer Res, 12(3 Pt 1), 819–826. https://doi.org/10.1158/1078-0432.CCR-05-1447
Dressman, Holly K., Christopher Hans, Andrea Bild, John A. Olson, Eric Rosen, P Kelly Marcom, Vlayka B. Liotcheva, et al. “Gene expression profiles of multiple breast cancer phenotypes and response to neoadjuvant chemotherapy.Clin Cancer Res 12, no. 3 Pt 1 (February 1, 2006): 819–26. https://doi.org/10.1158/1078-0432.CCR-05-1447.
Dressman HK, Hans C, Bild A, Olson JA, Rosen E, Marcom PK, et al. Gene expression profiles of multiple breast cancer phenotypes and response to neoadjuvant chemotherapy. Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):819–26.
Dressman, Holly K., et al. “Gene expression profiles of multiple breast cancer phenotypes and response to neoadjuvant chemotherapy.Clin Cancer Res, vol. 12, no. 3 Pt 1, Feb. 2006, pp. 819–26. Pubmed, doi:10.1158/1078-0432.CCR-05-1447.
Dressman HK, Hans C, Bild A, Olson JA, Rosen E, Marcom PK, Liotcheva VB, Jones EL, Vujaskovic Z, Marks J, Dewhirst MW, West M, Nevins JR, Blackwell K. Gene expression profiles of multiple breast cancer phenotypes and response to neoadjuvant chemotherapy. Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):819–826.

Published In

Clin Cancer Res

DOI

ISSN

1078-0432

Publication Date

February 1, 2006

Volume

12

Issue

3 Pt 1

Start / End Page

819 / 826

Location

United States

Related Subject Headings

  • Survival Rate
  • Retrospective Studies
  • Prognosis
  • Phenotype
  • Oncology & Carcinogenesis
  • Oligonucleotide Array Sequence Analysis
  • Neoplasm Staging
  • Neoadjuvant Therapy
  • Humans
  • Gene Expression Profiling